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Alphabet soup of stem cell acronyms could have included MUSE cells. The stem cell universe is populated by sometimes mysterious acronyms (see an image of a whole alphabet stem cell acronym soup), many of which refer to specific kinds of stem cells including one nebulous type called MUSE cells. MUSE cells clinical trials I’m not convinced that MUSE cells exist, but oddly there appear to be four cli
Purported STAP cells. What were people saying about STAP cells at the ISSCR 2014 meeting? It was a tale of two meetings when it came to STAP at ISSCR. Officially, bigwigs at the podiums only briefly mentioned it and they seemed to collectively argue that STAP was something unfortunate, but that the bigger danger was the overreaction to it. Thus, remarkably their key concern seemed to be their perc
Purported STAP stem cell culture. The ultimate fate of the two Nature STAP cell papers remains in troubled limbo. One of the senior STAP cell authors, Dr. Sasai, held a news conference yesterday in Japan that included a call for the papers to be retracted. He was variously quoted as believing in STAP cells or alternatively as just thinking it was an unproven hypothesis. Whether STAP cells or STAP
STAP cell mixup. I don’t really hear from almost anyone who fully believes in the STAP cell thing anymore. The most common thing I do hear is from people assuming STAP is largely or entirely wrong and asking, “what really happened?” There’s still a chance that STAP is real, but if I were in Vegas or at the race track I’d put the odds in the single digits at this point. Betting on STAP to be entire
STAP spheres nice and green? Purported STAP stem cells. Dr. Ken Lee’s lab has done some very important validation attempts on STAP cells and has posted them on ResearchGate. To my knowledge, his lab’s STAP experiments are the ones in the public domain that most closely matched the methods of the Nature STAP papers. Dr. Lee submitted the work to Nature Brief Communications Arising on STAP cells, bu
STAP Cell Protocol Page from Charles Vacanti lab. The Vacanti Lab at Brigham and Women’s Hospital/Harvard Medical School has now posted online their own version of the STAP cell production protocol. The thing that first struck me most strongly about this published protocol is that it is not the same protocol reported in the Nature papers and it also is not the same as the recently posted RIKEN STA
Guest post on STAP cells. By Jun Seita, M.D., Ph.D. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine English version is here. Oct3/4プロモーターに制御されたGFP蛍光タンパク質の発現を検出することは、オリジナルのSTAP論文[1, 2]においてSTAP細胞の定義として広範囲にわたって使用されています。そして同じ手法はSTAP論文の再現を目指す様々な第三者にも利用されています。一方、ストレスや障害を受けた細胞が自家蛍光を発することは良く知られた現象です。これはSTAP細胞について議論する時に特に重要です。様々な外部刺激はOct3/4-GFPレポーターの活性化とは独立
Dr. Charles Vacanti is scheduled as a special guest speaker on April 1 at Brigham and Women’s Hospital. He’ll be speaking on STAP cells. See image below of the announcement. Charles Vacanti speaking on STAP cells. The title of his talk is “Tissue Engineering and STAP Cells”. It is part of the Brigham and Women’s “Leaders in Regenerative Medicine Seminar Series”. Online registration is required to
Robert J. Geller. I’m a seismologist at the University of Tokyo, where I’ve been since 1984. I was the first tenured foreign faculty member in the history of our university. If you look at my publication list on the Researcher ID site you can see that my main research recent interests are modeling seismic wave propagation and analyzing observed seismic waveform data to determine the seismic veloci
I’m hearing from multiple sources that momentum is building in Japan and even inside RIKEN itself for retraction of the STAP cell papers. This whole situation is a tragedy on so many levels and has become a no-win situation, but is it so bad at this point that retraction could possibly be the least terrible of the entirely bad array of options? Why would some folks in Japan and even inside RIKEN t
A small group of the STAP authors via RIKEN have now released a detailed protocol also available at Nature Protocol Exchange for making STAP stem cells entitled “Essential technical tips for STAP cell conversion culture from somatic cells”. This comes about 5 weeks after publication of their Nature STAP stem cell papers. 2020 update: With the 4th and perhaps final Obokata paper retraction this yea
Are the Nature STAP stem cell papers compromised? Could Nature‘s investigation conclude with something as serious as retraction or rather a mild slap on the wrist? Somewhere in between? (note you may find this update post from 2020 to be of interest: Whatever happened to the STAP cell scientists including Haruko Obokata?) Why is this question even being raised? A large number of potentially seriou
Supposed STAP stem cells. We know quite a bit more about the Nature papers on stress-induced STAP stem cells than we did just a couple weeks ago when they were published, but there are many crucial outstanding questions too and odd things that remain unresolved. Below are my top STAP stem cell oddities. 10. Dr. Vacanti says that STAP stem cells are probably the same as “spore stem cells”, a contro
This is a crowdsource page for people who want to post their findings on their attempts to validate the STAP stem cell ( STAP細胞) method. I’m going to color successful or even moderately encouraging reports green and failures/discouraging results in red. *For those with longer attention spans, see some additional important considerations for this crowdsourcing effort at the bottom of this page. Pl
Exactly ten years ago today, on January 29, 2014, I wrote about two new Nature papers on so-called STAP cells. The papers claimed that stress alone could convert regular non-stem cells into some of the most powerful stem cells. More specifically, the authors claimed to make pluripotent stem cells similar to iPS cells this way. […]
In two Nature papers (here and here) published today researchers report the astounding finding of reprogramming differentiated cells back to a pluripotent or even totipotent state simply by exposing the cells to extreme environmental stress, creating cells they called STAP cells. Update: see more thoughts on STAP stem cells here. STAP cells: stressing the cell out No genes. No proteins. No nuclear
The FDA recently warned Frontier Biologics, LLC, a Texas perinatal tissue manufacturer firm. Tallying the many FDA biologics warnings in 2024 It can sometimes feel like there are an uncountable number of unproven stem cell clinics However, the good news is that the FDA has been doing much more on…
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