1.

COURSE DECRIPTION GENERAL INFORMATION

Professor Olga Kronja
Professor Valerije Vrek
1.1. Course teacher Assistant Professor Sandra Juri, PhD 1.6. Year of study 2nd
Assistant Professor Bernard Denegri,
PhD
1.2. Name of the course Organic Chemistry 1.7. Credit value (ECTS) 11.5
Mirela Mati, PhD 1.8. Type of instruction (number of
1.3. Associate teachers 60 + 45 + 30
Marijan Marijan, Mchem. hours L+E+S+e-learning)
1.4. Study programme
1.9. Expected enrolment in the
(undergraduate, graduate, Pharmacy integrated study programme course
130
integrated)
1.10. Level of use of e-learning (1,
2, 3 level), percentage of
1.5. Status of the course Compulsory instruction in the course on line
2nd
(20% maximum)
2. COURSE DESCRIPTION
Understand the general principles of organic chemistry, the basis of stereochemistry, organic analysis (spectroscopy),
2.1. Course objectives
key reaction mechanisms, as well as basic nucleophilic and electrophilic reactions.
2.2. Enrolment requirements and
required entry competences for Prerequisition: General chemistry with stoichiometry
the course
Application of basic knowledge of organic chemistry for analyzing the properties of drugs based on the structure of
2.3. Learning outcomes at the level of
the study programme to which active ingredients and also for prediction an interaction with active site, based on the functionality of the compound
the course contributes as well as for designing the synthesis of new biological active compounds.
After competition the course, the student will be competent to:
1. Describe the bonds in organic molecules, classify the organic compounds and name them;
2. Recognize the sterochemical features of a given molecule and analyse the impact of the stereochemistry to
2.4. Expected learning outcomes at
the level of the course (4-10 reactivity;
learning outcomes) 3. Estimate the acidity/basicity of organic molecules and describe the electronic effects that determine them;
4. Identify simple molecules by analysing the corresponding NMR and IR spectra;
5. Predict the products of simple nucleophilic addition and substitution on the carbonyl group, nucleophilic
substitution on saturated carbon, elimination and addition reactions and electrophilic substitution reactions;
6. Present the basic key reaction mechanisms and indicate the structural and electronic features of the substrate
that influence the reaction pathway;
7. Design the synthesis of simple organic compounds.
LECTURES
Binding in organic molecules
Classes and nomenclature of organic compounds
Stereochemistry - shapes of molecules
Stereochemistry- chirality and optical activity
Acidity and basicity of organic compounds and structural feature that determine them
Spectroscopy - basis of NMR and IR
Characteristic reactions in organic chemistry and reaction mechanisms
Nucleophilic addition to carbonyl group - aldehydes and ketones
Nucleophilic substitution on carbonyl groups - carboxylic acid derivatives
Nucleophilic substitution on saturated carbon
Elimination reactions - alkenes and alkynes
Reaction of the -carbanions - condensation reactions
Approach to organic synthesis
Electrophilic additions to unsaturated carbon
2.5. Course content broken down in Conjugated additions
detail by weekly class schedule Electrophilic aromatic substitutions
(syllabus) Heterocyclic compounds
SEMINARS
Binding in organic molecules
Classes and nomenclature of organic compounds
Stereochemistry - shapes of molecules
Stereochemistry- chirality and optical activity
Acidity and basicity of organic compounds and structural feature that determine them
Spectroscopy - basis of NMR and IR
Characteristic reactions in organic chemistry and reaction mechanisms
Nucleophilic addition to carbonyl group - aldehydes and ketones
Nucleophilic substitution on carbonyl groups - carboxylic acid derivatives
Nucleophilic substitution on saturated carbon
Elimination reactions - alkenes and alkynes
Reaction of the -carbanions - condensation reactions
Approach to organic synthesis
Electrophilic additions to unsaturated carbon
Conjugated additions
Electrophilic aromatic substitutions
Heterocyclic compounds
LABORATORY
Distillation
Synthesis ands isolation of aniline
Synthesis and isolation of acetanilide (crystallization)
Synthesis of ethyl acetate
Cannizzaro reaction (separation of acidic and neutral components)
Identification od compounds (melting and boiling points)
lectures independent study 2.7. Comments:
seminars and workshops multimedia and the internet
2.6. Type of instruction exercises laboratory
online in entirety work with the mentor
(other)
2.8. Student responsibilities
Class attendance 2 Research Practical training
2.9. Screening of students work Experimental work 1.5 Report
(specify the proportion of ECTS Essay Seminar essay 1 (Other--describe)
credits for each activity) Tests 1 Oral exam (Otherdescribe)
Written exam 6 Project (Otherdescribe)
2.1. Grading and evaluation of
Attendance, competition of the planed laboratory work and passing the exam. The overall grade is defined with final
student work over the course of
exam (contribution 40%), laboratory and colloquium (20%) and partial exams (40%).
instruction and at a final exam
Title
2.2. Required literature (available at
S. H. Pine Organic Chemistry, kolska knjiga 1994.
the library and via other media)
O. Kronja, S. Bori Praktikum iz preparativne organske kemije, kolska knjiga 2004.
2.12. Optional literature L. G. Wade, Organic Chemistry, 7. izd. , Prentice Hall, 2012.
2.13. Methods of monitoring quality
Learning outcomes1-6 are tested by partial exams during the semester and with final written exam. Learning outcome
that ensure acquisition of exit
7 is tested during practical work in laboratory and checked by colloquium.
competences