Aminoreks

Aminoreks
(IUPAC) ime
	(RS)-5-fenil-4,5-dihidro-1,3-oksazol-2-amin
Klinički podaci
Identifikatori
CAS broj	2207-50-3
ATC kod	nije dodeljen
PubChem	16630
DrugBank	DB01490
ChemSpider	15767
UNII	2SH16612I9
KEGG	D02909
ChEMBL	CHEMBL106258
Hemijski podaci
Formula	C9H10N2O
Mol. masa	162.19
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C9H10N2O/c10-9-11-6-8(12-9)7-4-2-1-3-5-7/h1-5,8H,6H2,(H2,10,11) ; Key: SYAKTDIEAPMBAL-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Schedule III (CA) Schedule I (SAD)

Aminoreks (Menocil, Apihel, aminoksafen, aminoksafen, McN-742) je anoreksni stimulans iz 2-amino-5-aril oksazolinske klase koji je razvijen 1962.^[6] On je blisko srodan sa 4-metilaminoreksom. Pokazano je da aminoreks deluje lokomotorni stimulans, koji je po jačini između dekstroamfetamina i metamfetamina. Smatra se da je dejstvo aminoreksa posledica oslobađanja kateholamina.^[7] Lek je povučen sa tržišta nakon što je utvrđeno da proizvodi plućnu hipertenziju.^[8]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ US Patent 3161650 - 2-Amino-5-Aryloxazoline Products
↑ Fishman AP. (Jan 1991). „Aminorex to fen/phen - An epidemic foretold”. Circulation 99 (1): 156–161. DOI:10.1161/01.CIR.99.1.156. ISSN 0009-7322. PMID 9884392.
↑ Gaine SP, Rubin LJ, Kmetzo JJ, Palevsky HI, Traill TA (November 2000). „Recreational use of aminorex and pulmonary hypertension”. Chest 118 (5): 1496–7. DOI:10.1378/chest.118.5.1496. PMID 11083709. Arhivirano iz originala na datum 2013-01-12. Pristupljeno 2014-04-05.

Povezano

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] US Patent 3161650 - 2-Amino-5-Aryloxazoline Products

[pmid9884392-7] Fishman AP. (Jan 1991). „Aminorex to fen/phen - An epidemic foretold”. Circulation 99 (1): 156–161. DOI:10.1161/01.CIR.99.1.156. ISSN 0009-7322. PMID 9884392.

[pmid11083709-8] Gaine SP, Rubin LJ, Kmetzo JJ, Palevsky HI, Traill TA (November 2000). „Recreational use of aminorex and pulmonary hypertension”. Chest 118 (5): 1496–7. DOI:10.1378/chest.118.5.1496. PMID 11083709. Arhivirano iz originala na datum 2013-01-12. Pristupljeno 2014-04-05.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]