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Cardiac muscle cell

Cardiac muscle cells or cardiomyocytes (also known as myocardiocytes or cardiac myocytes) are the muscle cells (myocytes) that make up the cardiac muscle. Each myocardial cell contains myofibrils, which are specialized organelles consisting of long chains of sarcomeres, the fundamental contractile units of muscle cells. Cardiomyocytes show striations similar to those on skeletal muscle cells. Unlike multinucleated skeletal cells, the majority of cardiomyocytes contain only one nucleus, although they may have as many as four. Cardiomyocytes have a high mitochondrial density, which allows them to produce adenosine triphosphate (ATP) quickly, making them highly resistant to fatigue.

Types of cells

There are two types of cells within the heart: the cardiomyocytes and the cardiac pacemaker cells. Cardiomyocytes make up the atria (the chambers in which blood enters the heart) and the ventricles (the chambers where blood is collected and pumped out of the heart). These cells must be able to shorten and lengthen their fibers and the fibers must be flexible enough to stretch. These functions are critical to the proper form during the beating of the heart.

Podcasts:

  • How the Heart Works Video: Cardiomyocyte

    Our "how the heart works video" focuses on cardiomyocyte. Your heart beats approximately 100,000 times a day to circulate 2000 gallons of blood. The force exerted is similar to squeezing a tennis ball in your hand every second, 24 hours a day for your entire life. The heart has tremendous endurance.

    published: 13 Dec 2016
  • Cardiomyocyte Electrophysiology & Calcium Handling

    This video is about the cellular and molecular basis of cardiac pumping. Topics include the electrophysiological basis of the cardiac action potential (which triggers the heart beat), and how that action potential is coupled to calcium signaling, and how calcium triggers contraction.

    published: 02 Aug 2019
  • Cardiomyocyte Cell Cycle & Regeneration

    Wuqiang (Wuk) Zhu, MD, PhD, discusses cardiomyocyte cell cycle including cardiomyocyte proliferation and stem cell and myocardial repair.

    published: 04 Dec 2018
  • How to differentiate pluripotent stem cells (PSC) into cardiomyocytes

    https://www.thermofisher.com/us/en/home/references/protocols/cell-culture/stem-cell-protocols.html?cid=bid_clb_scl_r01_co_cp1361_pjt5757_bid88888_0vi_yut_vo_awa_kt_s24_SS519 In this video you will see how to use the Gibco PSC Cardiomyocyte Differentiation Kit to generate beating cardiomyocytes from pluripotent stem cells. By using this easy-to-use three-part media system, you can start from a small population of pluripotent stem cells and obtain a large number of beating cardiomyocytes. You can access the product insert and the quick reference protocol online. A supplemental list of reagents used in this protocol can also be referenced here. First, prepare a complete Essential 8 Medium. Find details for this preparation on the web link listed below. Then prepare your substrate by c...

    published: 06 Jul 2020
  • The Cardiomyocyte Action Potential [Part 1]: The Action Potential Graph

    In this video, we take a look at the graph representing the cardiomyocyte action potential and what each region of the graph represents.

    published: 09 Nov 2019
  • Time-Lapse: Isolated Murine Cardiomyocyte by Dr. Christopher B. Jackson

    2013 Olympus BioScapes International Digital Imaging Competition Specimen: Isolated living cardiomyocytes from murine (rodent) heart. The cells still have a "heartbeat." Technique: Polarized light and differential interference contrast Credit: Dr. Christopher B. Jackson Prize: Honorable Mention For more information, visit: Olympus-LifeScience.com Find and Follow Olympus Life Science on: Facebook: http://www.facebook.com/pages/Olympus-Life-Science/312676668924012/ Twitter: http://www.twitter.com/@OlympusLifeSci LinkedIn: https://www.linkedin.com/company/olympus-life-science Google+: https://plus.google.com/115358294493885697412/about#115358294493885697412/about Instagram: http://instagram.com/olympuslifescience

    published: 30 Aug 2017
  • Action potentials in cardiac myocytes | Circulatory system physiology | NCLEX-RN | Khan Academy

    See how muscle cells in the heart contract by allowing Calcium to flow inside and bringing along some positive charge with it! Rishi is a pediatric infectious disease physician and works at Khan Academy. Created by Rishi Desai. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/nclex-rn-circulatory-system/heart-depolarization-ddp/v/reseting-cardiac-concentration-gradients?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/nclex-rn-circulatory-system/heart-depolarization-ddp/v/action-potentials-in-pacemaker-cells?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Cr...

    published: 08 Oct 2012
developed with YouTube
How the Heart Works Video: Cardiomyocyte
1:08

How the Heart Works Video: Cardiomyocyte

  • Order:
  • Duration: 1:08
  • Uploaded Date: 13 Dec 2016
  • views: 48149
Our "how the heart works video" focuses on cardiomyocyte. Your heart beats approximately 100,000 times a day to circulate 2000 gallons of blood. The force exerted is similar to squeezing a tennis ball in your hand every second, 24 hours a day for your entire life. The heart has tremendous endurance.
https://wn.com/How_The_Heart_Works_Video_Cardiomyocyte
Cardiomyocyte Electrophysiology & Calcium Handling
24:42

Cardiomyocyte Electrophysiology & Calcium Handling

  • Order:
  • Duration: 24:42
  • Uploaded Date: 02 Aug 2019
  • views: 2145
This video is about the cellular and molecular basis of cardiac pumping. Topics include the electrophysiological basis of the cardiac action potential (which triggers the heart beat), and how that action potential is coupled to calcium signaling, and how calcium triggers contraction.
https://wn.com/Cardiomyocyte_Electrophysiology_Calcium_Handling
Cardiomyocyte Cell Cycle & Regeneration
22:44

Cardiomyocyte Cell Cycle & Regeneration

  • Order:
  • Duration: 22:44
  • Uploaded Date: 04 Dec 2018
  • views: 1081
Wuqiang (Wuk) Zhu, MD, PhD, discusses cardiomyocyte cell cycle including cardiomyocyte proliferation and stem cell and myocardial repair.
https://wn.com/Cardiomyocyte_Cell_Cycle_Regeneration
How to differentiate pluripotent stem cells (PSC) into cardiomyocytes
4:36

How to differentiate pluripotent stem cells (PSC) into cardiomyocytes

  • Order:
  • Duration: 4:36
  • Uploaded Date: 06 Jul 2020
  • views: 1221
https://www.thermofisher.com/us/en/home/references/protocols/cell-culture/stem-cell-protocols.html?cid=bid_clb_scl_r01_co_cp1361_pjt5757_bid88888_0vi_yut_vo_awa_kt_s24_SS519 In this video you will see how to use the Gibco PSC Cardiomyocyte Differentiation Kit to generate beating cardiomyocytes from pluripotent stem cells. By using this easy-to-use three-part media system, you can start from a small population of pluripotent stem cells and obtain a large number of beating cardiomyocytes. You can access the product insert and the quick reference protocol online. A supplemental list of reagents used in this protocol can also be referenced here. First, prepare a complete Essential 8 Medium. Find details for this preparation on the web link listed below. Then prepare your substrate by coating a 12-well plate with a 1:100 Geltrex solution. And place in an incubator for at least one hour. Next, prepare a cell recovery solution by adding 250 µm of RevitaCell supplement to 25 mL of Essential 8 Medium. Let warm to room temperature. Remove the Geltrex coated plate from the incubator and aspirate the plate. Add 1 mL of cell recovery solution to each well. Quickly thaw a vial of cryopreserved pluripotent stem cells in a 37˚C water bath until just a small ice crystal remains. In the biosafety hood, transfer vial contents to a 15 mL tube and slowly add 10 mL cell recovery solution while swirling the tube. Centrifuge the cells at a relative centrifugal force of 200 x g for 5 minutes. After centrifugation, aspirate supernatant and gently flick the tube to dislodge cells. Resuspend cells by adding 2 mL cell recovery solution dropwise. Perform a viable cell count and calculate the cell density of the cell solution. Seed plate with the cell solution to achieve 30 to 70% confluence within 3 to 4 days. The differentiation efficiency of PSCs into cardiomyocytes varies between different PSC lines. A critical variable for the generation of a robust cardiomyocyte culture is the relative confluence at the onset of differentiation. The suggested confluence range at the time of induction is 30 to 70%, and it is strongly recommended that you perform a confluence range finding study to determine the seeding density needed to achieve the optimal confluence for your PSC line within 3 to 4 days of seeding. Confirm attachment of cells the following day. Refeed cells with pre-warmed Essential 8 Medium every day for 3 to 4 days to reach target confluency for your PSC line. Once the plate has achieved target confluency, replace the medium with Cardiomyocyte Differentiation Medium A. Note that the addition of medium should be done slowly and along the sides of the well, as forceful addition of medium will disrupt the differentiation process. Two days after Cardiomyocyte Differentiation Medium A induction, replace the medium with Cardiomyocyte Differentiation Medium B. Two days later, replace the medium with Cardiomyocyte Maintenance Medium. Continue to refeed cells with this medium every other day. 10 days after differentiation has begun using the PSC Cardiomyocyte Differentiation Kit you should observe beating syncytia of cardiomyocytes. These cells are now ready for further studies. #pscdifferentiation, #stemcelldifferentiation, #cardiomyocytedifferentiation, #differentiatingpluripotentstemcells, #PSCCardiomyocyteDifferentiationKit #thermofisherscientific
https://wn.com/How_To_Differentiate_Pluripotent_Stem_Cells_(Psc)_Into_Cardiomyocytes
The Cardiomyocyte Action Potential [Part 1]: The Action Potential Graph
7:53

The Cardiomyocyte Action Potential [Part 1]: The Action Potential Graph

  • Order:
  • Duration: 7:53
  • Uploaded Date: 09 Nov 2019
  • views: 3423
In this video, we take a look at the graph representing the cardiomyocyte action potential and what each region of the graph represents.
https://wn.com/The_Cardiomyocyte_Action_Potential_Part_1_The_Action_Potential_Graph
Time-Lapse: Isolated Murine Cardiomyocyte by Dr. Christopher B. Jackson
0:51

Time-Lapse: Isolated Murine Cardiomyocyte by Dr. Christopher B. Jackson

  • Order:
  • Duration: 0:51
  • Uploaded Date: 30 Aug 2017
  • views: 2234
2013 Olympus BioScapes International Digital Imaging Competition Specimen: Isolated living cardiomyocytes from murine (rodent) heart. The cells still have a "heartbeat." Technique: Polarized light and differential interference contrast Credit: Dr. Christopher B. Jackson Prize: Honorable Mention For more information, visit: Olympus-LifeScience.com Find and Follow Olympus Life Science on: Facebook: http://www.facebook.com/pages/Olympus-Life-Science/312676668924012/ Twitter: http://www.twitter.com/@OlympusLifeSci LinkedIn: https://www.linkedin.com/company/olympus-life-science Google+: https://plus.google.com/115358294493885697412/about#115358294493885697412/about Instagram: http://instagram.com/olympuslifescience
https://wn.com/Time_Lapse_Isolated_Murine_Cardiomyocyte_By_Dr._Christopher_B._Jackson
Action potentials in cardiac myocytes | Circulatory system physiology | NCLEX-RN | Khan Academy
12:11

Action potentials in cardiac myocytes | Circulatory system physiology | NCLEX-RN | Khan Academy

  • Order:
  • Duration: 12:11
  • Uploaded Date: 08 Oct 2012
  • views: 1019691
See how muscle cells in the heart contract by allowing Calcium to flow inside and bringing along some positive charge with it! Rishi is a pediatric infectious disease physician and works at Khan Academy. Created by Rishi Desai. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/nclex-rn-circulatory-system/heart-depolarization-ddp/v/reseting-cardiac-concentration-gradients?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/nclex-rn-circulatory-system/heart-depolarization-ddp/v/action-potentials-in-pacemaker-cells?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
https://wn.com/Action_Potentials_In_Cardiac_Myocytes_|_Circulatory_System_Physiology_|_Nclex_Rn_|_Khan_Academy
developed with YouTube
PLAYLIST TIME:
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  • How the Heart Works Video: Cardiomyocyte
    1:08
    How the Heart Works Video: Cardiomyocyteremove from playlist
  • Cardiomyocyte Electrophysiology & Calcium Handling
    24:42
    Cardiomyocyte Electrophysiology & Calcium Handlingremove from playlist
  • Cardiomyocyte Cell Cycle & Regeneration
    22:44
    Cardiomyocyte Cell Cycle & Regenerationremove from playlist
  • How to differentiate pluripotent stem cells (PSC) into cardiomyocytes
    4:36
    How to differentiate pluripotent stem cells (PSC) into cardiomyocytesremove from playlist
  • The Cardiomyocyte Action Potential [Part 1]: The Action Potential Graph
    7:53
    The Cardiomyocyte Action Potential [Part 1]: The Action Potential Graphremove from playlist
  • Time-Lapse: Isolated Murine Cardiomyocyte by Dr. Christopher B. Jackson
    0:51
    Time-Lapse: Isolated Murine Cardiomyocyte by Dr. Christopher B. Jacksonremove from playlist
  • Action potentials in cardiac myocytes | Circulatory system physiology | NCLEX-RN | Khan Academy
    12:11
    Action potentials in cardiac myocytes | Circulatory system physiology | NCLEX-RN | Khan Academyremove from playlist
developed with YouTube
PLAYLIST TIME:

How the Heart Works Video: Cardiomyocyte

Our "how the heart works video" focuses on cardiomyocyte. Your heart beats approximately 100,000 times a day to circulate 2000 gallons of blood. The force exerted is similar to squeezing a tennis ball in your hand every second, 24 hours a day for your entire life. The heart has tremendous endurance.
1:08
How the Heart Works Video: Cardiomyocyte
Our "how the heart works video" focuses on cardiomyocyte. Your heart beats approximately 1...
published: 13 Dec 2016
Play in Full Screen
24:42
Cardiomyocyte Electrophysiology & Calcium Handling
This video is about the cellular and molecular basis of cardiac pumping. Topics include th...
published: 02 Aug 2019
Play in Full Screen
22:44
Cardiomyocyte Cell Cycle & Regeneration
Wuqiang (Wuk) Zhu, MD, PhD, discusses cardiomyocyte cell cycle including cardiomyocyte pro...
published: 04 Dec 2018
Play in Full Screen
4:36
How to differentiate pluripotent stem cells (PSC) into cardiomyocytes
https://www.thermofisher.com/us/en/home/references/protocols/cell-culture/stem-cell-protoc...
published: 06 Jul 2020
Play in Full Screen
7:53
The Cardiomyocyte Action Potential [Part 1]: The Action Potential Graph
In this video, we take a look at the graph representing the cardiomyocyte action potential...
published: 09 Nov 2019
Play in Full Screen
0:51
Time-Lapse: Isolated Murine Cardiomyocyte by Dr. Christopher B. Jackson
2013 Olympus BioScapes International Digital Imaging Competition Specimen: Isolated livin...
published: 30 Aug 2017
Play in Full Screen
12:11
Action potentials in cardiac myocytes | Circulatory system physiology | NCLEX-RN | Khan Academy
See how muscle cells in the heart contract by allowing Calcium to flow inside and bringing...
published: 08 Oct 2012
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Cardiac muscle cell

Cardiac muscle cells or cardiomyocytes (also known as myocardiocytes or cardiac myocytes) are the muscle cells (myocytes) that make up the cardiac muscle. Each myocardial cell contains myofibrils, which are specialized organelles consisting of long chains of sarcomeres, the fundamental contractile units of muscle cells. Cardiomyocytes show striations similar to those on skeletal muscle cells. Unlike multinucleated skeletal cells, the majority of cardiomyocytes contain only one nucleus, although they may have as many as four. Cardiomyocytes have a high mitochondrial density, which allows them to produce adenosine triphosphate (ATP) quickly, making them highly resistant to fatigue.

Types of cells

There are two types of cells within the heart: the cardiomyocytes and the cardiac pacemaker cells. Cardiomyocytes make up the atria (the chambers in which blood enters the heart) and the ventricles (the chambers where blood is collected and pumped out of the heart). These cells must be able to shorten and lengthen their fibers and the fibers must be flexible enough to stretch. These functions are critical to the proper form during the beating of the heart.

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Latest News for: cardiomyocyte

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How To Read The Paper Claiming Semaglutide Reduces Cardiomyocyte Size and Cardiac Mass

Rumble 26 Nov 2024
Go to the source via the article link to view the video or click the video icon ....
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A novel strategy to efficiently distinguish subtype-specific cardiomyocytes from human iPS cells

Phys Dot Org 13 Mar 2024
hiPSC-derived cardiomyocytes are promising resources for drug discovery and regenerative medicine ... Specifically, the ventricle and atrium consist of ventricular cardiomyocytes (VCMs) and atrial cardiomyocytes (ACMs), respectively.
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Using iPS Cells from I Peace, Heartseed Succeeds in Stable Production of High Purity Cardiomyocytes, ...

The Galveston Daily News 02 Nov 2023
Heartseed has successfully produced high-purity cardiomyocytes consistently from all I Peace manufactured iPS cell lines used in this study ... Significance of stable production of high-purity cardiomyocytes derived from iPS cells.
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Heartseed Succeeds in Stable Production of High Purity Cardiomyocytes Using iPS Cells from I Peace, A Major Step Forward in Advancing Autologous Cardiac Regenerative Medicine

Pharmiweb 01 Nov 2023
Heartseed is developing HS-001 (open chest administration) and HS-005 (catheter administration), which are microtissues of highly purified cardiomyocytes (cardiomyocyte spheroids) generated from ...
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Using iPS Cells from I Peace, Heartseed Succeeds in Stable Production of High Purity Cardiomyocytes, A Major Step Forward in Advancing Autologous Cardiac Regenerative Medicine

PR Newswire 01 Nov 2023
Heartseed is developing HS-001 (open chest administration) and HS-005 (catheter administration), which are microtissues of highly purified cardiomyocytes (cardiomyocyte spheroids) generated from ...
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Inducing Cardiomyocyte Maturation

The Scientist 01 Aug 2023
By combining calcium and electrical pacing, researchers designed a scalable protocol for culturing mature cardiac tissues from induced pluripotent stem cells ... .
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Stembiosys Announces Launch Of Cellvotm Atrial Cardiomyocyte, A Technological Leap Forward In Cardiotoxicity Screening

MENA FN 13 Jun 2023
(MENAFN - PR Newswire) Developed in collaboration with REPROCELL, CELLvoTM Atrial Cardiomyocyte delivers non-genetically modified human heart cells that are chamber specific and derived from iPS ... .
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StemBioSys Announces Launch of CELLvo™ Atrial Cardiomyocyte, a Technological Leap Forward in Cardiotoxicity Screening

PR Newswire 13 Jun 2023
Developed in collaboration with REPROCELL, CELLvo™ Atrial Cardiomyocyte delivers non-genetically modified human heart cells that are chamber specific and derived from iPS (stem) cells ... cardiomyocytes.
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Nissan Chemical’s "prevelex® CC1" contributed to manufacturing allogeneic induced pluripotent stem cells (iPSCs)- derived cardiomyocyte spheroids (Nissan Chemical Corporation)

Public Technologies 07 Mar 2023
(hereinafter "Heartseed") with prevelex® CC1, a coating material, for Heartseed's production of allogeneic iPSC-derived cardiomyocyte spheroids.
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Help Therapeutics Announces IND Approval of First Universal iPSC-derived Cardiomyocyte Therapy for End-stage Heart Failure in China

PR Newswire 30 Jan 2023
The mechanism of action is that the transplanted cardiomyocytes electrically couple with the patient's myocardium to generate contractile force (remuscularization) ... "iPSC-cardiomyocytes might represent ...

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