'+pages+''); $('.stream > div:odd').addClass('bgr_color'); updateHeight('#history'); }); window.activateTabArea = ensure(function(tab, areas){ var parsed = false; var parts = (areas || '').split('/'); window.fsonload = $.inArray('fs', parts) >= 0; if(fsonload){ parts.splice(parts.indexOf('fs'), 1); } var replayMode = false; if($.inArray('replay', parts)>=0){ replayMode = 'replay'; } var noSoundMode = false; if($.inArray('nosound', parts)>=0){ noSoundMode = 'nosound'; } if($.inArray('ns', parts)>=0){ noSoundMode = 'ns'; } var previewMode = null; if($.inArray('p', parts)>=0){ previewMode = 'p'; } if($.inArray('preview', parts)>=0){ previewMode = 'preview'; } if($.inArray('repeat', parts)>=0){ replayMode = 'repeat'; } if($.inArray('r', parts)>=0 || $.inArray('ro', parts)>=0){ replayMode = 'r'; } if(replayMode){ parts.splice(parts.indexOf(replayMode), 1); } if(noSoundMode){ parts.splice(parts.indexOf(noSoundMode), 1); } if(previewMode){ parts.splice(parts.indexOf(previewMode), 1); } if(previewMode){ if(!parts.length){ parts = ['1-14', '999:59']; } } var area = parts[0]; if(tab == 'history' && false){ var page = parseInt(area || '1') || 1; $.ajax({ url: 'https://login.wn.com/recent/json/?pp='+history_pp+'&skip='+history_pp*(page-1), dataType: 'jsonp', success: function(response){ $ensure(function(){ renderHistory(response, page); }); } }); return true; } if(tab == 'global_history' && false){ var page = parseInt(area || '1') || 1; globalHistory.fetchStream(page, '', function(){ updateHeight('#global_history'); }); return true; } if(tab == 'my_playlists' && false){ var page = parseInt(area || '1') || 1; myPlaylists.fetchStream(page, '', function(){ updateHeight('#my_playlists'); }); return true; } if(tab == 'my_videos' && false){ var page = parseInt(area || '1') || 1; myVideos.fetchStream(page, '', function(){ updateHeight('#my_videos'); }); return true; } if(tab == 'related_sites' && areas && matchPosition(areas)){ var seconds = parsePosition(areas); scrollRelated(seconds); return false; } if(matchPosition(area) || matchAction(area)){ parts.unshift('1'); area = parts[0]; } if(tab == 'expand' && area && area.match(/\d+/)) { var num = parseInt(area); if(num < 100){ //FIX ME. 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var par = el.closest('.playlist_scrollarea'); par.scrollTop(el.offset().top-par.height()/2); } var updateVolumeState = function(){ if(noSoundMode){ if(noSoundMode == 'turn-on'){ clog("Sound is on, vsid="+vp.vsid); vp.setVolumeUnMute(); noSoundMode = false; }else{ clog("Sound is off, vsid="+vp.vsid); vp.setVolumeMute(); noSoundMode = 'turn-on'; } } } var playQueueUpdate = function(){ var playPosition = playQueue[playQueuePosition]; vp.playFromPlaylist(playPosition.video); scrollToPlaylistPosition(vp); playShouldStart = playPosition.start; playShouldStop = playPosition.stop; }; var playQueueAdvancePosition = function(){ clog("Advancing play position..."); playQueuePosition ++; while(playQueuePosition < playQueue.length && !playQueue[playQueuePosition].video){ playQueuePosition ++; } if(playQueuePosition < playQueue.length){ playQueueUpdate(); }else if(vp.getReplayCurrent()){ playQueuePosition = 0; playQueueUpdate(); vp.seekTo(playShouldStart); vp.playVideo(); }else{ vp.pauseVideo(); playShouldStop = null; playShouldStart = null; } }; function loadMoreVideos(playerId, vp, start, finish, callback){ var playlistInfo = playlists[playerId-1]; if(playlistInfo.loading >= finish) return; playlistInfo.loading = finish; $.ajax({ url: '/api/upge/cheetah-photo-search/query_videos2', dataType: 'json', data: { query: playlistInfo.query, orderby: playlistInfo.orderby, start: start, count: finish-start }, success: function(response){ var pl = vp.getPlaylist().slice(0); pl.push.apply(pl, response); vp.setPlaylist(pl); callback(); } }); } if(parts.length == 1 && matchDash(parts[0])){ var pl = vp.getActualPlaylist(); var vids = parseDash(parts[0]); parts = []; for(var i = 0; i < vids.length; i++){ playQueue.push({ 'video': pl[vids[i]-1], 'start': 0, 'stop': null }) } if(vids.length){ if(vids[vids.length-1]-1>=pl.length){ loadMoreVideos(playerId, vp, pl.length, vids[vids.length-1], function(){ if(fsonload){ activateTabArea(tab, parts[0]+'/fs'); }else{ activateTabArea(tab, parts[0]); } var pls = vp.getPlaylist(); vp.playFromPlaylist(pls[pls.length-1]); vp.playVideo(); scrollToPlaylistPosition(vp); }); return true; } } if(playQueue){ playQueueUpdate(); vp.playVideo(); parsed = true; playShouldStart = 0; } } if(previewMode){ var vids = []; var dur = 0; var pl = vp.getActualPlaylist(); area = parts[0]; if(parts.length == 1 && matchPosition(parts[0])){ vids = parseDash('1-'+pl.length); dur = parsePosition(parts[0]); parts = []; }else if(parts.length == 1 && matchDash(parts[0])){ vids = parseDash(parts[0]); dur = parsePosition("999:59"); parts = []; } if(parts.length == 2 && matchDash(parts[0]) && matchPosition(parts[1])){ vids = parseDash(parts[0]); dur = parsePosition(parts[1]); parts = []; } for(var i = 0; i < vids.length; i++){ playQueue.push({ 'video': pl[vids[i]-1], 'start': 0, 'stop': dur }) } if(playQueue){ playQueueUpdate(); vp.playVideo(); parsed = true; } } if(parts.length>1){ for(var i = 0; i < parts.length; i++){ var sel = findMatchingVideo(vp, parts[i]); if(sel){ playQueue.push({ 'video': sel, 'start': 0, 'stop': null }) } } if(playQueue){ playQueueUpdate(); vp.playVideo(); parsed = true; } }else if(area){ var sel = findMatchingVideo(vp, area); if(sel){ vp.playFromPlaylist(sel); playShouldStart = 0; parsed = true; } } if(fsonload || replayMode){ playShouldStart = 0; } if(document.location.search.match('at=|queue=')){ var opts = document.location.search.replace(/^\?/,'').split(/&/g); for(var o in opts){ if(opts[o].match(/^at=(\d+:)?(\d+:)?\d+$/)){ playShouldStart = parsePosition(opts[o].substr(3)) } if(opts[o].match(/^queue=/)){ playQueue = parseList(opts[o].substr(6)); if(playQueue){ playQueuePosition = 0; playQueueUpdate(); } } } } if(matchPosition(parts[1])){ playShouldStart = parsePosition(parts[1]); parsed = true; } if(matchAction(parts[1])){ var action = parseAction(vp, area+'/'+parts[1]); playShouldStart = action.start; playShouldStop = action.stop; parsed = true; } if(playShouldStart !== null && !playQueue.length){ playQueue.push({ video: vp.getCurrentVideo(), start: playShouldStart, stop: playShouldStop }); } if(playShouldStart != null){ setInterval(function(){ if(playShouldStop && vp.currentPlayer && vp.currentPlayer.getCurrentTime() > playShouldStop){ playShouldStop = null; if(vp.getCurrentVideo() == playQueue[playQueuePosition].video){ playQueueAdvancePosition(); }else{ playShouldStart = null; } } }, 500); vp.playerContainer.bind('videoplayer.player.statechange', function(e, state){ if(state == 'ended'){ // advance to the next video playQueueAdvancePosition(); } }); vp.playerContainer.bind('videoplayer.player.readychange', function(e, state){ if(state){ updateVolumeState(); if(playShouldStart !== null){ vp.seekTo(playShouldStart); playShouldStart = null; }else{ playShouldStop = null; // someone started other video, stop playing from playQueue } } if(fsonload) { triggerFullscreen(playerId); fsonload = false; } }); } } else if(tab.match(/^wiki\d+$/)){ if(firstTimeActivate){ load_wiki($('#'+tab), function(){ if(area){ var areaNode = $('#'+area); if(areaNode.length>0){ $('html, body').scrollTop(areaNode.offset().top + 10); return true; } } }); } } return parsed; }) window.activateTab = ensure(function(tab, area){ window.activeArea = null; if(tab == 'import_videos'){ if(area){ import_videos(area); }else{ start_import(); } return true; } if(tab == 'chat'){ update_chat_position($('.chat').eq(0)); window.activeArea = 'chat'; jQuery('.tabtrigger').offscreentabs('activateTab', 'chat'); return true; } if(tab in rev_names){ tab = rev_names[tab]; } if(tab.match(':')){ return false; } var sup = $('ul li a[id=#'+tab+']'); if(sup && sup.length>0){ window.activeArea = area; sup.first().click(); if(!window.activateTabArea(tab, area)){ window.activeArea = null; } window.activeArea = null; return true; }else{ var have_tabs = $('#playlist_menu li').length; if(tab.match(/^playlists?\d+$/)){ var to_add = +tab.substring(8).replace(/^s/,'')-have_tabs; if(to_add>0 && have_tabs){ add_more_videos(to_add); return true; } } } return false; }); window.currentPath = ensure(function(){ return window.lastHistory.replace(basepath, '').split('?')[0]; }); window.main_tab = window.main_tab || 'videos'; window.addHistory = ensure(function(path){ if(window.console && console.log) console.log("Adding to history: "+path); if(window.history && history.replaceState && document.location.hostname.match(/^(youtube\.)?(\w{2,3}\.)?wn\.com$/)){ if(path == main_tab || path == main_tab+'/' || path == '' || path == '/') { path = basepath; } else if( path.match('^'+main_tab+'/') ){ path = basepath + '/' + path.replace(main_tab+'/', '').replace('--','/'); } else { path = basepath + '/' + path.replace('--','/'); } if(document.location.search){ path += document.location.search; } if(window.lastHistory) { history.pushState(null, null, path); } else if(window.lastHistory != path){ history.replaceState(null, null, path); window.lastHistory = path; } } else{ path = path.replace('--','/'); if(path == main_tab || path == main_tab+'/' || path == '' || path == '/') { path = ''; } if(window.lastHistory != '/'+path){ window.location.hash = path? 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Catenin

Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as α-catenin and β-catenin. A-catenin can bind to β-catenin and can also bind actin. B-catenin binds the cytoplasmic domain of some cadherins. Additional catenins such as γ-catenin and δ-catenin have been identified. The name "catenin" was originally selected ('catena' means 'chain' in Latin) because it was suspected that catenins might link cadherins to the cytoskeleton.

Types

  • α-catenin
  • β-catenin
  • δ-catenin
  • γ-catenin
  • All but α-catenin contain armadillo repeats.

    Function

    Several types of catenins work with N-cadherins to play an important role in learning and memory (For full article, see Cadherin-catenin complex in learning and memory).

    Cell-cell adhesion complexes are required for simple epithelia in higher organisms to maintain structure, function and polarity. These complexes, which help regulate cell growth in addition to creating and maintaining epithelial layers, are known as adherens junctions and they typically include at least cadherin, β-catenin, and α-catenin. Catenins play roles in cellular organization and polarity long before the development and incorporation of Wnt signaling pathways and cadherins.

    Plakoglobin

    Plakoglobin, also known as junction plakoglobin or gamma-catenin, is a protein that in humans is encoded by the JUP gene. Plakoglobin is a member of the catenin protein family and homologous to β-catenin. Plakoglobin is a cytoplasmic component of desmosomes and adherens junctions structures located within intercalated discs of cardiac muscle that function to anchor sarcomeres and join adjacent cells in cardiac muscle. Mutations in plakoglobin are associated with arrhythmogenic right ventricular dysplasia and Pemphigus vulgaris.

    Structure

    Human plakoglobin is 81.7 kDa in molecular weight and 745 amino acids long. The JUP gene contains 13 exons spanning 17 kb on chromosome 17q21. Plakoglobin is a member of the catenin family, since it contains a distinct repeating amino acid motif called the armadillo repeat. Plakoglobin is highly homologous to β-catenin; both have 12 armadillo repeats as well as N-terminal and C-terminal globular domains of unknown structure. Plakoglobin was originally identified as a component of desmosomes, where it can bind to the cadherin family member desmoglein I. Plakoglobin also associates with classical cadherins such as E-cadherin; in that context, it was called gamma-catenin. Plakoglobin forms distinct complexes with cadherins and desmosomal cadherins.

    Beta-catenin

    Catenin beta-1 also known as β-catenin is a protein that in humans is encoded by the CTNNB1 gene.

    β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. In Drosophila, the homologous protein is called armadillo. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. Beta-catenin is widely expressed in many tissues. In cardiac muscle, beta-catenin localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocyte.

    Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. Alterations in the localization and expression levels of beta-catenin have been associated with various forms of heart disease, including dilated cardiomyopathy. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).

    Podcasts:

    • What does plakoglobin mean?

      What does plakoglobin mean? A spoken definition of plakoglobin. Intro Sound: Typewriter - Tamskp Licensed under CC:BA 3.0 Outro Music: Groove Groove - Kevin MacLeod (incompetech.com) Licensed under CC:BA 3.0 Intro/Outro Photo: The best days are not planned - Marcus Hansson Licensed under CC-BY-2.0 Book Image: Open Book template PSD - DougitDesign Licensed under CC:BA 3.0 Text derived from: http://en.wiktionary.org/wiki/plakoglobin

      published: 17 Oct 2017
    • Desmosomes: Structure and Functions

      ¿What are desmosomes? ¿What do they do? ¿What proteins are they made of? Here we talk about desmoglein and desmocolin, the desmosomal cadherins, and about the adaptors they use to bind to intermediate filaments giving mechanical resistance to tissues: plakophilin, plakoglobin and desmoplakin. Free slides at: https://www.flipyourlearning.com/desmosomas (bottom of the page)

      published: 31 May 2021
    • How to Pronounce Plakoglobin

      This video shows you how to pronounce Plakoglobin

      published: 01 Jun 2015
    • Transcription in Myc-Related Cancers

      Healthy cells regulate gene transcription as an essential checkpoint to prevent uncontrolled cellular growth that leads to disease. Watch this video to learn more about how RNA Polymerase II and the Super Elongation protein complex (SEC) influence gene transcription and how their misregulation may lead to disease. Researchers in Shilatifard’s laboratory are studying these mechanisms in order to understand the evolution of cancer and potentially discover targets for novel cancer therapeutics. This video was produced by Dani Bergey from the Biomedical Visualization graduate program at the University of Illinois at Chicago. __________________________________________________________ Related links: Dani Bergey: https://www.danibergey.com/ Biomedical Visualization program at UIC: https://ahs.u...

      published: 02 Oct 2019
    • Desmosomes

      In this video we have discussed about the desmosomes .

      published: 12 Dec 2023
    • Lecture-58: Inherited disorders of cornification, Part 4. Syndromic keratodermas. Rook's chapter 65.

      Also includes Porokeratosis and perforating disorders.

      published: 03 Jan 2021
    • Detecting Gene Ontology misannotations using... - Chengxin Zhang - Bio-Ontologies - ISMB 2020

      Detecting Gene Ontology misannotations using taxon-specific rate ratio comparisons - Chengxin Zhang - Bio-Ontologies - ISMB 2020

      published: 13 Jan 2021
    • Induction of Adherens Junctions within Granuloma Macrophages

      Movie of Tg(mfap4:tomato-caax); Gt(jup-citrine)ct520a animal shown in Figure 2. Magenta: macrophages, M. marinum: cyan, and green: plakoglobin. Individual frames display maximum projection images of 70 μm. Read more from Cronan et al. (2016) in Immunity: http://www.cell.com/immunity/fulltext/S1074-7613(16)30383-1

      published: 05 Oct 2017
    • Death 2 Pathways_pt2_Biological information available for correlations

      “Death to Pathways! A Case for Data-Driven, Cell-Specific Networks”. Lecture given on June 19, 2017, at the University of Colorado Anschutz Medical Campus to members of the Gates Center Summer Internship Program (GSIP). Videos provide support for data-driven, cell-specific methods for identifying gene-centered signaling networks using transcriptome data. Pearson correlations are used to find related genes to a target of interest in two large lung cancer cell line datasets. The intersection of correlated genes between the two datasets is used to vastly reduce the number of false positives and to construct the target-specific network. The target genes Junction Plakoglobin (JUP) and Glycogen Synthase Kinase 3 Beta (GSK3B) are used as examples in the presentation (references given below). S...

      published: 20 Jun 2017
    • Understanding Bioinformatics_Part 4_Using the crowd to find genes related to JUP

      This video is part 4 of a guest lecture on bioinformatics given to bioengineering graduate students in the Analytic Methods for Engineering Analysis class on Sept.17, 2015. Part 4 of the lecture gives a demonstration on how we can use correlation and different datasets to find connected genes. In this example, I use two different lung cancer cell line gene expression datasets to find common genes correlated to Junction Plakoglobin (JUP).

      published: 18 Sep 2015
    developed with YouTube
    What does plakoglobin mean?
    0:37

    What does plakoglobin mean?

    • Order:
    • Duration: 0:37
    • Uploaded Date: 17 Oct 2017
    • views: 65
    What does plakoglobin mean? A spoken definition of plakoglobin. Intro Sound: Typewriter - Tamskp Licensed under CC:BA 3.0 Outro Music: Groove Groove - Kevin MacLeod (incompetech.com) Licensed under CC:BA 3.0 Intro/Outro Photo: The best days are not planned - Marcus Hansson Licensed under CC-BY-2.0 Book Image: Open Book template PSD - DougitDesign Licensed under CC:BA 3.0 Text derived from: http://en.wiktionary.org/wiki/plakoglobin
    https://wn.com/What_Does_Plakoglobin_Mean
    Desmosomes: Structure and Functions
    6:07

    Desmosomes: Structure and Functions

    • Order:
    • Duration: 6:07
    • Uploaded Date: 31 May 2021
    • views: 13870
    ¿What are desmosomes? ¿What do they do? ¿What proteins are they made of? Here we talk about desmoglein and desmocolin, the desmosomal cadherins, and about the adaptors they use to bind to intermediate filaments giving mechanical resistance to tissues: plakophilin, plakoglobin and desmoplakin. Free slides at: https://www.flipyourlearning.com/desmosomas (bottom of the page)
    https://wn.com/Desmosomes_Structure_And_Functions
    How to Pronounce Plakoglobin
    0:19

    How to Pronounce Plakoglobin

    • Order:
    • Duration: 0:19
    • Uploaded Date: 01 Jun 2015
    • views: 244
    This video shows you how to pronounce Plakoglobin
    https://wn.com/How_To_Pronounce_Plakoglobin
    Transcription in Myc-Related Cancers
    3:29

    Transcription in Myc-Related Cancers

    • Order:
    • Duration: 3:29
    • Uploaded Date: 02 Oct 2019
    • views: 5036
    Healthy cells regulate gene transcription as an essential checkpoint to prevent uncontrolled cellular growth that leads to disease. Watch this video to learn more about how RNA Polymerase II and the Super Elongation protein complex (SEC) influence gene transcription and how their misregulation may lead to disease. Researchers in Shilatifard’s laboratory are studying these mechanisms in order to understand the evolution of cancer and potentially discover targets for novel cancer therapeutics. This video was produced by Dani Bergey from the Biomedical Visualization graduate program at the University of Illinois at Chicago. __________________________________________________________ Related links: Dani Bergey: https://www.danibergey.com/ Biomedical Visualization program at UIC: https://ahs.uic.edu/biomedical-health-information-sciences/admissions-and-programs/ms-in-biomedical-visualization/ Simpson Querrey Center for Epigenetics: https://www.feinberg.northwestern.edu/sites/epigenetics/ Shilatifard Laboratory: https://labs.feinberg.northwestern.edu/shilatifard/
    https://wn.com/Transcription_In_Myc_Related_Cancers
    Desmosomes
    1:30

    Desmosomes

    • Order:
    • Duration: 1:30
    • Uploaded Date: 12 Dec 2023
    • views: 245
    In this video we have discussed about the desmosomes .
    https://wn.com/Desmosomes
    Lecture-58: Inherited disorders of cornification, Part 4. Syndromic keratodermas. Rook's chapter 65.
    47:25

    Lecture-58: Inherited disorders of cornification, Part 4. Syndromic keratodermas. Rook's chapter 65.

    • Order:
    • Duration: 47:25
    • Uploaded Date: 03 Jan 2021
    • views: 5597
    Also includes Porokeratosis and perforating disorders.
    https://wn.com/Lecture_58_Inherited_Disorders_Of_Cornification,_Part_4._Syndromic_Keratodermas._Rook's_Chapter_65.
    Detecting Gene Ontology misannotations using... - Chengxin Zhang - Bio-Ontologies - ISMB 2020
    15:19

    Detecting Gene Ontology misannotations using... - Chengxin Zhang - Bio-Ontologies - ISMB 2020

    • Order:
    • Duration: 15:19
    • Uploaded Date: 13 Jan 2021
    • views: 130
    Detecting Gene Ontology misannotations using taxon-specific rate ratio comparisons - Chengxin Zhang - Bio-Ontologies - ISMB 2020
    https://wn.com/Detecting_Gene_Ontology_Misannotations_Using..._Chengxin_Zhang_Bio_Ontologies_Ismb_2020
    Induction of Adherens Junctions within Granuloma Macrophages
    0:20

    Induction of Adherens Junctions within Granuloma Macrophages

    • Order:
    • Duration: 0:20
    • Uploaded Date: 05 Oct 2017
    • views: 392
    Movie of Tg(mfap4:tomato-caax); Gt(jup-citrine)ct520a animal shown in Figure 2. Magenta: macrophages, M. marinum: cyan, and green: plakoglobin. Individual frames display maximum projection images of 70 μm. Read more from Cronan et al. (2016) in Immunity: http://www.cell.com/immunity/fulltext/S1074-7613(16)30383-1
    https://wn.com/Induction_Of_Adherens_Junctions_Within_Granuloma_Macrophages
    Death 2 Pathways_pt2_Biological information available for correlations
    7:10

    Death 2 Pathways_pt2_Biological information available for correlations

    • Order:
    • Duration: 7:10
    • Uploaded Date: 20 Jun 2017
    • views: 92
    “Death to Pathways! A Case for Data-Driven, Cell-Specific Networks”. Lecture given on June 19, 2017, at the University of Colorado Anschutz Medical Campus to members of the Gates Center Summer Internship Program (GSIP). Videos provide support for data-driven, cell-specific methods for identifying gene-centered signaling networks using transcriptome data. Pearson correlations are used to find related genes to a target of interest in two large lung cancer cell line datasets. The intersection of correlated genes between the two datasets is used to vastly reduce the number of false positives and to construct the target-specific network. The target genes Junction Plakoglobin (JUP) and Glycogen Synthase Kinase 3 Beta (GSK3B) are used as examples in the presentation (references given below). Sechler M, Borowicz S, Van Scoyk M, Avasarala S, Zerayesus S, Edwards MG, et al. Novel role for γ-catenin in the regulation of cancer cell migration via the induction of hepatocyte growth factor activator inhibitor type 1 (HAI-1). Journal of Biological Chemistry. 2015 Jun 19;290(25): 15610–20. Hoffman O, Burns N, Vadász I, Eltzschig HK, Edwards MG, Vohwinkel CU (2017) Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome. PLoS ONE 12(2): e0172116. pmid:28196122 For all business or lecture requests, you can contact me, Dr. Michael Edwards from Bioinfo Solutions, at this email address: michael.edwards@bioinfosolutions.com.
    https://wn.com/Death_2_Pathways_Pt2_Biological_Information_Available_For_Correlations
    Understanding Bioinformatics_Part 4_Using the crowd to find genes related to JUP
    12:07

    Understanding Bioinformatics_Part 4_Using the crowd to find genes related to JUP

    • Order:
    • Duration: 12:07
    • Uploaded Date: 18 Sep 2015
    • views: 411
    This video is part 4 of a guest lecture on bioinformatics given to bioengineering graduate students in the Analytic Methods for Engineering Analysis class on Sept.17, 2015. Part 4 of the lecture gives a demonstration on how we can use correlation and different datasets to find connected genes. In this example, I use two different lung cancer cell line gene expression datasets to find common genes correlated to Junction Plakoglobin (JUP).
    https://wn.com/Understanding_Bioinformatics_Part_4_Using_The_Crowd_To_Find_Genes_Related_To_Jup
    • Wnt/β-Catenin Signaling Pathway

      The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals into a cell through cell surface receptors. The canonical Wnt pathway or Wnt/β-catenin pathway is the Wnt pathway that causes an accumulation of β-catenin in the cytoplasm and its eventual translocation into the nucleus to act as a transcriptional coactivator of transcription factors that belong to the TCF/LEF family.

      published: 11 Jun 2018
    • Wnt/β-Catenin Signaling Pathway | Overview, Purpose and APC Mutations

      Lesson on the Wnt/β-Catenin signaling pathway (also known as simply the Wnt signaling pathway), including an introduction to the pathway, Wnt growth stimulatory factors, β-Catenin regulation and role of the pathway in growth, proliferation and development. Wnt proteins act as The Wnt signaling pathway is critically important in embryonic development, particularly in the development of the heart. As such the Wnt/β-Catenin signaling pathway is highly conserved. However, if mutations occur in proteins in the pathway, such as mutations in the adenomatous polyposis coli (APC) gene, this can lead to inappropriate activation of the Wnt/β-Catenin signaling pathway. NOTE: In the video, I misspoke and said that Beta catenin enters the "mitochondria" - I meant to say it enters the nucleus. Sorry ab...

      published: 06 Dec 2017
    • Wnt/ß-catenin Signaling Pathway

      Hey Friends, Wnt signaling is one of the most studied cellular pathways. Active Wnt/ß-catenin Signaling activates transcription of target genes that regulate cell fate decisions and cellular proliferation. Key players of the Wnt Pathway are often mutated in cancer. More references for a detailed view on Wnt/ß-catenin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634250/ https://www.nature.com/articles/onc2016304 Alberts, B. Molecular Biology of the Cell Cheers Henrik

      published: 25 Jan 2021
    • The Wnt/β-catenin signaling pathway

      Description: Animation showing a simplified version of the canonical Wnt/ β-catenin signaling pathway. For more information, see page 148 in Wolpert et al. Principles of Development 5th edition Oxford University Press, 2015. http://ukcatalogue.oup.com/product/9780199678143.do © Oxford University Press

      published: 27 Mar 2015
    • [yjzvisuals.com] 3D Molecular Animation - Inactive Wnt/beta-catenin pathway

      yjzvisuals.com Music by Kevin MacLeod

      published: 10 Sep 2016
    • A growing role for beta-catenin in colon cancer

      Copyright Broad Institute, 2013. All rights reserved. The Wnt/beta-catenin pathway is mutated in virtually all cases of colon cancer, but scientists have not been able to target it with drugs. In this video, Broad Institute senior associate member William Hahn, who is also an associate professor at the Dana--Farber Cancer Institute and Harvard Medical School, describes new work that uses RNAi and dozens of cell lines from the Cancer Cell Line Encyclopedia to reveal previously unknown members of that pathway, opening the door to potential new treatment strategies. Read more about this work in a Broad news story (https://www.broadinstitute.org/news/4509) Video courtesy of Nick Dua, Broad Communications

      published: 13 Dec 2012
    • The Wnt pathway in a normal and in a tumour cell

      In normal cells without a Wnt signal a cytosolic destruction complex phosphorylates the signaling protein -catenin leading to its degradation. In the presence of the extracellular Wnt factor, activation of the membrane bound receptor FZD leads to the dissociation of the destruction complex. As a result, the level of -catenin in the cytosol and also in the nucleus is increased. Nuclear -catenin activates transcription factors that lead to the expression of proto-oncogenes such as MYC and CCND1. In cells that carry mutations in a gene coding for a protein of the destruction complex such as APC or AXIN the level of -catenin is also increased, which leads to the activation of proliferation and inhibition of apoptosis.

      published: 22 Feb 2010
    • Wnt signaling pathway and its role in cancer and patterning of the brain

      published: 08 Jul 2018
    • Wnt signaling pathway

      Wnt signaling pathway - This lecture explains about the Wnt signaling pathway explained with Wnt signaling pathway animation. Wnt signaling is important for development of organisms where Wnt protein act as signaling molecule to signal cell growth and proliferation. Stay tuned to get answers to the following questions - What is Wnt signaling? What is Wnt signaling pathway? How Wnt signaling pathway works? What are the steps of Wnt signaling? Learn about Wnt signaling pathway for csir net life science exam. Wnt signaling pathway also known as the beta catenin pathway which is involved with the beta catenin for cell signaling pathway including Wnt signaling ligand. Join, Shomu's Biology csir net life science online coaching - http://www.shomusbiology.com/net-coaching Get Shomu's Biolo...

      published: 31 Aug 2022
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    Wnt/β-Catenin Signaling Pathway
    4:03

    Wnt/β-Catenin Signaling Pathway

    • Order:
    • Duration: 4:03
    • Uploaded Date: 11 Jun 2018
    • views: 112472
    The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals into a cell through cell surface receptors. The canonical Wnt pathway or Wnt/β-catenin pathway is the Wnt pathway that causes an accumulation of β-catenin in the cytoplasm and its eventual translocation into the nucleus to act as a transcriptional coactivator of transcription factors that belong to the TCF/LEF family.
    https://wn.com/Wnt_Β_Catenin_Signaling_Pathway
    Wnt/β-Catenin Signaling Pathway | Overview, Purpose and APC Mutations
    6:31

    Wnt/β-Catenin Signaling Pathway | Overview, Purpose and APC Mutations

    • Order:
    • Duration: 6:31
    • Uploaded Date: 06 Dec 2017
    • views: 205061
    Lesson on the Wnt/β-Catenin signaling pathway (also known as simply the Wnt signaling pathway), including an introduction to the pathway, Wnt growth stimulatory factors, β-Catenin regulation and role of the pathway in growth, proliferation and development. Wnt proteins act as The Wnt signaling pathway is critically important in embryonic development, particularly in the development of the heart. As such the Wnt/β-Catenin signaling pathway is highly conserved. However, if mutations occur in proteins in the pathway, such as mutations in the adenomatous polyposis coli (APC) gene, this can lead to inappropriate activation of the Wnt/β-Catenin signaling pathway. NOTE: In the video, I misspoke and said that Beta catenin enters the "mitochondria" - I meant to say it enters the nucleus. Sorry about the confusion everyone. Hope you find the video helpful :) Hey everyone, here is another biomedical lesson, and this one is on the canonical Wnt signaling pathway. In this lesson, you will be introduced to the Wnt signaling pathway, and the purpose of the Wnt pathway. You will also learn the signaling pathway in a step-by-step fashion, starting with how the Wnt/β-Catenin signaling pathway is regulated during inactivation, how cellular beta catenin levels are regulated by the destruction complex, and how the pathway can become activated by the extracellular signaling Wnt proteins, which are growth stimulatory factors. Finally, you will learn what happens when the APC protein in the destruction complex is mutated, leading to inappropriate activation of the Wnt signaling pathway. If you found this video helpful, please like and subscribe for more videos :) JJ *Subscribe for more free medical lessons* https://www.youtube.com/channel/UCFPvnkCZbHfBvV8ApBBE0vA?sub_confirmation=1 ------------------------------------------------------------------------------------------------------------- Try Audible and Get A Free Audiobook https://www.amazon.com/dp/B00NB86OYE/?_encoding=UTF8&ref_=sv_adbl_subnav_ref1_1 For books and more information on these topics https://www.amazon.com/shop/jjmedicine Please help support this channel and future lessons by becoming a patron (and get cool stuff) ➜ https://www.patreon.com/jjmedicine Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine Come join me on Facebook! ➜ https://www.facebook.com/JJ-Medicine-100642648161192/ Check out the best tool to help grow your YouTube channel (it’s helped me!) https://www.tubebuddy.com/jjmedicine ------------------------------------------------------------------------------------------------------------- Check out some of my other lessons. Medical Terminology - The Basics - Lesson 1: https://www.youtube.com/watch?v=04Wh2E9oNug Fatty Acid Synthesis Pathway: https://www.youtube.com/watch?v=WuQS_LpNMzo Wnt/B Catenin Signaling Pathway: https://www.youtube.com/watch?v=NGVP4J9jpgs Upper vs. Lower Motor Neuron Lesions: https://www.youtube.com/watch?v=itNd74V53ng Lesson on the Purine Synthesis and Salvage Pathway: https://www.youtube.com/watch?v=e2KFVvI8Akk Gastrulation | Formation of Germ Layers: https://www.youtube.com/watch?v=d6Kkn0SECJ4 Introductory lesson on Autophagy (Macroautophagy): https://www.youtube.com/watch?v=UmSVKzHc5yA Infectious Disease Playlist https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b Dermatology Playlist https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW Pharmacology Playlist https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR Hematology Playlist https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju Rheumatology Playlist https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle Endocrinology Playlist https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP Nephrology Playlist https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8 ---------------------------------------------------------------------------------------------------- **MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal. Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition. ---------------------------------------------------------------------------------------------------- *Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*
    https://wn.com/Wnt_Β_Catenin_Signaling_Pathway_|_Overview,_Purpose_And_Apc_Mutations
    Wnt/ß-catenin Signaling Pathway
    2:47

    Wnt/ß-catenin Signaling Pathway

    • Order:
    • Duration: 2:47
    • Uploaded Date: 25 Jan 2021
    • views: 25428
    Hey Friends, Wnt signaling is one of the most studied cellular pathways. Active Wnt/ß-catenin Signaling activates transcription of target genes that regulate cell fate decisions and cellular proliferation. Key players of the Wnt Pathway are often mutated in cancer. More references for a detailed view on Wnt/ß-catenin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634250/ https://www.nature.com/articles/onc2016304 Alberts, B. Molecular Biology of the Cell Cheers Henrik
    https://wn.com/Wnt_ß_Catenin_Signaling_Pathway
    The Wnt/β-catenin signaling pathway
    1:46

    The Wnt/β-catenin signaling pathway

    • Order:
    • Duration: 1:46
    • Uploaded Date: 27 Mar 2015
    • views: 128433
    Description: Animation showing a simplified version of the canonical Wnt/ β-catenin signaling pathway. For more information, see page 148 in Wolpert et al. Principles of Development 5th edition Oxford University Press, 2015. http://ukcatalogue.oup.com/product/9780199678143.do © Oxford University Press
    https://wn.com/The_Wnt_Β_Catenin_Signaling_Pathway
    [yjzvisuals.com] 3D Molecular Animation - Inactive Wnt/beta-catenin pathway
    1:18

    [yjzvisuals.com] 3D Molecular Animation - Inactive Wnt/beta-catenin pathway

    • Order:
    • Duration: 1:18
    • Uploaded Date: 10 Sep 2016
    • views: 3869
    yjzvisuals.com Music by Kevin MacLeod
    https://wn.com/Yjzvisuals.Com_3D_Molecular_Animation_Inactive_Wnt_Beta_Catenin_Pathway
    A growing role for beta-catenin in colon cancer
    3:21

    A growing role for beta-catenin in colon cancer

    • Order:
    • Duration: 3:21
    • Uploaded Date: 13 Dec 2012
    • views: 3254
    Copyright Broad Institute, 2013. All rights reserved. The Wnt/beta-catenin pathway is mutated in virtually all cases of colon cancer, but scientists have not been able to target it with drugs. In this video, Broad Institute senior associate member William Hahn, who is also an associate professor at the Dana--Farber Cancer Institute and Harvard Medical School, describes new work that uses RNAi and dozens of cell lines from the Cancer Cell Line Encyclopedia to reveal previously unknown members of that pathway, opening the door to potential new treatment strategies. Read more about this work in a Broad news story (https://www.broadinstitute.org/news/4509) Video courtesy of Nick Dua, Broad Communications
    https://wn.com/A_Growing_Role_For_Beta_Catenin_In_Colon_Cancer
    The Wnt pathway in a normal and in a tumour cell
    3:14

    The Wnt pathway in a normal and in a tumour cell

    • Order:
    • Duration: 3:14
    • Uploaded Date: 22 Feb 2010
    • views: 106462
    In normal cells without a Wnt signal a cytosolic destruction complex phosphorylates the signaling protein -catenin leading to its degradation. In the presence of the extracellular Wnt factor, activation of the membrane bound receptor FZD leads to the dissociation of the destruction complex. As a result, the level of -catenin in the cytosol and also in the nucleus is increased. Nuclear -catenin activates transcription factors that lead to the expression of proto-oncogenes such as MYC and CCND1. In cells that carry mutations in a gene coding for a protein of the destruction complex such as APC or AXIN the level of -catenin is also increased, which leads to the activation of proliferation and inhibition of apoptosis.
    https://wn.com/The_Wnt_Pathway_In_A_Normal_And_In_A_Tumour_Cell
    Wnt signaling pathway and its role in cancer and patterning of the brain
    8:09

    Wnt signaling pathway and its role in cancer and patterning of the brain

    • Order:
    • Duration: 8:09
    • Uploaded Date: 08 Jul 2018
    • views: 18061
    https://wn.com/Wnt_Signaling_Pathway_And_Its_Role_In_Cancer_And_Patterning_Of_The_Brain
    Wnt signaling pathway
    8:12

    Wnt signaling pathway

    • Order:
    • Duration: 8:12
    • Uploaded Date: 31 Aug 2022
    • views: 7591
    Wnt signaling pathway - This lecture explains about the Wnt signaling pathway explained with Wnt signaling pathway animation. Wnt signaling is important for development of organisms where Wnt protein act as signaling molecule to signal cell growth and proliferation. Stay tuned to get answers to the following questions - What is Wnt signaling? What is Wnt signaling pathway? How Wnt signaling pathway works? What are the steps of Wnt signaling? Learn about Wnt signaling pathway for csir net life science exam. Wnt signaling pathway also known as the beta catenin pathway which is involved with the beta catenin for cell signaling pathway including Wnt signaling ligand. Join, Shomu's Biology csir net life science online coaching - http://www.shomusbiology.com/net-coaching Get Shomu's Biology CSIR NET life science study materials here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching the cell signaling lecture on Wnt signaling pathway animation. #wntsignalingpathway #wntsignaling
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    Catenin

    Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as α-catenin and β-catenin. A-catenin can bind to β-catenin and can also bind actin. B-catenin binds the cytoplasmic domain of some cadherins. Additional catenins such as γ-catenin and δ-catenin have been identified. The name "catenin" was originally selected ('catena' means 'chain' in Latin) because it was suspected that catenins might link cadherins to the cytoskeleton.

    Types

  • α-catenin
  • β-catenin
  • δ-catenin
  • γ-catenin
  • All but α-catenin contain armadillo repeats.

    Function

    Several types of catenins work with N-cadherins to play an important role in learning and memory (For full article, see Cadherin-catenin complex in learning and memory).

    Cell-cell adhesion complexes are required for simple epithelia in higher organisms to maintain structure, function and polarity. These complexes, which help regulate cell growth in addition to creating and maintaining epithelial layers, are known as adherens junctions and they typically include at least cadherin, β-catenin, and α-catenin. Catenins play roles in cellular organization and polarity long before the development and incorporation of Wnt signaling pathways and cadherins.

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    The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals into a cell through cell surface receptors. The canonical Wnt pathway or Wnt/β-catenin pathway is the Wnt pathway that causes an accumulation of β-catenin in the cytoplasm and its eventual translocation into the nucleus to act as a transcriptional coactivator of transcription factors that belong to the TCF/LEF family.
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    This award is an important regulatory milestone that advances our approach to targeting genetic alterations in the Wnt/β-catenin signaling pathway, which are drivers of both pre-malignant and malignant disease," commented Dr.
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