Rhoシグナルä¼é”経路ã«ã‚ˆã‚‹è»¢å†™å…±å½¹å› åYAPãŠã‚ˆã³TAZã®æ´»æ€§åŒ–ã¯ãƒ’トã®ES細胞ã®ç¶æŒåŸ¹é¤Šã«å¿…è¦ã§ã‚ã‚‹ : ライフサイエンス æ–°ç€è«–文レビューRho-signaling-directed YAP/TAZ activity underlies the long-term survival and expansion of human embryonic stem cells. Masatoshi Ohgushi, Maki Minaguchi, Yoshiki Sasai Cell Stem Cell, 17, 448-461 (2015) è¦ ç´„ ãŒã‚“細胞ã®ã‚ˆã†ã«ã»ã¼ç„¡é™ã«æ‹¡å¤§åŸ¹é¤Šã®ã§ãる形質をä¸æ»æ€§ã¨ã‚ˆã¶ã“ã¨ãŒã‚る．ES細胞もåŒæ§˜ã®ä¸æ»æ€§ã‚’示ã™ãŒï¼Œã•ã¾ã–ã¾ãªéºä¼å変異をもã¤ãŒã‚“細胞ã¨ã¯ç•°ãªã‚Šï¼Œã‚²ãƒŽãƒ ã®æ£å¸¸æ€§ã‚’ç¶æŒã—ã¦ã„ã‚‹ã¨è€ƒãˆã‚‰ã‚Œã‚‹ï¼Žã“ã®ç ”究ã«ãŠã„ã¦ã¯ï¼Œã‚²ãƒŽãƒ ã®ç•°å¸¸ã«ã‚ˆã‚‰ãªã„ä¸æ»æ€§ã‚’ES細胞ã®ç‰¹å¾´ã®ã²ã¨ã¤ã¨ã¨ã‚‰ãˆï¼Œãã®åˆ†å機構ã«ã¤ã„ã¦è§£æžã—ãŸï¼Žãã®çµæžœï¼Œãƒ’トã®ES細胞ã®ç”Ÿå˜ã¯Rhoシグナルä¼é”経路ã«ã‚ˆã‚‹è»¢å†™å…±å½¹å› åYAPãŠã‚ˆã³
多能性幹細胞ã‹ã‚‰æ©Ÿèƒ½çš„ãªåµåを作製ã™ã‚‹ã“ã¨ã«æˆåŠŸ
Molecular alliance that sustains embryonic stem cell state
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