Benzilpiperazin

Benzilpiperazin
(IUPAC) ime
	1-benzilpiperazin
Klinički podaci
Identifikatori
CAS broj	2759-28-6
ATC kod	nije dodeljen
PubChem	75994
ChemSpider	68493
ChEMBL	CHEMBL113600
Hemijski podaci
Formula	C11H16N2
Mol. masa	176,258 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C11H16N2/c1-2-4-11(5-3-1)10-13-8-6-12-7-9-13/h1-5,12H,6-10H2 ; Key: IQXXEPZFOOTTBA-UHFFFAOYSA-N
Farmakokinetički podaci
Bioraspoloživost	Nepoznata
Metabolizam	Hepatički
Poluvreme eliminacije	5,5 sata
Izlučivanje	Renalno
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	POM (UK) Schedule I (SAD) Klasa C u Nevom Zelandu. Legalan u nekim zemljama
Način primene	Oralno, intravenozno, insuflacija

Benzilpiperazin (BZP) je rekreaciona droga sa euforičnim, stimulansnim svojstvima. BZIP dejstvo je slično sa amfetaminom. Nepoželjne nuspojave su primećene. U nih se ubrajaju akutna psihoza, renalna toksičnost, i epileptički napadi.^[6] Smrtni slučajevi nisu registrovani kao posledica njegove pojedinačne primene, mada je belo smrtnih slučajeva usled korištenja kombinacije BZP i MDMA. Njegova prodaja je zabranjena u više zemalja, uključujući Australiju, Novi Zeland, SAD, Irsku, Ujedinjeno Kraljevstvo, i delove Evrope.^[7]^[8] Njegov pravni status je manje ograničen u drugim zemljama, kao što je Kanada.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Antia U, Lee HS, Kydd RR, Tingle MD, Russell BR (April 2009). „Pharmacokinetics of 'party pill' drug N-benzylpiperazine (BZP) in healthy human participants”. Forensic Sci. Int. 186 (1–3): 63–7. DOI:10.1016/j.forsciint.2009.01.015. PMID 19261399.
↑ Schep LJ, Slaughter RJ, Vale JA, Beasley DM, Gee P (March 2011). „The clinical toxicology of the designer "party pills" benzylpiperazine and trifluoromethylphenylpiperazine”. Clin Toxicol (Phila) 49 (3): 131–41. DOI:10.3109/15563650.2011.572076. PMID 21495881.
↑ Topping, Alexandra (18. 6. 2007.). „Legal dance drug faces ban amid fears over side-effects”. The Guardian. Pristupljeno 26. 05. 2008.
↑ Examiner (18. 6. 2007.). „Harney announces ban on stimulant BZP”. The Irish Examiner. Arhivirano iz originala na datum 2009-04-06. Pristupljeno 28. 12. 2009.

Povezano

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] Antia U, Lee HS, Kydd RR, Tingle MD, Russell BR (April 2009). „Pharmacokinetics of 'party pill' drug N-benzylpiperazine (BZP) in healthy human participants”. Forensic Sci. Int. 186 (1–3): 63–7. DOI:10.1016/j.forsciint.2009.01.015. PMID 19261399.

[Schep2011-6] Schep LJ, Slaughter RJ, Vale JA, Beasley DM, Gee P (March 2011). „The clinical toxicology of the designer "party pills" benzylpiperazine and trifluoromethylphenylpiperazine”. Clin Toxicol (Phila) 49 (3): 131–41. DOI:10.3109/15563650.2011.572076. PMID 21495881.

[7] Topping, Alexandra (18. 6. 2007.). „Legal dance drug faces ban amid fears over side-effects”. The Guardian. Pristupljeno 26. 05. 2008.

[8] Examiner (18. 6. 2007.). „Harney announces ban on stimulant BZP”. The Irish Examiner. Arhivirano iz originala na datum 2009-04-06. Pristupljeno 28. 12. 2009.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]