Amitriptilin

Amitriptilin
(IUPAC) ime
	3-(10,11-dihidro-5H-dibenzo[a,d]ciklohepten-5-iliden)-N,N-dimetilpropan-1-amin
Klinički podaci
Robne marke	Triptomer, Elavil
AHFS/Drugs.com	Monografija
MedlinePlus	a682388
Identifikatori
CAS broj	50-48-6 ; 549-18-8 (hidrohlorid)
ATC kod	N06AA09
PubChem	2160
DrugBank	DB00321
ChemSpider	2075
UNII	1806D8D52K
KEGG	D07448
ChEBI	CHEBI:2666
ChEMBL	CHEMBL629
Hemijski podaci
Formula	C20H23N
Mol. masa	277,403 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3 ; Key: KRMDCWKBEZIMAB-UHFFFAOYSA-N
Farmakokinetički podaci
Bioraspoloživost	30–60% usled metabolizma prvog prolaza
Vezivanje za proteine plazme	> 90%
Metabolizam	Hepatički; CYP2C19, CYP1A2, CYP2D6
Poluvreme eliminacije	10–50 sata, sa prosekom od 15 sata
Izlučivanje	Renalno
Farmakoinformacioni podaci
Trudnoća	D(US)
Pravni status	℞ Prescription only
Način primene	Oralno

Amitriptilin (Triptomer, Elavil, Triptizol, Laroksil, Saroten, Saroteks, Lentizol, Endep) je triciklični antidepresiv (TCA).^[6]^[7] On je najšire korišćeni TCA i jednako je efikasan protiv depresije kao i novija klasa SSRI lekova.^[8] Osim redukovanja simptoma depresije, on olakšava migrene, glavobolje usled napetosti, napade anksioznosti i neke od simptoma šizofrenije. Takođe je poznato da redukuje agresivno i nasilno ponašanje. Neželjena dejstva uključuju: Sedaciju, konfuziju, motornu inkoordinaciju, suva usta, zamućenje vida, posturalna hipotenzija, snižavanje praga konvulzivne aktivnosti, rizik od iznenadne srčane smrti ^[9]

Povezano

Triciklični antidepresivi

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
↑ Pdr Staff (2009). PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr)). Rozelle, N.S.W: Thomson Reuters. ISBN 1-56363-748-0.
↑ Barbui C, Hotopf M (February 2001). „Amitriptyline v. the rest: still the leading antidepressant after 40 years of randomised controlled trials”. The British Journal of Psychiatry : the Journal of Mental Science 178 (2): 129–144. DOI:10.1192/bjp.178.2.129. PMID 11157426.
↑ James M. Rittter; Rod Flower; Graeme Henderson; Yoon Kong Loke; Humphrey P. Rang. Rang & Dale's Pharmacology (9th izd.). str. 603 - 621.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

PubChem Substance Summary: Amitriptyline National Center for Biotechnology Information.
TREPILINE-10 TABLETS; TREPILINE-25 TABLETS South African Electronic Package Inserts. 12 May 1978. Revised February 2004.
AMITRIP Amitriptyline hydrochloride 10 mg, 25 mg and 50 mg Capsules Medsafe NZ Physician Data Sheet. November 2004.
Endep Consumer Medicine Information Arhivirano 2008-06-25 na Wayback Machine-u, Australia. December 2005.
MedlinePlus Drug Information: Amitriptyline. US National Institutes of Health. January 2008.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[Goodman_Gilman-6] Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.

[PDR-7] Pdr Staff (2009). PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr)). Rozelle, N.S.W: Thomson Reuters. ISBN 1-56363-748-0.

[pmid11157426-8] Barbui C, Hotopf M (February 2001). „Amitriptyline v. the rest: still the leading antidepressant after 40 years of randomised controlled trials”. The British Journal of Psychiatry : the Journal of Mental Science 178 (2): 129–144. DOI:10.1192/bjp.178.2.129. PMID 11157426.

[9] James M. Rittter; Rod Flower; Graeme Henderson; Yoon Kong Loke; Humphrey P. Rang. Rang & Dale's Pharmacology (9th izd.). str. 603 - 621.

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