リポ多糖
グラム陰性細菌の外膜の構成成分で、脂肪酸のカルボキシル基に多糖が結合した高分子。強い免疫原性をもち、発熱を引き起こす発熱性物質(パイロジェン)である。
化合物名や化合物に関係する事項: | リゾホスファチジルコリン リボチミジン リポソーム リポ多糖 リン脂質2重層 リン脂質 リン酸結合 |
リポ多糖
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2023/02/22 02:02 UTC 版)
リポ多糖(リポたとう、英: lipopolysaccharide, LPS、中: 脂多糖)は、グラム陰性菌細胞壁外膜の構成成分であり、脂質及び多糖から構成される物質(糖脂質)である。LPSは内毒素(エンドトキシン、英: endotoxin)であり、ヒトや動物など他の生物の細胞に作用すると、多彩な生物活性を発現する。LPSの生理作用発現は、宿主細胞の細胞膜表面に存在するToll様受容体 (英: Toll-like receptor、TLR) 4 (TLR4) を介して行われる。
- ^ Galanos C, Lüderitz O, Rietschel ET, Westphal O, Brade H, Brade L, Freudenberg M, Schade U, Imoto M, Yoshimura H, Kusumoto S, Shiba T (1985). “Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities”. Eur. J. Biochem. 148 (1): 1-5. doi:10.1111/j.1432-1033.1985.tb08798.x. PMID 2579812.
- ^ Inohara N, Ogura Y, Chen FF, Muto A, Nuñez G (2001). “Human Nod1 confers responsiveness to bacterial lipopolysaccharides”. J. Biol. Chem. 276 (4): 2551-2554. doi:10.1074/jbc.M009728200. PMID 11058605.
- ^ Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K, Kimoto M (1999). “MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4”. J. Exp. Med. 189 (11): 1777-1782. doi:10.1084/jem.189.11.1777. PMC 2193086. PMID 10359581 .
- ^ Li X, Qin J (2005). “Modulation of Toll-interleukin 1 receptor mediated signaling”. J. Mol. Med. 83 (4): 258-266. doi:10.1007/s00109-004-0622-4. PMID 15662540.
- ^ Braun-Fahrlander C, Riedler J, Herz U, Eder W, Waser M, Grize L, et al. (2002). “Environmental exposure to endotoxin and its relation to asthma in school-age children.”. The New England journal of medicine. 347 (12): 869-877. doi:10.1056/NEJMoa020057. PMID 12239255.
- ^ Brandl K, Plitas G, Mihu CN, Ubeda C, Jia T, Fleisher M, et al. (2008). “Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits.”. Nature. 455 (7214): 804-807. doi:10.1038/nature07250.. PMC 2663337. PMID 18724361 .
- ^ Fukasaka M, Asari D, Kiyotoh E, Okazaki A, Gomi Y, Tanimoto T, et al. (2015). “A Lipopolysaccharide from Pantoea Agglomerans Is a Promising Adjuvant for Sublingual Vaccines to Induce Systemic and Mucosal Immune Responses in Mice via TLR4 Pathway.”. PloS one. 10 (5): e0126849.. doi:10.1371/journal.pone.0126849.. PMC 4433252. PMID 25978818 .
- ^ Brandt EB, Gibson AM, Bass S, Rydyznski C, Khurana Hershey GK. (2013). “Exacerbation of allergen-induced eczema in TLR4- and TRIF-deficient mice.”. Journal of immunology. 191 (7): 3519-3525. doi:10.4049/jimmunol.1300789.. PMC 3788607. PMID 23997219 .
- ^ Chen L, Guo S, Ranzer MJ, DiPietro LA. (2013). “Toll-like receptor 4 has an essential role in early skin wound healing.”. The Journal of investigative dermatology. 133 (1): 258-267. doi:10.1038/jid.2012.267.. PMC 3519973. PMID 22951730 .
- ^ Lewkowicz P, Lewkowicz N, Sasiak A, Tchorzewski H. (2006). “Lipopolysaccharide-activated CD4+CD25+ T regulatory cells inhibit neutrophil function and promote their apoptosis and death.”. Journal of immunology. 177 (10): 7155-7163. PMID 17082633.
- ^ Mitsui H, Watanabe T, Saeki H, Mori K, Fujita H, Tada Y, et al. (2004). “Differential expression and function of Toll-like receptors in Langerhans cells: comparison with splenic dendritic cells.”. The Journal of investigative dermatology. 122 (1): 95-102. doi:10.1046/j.0022-202X.2003.22116.x.. PMID 14962096.
- ^ Smythies LE, Sellers M, Clements RH, Mosteller-Barnum M, Meng G, Benjamin WH, et al. (2005). “Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity.”. The Journal of clinical investigation. 115 (1): 66-75. doi:10.1172/JCI19229.. PMC 539188. PMID 15630445 .
- ^ Baldridge JR, Crane RT. (1999). “Monophosphoryl Lipid A (MPL) Formulations for the Next Generation of Vaccines.”. Methods. 19 (1): 103–107. PMID 10525445.
- ^ Garçon N, Morel S, Didierlaurent A, Descamps D, Wettendorff M, Van Mechelen M. (2011). “Development of an AS04-adjuvanted HPV vaccine with the adjuvant system approach.”. BioDrugs. 25 (4): 217-226. doi:10.2165/11591760-000000000-00000.. PMID 21815697.
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