Amyloid- Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Jae-Eun Kang 1, Miranda M. Lim 1, Randall J. Bateman 2, James J. Lee 1, Liam P. Smyth 1, John R. Cirrito 3, Nobuhiro Fujiki 4, Seiji Nishino 4, David M. Holtzman 5* 1 Department of Neurology, Washington University, St. Louis, MO 63110, USA. 2 Department of Neurology, Washington University, St. Louis, MO 63110, USA.; Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.; Alzheimer's Disease Research Center, Washington University, St. Louis, MO 63110, USA. 3 Department of Neurology, Washington University, St. Louis, MO 63110, USA.; Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA. 4 Sleep and Circadian Neurobiology Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94304, USA. 5 Department of Neurology, Washington University, St. Louis, MO 63110, USA.; Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.; Alzheimer's Disease Research Center, Washington University, St. Louis, MO 63110, USA.; Department of Developmental Biology, Washington University, St. Louis, MO 63110, USA.
Published Online September 24, 2009 Science DOI: 10.1126/science.1180962