BP202T - Pharmaceutical Organic Chemistry I - Theory

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FACULTY OF PHARMACY

Second Semester Bachelor of Pharmacy


In Effect from Academic Year 2017-18

Subject Code: BP202T. Subject Title: Pharmaceutical Organic Chemistry I - Theory


Pre-requisite Subject - NONE -

Scope: This subject deals with classification and nomenclature of simple organic compounds, structural
isomerism, intermediates forming in reactions, important physical properties, reactions and methods of
preparation of these compounds. The syllabus also emphasizes on mechanisms and orientation of reactions.
Objectives:
Upon completion of the course the student shall be able to
1. Write the structure, name and the type of isomerism of the organic compound
2. Write the reaction, name the reaction and orientation of reactions
3. Account for reactivity/stability of compounds,
4. Identify/confirm the identification of organic compound

Teaching Scheme (Hours per week) Evaluation Scheme (Marks)


Theory(T)
Total Marks
Lecture Tutorial Practical Credit University Continuous
Assessment Assessment Theory
3 1 NA 4 75 25 100

Subject Contents
Total Weight
Sr.
Topic Hours (%)
No.
(45 hours)
General methods of preparation and reactions of compounds superscripted with asterisk (*) to be explained.
To emphasize on definition, types, classification, principles/mechanisms, applications, examples and
differences.
UNIT-I
 Classification, nomenclature and isomerism
Classification of Organic Compounds
1 07 15
Common and IUPAC systems of nomenclature of organic compounds
(up to 10 Carbons open chain and carbocyclic compounds), Structural
isomerisms in organic compounds
UNIT-II
 Alkanes*, Alkenes* and Conjugated dienes*
SP3 hybridization in alkanes, Halogenation of alkanes, uses of paraffins.
Stabilities of alkenes, SP2 hybridization in alkenes
2 E1 and E2 reactions – kinetics, order of reactivity of alkyl halides, 10 22
rearrangement of carbocations, Saytzeffs orientation and evidences. E1 verses
E2 reactions, Factors affecting E1 and E2 reactions. Ozonolysis, electrophilic
addition reactions of alkenes, Markownikoff’s orientation, free radical addition
reactions of alkenes, Anti Markownikoff’s orientation.
FACULTY OF PHARMACY
Second Semester Bachelor of Pharmacy
In Effect from Academic Year 2017-18

Stability of conjugated dienes, Diel-Alder, electrophilic addition, free radical


addition reactions of conjugated dienes, allylic rearrangement
UNIT-III
 Alkyl halides*
 SN1 and SN2 reactions - kinetics, order of reactivity of alkyl halides,
stereochemistry and rearrangement of carbocations.
 SN1 versus SN2 reactions, Factors affecting SN1 and SN2 reactions
3  Structure and uses of ethylchloride, Chloroform, trichloroethylene, 10 22
tetrachloroethylene, dichloromethane, tetrachloromethane and
iodoform.
 Alcohols*- Qualitative tests, Structure and uses of Ethyl alcohol, Methyl
alcohol, chlorobutanol, Cetosteryl alcohol, Benzyl alcohol, Glycerol,
Propylene glycol
UNIT IV
 Carbonyl compounds* (Aldehydes and ketones)
Nucleophilic addition, Electromeric effect, aldol condensation, Crossed Aldol
4 condensation, Cannizzaro reaction, Crossed Cannizzaro reaction, Benzoin 10 22
condensation, Perkin condensation, qualitative tests, Structure and uses of
Formaldehyde, Paraldehyde, Acetone, Chloral hydrate, Hexamine,
Benzaldehyde, Vanilin, Cinnamaldehyde
UNIT V
 Carboxylic acids*
Acidity of carboxylic acids, effect of substituents on acidity, inductive effect
and qualitative tests for carboxylic acids ,amide and ester.
5 Structure and Uses of Acetic acid, Lactic acid, Tartaric acid, Citric acid, 08 19
Succinic acid. Oxalic acid, Salicylic acid, Benzoic acid, Benzyl benzoate,
Dimethyl phthalate, Methyl salicylate and Acetyl salicylic acid
 Aliphatic amines* - Basicity, effect of substituent on Basicity. Qualitative
test, Structure and uses of Ethanolamine, Ethylenediamine, Amphetamine

Recommended Books: (Latest Editions)

1. Organic Chemistry by Morrison and Boyd


2. Organic Chemistry by I.L. Finar , Volume-I
3. Textbook of Organic Chemistry by B.S. Bahl & Arun Bahl.
4. Organic Chemistry by P.L.Soni
5. Practical Organic Chemistry byMann and Saunders.
6. Vogel’s text book of Practical Organic Chemistry
7. Advanced Practical organic chemistry by N.K.Vishnoi.
8. Introduction to Organic Laboratory techniques by Pavia, Lampman and Kriz.
9. Reaction and reaction mechanism by Ahluwaliah/Chatwal.

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