Ksilamidin

Ksilamidin
(IUPAC) ime
	N'-[2-(3-methoxyphenoxy)propyl]-2-(3-methylphenyl)ethanimidamide
Klinički podaci
Identifikatori
CAS broj	6443-50-1
ATC kod	nije dodeljen
PubChem	22951
Hemijski podaci
Formula	C19H24N2O2
Mol. masa	312.406 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C19H24N2O2/c1-14-6-4-7-16(10-14)11-19(20)21-13-15(2)23-18-9-5-8-17(12-18)22-3/h4-10,12,15H,11,13H2,1-3H3,(H2,20,21) ; Key: JRYTUFKIORWTNI-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Ksilamidin je lek koji deluje kao antagonist 5HT_2A receptora, i u manjoj meri 5HT_1A receptora. On ne prelazi krvno moždanu barijeru iz kog razloga je koristan za blokiranje perifernih serotonergijskih responsa poput kardiovaskularnog^[3]^[4] i gastrointestinalnog dejstva,^[5] bez proizvođenja centralnih efekata 5HT_2A blokade kao što je sedacija, ili ometanja centralno delujućih 5HT_2A agonista.^[6]

Literatura

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Fuller, RW; Kurz, KD; Mason, NR; Cohen, ML (1986). „Antagonism of a peripheral vascular but not an apparently central serotonergic response by xylamidine and BW 501C67”. European journal of pharmacology 125 (1): 71–7. PMID 3732393.
↑ Dedeoğlu, A; Fisher, LA (1991). „Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms”. The Journal of pharmacology and experimental therapeutics 259 (3): 1027–34. PMID 1762059.
↑ Baker, BJ; Duggan, JP; Barber, DJ; Booth, DA (1988). „Effects of dl-fenfluramine and xylamidine on gastric emptying of maintenance diet in freely feeding rats”. European journal of pharmacology 150 (1-2): 137–42. PMID 3402534.
↑ Dave, KD; Quinn, JL; Harvey, JA; Aloyo, VJ (2004). „Role of central 5-HT2 receptors in mediating head bobs and body shakes in the rabbit”. Pharmacology, biochemistry, and behavior 77 (3): 623–9. DOI:10.1016/j.pbb.2003.12.017. PMID 15006475.

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