Setiptilin

Setiptilin
(IUPAC) ime
	2-metil-2,3,4,9-tetrahidro-1H-dibenzo[3,4:6,7]ciklohepta[1,2-c]piridin
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	57262-94-9
ATC kod	nije dodeljen
PubChem	5205
ChemSpider	5016
UNII	7L38105Z6E
KEGG	D08511
Hemijski podaci
Formula	C19H19N
Mol. masa	261,36 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C19H19N/c1-20-11-10-18-16-8-4-2-6-14(16)12-15-7-3-5-9-17(15)19(18)13-20/h2-9H,10-13H2,1H3 ; Key: GVPIXRLYKVFFMK-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	℞ Prescription only
Način primene	Oralno

Setiptilin (Tecipul, teciptilin) je tetraciklični antidepresiv (TeCA) koji deluje kao noradrenergički i specifični serotonergički antidepresiv (NaSSA). Kompanija Močida ga je plasirala na tržište 1989. godine kao lek za tretman depresije u Japanu.^[5]^[6]

Hemija

Setiptilin sadrži tetracikličnu strukturu. On je analog mijanserina i mirtazapina. Setiptilin je delta(13b,4a),4a-karba-mianserin, dok je mirtazapin 6-aza-mianserin.

Farmakologija

Setiptilin deluje kao inhibitor preuzimanja norepinefrina,^[7] antagonist α₂-adrenergičkog receptora,^[8] i antagonist serotoninskih receptora,^[9] 5-HT_2A, 5-HT_2C, i/ili 5-HT₃, kao i inverzni agonist H₁ receptor.^[7]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Buschmann, H.; Torrens, A.; Vela, J. M. (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. 1. Wiley VCH. str. 248. ISBN 978-3-527-31058-6. ^{[mrtav link]}
↑ Swiss Pharmaceutical Society, ur. (2000). Index Nominum 2000: International Drug Directory. Medpharm Scientific Publishers. str. 942. ISBN 978-3-88763-075-1.
↑ ^7,0 ^7,1 Niho, T.; Ito, C.; Shibutani, Y.; Hashizume, H.; Yamaguchi, K. (1986). „Pharmacological Properties of MO-8282, a Novel Antidepressant”. Nihon yakurigaku zasshi. Folia Pharmacologica Japonica 88 (4): 309-320. PMID 3792961.
↑ Mizota, M.; Oikawa, Y.; Nakayama, K.; Mizuguchi, K.; Takarada, T.; Kojima, M.; Kanehiro, H.; Funato, H. i dr.. (1986). „Pharmacological Studies of MO-8282, a New Antidepressant”. Nihon yakurigaku zasshi. Folia Pharmacologica Japonica 88 (6): 457-466. PMID 2881854.
↑ Przegaliński, E.; Baran, L.; Siwanowicz, J.; Rawłów, A. (1986). „The Lack of Antidepressant Properties and a Potent Central Antiserotonin Activity of Org 8282”. Polish Journal of Pharmacology and Pharmacy 38 (4): 377-384. PMID 3774630.

Literatura

Buschmann, H.; Torrens, A.; Vela, J. M. (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. 1. Wiley VCH. str. 248. ISBN 978-3-527-31058-6. ^{[mrtav link]}

Povezano

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Buschmann, H.; Torrens, A.; Vela, J. M. (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. 1. Wiley VCH. str. 248. ISBN 978-3-527-31058-6. ^{[mrtav link]}

[IndexNominum-6] Swiss Pharmaceutical Society, ur. (2000). Index Nominum 2000: International Drug Directory. Medpharm Scientific Publishers. str. 942. ISBN 978-3-88763-075-1.

[pmid3792961-7] 7,0 ^7,1 Niho, T.; Ito, C.; Shibutani, Y.; Hashizume, H.; Yamaguchi, K. (1986). „Pharmacological Properties of MO-8282, a Novel Antidepressant”. Nihon yakurigaku zasshi. Folia Pharmacologica Japonica 88 (4): 309-320. PMID 3792961.

[8] Mizota, M.; Oikawa, Y.; Nakayama, K.; Mizuguchi, K.; Takarada, T.; Kojima, M.; Kanehiro, H.; Funato, H. i dr.. (1986). „Pharmacological Studies of MO-8282, a New Antidepressant”. Nihon yakurigaku zasshi. Folia Pharmacologica Japonica 88 (6): 457-466. PMID 2881854.

[9] Przegaliński, E.; Baran, L.; Siwanowicz, J.; Rawłów, A. (1986). „The Lack of Antidepressant Properties and a Potent Central Antiserotonin Activity of Org 8282”. Polish Journal of Pharmacology and Pharmacy 38 (4): 377-384. PMID 3774630.

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