Dinapsolin

Dinapsolin
(IUPAC) ime
	8,9-dihidroksi-2,3,7,11b-tetrahidro-1H-naf[1,2,3-de]izohinolin
Klinički podaci
Identifikatori
CAS broj	458563-40-1
ATC kod	nije dodeljen
PubChem	9816455
Hemijski podaci
Formula	C16H15NO2
Mol. masa	253,295 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C16H15NO2/c18-14-5-4-11-12(16(14)19)6-9-2-1-3-10-7-17-8-13(11)15(9)10/h1-5,13,17-19H,6-8H2/t13-/m0/s1 ; Key: ZQTSNGJHMUKLOM-ZDUSSCGKSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Dinapsolin je lek koji je razvijen za treatman Parkinsonove bolesti.^[3] On deluje kao selektivni puni agonist dopaminskog D₁ receptora.^[4]^[5]^[6]^[7]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gulwadi AG, Korpinen CD, Mailman RB, Nichols DE, Sit SY, Taber MT (February 2001). „Dinapsoline: characterization of a D1 dopamine receptor agonist in a rat model of Parkinson's disease”. The Journal of Pharmacology and Experimental Therapeutics 296 (2): 338–44. PMID 11160615.
↑ Ghosh D, Snyder SE, Watts VJ, Mailman RB, Nichols DE (January 1996). „9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore”. Journal of Medicinal Chemistry 39 (2): 549–55. DOI:10.1021/jm950707. PMID 8558526.
↑ Sit SY, Xie K, Jacutin-Porte S, Taber MT, Gulwadi AG, Korpinen CD, Burris KD, Molski TF, Ryan E, Xu C, Wong H, Zhu J, Krishnananthan S, Gao Q, Verdoorn T, Johnson G (August 2002). „(+)-Dinapsoline: an efficient synthesis and pharmacological profile of a novel dopamine agonist”. Journal of Medicinal Chemistry 45 (17): 3660–8. DOI:10.1021/jm0101545. PMID 12166939.
↑ Sit SY, Xie K, Jacutin-Porte S, Boy KM, Seanz J, Taber MT, Gulwadi AG, Korpinen CD, Burris KD, Molski TF, Ryan E, Xu C, Verdoorn T, Johnson G, Nichols DE, Mailman RB (February 2004). „Synthesis and SAR exploration of dinapsoline analogues”. Bioorg. Med. Chem. 12 (4): 715–34. DOI:10.1016/j.bmc.2003.11.015. PMID 14759732.
↑ Gleason SD, Witkin JM (May 2006). „Effects of dopamine D1 receptor agonists in rats trained to discriminate dihydrexidine”. Psychopharmacology (Berl.) 186 (1): 25–31. DOI:10.1007/s00213-006-0342-2. PMID 16575553.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[pmid11160615-3] Gulwadi AG, Korpinen CD, Mailman RB, Nichols DE, Sit SY, Taber MT (February 2001). „Dinapsoline: characterization of a D1 dopamine receptor agonist in a rat model of Parkinson's disease”. The Journal of Pharmacology and Experimental Therapeutics 296 (2): 338–44. PMID 11160615.

[pmid8558526-4] Ghosh D, Snyder SE, Watts VJ, Mailman RB, Nichols DE (January 1996). „9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore”. Journal of Medicinal Chemistry 39 (2): 549–55. DOI:10.1021/jm950707. PMID 8558526.

[pmid12166939-5] Sit SY, Xie K, Jacutin-Porte S, Taber MT, Gulwadi AG, Korpinen CD, Burris KD, Molski TF, Ryan E, Xu C, Wong H, Zhu J, Krishnananthan S, Gao Q, Verdoorn T, Johnson G (August 2002). „(+)-Dinapsoline: an efficient synthesis and pharmacological profile of a novel dopamine agonist”. Journal of Medicinal Chemistry 45 (17): 3660–8. DOI:10.1021/jm0101545. PMID 12166939.

[pmid14759732-6] Sit SY, Xie K, Jacutin-Porte S, Boy KM, Seanz J, Taber MT, Gulwadi AG, Korpinen CD, Burris KD, Molski TF, Ryan E, Xu C, Verdoorn T, Johnson G, Nichols DE, Mailman RB (February 2004). „Synthesis and SAR exploration of dinapsoline analogues”. Bioorg. Med. Chem. 12 (4): 715–34. DOI:10.1016/j.bmc.2003.11.015. PMID 14759732.

[pmid16575553-7] Gleason SD, Witkin JM (May 2006). „Effects of dopamine D1 receptor agonists in rats trained to discriminate dihydrexidine”. Psychopharmacology (Berl.) 186 (1): 25–31. DOI:10.1007/s00213-006-0342-2. PMID 16575553.

[1]

[2]

[3]

[4]

[5]

[6]

[7]