Rare variant association analysis methods for complex traits - ryamadaã®éºä¼å¦ãƒ»éºä¼çµ±è¨ˆå¦ãƒ¡ãƒ¢ãƒ¬ãƒ“ュー Rare variant association analysis methods for complex traits, by J. Asimit and E.Zeggini in Anu.Rev.Genet. 2010. 44:293-308 レアãƒãƒªã‚¢ãƒ³ãƒˆ(マイナーアレルãŒ<5%, <1%,further less) Multiple rare variant(MRV) hypothesis vs. Common disease common varinat hypothesis 複数ã®ã€æ¯”較的寄与度ã®å¼·ã„レアãƒãƒªã‚¢ãƒ³ãƒˆãŒç–¾æ‚£ãƒªã‚¹ã‚¯ã‚’構æˆã—ã¦ã„る。個人ã¯ã€ã“ã®ã†ã¡ã®ã„ãã¤ã‹ã‚’æŒã¤ã“ã¨ã§ãƒªã‚¹ã‚¯ãŒä¸ŠãŒã£ã¦ã„ã‚‹ Common diseases ã«ãŠã‘ã‚‹MRVã®å¯„与ã«é–¢ã™ã‚‹å®Ÿä¾‹ç´¹ä»‹ LD mappinng ã¯ãƒ¬ã‚¢ãƒãƒªã‚¢ãƒ³ãƒˆã«ä¸å‘ã LDã§ã‚¿ã‚°ãƒžãƒ¼ã‚«ãƒ¼ã‚’å–り出ã›ãªã„ 解æžæ–¹æ³•ï¼“分類
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Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development
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