Chem Sem 4

BSC.

(PHYSICAL SCIENCES)- CHEMISTRY COMPONENT

SEMESTER - IV
DISCIPLINE SPECIFIC CORE COURSE CHEM-DSC -10: Chemistry- IV: Chemistry of

Carboxylic Acids & their Derivatives, Amines and Heterocycles
CREDIT DISTRIBUTION, ELIGIBILITY AND PRE-REQUISITES OF THE COURSE
Course title Credits Credit distribution of the Eligibility Pre-

& Code course criteria requisite
Lecture Tutorial Practical/ of the
Practice course
(if any)
Chemistry 04 02 - 02 Class 12th
of with Physics,
Carboxylic Chemistry,
Acids & Mathematics
their
Derivatives,
Amines and
Heterocycles
DSC-10:
Chemistry-
IV
Learning Objectives
The Learning Objectives of this course are as follows:

• To make students learn about the chemistry of carboxylic acids and their derivatives
(aliphatic and aromatic)
• To give basic understanding of amines (aliphatic & aromatic), diazonium salts
• To provide basic understanding of heterocyclic systems.
Learning outcomes
By studying this course, students will be able to:

• Understand reactions of carboxylic acids, esters, amides, amines and diazonium salts
• Understand the concept of protection and deprotection.
• Use the synthetic chemistry learnt in this course to do functional group transformations.
• Gain theoretical understanding of chemistry of heterocyclic compounds.
Syllabus
Unit 1: Carboxylic Acids and their Derivatives (aliphatic and aromatic) ( 1 3 Lectures)
Preparation: Oxidation reactions of alcohols, aldehydes and ketones, Acidic and alkaline
74
hydrolysis of esters; Reactions: Hell-Volhard Zelinsky reaction,
Carboxylic acid derivatives (aliphatic): Preparation: Acid chlorides, anhydrides, esters and
amides from acids and their interconversion, Claisen condensation. Reactions: Relative
reactivities of acid derivatives towards nucleophiles, Reformatsky reaction, Perkin
condensation.
Active methylene compounds: Keto-enol tautomerism. Preparation and synthetic applications
of ethyl acetoacetate
Unit 2: Amines (aliphatic & aromatic) and Diazonium Salts (Hours:10)

Amines
Preparation: from alkyl halides, Gabriel's Phthalimide synthesis, Hoffmann bromamide
reaction. Reactions: Hoffmann vs Saytzeff elimination, carbylamine test, Hinsberg test, reaction
with HNO2, Schotten-Baumann reaction. Electrophilic substitution (case aniline): nitration,
bromination, sulphonation; basicity of amines.
Diazonium salt
Preparation: from aromatic amines; Reactions: conversion to benzene, phenol and dyes.
Unit 3: Heterocyclic Compounds (Hours: 7)

Introduction, classification, structure, nomenclature and uses. Preparation and properties of the
following heterocyclic compounds with reference to electrophilic and nucleophilic
substitution: furan, pyrrole, thiophene, and pyridine.
Practical Component: Credits: 02

(Laboratory periods: 60)
1. Systematic qualitative analysis and preparation of suitable crystalline derivative

(carboxylic acids, carbonyl, alcohols, phenols, amines (1°, 2°, 3°) and amides).
2. Preparation:
a. Acetylation of Aniline and Phenols.
b. Benzoylation of Aniline and phenols
The above derivatives should be prepared using 0.5-1g of the organic compound. The solid
samples must be collected and may be used for recrystallization and melting point.
References:
Theory:
1. Morrison, R. N.; Boyd, R. N. Organic Chemistry, Dorling Kindersley (India) Pvt. Ltd.
(Pearson Education).
2. Finar, I. L. Organic Chemistry (Volume 1), Dorling Kindersley (India) Pvt. Ltd. (Pearson
75
Education).
3. Ahluwalia, V.K.; Bhagat, P.; Aggarwal, R.; Chandra, R. (2005), Intermediate for Organic
Synthesis, I.K. International.
4. Solomons, T. W. G.; Fryhle, C. B. ; Snyder, S. A. (2016), Organic Chemistry, 12th Ed.,
Wiley.
Practical:
1. Ahluwalia, V.K.; Dhingra, S.; Gulati, A. (2005), College Practical Chemistry, University
Press (India) Ltd.
2. Ahluwalia, V.K.; Dhingra, S. (2004), Comprehensive Practical Organic Chemistry:
Qualitative Analysis, University Press.
3. Pasricha, S., Chaudhary, A. (2021), Practical Organic Chemistry: Volume I, I K
International Publishing House Pvt. Ltd., New Delhi.
4. Pasricha, S., Chaudhary, A. (2021), Practical Organic Chemistry: Volume II, I K
International Publishing House Pvt. Ltd., New Delhi.
5. Vogel, A.I. (1972), Textbook of Practical Organic Chemistry, Prentice-Hall.
6. Jeffery, G.H.; Bassett, J.; Mendham, J.; Denney, R.C. (1989), Vogel’s Textbook of
Quantitative Chemical Analysis, John Wiley and Sons.
Note: Examination scheme and mode shall be as prescribed by the Examination Branch, University of
Delhi, from time to time.
76

Chem Sem 4

Uploaded by

Copyright:

Available Formats

Chem Sem 4

Uploaded by

Document Information

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Chem Sem 4

Uploaded by

Copyright:

Available Formats

BSC.

(PHYSICAL SCIENCES)- CHEMISTRY COMPONENT

DISCIPLINE SPECIFIC CORE COURSE CHEM-DSC -10: Chemistry- IV: Chemistry of

CREDIT DISTRIBUTION, ELIGIBILITY AND PRE-REQUISITES OF THE COURSE

Course title Credits Credit distribution of the Eligibility Pre-

The Learning Objectives of this course are as follows:

By studying this course, students will be able to:

Unit 2: Amines (aliphatic & aromatic) and Diazonium Salts (Hours:10)

Unit 3: Heterocyclic Compounds (Hours: 7)

Practical Component: Credits: 02

1. Systematic qualitative analysis and preparation of suitable crystalline derivative

You might also like