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PowerPoint® Lecture Slides prepared by Vince Austin, University of Kentucky

The Integumentary System

5
Human Anatomy & Physiology, Sixth Edition
Elaine N. Marieb
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Skin (Integument)
 Consists of three major regions

 Epidermis – outermost superficial region
 Dermis – middle region
 Hypodermis (superficial fascia) – deepest region

Skin (Integument)
Figure 5.1
Epidermis
 Composed of keratinized stratified squamous

epithelium, consisting of four distinct cell types and
four or five layers
 Cell types include keratinocytes, melanocytes,
Merkel cells, and Langerhans’ cells
 Outer portion of the skin is exposed to the external
environment and functions in protection

Cells of the Epidermis
 Keratinocytes – produce the fibrous protein keratin
 Melanocytes – produce the brown pigment melanin
 Langerhans’ cells – epidermal macrophages that

help activate the immune system
 Merkel cells – function as touch receptors in
association with sensory nerve endings

Layers of the Epidermis: Stratum Basale
(Basal Layer)
 Deepest epidermal layer firmly attached to the

dermis
 Consists of a single row of the youngest
keratinocytes
 Cells undergo rapid division, hence its alternate
name, stratum germinativum

Layers of the Epidermis: Stratum Basale
(Basal Layer)
Figure 5.2b
Layers of the Epidermis: Stratum Spinosum
(Prickly Layer)
 Cells contain a weblike system of intermediate

filaments attached to desmosomes
 Melanin granules and Langerhans’ cells are
abundant in this layer

Layers of the Epidermis: Stratum Granulosum
(Granular Layer)
 Thin; three to five cell layers in which drastic

changes in keratinocyte appearance occurs
 Keratohyaline and lamellated granules accumulate

in the cells of this layer

Layers of the Epidermis: Stratum Lucidum
(Clear Layer)
 Thin, transparent band superficial to the stratum

granulosum
 Consists of a few rows of flat, dead keratinocytes
 Present only in thick skin

Layers of the Epidermis: Stratum Corneum
(Horny Layer)
 Outermost layer of keratinized cells
 Accounts for three quarters of the epidermal

thickness
 Functions include:
 Waterproofing
 Protection from abrasion and penetration
 Rendering the body relatively insensitive to

biological, chemical, and physical assaults
Dermis
 Second major skin region containing strong, flexible

connective tissue
 Cell types include fibroblasts, macrophages, and
occasionally mast cells and white blood cells
 Composed of two layers – papillary and reticular

Layers of the Dermis: Papillary Layer
 Papillary layer
 Areolar connective tissue with collagen and elastic
fibers
 Its superior surface contains peglike projections
called dermal papillae
 Dermal papillae contain capillary loops, Meissner’s
corpuscles, and free nerve endings

Layers of the Dermis: Reticular Layer
 Reticular layer
 Accounts for approximately 80% of the thickness
of the skin
 Collagen fibers in this layer add strength and
resiliency to the skin
 Elastin fibers provide stretch-recoil properties

Hypodermis
 Subcutaneous layer deep to the skin
 Composed of adipose and areolar connective tissue

Skin Color
 Three pigments contribute to skin color

 Melanin – yellow to reddish-brown to black
pigment, responsible for dark skin colors
 Freckles and pigmented moles – result from
local accumulations of melanin
 Carotene – yellow to orange pigment, most obvious
in the palms and soles of the feet
 Hemoglobin – reddish pigment responsible for the
pinkish hue of the skin
Sweat Glands
 Different types prevent overheating of the body;
secrete cerumen and milk
 Eccrine sweat glands – found in palms, soles of the
feet, and forehead
 Apocrine sweat glands – found in axillary and
anogenital areas
 Ceruminous glands – modified apocrine glands in
external ear canal that secrete cerumen
 Mammary glands – specialized sweat glands that
secrete milk
Sebaceous Glands
 Simple alveolar glands found all over the body
 Soften skin when stimulated by hormones
 Secrete an oily secretion called sebum

Structure of a Nail
 Scalelike modification of the epidermis on the distal,

dorsal surface of fingers and toes
Figure 5.4
Hair
 Filamentous strands of dead keratinized cells

produced by hair follicles
 Contains hard keratin which is tougher and more
durable than soft keratin of the skin
 Made up of the shaft projecting from the skin, and
the root embedded in the skin
 Consists of a core called the medulla, a cortex, and
an outermost cuticle
 Pigmented by melanocytes at the base of the hair
Hair Function and Distribution
 Functions of hair include:

 Helping to maintain warmth
 Alerting the body to presence of insects on the skin
 Guarding the scalp against physical trauma, heat

loss, and sunlight
 Hair is distributed over the entire skin surface except

 Palms, soles, and lips
 Nipples and portions of the external genitalia

Hair Follicle
 Root sheath extending from the epidermal surface

into the dermis
 Deep end is expanded forming a hair bulb
 A knot of sensory nerve endings (a root hair plexus)

wraps around each hair bulb
 Bending a hair stimulates these endings, hence our
hairs act as sensitive touch receptors

Hair Follicle
Figure 5.6a
Hair Follicle
Figure 5.6c
Types of Hair
 Vellus – pale, fine body hair found in children and

the adult female
 Terminal – coarse, long hair of eyebrows, scalp,
axillary, and pubic regions

Hair Thinning and Baldness
 Alopecia – hair thinning in both sexes
 True, or frank, baldness

 Genetically determined and sex-influenced
condition
 Male pattern baldness – caused by follicular
response to DHT

Functions of the Integumentary System
 Protection – chemical, physical, and mechanical

barrier
 Body temperature regulation is accomplished by:
 Dilation (cooling) and constriction (warming) of
dermal vessels
 Increasing sweat gland secretions to cool the body
 Cutaneous sensation – exoreceptors sense touch and

pain
Functions of the Integumentary System
 Metabolic functions – synthesis of vitamin D in

dermal blood vessels
 Blood reservoir – skin blood vessels store up to 5%
of the body’s blood volume
 Excretion – limited amounts of nitrogenous wastes
are eliminated from the body in sweat

Skin Cancer
 Most skin tumors are benign and do not metastasize
 A crucial risk factor for nonmelanoma skin cancers

is the disabling of the p53 gene
 Newly developed skin lotions can fix damaged DNA

Skin Cancer
 The three major types of skin cancer are:

 Basal cell carcinoma
 Squamous cell carcinoma
 Melanoma

Basal Cell Carcinoma
 Least malignant and most common skin cancer
 Stratum basale cells proliferate and invade the

dermis and hypodermis
 Slow growing and do not often metastasize
 Can be cured by surgical excision in 99% of the

cases

Squamous Cell Carcinoma
 Arises from keratinocytes of stratum spinosum
 Arise most often on scalp, ears, and lower lip
 Grows rapidly and metastasizes if not removed
 Prognosis is good if treated by radiation therapy or

removed surgically

Melanoma
 Cancer of melanocytes is the most dangerous type of

skin cancer because it is:
 Highly metastatic
 Resistant to chemotherapy

Melanoma
 Melanomas have the following characteristics

(ABCD rule)
 A: Asymmetry; the two sides of the pigmented
area do not match
 B: Border is irregular and exhibits indentations
 C: Color (pigmented area) is black, brown, tan, and

sometimes red or blue
 D: Diameter is larger than 6 mm (size of a pencil
eraser)
Melanoma
 Treated by wide surgical excision accompanied by

immunotherapy
 Chance of survival is poor if the lesion is over 4 mm
thick

Burns
 First-degree – only the epidermis is damaged

 Symptoms include localized redness, swelling, and
pain
 Second-degree – epidermis and upper regions of
dermis are damaged
 Symptoms mimic first degree burns, but blisters also
appear
 Third-degree – entire thickness of the skin is damaged
 Burned area appears gray-white, cherry red, or black;
there is no initial edema or pain (since nerve endings
are destroyed)
Rule of Nines
 Estimates the severity of burns
 Burns considered critical if:

 Over 25% of the body has second-degree burns
 Over 10% of the body has third-degree burns
 There are third-degree burns on face, hands, or feet

Rule of Nines
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 5.8a
Developmental Aspects of the Integument:
Fetal
 Epidermis develops from ectoderm
 Dermis and hypodermis develop from mesoderm
 Lanugo – downy coat of delicate hairs covering the

fetus
 Vernix caseosa – substance produced by sebaceous
glands that protects the skin of the fetus in the
amnion

Adolescent to Adult
 Skin and hair become oilier and acne may appear
 Skin shows the effects of cumulative environmental

assaults around age 30
 Scaling and dermatitis become more common

Old Age
 Epidermal replacement of cells slows and skin
becomes thinner
 Skin becomes dry and itchy
 Subcutaneous fat layer diminishes, leading to

intolerance of cold
 Decreased elasticity and loss of subcutaneous tissue
leads to wrinkles
 Decreased numbers of melanocytes and Langerhans’
cells increase the risk of skin cancer

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PowerPoint® Lecture Slides prepared by Vince Austin, University of Kentucky

The Integumentary System

 Consists of three major regions

 Dermis – middle region

 Hypodermis (superficial fascia) – deepest region

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

 Composed of keratinized stratified squamous

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

 Keratinocytes – produce the fibrous protein keratin

 Melanocytes – produce the brown pigment melanin

 Langerhans’ cells – epidermal macrophages that

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

 Deepest epidermal layer firmly attached to the

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

 Cells contain a weblike system of intermediate

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

 Thin; three to five cell layers in which drastic

 Keratohyaline and lamellated granules accumulate

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

 Thin, transparent band superficial to the stratum

 Present only in thick skin

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

 Outermost layer of keratinized cells

 Accounts for three quarters of the epidermal

 Protection from abrasion and penetration

 Rendering the body relatively insensitive to

 Second major skin region containing strong, flexible

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

 Subcutaneous layer deep to the skin

 Composed of adipose and areolar connective tissue

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

 Three pigments contribute to skin color

 Simple alveolar glands found all over the body

 Soften skin when stimulated by hormones

 Secrete an oily secretion called sebum

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

 Scalelike modification of the epidermis on the distal,

 Filamentous strands of dead keratinized cells

 Functions of hair include:

 Alerting the body to presence of insects on the skin

 Guarding the scalp against physical trauma, heat

 Hair is distributed over the entire skin surface except

 Nipples and portions of the external genitalia

 Root sheath extending from the epidermal surface

 A knot of sensory nerve endings (a root hair plexus)

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

 Vellus – pale, fine body hair found in children and

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

 Alopecia – hair thinning in both sexes

 True, or frank, baldness

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

 Protection – chemical, physical, and mechanical

 Cutaneous sensation – exoreceptors sense touch and

 Metabolic functions – synthesis of vitamin D in

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

 Most skin tumors are benign and do not metastasize

 A crucial risk factor for nonmelanoma skin cancers

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings