-
What does plakoglobin mean?
What does plakoglobin mean?
A spoken definition of plakoglobin.
Intro Sound:
Typewriter - Tamskp
Licensed under CC:BA 3.0
Outro Music:
Groove Groove - Kevin MacLeod (incompetech.com)
Licensed under CC:BA 3.0
Intro/Outro Photo:
The best days are not planned - Marcus Hansson
Licensed under CC-BY-2.0
Book Image:
Open Book template PSD - DougitDesign
Licensed under CC:BA 3.0
Text derived from:
http://en.wiktionary.org/wiki/plakoglobin
published: 17 Oct 2017
-
Desmosomes: Structure and Functions
¿What are desmosomes? ¿What do they do? ¿What proteins are they made of? Here we talk about desmoglein and desmocolin, the desmosomal cadherins, and about the adaptors they use to bind to intermediate filaments giving mechanical resistance to tissues: plakophilin, plakoglobin and desmoplakin.
Free slides at: https://www.flipyourlearning.com/desmosomas (bottom of the page)
published: 31 May 2021
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How to Pronounce Plakoglobin
This video shows you how to pronounce Plakoglobin
published: 01 Jun 2015
-
Transcription in Myc-Related Cancers
Healthy cells regulate gene transcription as an essential checkpoint to prevent uncontrolled cellular growth that leads to disease.
Watch this video to learn more about how RNA Polymerase II and the Super Elongation protein complex (SEC) influence gene transcription and how their misregulation may lead to disease.
Researchers in Shilatifard’s laboratory are studying these mechanisms in order to understand the evolution of cancer and potentially discover targets for novel cancer therapeutics.
This video was produced by Dani Bergey from the Biomedical Visualization graduate program at the University of Illinois at Chicago.
__________________________________________________________
Related links:
Dani Bergey: https://www.danibergey.com/
Biomedical Visualization program at UIC: https://ahs.u...
published: 02 Oct 2019
-
Desmosomes
In this video we have discussed about the desmosomes .
published: 12 Dec 2023
-
Lecture-58: Inherited disorders of cornification, Part 4. Syndromic keratodermas. Rook's chapter 65.
Also includes Porokeratosis and perforating disorders.
published: 03 Jan 2021
-
Detecting Gene Ontology misannotations using... - Chengxin Zhang - Bio-Ontologies - ISMB 2020
Detecting Gene Ontology misannotations using taxon-specific rate ratio comparisons - Chengxin Zhang - Bio-Ontologies - ISMB 2020
published: 13 Jan 2021
-
Induction of Adherens Junctions within Granuloma Macrophages
Movie of Tg(mfap4:tomato-caax); Gt(jup-citrine)ct520a animal shown in Figure 2. Magenta: macrophages, M. marinum: cyan, and green: plakoglobin. Individual frames display maximum projection images of 70 μm.
Read more from Cronan et al. (2016) in Immunity: http://www.cell.com/immunity/fulltext/S1074-7613(16)30383-1
published: 05 Oct 2017
-
Death 2 Pathways_pt2_Biological information available for correlations
“Death to Pathways! A Case for Data-Driven, Cell-Specific Networks”. Lecture given on June 19, 2017, at the University of Colorado Anschutz Medical Campus to members of the Gates Center Summer Internship Program (GSIP). Videos provide support for data-driven, cell-specific methods for identifying gene-centered signaling networks using transcriptome data. Pearson correlations are used to find related genes to a target of interest in two large lung cancer cell line datasets. The intersection of correlated genes between the two datasets is used to vastly reduce the number of false positives and to construct the target-specific network. The target genes Junction Plakoglobin (JUP) and Glycogen Synthase Kinase 3 Beta (GSK3B) are used as examples in the presentation (references given below).
S...
published: 20 Jun 2017
-
Understanding Bioinformatics_Part 4_Using the crowd to find genes related to JUP
This video is part 4 of a guest lecture on bioinformatics given to bioengineering graduate students in the Analytic Methods for Engineering Analysis class on Sept.17, 2015. Part 4 of the lecture gives a demonstration on how we can use correlation and different datasets to find connected genes. In this example, I use two different lung cancer cell line gene expression datasets to find common genes correlated to Junction Plakoglobin (JUP).
published: 18 Sep 2015
0:37
What does plakoglobin mean?
What does plakoglobin mean?
A spoken definition of plakoglobin.
Intro Sound:
Typewriter - Tamskp
Licensed under CC:BA 3.0
Outro Music:
Groove Groove -...
What does plakoglobin mean?
A spoken definition of plakoglobin.
Intro Sound:
Typewriter - Tamskp
Licensed under CC:BA 3.0
Outro Music:
Groove Groove - Kevin MacLeod (incompetech.com)
Licensed under CC:BA 3.0
Intro/Outro Photo:
The best days are not planned - Marcus Hansson
Licensed under CC-BY-2.0
Book Image:
Open Book template PSD - DougitDesign
Licensed under CC:BA 3.0
Text derived from:
http://en.wiktionary.org/wiki/plakoglobin
https://wn.com/What_Does_Plakoglobin_Mean
What does plakoglobin mean?
A spoken definition of plakoglobin.
Intro Sound:
Typewriter - Tamskp
Licensed under CC:BA 3.0
Outro Music:
Groove Groove - Kevin MacLeod (incompetech.com)
Licensed under CC:BA 3.0
Intro/Outro Photo:
The best days are not planned - Marcus Hansson
Licensed under CC-BY-2.0
Book Image:
Open Book template PSD - DougitDesign
Licensed under CC:BA 3.0
Text derived from:
http://en.wiktionary.org/wiki/plakoglobin
- published: 17 Oct 2017
- views: 65
6:07
Desmosomes: Structure and Functions
¿What are desmosomes? ¿What do they do? ¿What proteins are they made of? Here we talk about desmoglein and desmocolin, the desmosomal cadherins, and about the a...
¿What are desmosomes? ¿What do they do? ¿What proteins are they made of? Here we talk about desmoglein and desmocolin, the desmosomal cadherins, and about the adaptors they use to bind to intermediate filaments giving mechanical resistance to tissues: plakophilin, plakoglobin and desmoplakin.
Free slides at: https://www.flipyourlearning.com/desmosomas (bottom of the page)
https://wn.com/Desmosomes_Structure_And_Functions
¿What are desmosomes? ¿What do they do? ¿What proteins are they made of? Here we talk about desmoglein and desmocolin, the desmosomal cadherins, and about the adaptors they use to bind to intermediate filaments giving mechanical resistance to tissues: plakophilin, plakoglobin and desmoplakin.
Free slides at: https://www.flipyourlearning.com/desmosomas (bottom of the page)
- published: 31 May 2021
- views: 13870
0:19
How to Pronounce Plakoglobin
This video shows you how to pronounce Plakoglobin
This video shows you how to pronounce Plakoglobin
https://wn.com/How_To_Pronounce_Plakoglobin
This video shows you how to pronounce Plakoglobin
- published: 01 Jun 2015
- views: 244
3:29
Transcription in Myc-Related Cancers
Healthy cells regulate gene transcription as an essential checkpoint to prevent uncontrolled cellular growth that leads to disease.
Watch this video to learn mo...
Healthy cells regulate gene transcription as an essential checkpoint to prevent uncontrolled cellular growth that leads to disease.
Watch this video to learn more about how RNA Polymerase II and the Super Elongation protein complex (SEC) influence gene transcription and how their misregulation may lead to disease.
Researchers in Shilatifard’s laboratory are studying these mechanisms in order to understand the evolution of cancer and potentially discover targets for novel cancer therapeutics.
This video was produced by Dani Bergey from the Biomedical Visualization graduate program at the University of Illinois at Chicago.
__________________________________________________________
Related links:
Dani Bergey: https://www.danibergey.com/
Biomedical Visualization program at UIC: https://ahs.uic.edu/biomedical-health-information-sciences/admissions-and-programs/ms-in-biomedical-visualization/
Simpson Querrey Center for Epigenetics: https://www.feinberg.northwestern.edu/sites/epigenetics/
Shilatifard Laboratory: https://labs.feinberg.northwestern.edu/shilatifard/
https://wn.com/Transcription_In_Myc_Related_Cancers
Healthy cells regulate gene transcription as an essential checkpoint to prevent uncontrolled cellular growth that leads to disease.
Watch this video to learn more about how RNA Polymerase II and the Super Elongation protein complex (SEC) influence gene transcription and how their misregulation may lead to disease.
Researchers in Shilatifard’s laboratory are studying these mechanisms in order to understand the evolution of cancer and potentially discover targets for novel cancer therapeutics.
This video was produced by Dani Bergey from the Biomedical Visualization graduate program at the University of Illinois at Chicago.
__________________________________________________________
Related links:
Dani Bergey: https://www.danibergey.com/
Biomedical Visualization program at UIC: https://ahs.uic.edu/biomedical-health-information-sciences/admissions-and-programs/ms-in-biomedical-visualization/
Simpson Querrey Center for Epigenetics: https://www.feinberg.northwestern.edu/sites/epigenetics/
Shilatifard Laboratory: https://labs.feinberg.northwestern.edu/shilatifard/
- published: 02 Oct 2019
- views: 5036
1:30
Desmosomes
In this video we have discussed about the desmosomes .
In this video we have discussed about the desmosomes .
https://wn.com/Desmosomes
In this video we have discussed about the desmosomes .
- published: 12 Dec 2023
- views: 245
15:19
Detecting Gene Ontology misannotations using... - Chengxin Zhang - Bio-Ontologies - ISMB 2020
Detecting Gene Ontology misannotations using taxon-specific rate ratio comparisons - Chengxin Zhang - Bio-Ontologies - ISMB 2020
Detecting Gene Ontology misannotations using taxon-specific rate ratio comparisons - Chengxin Zhang - Bio-Ontologies - ISMB 2020
https://wn.com/Detecting_Gene_Ontology_Misannotations_Using..._Chengxin_Zhang_Bio_Ontologies_Ismb_2020
Detecting Gene Ontology misannotations using taxon-specific rate ratio comparisons - Chengxin Zhang - Bio-Ontologies - ISMB 2020
- published: 13 Jan 2021
- views: 130
0:20
Induction of Adherens Junctions within Granuloma Macrophages
Movie of Tg(mfap4:tomato-caax); Gt(jup-citrine)ct520a animal shown in Figure 2. Magenta: macrophages, M. marinum: cyan, and green: plakoglobin. Individual frame...
Movie of Tg(mfap4:tomato-caax); Gt(jup-citrine)ct520a animal shown in Figure 2. Magenta: macrophages, M. marinum: cyan, and green: plakoglobin. Individual frames display maximum projection images of 70 μm.
Read more from Cronan et al. (2016) in Immunity: http://www.cell.com/immunity/fulltext/S1074-7613(16)30383-1
https://wn.com/Induction_Of_Adherens_Junctions_Within_Granuloma_Macrophages
Movie of Tg(mfap4:tomato-caax); Gt(jup-citrine)ct520a animal shown in Figure 2. Magenta: macrophages, M. marinum: cyan, and green: plakoglobin. Individual frames display maximum projection images of 70 μm.
Read more from Cronan et al. (2016) in Immunity: http://www.cell.com/immunity/fulltext/S1074-7613(16)30383-1
- published: 05 Oct 2017
- views: 392
7:10
Death 2 Pathways_pt2_Biological information available for correlations
“Death to Pathways! A Case for Data-Driven, Cell-Specific Networks”. Lecture given on June 19, 2017, at the University of Colorado Anschutz Medical Campus to me...
“Death to Pathways! A Case for Data-Driven, Cell-Specific Networks”. Lecture given on June 19, 2017, at the University of Colorado Anschutz Medical Campus to members of the Gates Center Summer Internship Program (GSIP). Videos provide support for data-driven, cell-specific methods for identifying gene-centered signaling networks using transcriptome data. Pearson correlations are used to find related genes to a target of interest in two large lung cancer cell line datasets. The intersection of correlated genes between the two datasets is used to vastly reduce the number of false positives and to construct the target-specific network. The target genes Junction Plakoglobin (JUP) and Glycogen Synthase Kinase 3 Beta (GSK3B) are used as examples in the presentation (references given below).
Sechler M, Borowicz S, Van Scoyk M, Avasarala S, Zerayesus S, Edwards MG, et al. Novel role for γ-catenin in the regulation of cancer cell migration via the induction of hepatocyte growth factor activator inhibitor type 1 (HAI-1). Journal of Biological Chemistry. 2015 Jun 19;290(25): 15610–20.
Hoffman O, Burns N, Vadász I, Eltzschig HK, Edwards MG, Vohwinkel CU (2017) Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome. PLoS ONE 12(2): e0172116. pmid:28196122
For all business or lecture requests, you can contact me, Dr. Michael Edwards from Bioinfo Solutions, at this email address: michael.edwards@bioinfosolutions.com.
https://wn.com/Death_2_Pathways_Pt2_Biological_Information_Available_For_Correlations
“Death to Pathways! A Case for Data-Driven, Cell-Specific Networks”. Lecture given on June 19, 2017, at the University of Colorado Anschutz Medical Campus to members of the Gates Center Summer Internship Program (GSIP). Videos provide support for data-driven, cell-specific methods for identifying gene-centered signaling networks using transcriptome data. Pearson correlations are used to find related genes to a target of interest in two large lung cancer cell line datasets. The intersection of correlated genes between the two datasets is used to vastly reduce the number of false positives and to construct the target-specific network. The target genes Junction Plakoglobin (JUP) and Glycogen Synthase Kinase 3 Beta (GSK3B) are used as examples in the presentation (references given below).
Sechler M, Borowicz S, Van Scoyk M, Avasarala S, Zerayesus S, Edwards MG, et al. Novel role for γ-catenin in the regulation of cancer cell migration via the induction of hepatocyte growth factor activator inhibitor type 1 (HAI-1). Journal of Biological Chemistry. 2015 Jun 19;290(25): 15610–20.
Hoffman O, Burns N, Vadász I, Eltzschig HK, Edwards MG, Vohwinkel CU (2017) Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome. PLoS ONE 12(2): e0172116. pmid:28196122
For all business or lecture requests, you can contact me, Dr. Michael Edwards from Bioinfo Solutions, at this email address: michael.edwards@bioinfosolutions.com.
- published: 20 Jun 2017
- views: 92
12:07
Understanding Bioinformatics_Part 4_Using the crowd to find genes related to JUP
This video is part 4 of a guest lecture on bioinformatics given to bioengineering graduate students in the Analytic Methods for Engineering Analysis class on Se...
This video is part 4 of a guest lecture on bioinformatics given to bioengineering graduate students in the Analytic Methods for Engineering Analysis class on Sept.17, 2015. Part 4 of the lecture gives a demonstration on how we can use correlation and different datasets to find connected genes. In this example, I use two different lung cancer cell line gene expression datasets to find common genes correlated to Junction Plakoglobin (JUP).
https://wn.com/Understanding_Bioinformatics_Part_4_Using_The_Crowd_To_Find_Genes_Related_To_Jup
This video is part 4 of a guest lecture on bioinformatics given to bioengineering graduate students in the Analytic Methods for Engineering Analysis class on Sept.17, 2015. Part 4 of the lecture gives a demonstration on how we can use correlation and different datasets to find connected genes. In this example, I use two different lung cancer cell line gene expression datasets to find common genes correlated to Junction Plakoglobin (JUP).
- published: 18 Sep 2015
- views: 411
-
Wnt/β-Catenin Signaling Pathway
The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals into a cell through cell surface receptors.
The canonical Wnt pathway or Wnt/β-catenin pathway is the Wnt pathway that causes an accumulation of β-catenin in the cytoplasm and its eventual translocation into the nucleus to act as a transcriptional coactivator of transcription factors that belong to the TCF/LEF family.
published: 11 Jun 2018
-
Wnt/β-Catenin Signaling Pathway | Overview, Purpose and APC Mutations
Lesson on the Wnt/β-Catenin signaling pathway (also known as simply the Wnt signaling pathway), including an introduction to the pathway, Wnt growth stimulatory factors, β-Catenin regulation and role of the pathway in growth, proliferation and development. Wnt proteins act as The Wnt signaling pathway is critically important in embryonic development, particularly in the development of the heart. As such the Wnt/β-Catenin signaling pathway is highly conserved. However, if mutations occur in proteins in the pathway, such as mutations in the adenomatous polyposis coli (APC) gene, this can lead to inappropriate activation of the Wnt/β-Catenin signaling pathway.
NOTE: In the video, I misspoke and said that Beta catenin enters the "mitochondria" - I meant to say it enters the nucleus. Sorry ab...
published: 06 Dec 2017
-
Wnt/ß-catenin Signaling Pathway
Hey Friends,
Wnt signaling is one of the most studied cellular pathways. Active Wnt/ß-catenin Signaling activates transcription of target genes that regulate cell fate decisions and cellular proliferation. Key players of the Wnt Pathway are often mutated in cancer.
More references for a detailed view on Wnt/ß-catenin:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634250/
https://www.nature.com/articles/onc2016304
Alberts, B. Molecular Biology of the Cell
Cheers
Henrik
published: 25 Jan 2021
-
The Wnt/β-catenin signaling pathway
Description: Animation showing a simplified version of the canonical Wnt/ β-catenin signaling pathway. For more information, see page 148 in Wolpert et al. Principles of Development 5th edition Oxford University Press, 2015. http://ukcatalogue.oup.com/product/9780199678143.do
© Oxford University Press
published: 27 Mar 2015
-
[yjzvisuals.com] 3D Molecular Animation - Inactive Wnt/beta-catenin pathway
yjzvisuals.com
Music by Kevin MacLeod
published: 10 Sep 2016
-
A growing role for beta-catenin in colon cancer
Copyright Broad Institute, 2013. All rights reserved.
The Wnt/beta-catenin pathway is mutated in virtually all cases of colon cancer, but scientists have not been able to target it with drugs. In this video, Broad Institute senior associate member William Hahn, who is also an associate professor at the Dana--Farber Cancer Institute and Harvard Medical School, describes new work that uses RNAi and dozens of cell lines from the Cancer Cell Line Encyclopedia to reveal previously unknown members of that pathway, opening the door to potential new treatment strategies.
Read more about this work in a Broad news story (https://www.broadinstitute.org/news/4509)
Video courtesy of Nick Dua, Broad Communications
published: 13 Dec 2012
-
The Wnt pathway in a normal and in a tumour cell
In normal cells without a Wnt signal a cytosolic destruction complex phosphorylates the signaling protein -catenin leading to its degradation. In the presence of the extracellular Wnt factor, activation of the membrane bound receptor FZD leads to the dissociation of the destruction complex. As a result, the level of -catenin in the cytosol and also in the nucleus is increased. Nuclear -catenin activates transcription factors that lead to the expression of proto-oncogenes such as MYC and CCND1. In cells that carry mutations in a gene coding for a protein of the destruction complex such as APC or AXIN the level of -catenin is also increased, which leads to the activation of proliferation and inhibition of apoptosis.
published: 22 Feb 2010
-
Wnt signaling pathway and its role in cancer and patterning of the brain
published: 08 Jul 2018
-
Wnt signaling pathway
Wnt signaling pathway - This lecture explains about the Wnt signaling pathway explained with Wnt signaling pathway animation. Wnt signaling is important for development of organisms where Wnt protein act as signaling molecule to signal cell growth and proliferation. Stay tuned to get answers to the following questions -
What is Wnt signaling?
What is Wnt signaling pathway?
How Wnt signaling pathway works?
What are the steps of Wnt signaling?
Learn about Wnt signaling pathway for csir net life science exam.
Wnt signaling pathway also known as the beta catenin pathway which is involved with the beta catenin for cell signaling pathway including Wnt signaling ligand.
Join, Shomu's Biology csir net life science online coaching -
http://www.shomusbiology.com/net-coaching
Get Shomu's Biolo...
published: 31 Aug 2022
4:03
Wnt/β-Catenin Signaling Pathway
The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals into a cell through cell surface receptors.
The canon...
The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals into a cell through cell surface receptors.
The canonical Wnt pathway or Wnt/β-catenin pathway is the Wnt pathway that causes an accumulation of β-catenin in the cytoplasm and its eventual translocation into the nucleus to act as a transcriptional coactivator of transcription factors that belong to the TCF/LEF family.
https://wn.com/Wnt_Β_Catenin_Signaling_Pathway
The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals into a cell through cell surface receptors.
The canonical Wnt pathway or Wnt/β-catenin pathway is the Wnt pathway that causes an accumulation of β-catenin in the cytoplasm and its eventual translocation into the nucleus to act as a transcriptional coactivator of transcription factors that belong to the TCF/LEF family.
- published: 11 Jun 2018
- views: 112472
6:31
Wnt/β-Catenin Signaling Pathway | Overview, Purpose and APC Mutations
Lesson on the Wnt/β-Catenin signaling pathway (also known as simply the Wnt signaling pathway), including an introduction to the pathway, Wnt growth stimulatory...
Lesson on the Wnt/β-Catenin signaling pathway (also known as simply the Wnt signaling pathway), including an introduction to the pathway, Wnt growth stimulatory factors, β-Catenin regulation and role of the pathway in growth, proliferation and development. Wnt proteins act as The Wnt signaling pathway is critically important in embryonic development, particularly in the development of the heart. As such the Wnt/β-Catenin signaling pathway is highly conserved. However, if mutations occur in proteins in the pathway, such as mutations in the adenomatous polyposis coli (APC) gene, this can lead to inappropriate activation of the Wnt/β-Catenin signaling pathway.
NOTE: In the video, I misspoke and said that Beta catenin enters the "mitochondria" - I meant to say it enters the nucleus. Sorry about the confusion everyone. Hope you find the video helpful :)
Hey everyone, here is another biomedical lesson, and this one is on the canonical Wnt signaling pathway. In this lesson, you will be introduced to the Wnt signaling pathway, and the purpose of the Wnt pathway. You will also learn the signaling pathway in a step-by-step fashion, starting with how the Wnt/β-Catenin signaling pathway is regulated during inactivation, how cellular beta catenin levels are regulated by the destruction complex, and how the pathway can become activated by the extracellular signaling Wnt proteins, which are growth stimulatory factors. Finally, you will learn what happens when the APC protein in the destruction complex is mutated, leading to inappropriate activation of the Wnt signaling pathway.
If you found this video helpful, please like and subscribe for more videos :)
JJ
*Subscribe for more free medical lessons* https://www.youtube.com/channel/UCFPvnkCZbHfBvV8ApBBE0vA?sub_confirmation=1
-------------------------------------------------------------------------------------------------------------
Try Audible and Get A Free Audiobook
https://www.amazon.com/dp/B00NB86OYE/?_encoding=UTF8&ref_=sv_adbl_subnav_ref1_1
For books and more information on these topics
https://www.amazon.com/shop/jjmedicine
Please help support this channel and future lessons by becoming a patron (and get cool stuff) ➜ https://www.patreon.com/jjmedicine
Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine
Come join me on Facebook! ➜ https://www.facebook.com/JJ-Medicine-100642648161192/
Check out the best tool to help grow your YouTube channel (it’s helped me!)
https://www.tubebuddy.com/jjmedicine
-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b
Dermatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW
Pharmacology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR
Hematology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju
Rheumatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle
Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP
Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8
----------------------------------------------------------------------------------------------------
**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
----------------------------------------------------------------------------------------------------
*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*
https://wn.com/Wnt_Β_Catenin_Signaling_Pathway_|_Overview,_Purpose_And_Apc_Mutations
Lesson on the Wnt/β-Catenin signaling pathway (also known as simply the Wnt signaling pathway), including an introduction to the pathway, Wnt growth stimulatory factors, β-Catenin regulation and role of the pathway in growth, proliferation and development. Wnt proteins act as The Wnt signaling pathway is critically important in embryonic development, particularly in the development of the heart. As such the Wnt/β-Catenin signaling pathway is highly conserved. However, if mutations occur in proteins in the pathway, such as mutations in the adenomatous polyposis coli (APC) gene, this can lead to inappropriate activation of the Wnt/β-Catenin signaling pathway.
NOTE: In the video, I misspoke and said that Beta catenin enters the "mitochondria" - I meant to say it enters the nucleus. Sorry about the confusion everyone. Hope you find the video helpful :)
Hey everyone, here is another biomedical lesson, and this one is on the canonical Wnt signaling pathway. In this lesson, you will be introduced to the Wnt signaling pathway, and the purpose of the Wnt pathway. You will also learn the signaling pathway in a step-by-step fashion, starting with how the Wnt/β-Catenin signaling pathway is regulated during inactivation, how cellular beta catenin levels are regulated by the destruction complex, and how the pathway can become activated by the extracellular signaling Wnt proteins, which are growth stimulatory factors. Finally, you will learn what happens when the APC protein in the destruction complex is mutated, leading to inappropriate activation of the Wnt signaling pathway.
If you found this video helpful, please like and subscribe for more videos :)
JJ
*Subscribe for more free medical lessons* https://www.youtube.com/channel/UCFPvnkCZbHfBvV8ApBBE0vA?sub_confirmation=1
-------------------------------------------------------------------------------------------------------------
Try Audible and Get A Free Audiobook
https://www.amazon.com/dp/B00NB86OYE/?_encoding=UTF8&ref_=sv_adbl_subnav_ref1_1
For books and more information on these topics
https://www.amazon.com/shop/jjmedicine
Please help support this channel and future lessons by becoming a patron (and get cool stuff) ➜ https://www.patreon.com/jjmedicine
Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine
Come join me on Facebook! ➜ https://www.facebook.com/JJ-Medicine-100642648161192/
Check out the best tool to help grow your YouTube channel (it’s helped me!)
https://www.tubebuddy.com/jjmedicine
-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b
Dermatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW
Pharmacology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR
Hematology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju
Rheumatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle
Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP
Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*
- published: 06 Dec 2017
- views: 205061
2:47
Wnt/ß-catenin Signaling Pathway
Hey Friends,
Wnt signaling is one of the most studied cellular pathways. Active Wnt/ß-catenin Signaling activates transcription of target genes that regulate c...
Hey Friends,
Wnt signaling is one of the most studied cellular pathways. Active Wnt/ß-catenin Signaling activates transcription of target genes that regulate cell fate decisions and cellular proliferation. Key players of the Wnt Pathway are often mutated in cancer.
More references for a detailed view on Wnt/ß-catenin:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634250/
https://www.nature.com/articles/onc2016304
Alberts, B. Molecular Biology of the Cell
Cheers
Henrik
https://wn.com/Wnt_ß_Catenin_Signaling_Pathway
Hey Friends,
Wnt signaling is one of the most studied cellular pathways. Active Wnt/ß-catenin Signaling activates transcription of target genes that regulate cell fate decisions and cellular proliferation. Key players of the Wnt Pathway are often mutated in cancer.
More references for a detailed view on Wnt/ß-catenin:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634250/
https://www.nature.com/articles/onc2016304
Alberts, B. Molecular Biology of the Cell
Cheers
Henrik
- published: 25 Jan 2021
- views: 25428
1:46
The Wnt/β-catenin signaling pathway
Description: Animation showing a simplified version of the canonical Wnt/ β-catenin signaling pathway. For more information, see page 148 in Wolpert et al. Prin...
Description: Animation showing a simplified version of the canonical Wnt/ β-catenin signaling pathway. For more information, see page 148 in Wolpert et al. Principles of Development 5th edition Oxford University Press, 2015. http://ukcatalogue.oup.com/product/9780199678143.do
© Oxford University Press
https://wn.com/The_Wnt_Β_Catenin_Signaling_Pathway
Description: Animation showing a simplified version of the canonical Wnt/ β-catenin signaling pathway. For more information, see page 148 in Wolpert et al. Principles of Development 5th edition Oxford University Press, 2015. http://ukcatalogue.oup.com/product/9780199678143.do
© Oxford University Press
- published: 27 Mar 2015
- views: 128433
3:21
A growing role for beta-catenin in colon cancer
Copyright Broad Institute, 2013. All rights reserved.
The Wnt/beta-catenin pathway is mutated in virtually all cases of colon cancer, but scientists have not be...
Copyright Broad Institute, 2013. All rights reserved.
The Wnt/beta-catenin pathway is mutated in virtually all cases of colon cancer, but scientists have not been able to target it with drugs. In this video, Broad Institute senior associate member William Hahn, who is also an associate professor at the Dana--Farber Cancer Institute and Harvard Medical School, describes new work that uses RNAi and dozens of cell lines from the Cancer Cell Line Encyclopedia to reveal previously unknown members of that pathway, opening the door to potential new treatment strategies.
Read more about this work in a Broad news story (https://www.broadinstitute.org/news/4509)
Video courtesy of Nick Dua, Broad Communications
https://wn.com/A_Growing_Role_For_Beta_Catenin_In_Colon_Cancer
Copyright Broad Institute, 2013. All rights reserved.
The Wnt/beta-catenin pathway is mutated in virtually all cases of colon cancer, but scientists have not been able to target it with drugs. In this video, Broad Institute senior associate member William Hahn, who is also an associate professor at the Dana--Farber Cancer Institute and Harvard Medical School, describes new work that uses RNAi and dozens of cell lines from the Cancer Cell Line Encyclopedia to reveal previously unknown members of that pathway, opening the door to potential new treatment strategies.
Read more about this work in a Broad news story (https://www.broadinstitute.org/news/4509)
Video courtesy of Nick Dua, Broad Communications
- published: 13 Dec 2012
- views: 3254
3:14
The Wnt pathway in a normal and in a tumour cell
In normal cells without a Wnt signal a cytosolic destruction complex phosphorylates the signaling protein -catenin leading to its degradation. In the presence ...
In normal cells without a Wnt signal a cytosolic destruction complex phosphorylates the signaling protein -catenin leading to its degradation. In the presence of the extracellular Wnt factor, activation of the membrane bound receptor FZD leads to the dissociation of the destruction complex. As a result, the level of -catenin in the cytosol and also in the nucleus is increased. Nuclear -catenin activates transcription factors that lead to the expression of proto-oncogenes such as MYC and CCND1. In cells that carry mutations in a gene coding for a protein of the destruction complex such as APC or AXIN the level of -catenin is also increased, which leads to the activation of proliferation and inhibition of apoptosis.
https://wn.com/The_Wnt_Pathway_In_A_Normal_And_In_A_Tumour_Cell
In normal cells without a Wnt signal a cytosolic destruction complex phosphorylates the signaling protein -catenin leading to its degradation. In the presence of the extracellular Wnt factor, activation of the membrane bound receptor FZD leads to the dissociation of the destruction complex. As a result, the level of -catenin in the cytosol and also in the nucleus is increased. Nuclear -catenin activates transcription factors that lead to the expression of proto-oncogenes such as MYC and CCND1. In cells that carry mutations in a gene coding for a protein of the destruction complex such as APC or AXIN the level of -catenin is also increased, which leads to the activation of proliferation and inhibition of apoptosis.
- published: 22 Feb 2010
- views: 106462
8:12
Wnt signaling pathway
Wnt signaling pathway - This lecture explains about the Wnt signaling pathway explained with Wnt signaling pathway animation. Wnt signaling is important for dev...
Wnt signaling pathway - This lecture explains about the Wnt signaling pathway explained with Wnt signaling pathway animation. Wnt signaling is important for development of organisms where Wnt protein act as signaling molecule to signal cell growth and proliferation. Stay tuned to get answers to the following questions -
What is Wnt signaling?
What is Wnt signaling pathway?
How Wnt signaling pathway works?
What are the steps of Wnt signaling?
Learn about Wnt signaling pathway for csir net life science exam.
Wnt signaling pathway also known as the beta catenin pathway which is involved with the beta catenin for cell signaling pathway including Wnt signaling ligand.
Join, Shomu's Biology csir net life science online coaching -
http://www.shomusbiology.com/net-coaching
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Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
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Thank you for watching the cell signaling lecture on Wnt signaling pathway animation.
#wntsignalingpathway #wntsignaling
https://wn.com/Wnt_Signaling_Pathway
Wnt signaling pathway - This lecture explains about the Wnt signaling pathway explained with Wnt signaling pathway animation. Wnt signaling is important for development of organisms where Wnt protein act as signaling molecule to signal cell growth and proliferation. Stay tuned to get answers to the following questions -
What is Wnt signaling?
What is Wnt signaling pathway?
How Wnt signaling pathway works?
What are the steps of Wnt signaling?
Learn about Wnt signaling pathway for csir net life science exam.
Wnt signaling pathway also known as the beta catenin pathway which is involved with the beta catenin for cell signaling pathway including Wnt signaling ligand.
Join, Shomu's Biology csir net life science online coaching -
http://www.shomusbiology.com/net-coaching
Get Shomu's Biology CSIR NET life science study materials here-
http://www.shomusbiology.com/dvd-store/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
Our Website – www.shomusbiology.com
Facebook page- https://www.facebook.com/ShomusBiology/
Twitter - https://twitter.com/shomusbiology
SlideShare- www.slideshare.net/shomusbiology
Google plus- https://plus.google.com/113648584982732129198
LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661
Youtube- https://www.youtube.com/user/TheFunsuman
Thank you for watching the cell signaling lecture on Wnt signaling pathway animation.
#wntsignalingpathway #wntsignaling
- published: 31 Aug 2022
- views: 7591