2-Aminotetralin

2-Aminotetralin
(IUPAC) ime
	1,2,3,4-tetrahidronaftalen-2-amin
Klinički podaci
Identifikatori
CAS broj	2954-50-9
ATC kod	nije dodeljen
PubChem	34677
ChemSpider	31912
ChEMBL	CHEMBL30294
Hemijski podaci
Formula	C10H13N
Mol. masa	147,217 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C10H13N/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-4,10H,5-7,11H2 ; Key: LCGFVWKNXLRFIF-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Nije kontrolisana supstanca
Način primene	Oralno

'2-Aminotetralin (2-AT, 1,2,3,4-tetrahidronaftalen-2-amin, THN) je stimulansni lek. Njegova hemijska struktura se sastoji od tetralinske grupe sa aminskim supstituentom.^[5]^[6]

2-AT je krut analog fenilizobutilamina. On potpuno zamenjuje d-amfetamin u testovima diskriminacije na pacovima, mada ima jednu osminu potentnosti.^[5] Pokazano je da inhibira ponovno preuzimanje serotonina i norepinefrina, te da verovatno indukuje njihovo otpuštanje.^[7]^[8] Verovatno je da ima uticaja na dopamin jer potpuno zamenjuje d-amfetamin u studijama na glodarima.^[5]

Hemijski derivati

Postoji znatan broj derivata 2-aminotetralina, među kojima su:

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ ^5,0 ^5,1 ^5,2 Oberlender R, Nichols DE. (1991). „Structural variation and (+)-amphetamine-like discriminative stimulus properties.”. Pharmacol Biochem Behav. 38 (3): 581–586. DOI:10.1016/0091-3057(91)90017-V. PMID 2068194.
↑ Marley E, Stephenson JD (August 1971). „Actions of dexamphetamine and amphetamine-like amines in chickens with brain transections”. British Journal of Pharmacology 42 (4): 522–42. PMC 1665761. PMID 5116035.
↑ Bruinvels J (June 1971). „Evidence for inhibition of the reuptake of 5-hydroxytryptamine and noradrenaline by tetrahydronaphthylamine in rat brain”. British Journal of Pharmacology 42 (2): 281–6. PMC 1667157. PMID 5091160.
↑ Bruinvels J, Kemper GC (September 1971). „Role of noradrenaline and 5-hydroxytryptamine in tetrahydronaphthylamine-induced temperature changes in the rat”. British Journal of Pharmacology 43 (1): 1–9. PMC 1665934. PMID 4257629.

Povezano

Spoljašnje veze

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid2068194-5] 5,0 ^5,1 ^5,2 Oberlender R, Nichols DE. (1991). „Structural variation and (+)-amphetamine-like discriminative stimulus properties.”. Pharmacol Biochem Behav. 38 (3): 581–586. DOI:10.1016/0091-3057(91)90017-V. PMID 2068194.

[pmid5116035-6] Marley E, Stephenson JD (August 1971). „Actions of dexamphetamine and amphetamine-like amines in chickens with brain transections”. British Journal of Pharmacology 42 (4): 522–42. PMC 1665761. PMID 5116035.

[pmid5091160-7] Bruinvels J (June 1971). „Evidence for inhibition of the reuptake of 5-hydroxytryptamine and noradrenaline by tetrahydronaphthylamine in rat brain”. British Journal of Pharmacology 42 (2): 281–6. PMC 1667157. PMID 5091160.

[pmid4257629-8] Bruinvels J, Kemper GC (September 1971). „Role of noradrenaline and 5-hydroxytryptamine in tetrahydronaphthylamine-induced temperature changes in the rat”. British Journal of Pharmacology 43 (1): 1–9. PMC 1665934. PMID 4257629.

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