慢性的ç¡çœ ä¸è¶³ã¯è„³ã«å¯¾ã—ã¦ã€ã“ã‚Œã¾ã§è€ƒãˆã‚‰ã‚Œã¦ã„ãŸã‚ˆã‚Šã‚‚長期的ãªå½±éŸ¿ã‚’åŠã¼ã™ãŠãã‚Œã®ã‚ã‚‹ã“ã¨ãŒã€ãƒžã‚¦ã‚¹ã‚’使ã£ãŸæ–°ãŸãªç ”究ã§æ˜Žã‚‰ã‹ã«ãªã£ãŸã€‚
慢性的ç¡çœ ä¸è¶³ã§è„³ç¥žçµŒãŒæ»æ»…：マウスã§å®Ÿè¨¼
慢性的ç¡çœ ä¸è¶³ã¯è„³ã«å¯¾ã—ã¦ã€ã“ã‚Œã¾ã§è€ƒãˆã‚‰ã‚Œã¦ã„ãŸã‚ˆã‚Šã‚‚長期的ãªå½±éŸ¿ã‚’åŠã¼ã™ãŠãã‚Œã®ã‚ã‚‹ã“ã¨ãŒã€ãƒžã‚¦ã‚¹ã‚’使ã£ãŸæ–°ãŸãªç ”究ã§æ˜Žã‚‰ã‹ã«ãªã£ãŸã€‚
æ–°ãŸãªéºä¼ã‚³ãƒ¼ãƒ‰ã‚’発見ã€éºä¼å制御ã«é–¢ä¸Žã‹ å›½éš›ç ”ç©¶
ä»ãƒŠãƒ³ãƒˆï¼ˆNantes）ã«ã‚ã‚‹ç ”ç©¶å®¤ã§æ’®å½±ã•ã‚ŒãŸDNAサンプル（2013å¹´2月22日撮影ã€è³‡æ–™å†™çœŸï¼‰ã€‚(c)AFP/FRANK PERRY ã€12月13æ—¥ AFP】米科å¦èªŒã‚µã‚¤ã‚¨ãƒ³ã‚¹ï¼ˆScience）ã§12æ—¥ã«ç™ºè¡¨ã•ã‚ŒãŸç ”究論文ã«ã‚ˆã‚‹ã¨ã€éºä¼åã®åˆ¶å¾¡ã«é–¢ã—ã¦æŒ‡ç¤ºã‚’出ã—ã¦ã„ã‚‹ã¨è€ƒãˆã‚‰ã‚Œã‚‹æ–°ãŸãªDNAコードãŒè¦‹ã¤ã‹ã£ãŸã¨ã„ã†ã€‚科å¦è€…らã¯ã“ã‚Œã¾ã§ã€DNA（デオã‚ã‚·ãƒªãƒœæ ¸é…¸ï¼‰ã¯ç´°èƒžã«ã‚¿ãƒ³ãƒ‘ク質ã®ä½œã‚Šæ–¹ã‚’æ•™ãˆã‚‹ã‚‚ã®ã¨é•·å¹´ä¿¡ã˜ã¦ããŸã€‚ ã“ã®ç ”究çµæžœã«ã¤ã„ã¦ã¯ã€åŒ»ç™‚関係者らãŒç—…気を解明ã—ãŸã‚Šè¨ºæ–ã—ãŸã‚Šã™ã‚‹ãŸã‚ã«æ‚£è€…ã®ã‚²ãƒŽãƒ （全éºä¼æƒ…å ±ï¼‰ã‚’ã©ã®ã‚ˆã†ã«åˆ©ç”¨ã™ã‚‹ã‹ã‚’ã‚ãã‚Šã€å¤§ããªæ„味をæŒã¤ã‹ã‚‚ã—ã‚Œãªã„ã¨ç ”究者らã¯è©±ã—ã¦ã„る。 人体ã®ã»ã¼ã™ã¹ã¦ã®ç´°èƒžã«å˜åœ¨ã™ã‚‹éºä¼ç‰©è³ªã§ã‚ã‚‹DNA内ã§æ–°ãŸã«ç™ºè¦‹ã•ã‚ŒãŸéºä¼ã‚³ãƒ¼ãƒ‰ã¯ã€ç§‘å¦è€…らãŒã™ã§ã«è§£èªæ¸ˆã¿ã®DNAコードã«ã€Œé‡ãã¦ã€æ›¸ã‹ã‚Œã¦ã„ã‚‹ã¨ã„ã†ã€‚ ã“ã®æ–°ãŸã«è¦‹ã¤ã‹ã£ãŸDNAコ
体内時計ã®ãƒªã‚ºãƒ 　京大教授ら関係性解明 （京都新èžï¼‰ - Yahoo!ニュース
体内ã§å‘¨æœŸçš„ã«å¢—減を繰り返ã™ã‚¿ãƒ³ãƒ‘ク質ãŒãƒªã‚ºãƒ を刻むã®ã«ã€éºä¼åã®ç©ºç™½éƒ¨åˆ†ã€Œã‚¤ãƒ³ãƒˆãƒãƒ³ã€ãŒé‡è¦ãªåƒãã‚’ã—ã¦ã„ã‚‹ã“ã¨ã‚’ã€äº¬éƒ½å¤§ã‚¦ã‚¤ãƒ«ã‚¹ç ”究所ã®å½±å±±é¾ä¸€éƒŽæ•™æŽˆãŸã¡ã®ã‚°ãƒ«ãƒ¼ãƒ—ãŒçªãæ¢ã‚ãŸã€‚機能ãŒè©³ã—ã分ã‹ã£ã¦ã„ãªã„「イントãƒãƒ³ã€ã¨ä½“内時計ã®é–¢ä¿‚を解明ã—ãŸã€‚米国科å¦ã‚¢ã‚«ãƒ‡ãƒŸãƒ¼ç´€è¦ã§ï¼˜æ—¥ç™ºè¡¨ã™ã‚‹ã€‚ éºä¼åã«ã¯ã€ã‚¿ãƒ³ãƒ‘ク質を作るã®ã«ç›´æŽ¥å¿…è¦ã§ãªã„æƒ…å ±ãŒæ›¸ãè¾¼ã¾ã‚ŒãŸéƒ¨åˆ†ã€Œã‚¤ãƒ³ãƒˆãƒãƒ³ã€ãŒå˜åœ¨ã™ã‚‹ãŒã€æ©Ÿèƒ½ã¯ä¸æ˜Žãªéƒ¨åˆ†ãŒå¤šã„。 影山教授ãŸã¡ã¯ã€ãƒžã‚¦ã‚¹ã‚’使ã£ãŸå®Ÿé¨“ã§ã€èƒŽå…期ã«è‚‹éª¨ï¼ˆã‚ã£ã“ã¤ï¼‰ã‚„背骨ãªã©ä½“ã®éª¨æ ¼ã‚’è¦å‰‡æ£ã—ã作るãŸã‚ã«ï¼’時間周期ã§å¢—減を繰り返ã—ã¦åƒãタンパク質Ｈｅｓ７ã®éºä¼åã‹ã‚‰ã€ã€Œã‚¤ãƒ³ãƒˆãƒãƒ³ã€ã‚’å–り除ã„ãŸã€‚ãã®çµæžœã€ï¼¨ï½…ｓ７ã¯ä¸€å®šé‡ã‚’ä¿ã£ãŸã¾ã¾å¢—減ã—ãªããªã‚Šã€éª¨æ ¼ãŒæ£ã—ã作られãšã€ãƒžã‚¦ã‚¹ã¯ç”Ÿå¾Œã™ãã«æ»ã‚“ã§ã—ã¾ã£ãŸã€‚「イントãƒãƒ³ã€ã‚’ãªãã—ãŸã“ã¨ã§ã€éºä¼åã‹ã‚‰ã‚¿ãƒ³ãƒ‘ク質ãŒä½œã‚‰ã‚Œã‚‹ã®ã«ã‹ã‹ã‚‹æ™‚é–“ãŒçŸ
動画共有サイト：毎日動画「ãŸã‚“ã±ã質：「æ©ã姿ã€æ’®å½±æˆåŠŸã€€é‡‘沢大ãªã©ã®ã‚°ãƒ«ãƒ¼ãƒ—〠投稿者： mainichiã•ã‚“
２本脚ã®æ§‹é€ ã‚’æŒã¤ãŸã‚“ã±ã質「ミオシンＶã€ãŒã€è„šã‚’交互ã«å‰ã«å‡ºã—ã¦ç§»å‹•ã™ã‚‹å‹•ç”»ã®æ’®å½±ã«ã€é‡‘沢大ãªã©ã®ç ”究グループãŒåˆã‚ã¦æˆåŠŸã€‚１ï¼æ—¥ï¼ˆç¾åœ°æ™‚間）ã®è‹±ç§‘å¦èªŒã€Œãƒã‚¤ãƒãƒ£ãƒ¼ã€ï¼ˆé›»å版）ã§ç™ºè¡¨ã—ãŸã€‚分åを観察ã™ã‚‹åŽŸå間力顕微é¡ï¼ˆï¼¡ï¼¦ï¼ï¼‰ã‚’約５年å‰ã«ã€ï¼‘ï¼ï¼ï¼å€é€Ÿã§å®Ÿç”¨åŒ–ã—ãŸé«˜é€Ÿï¼¡ï¼¦ï¼ã§æ’®å½±ã—ãŸã€‚応用ã®å¹…を広ã’ã‚‹ã“ã¨ã§ã€ãƒŠãƒŽãƒ¬ãƒ™ãƒ«ã®ç‰©è³ªã®è§£æ˜ŽãŒæœŸå¾…ã•ã‚Œã‚‹ã€‚
Facio the 3D-Molecular Modeling Software
Facio is a free GUI for computational chemistry softwares (TINKER, MSMS, Firefly, Gamess, MOPAC and Gaussian). It will be helpful to your study and research on theoretical chemistry. Current Version : 19.1.6  (released on February 17, 2016) for Windows & Linux                     for Mac OS X (10.6 or later) This software is indispensable to FMO (Fragment Molecular Orbital) method of Gamess becau
Together We Are Powerful - Folding@home
TOGETHER, WE ARE POWERFUL Together, we have created the most powerful supercomputer on the planet, and are using it to help understand SARS-CoV-2/COVID-19 and develop new therapies. We need your help pushing toward a potent, patent-free drug. Use your PC to help fight COVID-19. DOWNLOAD FOLDINGATHOME [Available for Windows, Mac, Linux] Progress on the current COVID Moonshot sprint to assess potent
ubiquitin
図１　ユビã‚ãƒãƒ³ä¿®é£¾ç³»ã®æ¦‚ç•¥ ユビã‚ãƒãƒ³ä¿®é£¾ç³»ã¯E1(æ´»æ€§åŒ–é…µç´ )/E2(çµåˆé…µç´ )/E3(ユビã‚ãƒãƒ³ãƒªã‚¬ãƒ¼ã‚¼)ã®ï¼“種ã®é…µç´ 群ã®åƒãã«ã‚ˆã‚Šã€æ¨™çš„タンパク質ã«ãƒ¦ãƒ“ã‚ãƒãƒ³ã‚’çµåˆã•ã›ã‚‹ç¿»è¨³å¾Œä¿®é£¾ç³»ã§ã‚ã‚Šã€å¤šãã®å ´åˆã¯é€£ç¶šçš„ã«ãƒ¦ãƒ“ã‚ãƒãƒ³ãŒçµåˆã™ã‚‹ã“ã¨ã§ç”Ÿã˜ã‚‹ãƒãƒªãƒ¦ãƒ“ã‚ãƒãƒ³éŽ–ãŒæŒ‡æ¨™ã¨ãªã‚Šã‚¿ãƒ³ãƒ‘ク質ã®æ©Ÿèƒ½ã‚’制御ã™ã‚‹ã€‚ユビã‚ãƒãƒ³ã®48番目ã®ãƒªã‚¸ãƒ³ï¼ˆK48）を介ã—ãŸãƒãƒªãƒ¦ãƒ“ã‚ãƒãƒ³éŽ–ã¯æ¨™çš„タンパク質ã®ãƒ—ãƒãƒ†ã‚¢ã‚½ãƒ¼ãƒ ã«ã‚ˆã‚‹åˆ†è§£ã‚·ã‚°ãƒŠãƒ«ã¨ãªã‚‹ãŒ(A)ã€K63を介ã—ãŸãƒãƒªãƒ¦ãƒ“ã‚ãƒãƒ³éŽ–ã¯ã‚¿ãƒ³ãƒ‘ク質çµåˆãƒ‰ãƒ¡ã‚¤ãƒ³ã¨ã—ã¦æ©Ÿèƒ½ã—ã€ã‚·ã‚°ãƒŠãƒ«ä¼é”ã‚„DNA修復ã«é–¢ä¸Žã™ã‚‹(B)。モノã¾ãŸã¯ã‚¸ãƒ¦ãƒ“ã‚ãƒãƒ³ãŒã‚¿ãƒ³ãƒ‘ク質ã®å†…在化シグナルã¨ãªã‚‹ã“ã¨ã‚‚知られã¦ã„ã‚‹(C)。 ユビã‚ãƒãƒ³ä¿®é£¾ç³»ã¯1978å¹´ã«ã‚¨ãƒãƒ«ã‚®ãƒ¼ä¾å˜çš„タンパク質分解系ã®ä¸€éƒ¨ã¨ã—ã¦ç™ºè¦‹ã•ã‚ŒãŸã€ã‚¿ãƒ³ãƒ‘ク質翻訳後修飾系ã§ã™ã€‚ユビã‚ãƒãƒ³ã¯76アミノ酸ã‹ã‚‰ãªã‚‹é…µæ¯ã‹ã‚‰ãƒ’トã«è‡³ã‚‹ã¾ã§éžå¸¸
ã€GEヘルスケア】　タンパク質溶液ã®æ¿ƒç¸®
実験ã§å分ãªçµæžœã‚’å¾—ã‚‹ãŸã‚ã«ã¯ã€ãã®å®Ÿé¨“ç³»ã«é©åˆ‡ãªã‚¿ãƒ³ãƒ‘ク質濃度を知ã£ã¦ãŠãã“ã¨ãŒé‡è¦ã§ã™ã€‚濃度ãŒæ¿ƒã„å ´åˆã«ã¯åŒã˜æº¶æ¶²ã§å¸Œé‡ˆã™ã‚Œã°ã‚ˆã„ã§ã™ãŒã€ãã®æ™‚点ã§ã®ã‚µãƒ³ãƒ—ルã«ãŠã‘るタンパク質濃度ãŒè–„ã„å ´åˆã«ã¯ã€ä½•ã‚‰ã‹ã®æ–¹æ³•ã§æ¿ƒç¸®ã‚’è¡Œã„ã¾ã™ã€‚ã“ã“ã§ã¯ã€ã‚¿ãƒ³ãƒ‘ク質溶液ã®æ¿ƒç¸®æ³•ã«ã¤ã„ã¦ã”紹介ã—ã¾ã™ã€‚ ※硫安分画やå…疫沈é™ãªã©ã®åˆ†ç”»ï¼ˆãƒ•ãƒ©ã‚¯ã‚·ãƒ§ãƒãƒ¼ã‚·ãƒ§ãƒ³ï¼‰æ“作もã€ç›®çš„タンパク質ã®æ¿ƒç¸®ã«ã¤ãªãŒã‚Šã¾ã™ã€‚ 分画・フラクショãƒãƒ¼ã‚·ãƒ§ãƒ³ã«ã¤ã„ã¦ã®è©³ç´° ã“ã®ãƒšãƒ¼ã‚¸ã®ç›®æ¬¡
シャペãƒãƒ‹ãƒ³GroEL
タンパク質フォールディングã®ã‚†ã‚Šã‹ã”：シャペãƒãƒ‹ãƒ³GroEL ã€ã‚·ãƒ£ãƒšãƒãƒ‹ãƒ³ã€‘シャペãƒãƒ‹ãƒ³ã¯ã‚¿ãƒ³ãƒ‘ク質ã®ãƒ•ã‚©ãƒ¼ãƒ«ãƒ‡ã‚£ãƒ³ã‚°ã‚’助ã‘ã‚‹ã™ã¹ã¦ã®ç´°èƒžã«å¿…é ˆã®åˆ†åシャペãƒãƒ³ã®ä»£è¡¨ã§ã™ã€‚シャペãƒãƒ³ã®æ¦‚念ãŒé†¸æˆã•ã‚Œã¦ã„ããã£ã‹ã‘ã«ã‚‚ãªã‚Šã¾ã—ãŸï¼ˆã‚·ãƒ£ãƒšãƒãƒ³ã¨ã‚·ãƒ£ãƒšãƒãƒ‹ãƒ³ã¯æ··åŒã•ã‚ŒãŒã¡ã§ã™ãŒã€ã‚·ãƒ£ãƒšãƒãƒ³ã¯ã‚·ãƒ£ãƒšãƒãƒ³çš„ã«æ©Ÿèƒ½ã™ã‚‹ã‚¿ãƒ³ãƒ‘ク質ã®ç·ç§°ã§ã€ä»£è¡¨çš„ãªã‚‚ã®ã«Hsp70/DnaKã€Hsp90ã€Hsp104/ClpBã€ãã—ã¦ã‚·ãƒ£ãƒšãƒãƒ‹ãƒ³ï¼ˆGroEL/CCT）ãªã©ãŒã‚ã‚Šã¾ã™ã€‚シャペãƒãƒ‹ãƒ³ã¯ã‚·ãƒ£ãƒšãƒãƒ³ã¨ã„ã†å¤§ããªé›†å›£ã®ä¸€ã¤ã«ã™ãŽã¾ã›ã‚“）。 ã€GroEL：ãƒã‚¯ãƒ†ãƒªã‚¢ã®ã‚·ãƒ£ãƒšãƒãƒ‹ãƒ³ã€‘ãƒã‚¯ãƒ†ãƒªã‚¢ï¼ˆçœŸæ£ç´°èŒï¼‰ã®ã‚·ãƒ£ãƒšãƒãƒ‹ãƒ³ã¯GroELã¨å‘¼ã°ã‚Œã¦ã„ã¦ã€å¤§è…¸èŒã®GroELãŒã‚‚ã£ã¨ã‚‚ç ”ç©¶ã•ã‚Œã¦ã„ã¾ã™ï¼ˆå…¨ã¦ã®ã‚·ãƒ£ãƒšãƒãƒ³ã®ä¸ã§ã‚‚最もよãç ”ç©¶ã•ã‚Œã¦ã„ã‚‹ã¨ã‚‚言ãˆã¾ã™ï¼‰ã€‚大腸èŒã§ã¯ã€GroELã¨è£œåŠ©å› åã§ã‚ã‚‹GroESã¯å…±ã«å¿…é ˆã®ã‚¿ãƒ³
NCBI - National Center for Biotechnology Information
An official website of the United States government Here's how you know The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted sec
1
リリースã€éšœå®³æƒ…å ±ãªã©ã®ã‚µãƒ¼ãƒ“スã®ãŠçŸ¥ã‚‰ã›
最新ã®äººæ°—エントリーã®é…ä¿¡
j次ã®ãƒ–ックマーク
kå‰ã®ãƒ–ックマーク
lã‚ã¨ã§èªã‚€
eコメント一覧を開ã
oページを開ã
bioportal.jp
{{#tags}}- {{label}}
{{/tags}}