Atiprosin

Atiprosin
(IUPAC) ime
	(4aR,12bS)-1-etil-12-metil-4-(propan-2-il)-1,2,3,4,4a,5,6,12b-oktahidropirazino[2',3':3,4]pirido[1,2-a]indol
Klinički podaci
Identifikatori
CAS broj	89303-63-9
ATC kod	nije dodeljen
PubChem	71770
ChemSpider	64808
UNII	ALS52889WF
Hemijski podaci
Formula	C20H29N3
Mol. masa	311,46 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C20H29N3/c1-5-21-12-13-22(14(2)3)18-10-11-23-17-9-7-6-8-16(17)15(4)19(23)20(18)21/h6-9,14,18,20H,5,10-13H2,1-4H3/t18-,20+/m1/s1 ; Key: WXNVFYIBELASJW-QUCCMNQESA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Nije kontrolisan
Način primene	Oralno

Atiprosin (AY-28,228) je antihipertenzivni lek koji se koristi kao selektivni antagonist α₁-adrenergičkog receptora.^[4]^[5]^[6]^[7] On takođe poseduje izvesnu antihistaminsku aktivnost, mada je ona slaba.^[6] On nije plasiran na tržište.^[4]

Sinteza

Jedan od mogućih sintetičkih puteva je^[8]:

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ ^4,0 ^4,1 Triggle, David J. (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.
↑ Jirkovsky I, Santroch G, Baudy R, Oshiro G (February 1987). „Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents”. Journal of Medicinal Chemistry 30 (2): 388–94. DOI:10.1021/jm00385a022. PMID 3806618.
↑ ^6,0 ^6,1 Grimes D, Rimele TJ, Henry DE, et al. (September 1987). „In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound”. Journal of Cardiovascular Pharmacology 10 (3): 249–58. DOI:10.1097/00005344-198709000-00001. PMID 2444771.
↑ Oshiro G, Wojdan A, Klein M, Metcalf G (September 1987). „Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys”. Journal of Cardiovascular Pharmacology 10 (3): 341–9. DOI:10.1097/00005344-198709000-00014. PMID 2444784.
↑ Jirkovsky, Ivo; George Santroch, Reinhardt Baudy, George Oshiro (1987). „Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents”. Journal of Medical Chemistry 30 (2): 388–394. DOI:10.1021/jm00385a022. PMID 3806618.

Povezano

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[isbn0-412-46630-9-4] 4,0 ^4,1 Triggle, David J. (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.

[pmid3806618-5] Jirkovsky I, Santroch G, Baudy R, Oshiro G (February 1987). „Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents”. Journal of Medicinal Chemistry 30 (2): 388–94. DOI:10.1021/jm00385a022. PMID 3806618.

[pmid2444771-6] 6,0 ^6,1 Grimes D, Rimele TJ, Henry DE, et al. (September 1987). „In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound”. Journal of Cardiovascular Pharmacology 10 (3): 249–58. DOI:10.1097/00005344-198709000-00001. PMID 2444771.

[pmid2444784-7] Oshiro G, Wojdan A, Klein M, Metcalf G (September 1987). „Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys”. Journal of Cardiovascular Pharmacology 10 (3): 341–9. DOI:10.1097/00005344-198709000-00014. PMID 2444784.

[8] Jirkovsky, Ivo; George Santroch, Reinhardt Baudy, George Oshiro (1987). „Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents”. Journal of Medical Chemistry 30 (2): 388–394. DOI:10.1021/jm00385a022. PMID 3806618.

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