Izamoltan

Izamoltan
(IUPAC) ime
	1-(propan-2-ilamino)-3-(2-pirol-1-ilfenoksi)propan-2-ol
Klinički podaci
Identifikatori
CAS broj	99740-06-4
ATC kod	nije dodeljen
PubChem	127403
ChemSpider	113051
Hemijski podaci
Formula	C16H22N2O2
Mol. masa	274,357 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C16H22N2O2/c1-13(2)17-11-14(19)12-20-16-8-4-3-7-15(16)18-9-5-6-10-18/h3-10,13-14,17,19H,11-12H2,1-2H3 ; Key: XVTVPGKWYHWYAD-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Izamoltan (CGP-361A) je lek koji se koristi u naučnim istraživanjima. On deluje kao antagonist β-adrenergičkog, 5-HT_1A, i 5-HT_1B receptora. On je oko pet puta potentniji na 5-HT_1B receptoru (21 nmol/l) u odnosu na 5-HT_1A receptor (112 nmol/l).^[4] On ima anksiolitičko dejstvo na glodarima.^[5]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Rényi L, Larsson LG, Berg S, Svensson BE, Thorell G, Ross SB. (1991). „Biochemical and behavioural effects of isamoltane, a beta-adrenoceptor antagonist with affinity for the 5-HT1B receptor of rat brain.”. Naunyn Schmiedebergs Arch Pharmacol. 343 (1): 1–6. PMID 1674359.
↑ Waldmeier PC, Williams M, Baumann PA, Bischoff S, Sills MA, Neale RF. (1988). „Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with 5-HT1 receptor subtypes in the rat brain.”. Naunyn Schmiedebergs Arch Pharmacol. 337 (6): 609–620. PMID 2905765.

	Portal Medicina
	Portal Hemija