The Tissue Level of Organization: Powerpoint® Lecture Slides Prepared by Jason Lapres Lone Star College - North Harris

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Chapter

4
The Tissue
Level of
Organization
PowerPoint® Lecture Slides
prepared by Jason LaPres
Lone Star College - North Harris

Copyright © 2009 Pearson Education, Inc.,


Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings
publishing as Pearson Benjamin Cummings
Four Types of Tissues

 Tissues are collections of cells and cell


products that perform specific, limited
functions
 Types of tissue
 Epithelial tissue
 Covers exposed surfaces
 Lines internal passageways
 Forms glands

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Four Types of Tissues
 Types of Tissue (cont’d)
 Connective tissue
 Fills internal spaces
 Supports other tissues
 Transports materials
 Stores energy
 Muscle tissue
 Specialized for contraction
 Skeletal muscle, heart muscle, and walls of hollow organs
 Neural tissue
 Carries electrical signals from one part of the body to another

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Epithelial Tissues

 Epithelia
 Layers of cells covering internal or external
surfaces
 Glands
 Structures that produce secretions

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Epithelial Tissues

 Characteristics of Epithelia
 Cellularity (cell junctions)
 Polarity (apical and basal surfaces)
 Attachment (basal lamina)
 Avascularity
 Regeneration

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Epithelial Tissues

Figure 4–1 The Polarity of Epithelial Cells.


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Epithelial Tissues

 Functions of Epithelial Tissue


 Provide physical protection
 Control permeability
 Provide sensation
 Produce specialized secretions (glandular
epithelium)

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Epithelial Tissues
 Specializations of Epithelial Cells
 Move fluids over the epithelium (protection)
 Move fluids through the epithelium (permeability)
 Produce secretions (protection and messengers)
 Free Surface and Attached Surface
 Polarity
 Apical surfaces:
– microvilli increase absorption or secretion
– cilia (ciliated epithelium) move fluid
 Basolateral surfaces

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Epithelial Tissues

 Maintaining the Integrity of Epithelia


 Intercellular connections

 Attachment to basal lamina

 Epithelial maintenance and repair

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Epithelial Tissues

 Intercellular Connections
 Support and communication
 CAMs (cell adhesion molecules):
– transmembrane proteins

 Intercellular cement:
– proteoglycans

 Hyaluronan (hyaluronic acid):


– glycosaminoglycans

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Epithelial Tissues

 Intercellular Connections
 Cell junctions
 Form bonds with other cells or extracellular material:
– occluding (tight) junctions

– gap junctions

– macula adherens (desmosomes)

Intercellular Connections

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Epithelial Tissues
 Cell Junctions
 Occluding (Tight) junctions—between two plasma
membranes
 Adhesion belt attaches to terminal web
 Prevents passage of water and solutes
 Isolates wastes in the lumen

 Gap junctions—allow rapid communication


 Held together by channel proteins (junctional proteins,
connexons)
 Allow ions to pass
 Coordinate contractions in heart muscle
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Epithelial Tissues
 Cell Junctions
 Macula adherens (Desmosomes)
 CAMs, dense areas, and intercellular
cement
 Spot desmosomes
– tie cells together
– allow bending and twisting
 Hemidesmosomes
– attach cells to the basal lamina
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Epithelial Tissues

 Attachment to the Basal Lamina


 Clear layer (Lamina lucida)
 Thin layer
 Secreted by epithelia
 Barrier to proteins
 Dense layer (Lamina densa)
 Thick fibers
 Produced by connective tissue
 Strength and filtration

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Epithelial Tissues

Figure 4–2 Intercellular Connections

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Epithelial Tissues

Figure 4–2 Intercellular Connections

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Epithelial Tissues

Figure 4–2 Intercellular Connections

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Epithelial Tissues

Figure 4–2 Intercellular Connections

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Epithelial Tissues

 Epithelial Maintenance and Repair


 Epithelia are replaced by division of
germinative cells (stem cells)
 Near basal lamina

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Classification of Epithelia

 Singular epithelium; plural epithelia


 Classes of Epithelia
 Based on shape
 Squamous epithelia: thin and flat
 Cuboidal epithelia: square shaped
 Columnar epithelia: tall, slender rectangles

 Based on layers
 Simple epithelium: single layer of cells
 Stratified epithelium: several layers of cells

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Classification of Epithelia

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Classification of Epithelia

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Classification of Epithelia

 Squamous Epithelia
 Simple squamous epithelium
 Absorption and diffusion

 Mesothelium
 Lines body cavities

 Endothelium
 Lines heart and blood vessels

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Classification of Epithelia

Figure 4–3 Squamous Epithelia.

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Classification of Epithelia

 Squamous Epithelia
 Stratified squamous epithelium
 Protects against attacks

 Keratin protein adds strength and water resistance

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Classification of Epithelia

Figure 4–3 Squamous Epithelia.

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Classification of Epithelia

 Cuboidal Epithelia
 Simple cuboidal epithelium
 Secretion and absorption

 Stratified cuboidal epithelia


 Sweat ducts and mammary ducts

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Classification of Epithelia

Figure 4–4 Cuboidal Epithelia.

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Classification of Epithelia

Figure 4–4 Cuboidal Epithelia.

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Classification of Epithelia

 Transitional Epithelium
 Tolerates repeated cycles of stretching and recoiling
and returns to its previous shape without damage
 Appearance changes as stretching occurs

 Situated in regions of the urinary system (e.g. urinary


bladder)

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Classification of Epithelia

Figure 4–4 Cuboidal Epithelia.

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Classification of Epithelia

 Columnar Epithelia
 Simple columnar epithelium
 Absorption and secretion

 Pseudostratified columnar epithelium


 Cilia movement

 Stratified columnar epithelium


 Protection

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Classification of Epithelia

Figure 4–5 Columnar Epithelia.

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Classification of Epithelia

Figure 4–5 Columnar Epithelia.

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Classification of Epithelia

Figure 4–5 Columnar Epithelia.

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Classification of Epithelia

 Glandular Epithelia
 Endocrine glands
 Release hormones:
– into interstitial fluid
– no ducts

 Exocrine glands
 Produce secretions:
– onto epithelial surfaces
– through ducts

Mechanisms of Glandular Secretion

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Classification of Epithelia
 Modes of Secretion in Glandular Epithelia
 Merocrine secretion
 Is produced in Golgi apparatus
 Is released by vesicles (exocytosis)
 For example, sweat glands
 Apocrine secretion
 Is produced in Golgi apparatus
 Is released by shedding cytoplasm
 For example, mammary gland
 Holocrine secretion
 Is released by cells bursting, killing gland cells
 Gland cells replaced by stem cells
 For example, sebaceous gland
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Classification of Epithelia

Figure 4–6 Modes of Glandular Secretion.

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Classification of Epithelia

Figure 4–6 Modes of Glandular Secretion.

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Classification of Epithelia

Figure 4–6 Modes of Glandular Secretion.

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Classification of Epithelia

Figure 4–6 Modes of Glandular Secretion.

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Classification of Epithelia

 Glandular Epithelia
 Types of secretions
 Serous glands:
– watery secretions

 Mucous glands:
– secrete mucins

 Mixed exocrine glands:


– both serous and mucous

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Classification of Epithelia

 Glandular Epithelia
 Gland structure
 Unicellular glands
– Mucous (goblet) cells are the only unicellular
exocrine glands:
» scattered among epithelia
» for example, in intestinal lining

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Classification of Epithelia

 Glandular Epithelia
 Gland structure
 Multicellular glands:
– structure of the duct:
» simple (undivided)
» compound (divided)
– shape of secretory portion of the gland:
» tubular (tube shaped)
» alveolar or acinar (blind pockets)
– relationship between ducts and glandular areas:
» branched (several secretory areas sharing one
duct)

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Classification of Epithelia

Figure 4–7 A Structural Classification of Exocrine Glands.

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Classification of Epithelia

Figure 4–7 A Structural Classification of Exocrine Glands.

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Connective Tissues

 Connect epithelium to the rest of the body


(basal lamina)
 Provide structure (bone)
 Store energy (fat)
 Transport materials (blood)
 Have no contact with environment

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Connective Tissues

 Characteristics of Connective Tissues


 Specialized cells
 Solid extracellular protein fibers
 Fluid extracellular ground substance
 The extracellular components of connective
tissues (fibers and ground substance) make up
the matrix
 Majority of tissue volume
 Determines specialized function
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Connective Tissues

 Classification of Connective Tissues


 Connective tissue proper
 Connect and protect

 Fluid connective tissues


 Transport

 Supportive connective tissues


 Structural strength

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Connective Tissues

 Categories of Connective Tissue Proper


 Loose connective tissue
 More ground substance, less fibers

 For example, fat (adipose tissue)

 Dense connective tissue


 More fibers, less ground substance

 For example, tendons

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Connective Tissues

Nine Cell Types of Connective Tissue Proper

 Fibroblasts  Melanocytes
 Fibrocytes  Mast cells
 Macrophages  Lymphocytes
 Adipocytes  Microphages
 Mesenchymal cells

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Connective Tissues

 Connective Tissue Proper Cells


 Fibroblasts
 The most abundant cell type:
– found in all connective tissue proper
– secrete proteins and hyaluronan (cellular cement)

 Fibrocytes
 The second most abundant cell type:
– found in all connective tissue proper
– maintain the fibers of connective tissue proper

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Connective Tissues

 Connective Tissue Proper Cells


 Macrophages
 Large, amoeba-like cells of the immune system:
– eat pathogens and damaged cells
– fixed macrophages stay in tissue
– free macrophages migrate
 Adipocytes
 Fat cells:
– each cell stores a single, large fat droplet
 Mesenchymal Cells
 Stem cells that respond to injury or infection:
– differentiate into fibroblasts, macrophages, etc.

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Connective Tissues

 Connective Tissue Proper Cells


 Melanocytes
 Synthesize and store the brown pigment melanin

 Mast Cells
 Stimulate inflammation after injury or infection:
– release histamine and heparin

 Basophils are leukocytes (white blood cells) that


also contain histamine and heparin

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Connective Tissues

 Connective Tissue Proper Cells


 Lymphocytes
 Specialized immune cells in lymphoid (lymphatic) system:
– For example, lymphocytes may develop into plasma cells
(plasmocytes) that produce antibodies

 Microphages
 Phagocytic blood cells:
– respond to signals from macrophages and mast cells

– For example, neutrophils and eosinophils

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Connective Tissues

 Connective Tissue Fibers


 Collagen fibers
 Most common fibers in connective tissue proper

 Long, straight, and unbranched

 Strong and flexible

 Resist force in one direction

 For example, tendons and ligaments

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Connective Tissues

 Connective Tissue Fibers


 Reticular fibers
 Network of interwoven fibers (stroma)
 Strong and flexible
 Resist force in many directions
 Stabilize functional cells (parenchyma) and
structures
 For example, sheaths around organs

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Connective Tissues

 Connective Tissue Fibers


 Elastic fibers
 Contain elastin

 Branched and wavy

 Return to original length after stretching

 For example, elastic ligaments of vertebrae

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Connective Tissues

 Ground Substance
 Is clear, colorless, and viscous

 Fills spaces between cells and slows


pathogen movement

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Connective Tissues

Figure 4–8 The Cells and Fibers of Connective Tissue Proper.

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Connective Tissues

Figure 4–8 The Cells and Fibers of Connective Tissue Proper.

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Connective Tissues

 Embryonic Connective Tissues


 Are not found in adults

 Mesenchyme (embryonic stem cells)


 The first connective tissue in embryos

 Mucous connective tissue


 Loose embryonic connective tissue

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Connective Tissues

Figure 4–9 Connective Tissues in Embryos.

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Connective Tissues

[INSERT FIG. 4.9b]

Figure 4–9 Connective Tissues in Embryos.

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Connective Tissues

 Loose Connective Tissues


 The packing materials of the body
 Three types in adults
 Areolar
 Adipose
 Reticular

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Connective Tissues

 Areolar Tissue
 Least specialized
 Open framework
 Viscous ground substance
 Elastic fibers
 Holds blood vessels and capillary beds
 For example, under skin (subcutaneous layer)

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Connective Tissues
 Adipose Tissue
 Contains many adipocytes (fat cells)
 Types of adipose tissue
 White fat:
– most common
– stores fat
– absorbs shocks
– slows heat loss (insulation)
 Brown fat:
– more vascularized
– adipocytes have many mitochondria
– when stimulated by nervous system, fat break down
accelerates, releasing energy
– absorbs energy from surrounding tissues

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Connective Tissues

 Adipose Tissue
 Adipose cells
 Adipocytes in adults do not divide:
– expand to store fat
– shrink as fats are released
 Mesenchymal cells divide and
differentiate:
– to produce more fat cells
– when more storage is needed

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Connective Tissues

 Reticular Tissue
 Provides support

 Complex, three-dimensional network

 Supportive fibers (stroma)


 Support functional cells (parenchyma)

 Reticular organs
 Spleen, liver, lymph nodes, and bone marrow

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Connective Tissues

Figure 4–10 Adipose and Reticular Tissues.

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Connective Tissues

Figure 4–10 Adipose and Reticular Tissues.

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Connective Tissues

 Dense Connective Tissues


 Connective tissues proper, tightly packed with
high numbers of collagen or elastic fibers
 Dense regular connective tissue

 Dense irregular connective tissue

 Elastic tissue

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Connective Tissues

 Dense Regular Connective Tissue


 Tightly packed, parallel collagen fibers

 Tendons attach muscles to bones

 Ligaments connect bone to bone and stabilize


organs
 Aponeuroses attach in sheets to large, flat
muscles

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Connective Tissues

Figure 4–11 Dense Connective Tissues.

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Connective Tissues

 Dense Irregular Connective Tissue


 Interwoven networks of collagen fibers
 Layered in skin

 Around cartilages (perichondrium)

 Around bones (periosteum)

 Form capsules around some organs (e.g., liver,


kidneys)

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Connective Tissues

Figure 4–11 Dense Connective Tissues.

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Connective Tissues

 Elastic Tissue
 Made of elastic fibers
 For example, elastic ligaments of spinal vertebrae

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Connective Tissues

Figure 4–11 Dense Connective Tissues.

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Connective Tissues

 Fluid Connective Tissues


 Blood and lymph

 Watery matrix of dissolved proteins

 Carry specific cell types (formed elements)

 Formed elements of blood


– red blood cells (erythrocytes)

– white blood cells (leukocytes)

– platelets

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Connective Tissues

 Fluid Elements of Fluid Connective


Tissues
 Extracellular
 Plasma

 Interstitial fluid

 Lymph

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Connective Tissues

Figure 4–12 Formed Elements of the Blood.

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Connective Tissues

 Lymph
 Extracellular fluid
 Collected from interstitial space

 Monitored by immune system

 Transported by lymphoid (lymphatic) system

 Returned to venous system

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Connective Tissues

 Fluid Tissue Transport Systems


 Cardiovascular system (blood)
 Arteries
 Capillaries
 Veins
 Lymphoid (lymphatic) system (lymph)
 Lymphatic vessels

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Supportive Connective Tissues

 Support soft tissues and body weight


 Cartilage
 Gel-type ground substance

 For shock absorption and protection

 Bone
 Calcified (made rigid by calcium salts, minerals)

 For weight support

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Supportive Connective Tissues

 Cartilage Matrix
 Proteoglycans derived from chondroitin sulfates

 Ground substance proteins

 Chondrocytes (cartilage cells) surrounded by


lacunae (chambers)

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Supportive Connective Tissues

 Cartilage Structure
 No blood vessels:

 Chondrocytes produce antiangiogenesis factor

 Perichondrium:

 Outer, fibrous layer (for strength)

 Inner, cellular layer (for growth and maintenance)

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Supportive Connective Tissues

Figure 4–13 The Growth of Cartilage.


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Supportive Connective Tissues

Figure 4–13 The Growth of Cartilage.

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Supportive Connective Tissues
 Types of Cartilage
 Hyaline cartilage
 Stiff, flexible support
 Reduces friction between bones
 Found in synovial joints, rib tips, sternum, and trachea
 Elastic cartilage
 Supportive but bends easily
 Found in external ear and epiglottis
 Fibrous cartilage (fibrocartilage)
 Limits movement
 Prevents bone-to-bone contact
 Pads knee joints
 Found between pubic bones and intervertebral discs
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Supportive Connective Tissues

Figure 4–14 The Types of Cartilage.

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Supportive Connective Tissues

Figure 4–14 The Types of Cartilage.

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Supportive Connective Tissues

Figure 4–14 The Types of Cartilage.

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Supportive Connective Tissues
 Bone or osseous tissue
 Strong (calcified: calcium salt deposits)
 Resists shattering (flexible collagen fibers)
 Bone cells or osteocytes
 Arranged around central canals within matrix
 Small channels through matrix (canaliculi) access
blood supply
 Periosteum
 Covers bone surfaces
 Fibrous layer
 Cellular layer

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Supportive Connective Tissues

Figure 4–15 Bone.

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Supportive Connective Tissues

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Membranes

 Membranes
 Are physical barriers

 That line or cover portions of the body

 Consist of
 An epithelium

 Supported by connective tissues

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Membranes

 Four Types of Membranes


 Mucous membranes

 Serous membranes

 Cutaneous membrane

 Synovial membranes

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Membranes

 Mucous membranes (mucosae)


 Line passageways that have external connections
 In digestive, respiratory, urinary, and reproductive
tracts
 Epithelial surfaces must be moist
 To reduce friction
 To facilitate absorption and excretion

 Lamina propria
 Is areolar tissue

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Membranes

 Serous Membranes
 Line cavities not open to the outside
 Are thin but strong
 Have fluid transudate to reduce friction
 Have a parietal portion covering the cavity
 Have a visceral portion (serosa) covering the
organs

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Membranes

 Three Serous Membranes


 Pleura:
 Lines pleural cavities
 Covers lungs
 Peritoneum:
 Lines peritoneal cavity
 Covers abdominal organs
 Pericardium:
 Lines pericardial cavity
 Covers heart
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Membranes

Figure 4–16 Membranes.

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Membranes

 Cutaneous membrane
 Is skin, surface of the body
 Thick, waterproof, and dry

 Synovial membranes
 Line moving, articulating joint cavities
 Produce synovial fluid (lubricant)
 Protect the ends of bones
 Lack a true epithelium

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Membranes

Figure 4–16 Membranes.

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Internal Framework of the Body
 Connective tissues
 Provide strength and stability
 Maintain positions of internal organs
 Provide routes for blood vessels, lymphatic vessels, and
nerves
 Fasciae
 Singular form is fascia
 The body’s framework of connective tissue
 Layers and wrappings that support or surround organs

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Internal Framework of the Body

 Three Types of Fasciae


 Superficial fascia

 Deep fascia

 Subserous fascia

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Internal Framework of the Body

Figure 4–17 The Fasciae.

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Muscle Tissue

 Specialized for contraction


 Produces all body movement
 Three types of muscle tissue
 Skeletal muscle
 Large body muscles responsible for movement
 Cardiac muscle
 Found only in the heart
 Smooth muscle
 Found in walls of hollow, contracting organs (blood vessels;
urinary bladder; respiratory, digestive, and reproductive
tracts)
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Muscle Tissue
 Classification of Muscle Cells
 Striated (muscle cells with a banded appearance)
 Nonstriated (not banded; smooth)
 Muscle cells can have a single nucleus
 Muscle cells can be multinucleate
 Muscle cells can be controlled voluntarily (consciously)
 Muscle cells can be controlled involuntarily
(automatically)

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Muscle Tissue

 Skeletal Muscle Cells


 Are long and thin

 Are usually called muscle fibers

 Do not divide

 New fibers are produced by stem cells


(myosatellite cells)

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Muscle Tissue

Figure 4–18 Muscle Tissue.

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Muscle Tissue

 Cardiac muscle cells


 Are called cardiocytes
 Form branching networks connected at
intercalated discs
 Are regulated by pacemaker cells
 Smooth muscle cells
 Are small and tapered
 Can divide and regenerate
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Muscle Tissue

Figure 4–18 Muscle Tissue.

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Muscle Tissue

Figure 4–18 Muscle Tissue.

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Neural Tissue

 Also called nervous or nerve tissue


 Specialized for conducting electrical impulses

 Rapidly senses internal or external


environment
 Processes information and controls
responses

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Neural Tissue

 Neural tissue is concentrated in the


central nervous system
 Brain

 Spinal cord

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Neural Tissue

 Two Kinds of Neural Cells


 Neurons
 Nerve cells

 Perform electrical communication

 Neuroglia
 Supporting cells

 Repair and supply nutrients to neurons

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Neural Tissue

 Cell Parts of a Neuron


 Cell body
 Contains the nucleus and nucleolus

 Dendrites
 Short branches extending from the cell body
 Receive incoming signals

 Axon (nerve fiber)


 Long, thin extension of the cell body
 Carries outgoing electrical signals to their destination

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Neural Tissue

Figure 4–19 Neural Tissue.

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Tissue Injuries and Repair

 Tissues respond to injuries to maintain


homeostasis
 Cells restore homeostasis with two processes
 Inflammation

 Regeneration

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Tissue Injuries and Repair

 Inflammation = inflammatory response


 The tissue’s first response to injury
 Signs and symptoms of the inflammatory
response include
 Swelling
 Redness
 Heat
 Pain

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Tissue Injuries and Repair

 Inflammatory Response
 Can be triggered by
 Trauma (physical injury)

 Infection (the presence of harmful pathogens)

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Tissue Injuries and Repair

 The Process of Inflammation


 Damaged cells release chemical signals into the
surrounding interstitial fluid
 Prostaglandins
 Proteins
 Potassium ions
 As cells break down
 Lysosomes release enzymes
 That destroy the injured cell
 And attack surrounding tissues
 Tissue destruction is called necrosis
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Tissue Injuries and Repair

 The Process of Inflammation


 Necrotic tissues and cellular debris (pus) accumulate
in the wound
 Abscess:
– pus trapped in an enclosed area

 Injury stimulates mast cells to release


 Histamine
 Heparin
 Prostaglandins

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Tissue Injuries and Repair

 The Process of Inflammation


 Dilation of blood vessels
 Increases blood circulation in the area
 Causes warmth and redness
 Brings more nutrients and oxygen to the area
 Removes wastes
 Plasma diffuses into the area
 Causing swelling and pain
 Phagocytic white blood cells
 Clean up the area
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Tissue Injuries and Repair

Figure 4–20 An Introduction to Inflammation.

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Tissue Injuries and Repair

 Regeneration
 When the injury or infection is cleaned up
 Healing (regeneration) begins

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Tissue Injuries and Repair

 The Process of Regeneration


 Fibrocytes move into necrotic area
 Lay down collagen fibers
 To bind the area together (scar tissue)

 New cells migrate into area


 Or are produced by mesenchymal stem cells

 Not all tissues can regenerate


 Epithelia and connective tissues regenerate well
 Cardiac cells and neurons do not regenerate (or regenerate
poorly)

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Aging and Tissue

 Aging and Tissue Structure


 Speed and efficiency of tissue repair
decreases with age, due to
 Slower rate of energy consumption (metabolism)

 Hormonal alterations

 Reduced physical activity

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Aging and Tissue

 Effects of Aging
 Chemical and structural tissue changes
 Thinning epithelia and connective tissues
 Increased bruising and bone brittleness
 Joint pain and broken bones
 Cardiovascular disease
 Mental deterioration

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Aging and Tissue

 Aging and Cancer Incidence


 Cancer rates increase with age

 1 in 4 people in the United States develops cancer

 Cancer is the #2 cause of death in the United


States
 Environmental chemicals and cigarette smoke
cause cancer

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