'+pages+''); $('.stream > div:odd').addClass('bgr_color'); updateHeight('#history'); }); window.activateTabArea = ensure(function(tab, areas){ var parsed = false; var parts = (areas || '').split('/'); window.fsonload = $.inArray('fs', parts) >= 0; if(fsonload){ parts.splice(parts.indexOf('fs'), 1); } var replayMode = false; if($.inArray('replay', parts)>=0){ replayMode = 'replay'; } var noSoundMode = false; if($.inArray('nosound', parts)>=0){ noSoundMode = 'nosound'; } if($.inArray('ns', parts)>=0){ noSoundMode = 'ns'; } var previewMode = null; if($.inArray('p', parts)>=0){ previewMode = 'p'; } if($.inArray('preview', parts)>=0){ previewMode = 'preview'; } if($.inArray('repeat', parts)>=0){ replayMode = 'repeat'; } if($.inArray('r', parts)>=0 || $.inArray('ro', parts)>=0){ replayMode = 'r'; } if(replayMode){ parts.splice(parts.indexOf(replayMode), 1); } if(noSoundMode){ parts.splice(parts.indexOf(noSoundMode), 1); } if(previewMode){ parts.splice(parts.indexOf(previewMode), 1); } if(previewMode){ if(!parts.length){ parts = ['1-14', '999:59']; } } var area = parts[0]; if(tab == 'history' && false){ var page = parseInt(area || '1') || 1; $.ajax({ url: 'https://login.wn.com/recent/json/?pp='+history_pp+'&skip='+history_pp*(page-1), dataType: 'jsonp', success: function(response){ $ensure(function(){ renderHistory(response, page); }); } }); return true; } if(tab == 'global_history' && false){ var page = parseInt(area || '1') || 1; globalHistory.fetchStream(page, '', function(){ updateHeight('#global_history'); }); return true; } if(tab == 'my_playlists' && false){ var page = parseInt(area || '1') || 1; myPlaylists.fetchStream(page, '', function(){ updateHeight('#my_playlists'); }); return true; } if(tab == 'my_videos' && false){ var page = parseInt(area || '1') || 1; myVideos.fetchStream(page, '', function(){ updateHeight('#my_videos'); }); return true; } if(tab == 'related_sites' && areas && matchPosition(areas)){ var seconds = parsePosition(areas); scrollRelated(seconds); return false; } if(matchPosition(area) || matchAction(area)){ parts.unshift('1'); area = parts[0]; } if(tab == 'expand' && area && area.match(/\d+/)) { var num = parseInt(area); if(num < 100){ //FIX ME. 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var par = el.closest('.playlist_scrollarea'); par.scrollTop(el.offset().top-par.height()/2); } var updateVolumeState = function(){ if(noSoundMode){ if(noSoundMode == 'turn-on'){ clog("Sound is on, vsid="+vp.vsid); vp.setVolumeUnMute(); noSoundMode = false; }else{ clog("Sound is off, vsid="+vp.vsid); vp.setVolumeMute(); noSoundMode = 'turn-on'; } } } var playQueueUpdate = function(){ var playPosition = playQueue[playQueuePosition]; vp.playFromPlaylist(playPosition.video); scrollToPlaylistPosition(vp); playShouldStart = playPosition.start; playShouldStop = playPosition.stop; }; var playQueueAdvancePosition = function(){ clog("Advancing play position..."); playQueuePosition ++; while(playQueuePosition < playQueue.length && !playQueue[playQueuePosition].video){ playQueuePosition ++; } if(playQueuePosition < playQueue.length){ playQueueUpdate(); }else if(vp.getReplayCurrent()){ playQueuePosition = 0; playQueueUpdate(); vp.seekTo(playShouldStart); vp.playVideo(); }else{ vp.pauseVideo(); playShouldStop = null; playShouldStart = null; } }; function loadMoreVideos(playerId, vp, start, finish, callback){ var playlistInfo = playlists[playerId-1]; if(playlistInfo.loading >= finish) return; playlistInfo.loading = finish; $.ajax({ url: '/api/upge/cheetah-photo-search/query_videos2', dataType: 'json', data: { query: playlistInfo.query, orderby: playlistInfo.orderby, start: start, count: finish-start }, success: function(response){ var pl = vp.getPlaylist().slice(0); pl.push.apply(pl, response); vp.setPlaylist(pl); callback(); } }); } if(parts.length == 1 && matchDash(parts[0])){ var pl = vp.getActualPlaylist(); var vids = parseDash(parts[0]); parts = []; for(var i = 0; i < vids.length; i++){ playQueue.push({ 'video': pl[vids[i]-1], 'start': 0, 'stop': null }) } if(vids.length){ if(vids[vids.length-1]-1>=pl.length){ loadMoreVideos(playerId, vp, pl.length, vids[vids.length-1], function(){ if(fsonload){ activateTabArea(tab, parts[0]+'/fs'); }else{ activateTabArea(tab, parts[0]); } var pls = vp.getPlaylist(); vp.playFromPlaylist(pls[pls.length-1]); vp.playVideo(); scrollToPlaylistPosition(vp); }); return true; } } if(playQueue){ playQueueUpdate(); vp.playVideo(); parsed = true; playShouldStart = 0; } } if(previewMode){ var vids = []; var dur = 0; var pl = vp.getActualPlaylist(); area = parts[0]; if(parts.length == 1 && matchPosition(parts[0])){ vids = parseDash('1-'+pl.length); dur = parsePosition(parts[0]); parts = []; }else if(parts.length == 1 && matchDash(parts[0])){ vids = parseDash(parts[0]); dur = parsePosition("999:59"); parts = []; } if(parts.length == 2 && matchDash(parts[0]) && matchPosition(parts[1])){ vids = parseDash(parts[0]); dur = parsePosition(parts[1]); parts = []; } for(var i = 0; i < vids.length; i++){ playQueue.push({ 'video': pl[vids[i]-1], 'start': 0, 'stop': dur }) } if(playQueue){ playQueueUpdate(); vp.playVideo(); parsed = true; } } if(parts.length>1){ for(var i = 0; i < parts.length; i++){ var sel = findMatchingVideo(vp, parts[i]); if(sel){ playQueue.push({ 'video': sel, 'start': 0, 'stop': null }) } } if(playQueue){ playQueueUpdate(); vp.playVideo(); parsed = true; } }else if(area){ var sel = findMatchingVideo(vp, area); if(sel){ vp.playFromPlaylist(sel); playShouldStart = 0; parsed = true; } } if(fsonload || replayMode){ playShouldStart = 0; } if(document.location.search.match('at=|queue=')){ var opts = document.location.search.replace(/^\?/,'').split(/&/g); for(var o in opts){ if(opts[o].match(/^at=(\d+:)?(\d+:)?\d+$/)){ playShouldStart = parsePosition(opts[o].substr(3)) } if(opts[o].match(/^queue=/)){ playQueue = parseList(opts[o].substr(6)); if(playQueue){ playQueuePosition = 0; playQueueUpdate(); } } } } if(matchPosition(parts[1])){ playShouldStart = parsePosition(parts[1]); parsed = true; } if(matchAction(parts[1])){ var action = parseAction(vp, area+'/'+parts[1]); playShouldStart = action.start; playShouldStop = action.stop; parsed = true; } if(playShouldStart !== null && !playQueue.length){ playQueue.push({ video: vp.getCurrentVideo(), start: playShouldStart, stop: playShouldStop }); } if(playShouldStart != null){ setInterval(function(){ if(playShouldStop && vp.currentPlayer && vp.currentPlayer.getCurrentTime() > playShouldStop){ playShouldStop = null; if(vp.getCurrentVideo() == playQueue[playQueuePosition].video){ playQueueAdvancePosition(); }else{ playShouldStart = null; } } }, 500); vp.playerContainer.bind('videoplayer.player.statechange', function(e, state){ if(state == 'ended'){ // advance to the next video playQueueAdvancePosition(); } }); vp.playerContainer.bind('videoplayer.player.readychange', function(e, state){ if(state){ updateVolumeState(); if(playShouldStart !== null){ vp.seekTo(playShouldStart); playShouldStart = null; }else{ playShouldStop = null; // someone started other video, stop playing from playQueue } } if(fsonload) { triggerFullscreen(playerId); fsonload = false; } }); } } else if(tab.match(/^wiki\d+$/)){ if(firstTimeActivate){ load_wiki($('#'+tab), function(){ if(area){ var areaNode = $('#'+area); if(areaNode.length>0){ $('html, body').scrollTop(areaNode.offset().top + 10); return true; } } }); } } return parsed; }) window.activateTab = ensure(function(tab, area){ window.activeArea = null; if(tab == 'import_videos'){ if(area){ import_videos(area); }else{ start_import(); } return true; } if(tab == 'chat'){ update_chat_position($('.chat').eq(0)); window.activeArea = 'chat'; jQuery('.tabtrigger').offscreentabs('activateTab', 'chat'); return true; } if(tab in rev_names){ tab = rev_names[tab]; } if(tab.match(':')){ return false; } var sup = $('ul li a[id=#'+tab+']'); if(sup && sup.length>0){ window.activeArea = area; sup.first().click(); if(!window.activateTabArea(tab, area)){ window.activeArea = null; } window.activeArea = null; return true; }else{ var have_tabs = $('#playlist_menu li').length; if(tab.match(/^playlists?\d+$/)){ var to_add = +tab.substring(8).replace(/^s/,'')-have_tabs; if(to_add>0 && have_tabs){ add_more_videos(to_add); return true; } } } return false; }); window.currentPath = ensure(function(){ return window.lastHistory.replace(basepath, '').split('?')[0]; }); window.main_tab = window.main_tab || 'videos'; window.addHistory = ensure(function(path){ if(window.console && console.log) console.log("Adding to history: "+path); 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'/'+path : ''; window.lastHistory = '/'+path; } } }); $('.tabtrigger li a').live('click', ensure(function() { var tab = $(this).attr('id'); if(tab.substring(0,1) == '#'){ var name = tab.substring(1); if(name in menu_names){ name = menu_names[name][0]; } realTab = rev_names[name]; $('#'+realTab).show(); if(window.console && console.log) console.log("Triggering tab: "+name+(window.activeArea?" activeArea="+window.activeArea:'')); var path = name; if(window.activeArea){ path = path + '/' + window.activeArea; } if(tab.match(/#playlist\d+/) || tab.match(/#details\d+/)){ $('.multiple-playlists').show(); $('.related_playlist').show(); $('.longest_videos_playlist').show(); }else { $('.multiple-playlists').hide(); $('.related_playlist').hide(); $('.longest_videos_playlist').hide(); } // start the related script only when the tab is on screen showing if (tab.match(/related_sites/)) { if (mc) { mc.startCredits(); } } window.activeTab = realTab; addHistory(path); setTimeout(ensure(function(){ if(tab.match(/language--/)){ $('.tabtrigger').offscreentabs('activateTab', 'language'); } if(tab.match(/weather/)) { $('.tabtrigger').offscreentabs('activateTab', 'weather'); loadContinent(); } updateMenus(tab); updateHeight(); }), 10); } return false; })); }); -->

Plakoglobin

Plakoglobin, also known as junction plakoglobin or gamma-catenin, is a protein that in humans is encoded by the JUP gene. Plakoglobin is a member of the catenin protein family and homologous to β-catenin. Plakoglobin is a cytoplasmic component of desmosomes and adherens junctions structures located within intercalated discs of cardiac muscle that function to anchor sarcomeres and join adjacent cells in cardiac muscle. Mutations in plakoglobin are associated with arrhythmogenic right ventricular dysplasia and Pemphigus vulgaris.

Structure

Human plakoglobin is 81.7 kDa in molecular weight and 745 amino acids long. The JUP gene contains 13 exons spanning 17 kb on chromosome 17q21. Plakoglobin is a member of the catenin family, since it contains a distinct repeating amino acid motif called the armadillo repeat. Plakoglobin is highly homologous to β-catenin; both have 12 armadillo repeats as well as N-terminal and C-terminal globular domains of unknown structure. Plakoglobin was originally identified as a component of desmosomes, where it can bind to the cadherin family member desmoglein I. Plakoglobin also associates with classical cadherins such as E-cadherin; in that context, it was called gamma-catenin. Plakoglobin forms distinct complexes with cadherins and desmosomal cadherins.

Podcasts:

  • What does plakoglobin mean?

    What does plakoglobin mean? A spoken definition of plakoglobin. Intro Sound: Typewriter - Tamskp Licensed under CC:BA 3.0 Outro Music: Groove Groove - Kevin MacLeod (incompetech.com) Licensed under CC:BA 3.0 Intro/Outro Photo: The best days are not planned - Marcus Hansson Licensed under CC-BY-2.0 Book Image: Open Book template PSD - DougitDesign Licensed under CC:BA 3.0 Text derived from: http://en.wiktionary.org/wiki/plakoglobin

    published: 17 Oct 2017
  • Desmosomes: Structure and Functions

    ¿What are desmosomes? ¿What do they do? ¿What proteins are they made of? Here we talk about desmoglein and desmocolin, the desmosomal cadherins, and about the adaptors they use to bind to intermediate filaments giving mechanical resistance to tissues: plakophilin, plakoglobin and desmoplakin. Free slides at: https://www.flipyourlearning.com/desmosomas (bottom of the page)

    published: 31 May 2021
  • How to Pronounce Plakoglobin

    This video shows you how to pronounce Plakoglobin

    published: 01 Jun 2015
  • Transcription in Myc-Related Cancers

    Healthy cells regulate gene transcription as an essential checkpoint to prevent uncontrolled cellular growth that leads to disease. Watch this video to learn more about how RNA Polymerase II and the Super Elongation protein complex (SEC) influence gene transcription and how their misregulation may lead to disease. Researchers in Shilatifard’s laboratory are studying these mechanisms in order to understand the evolution of cancer and potentially discover targets for novel cancer therapeutics. This video was produced by Dani Bergey from the Biomedical Visualization graduate program at the University of Illinois at Chicago. __________________________________________________________ Related links: Dani Bergey: https://www.danibergey.com/ Biomedical Visualization program at UIC: https://ahs.u...

    published: 02 Oct 2019
  • Desmosomes

    In this video we have discussed about the desmosomes .

    published: 12 Dec 2023
  • Lecture-58: Inherited disorders of cornification, Part 4. Syndromic keratodermas. Rook's chapter 65.

    Also includes Porokeratosis and perforating disorders.

    published: 03 Jan 2021
  • Detecting Gene Ontology misannotations using... - Chengxin Zhang - Bio-Ontologies - ISMB 2020

    Detecting Gene Ontology misannotations using taxon-specific rate ratio comparisons - Chengxin Zhang - Bio-Ontologies - ISMB 2020

    published: 13 Jan 2021
  • Induction of Adherens Junctions within Granuloma Macrophages

    Movie of Tg(mfap4:tomato-caax); Gt(jup-citrine)ct520a animal shown in Figure 2. Magenta: macrophages, M. marinum: cyan, and green: plakoglobin. Individual frames display maximum projection images of 70 μm. Read more from Cronan et al. (2016) in Immunity: http://www.cell.com/immunity/fulltext/S1074-7613(16)30383-1

    published: 05 Oct 2017
  • Death 2 Pathways_pt2_Biological information available for correlations

    “Death to Pathways! A Case for Data-Driven, Cell-Specific Networks”. Lecture given on June 19, 2017, at the University of Colorado Anschutz Medical Campus to members of the Gates Center Summer Internship Program (GSIP). Videos provide support for data-driven, cell-specific methods for identifying gene-centered signaling networks using transcriptome data. Pearson correlations are used to find related genes to a target of interest in two large lung cancer cell line datasets. The intersection of correlated genes between the two datasets is used to vastly reduce the number of false positives and to construct the target-specific network. The target genes Junction Plakoglobin (JUP) and Glycogen Synthase Kinase 3 Beta (GSK3B) are used as examples in the presentation (references given below). S...

    published: 20 Jun 2017
  • Understanding Bioinformatics_Part 4_Using the crowd to find genes related to JUP

    This video is part 4 of a guest lecture on bioinformatics given to bioengineering graduate students in the Analytic Methods for Engineering Analysis class on Sept.17, 2015. Part 4 of the lecture gives a demonstration on how we can use correlation and different datasets to find connected genes. In this example, I use two different lung cancer cell line gene expression datasets to find common genes correlated to Junction Plakoglobin (JUP).

    published: 18 Sep 2015
developed with YouTube
What does plakoglobin mean?
0:37

What does plakoglobin mean?

  • Order:
  • Duration: 0:37
  • Uploaded Date: 17 Oct 2017
  • views: 65
What does plakoglobin mean? A spoken definition of plakoglobin. Intro Sound: Typewriter - Tamskp Licensed under CC:BA 3.0 Outro Music: Groove Groove - Kevin MacLeod (incompetech.com) Licensed under CC:BA 3.0 Intro/Outro Photo: The best days are not planned - Marcus Hansson Licensed under CC-BY-2.0 Book Image: Open Book template PSD - DougitDesign Licensed under CC:BA 3.0 Text derived from: http://en.wiktionary.org/wiki/plakoglobin
https://wn.com/What_Does_Plakoglobin_Mean
Desmosomes: Structure and Functions
6:07

Desmosomes: Structure and Functions

  • Order:
  • Duration: 6:07
  • Uploaded Date: 31 May 2021
  • views: 13870
¿What are desmosomes? ¿What do they do? ¿What proteins are they made of? Here we talk about desmoglein and desmocolin, the desmosomal cadherins, and about the adaptors they use to bind to intermediate filaments giving mechanical resistance to tissues: plakophilin, plakoglobin and desmoplakin. Free slides at: https://www.flipyourlearning.com/desmosomas (bottom of the page)
https://wn.com/Desmosomes_Structure_And_Functions
How to Pronounce Plakoglobin
0:19

How to Pronounce Plakoglobin

  • Order:
  • Duration: 0:19
  • Uploaded Date: 01 Jun 2015
  • views: 244
This video shows you how to pronounce Plakoglobin
https://wn.com/How_To_Pronounce_Plakoglobin
Transcription in Myc-Related Cancers
3:29

Transcription in Myc-Related Cancers

  • Order:
  • Duration: 3:29
  • Uploaded Date: 02 Oct 2019
  • views: 5036
Healthy cells regulate gene transcription as an essential checkpoint to prevent uncontrolled cellular growth that leads to disease. Watch this video to learn more about how RNA Polymerase II and the Super Elongation protein complex (SEC) influence gene transcription and how their misregulation may lead to disease. Researchers in Shilatifard’s laboratory are studying these mechanisms in order to understand the evolution of cancer and potentially discover targets for novel cancer therapeutics. This video was produced by Dani Bergey from the Biomedical Visualization graduate program at the University of Illinois at Chicago. __________________________________________________________ Related links: Dani Bergey: https://www.danibergey.com/ Biomedical Visualization program at UIC: https://ahs.uic.edu/biomedical-health-information-sciences/admissions-and-programs/ms-in-biomedical-visualization/ Simpson Querrey Center for Epigenetics: https://www.feinberg.northwestern.edu/sites/epigenetics/ Shilatifard Laboratory: https://labs.feinberg.northwestern.edu/shilatifard/
https://wn.com/Transcription_In_Myc_Related_Cancers
Desmosomes
1:30

Desmosomes

  • Order:
  • Duration: 1:30
  • Uploaded Date: 12 Dec 2023
  • views: 245
In this video we have discussed about the desmosomes .
https://wn.com/Desmosomes
Lecture-58: Inherited disorders of cornification, Part 4. Syndromic keratodermas. Rook's chapter 65.
47:25

Lecture-58: Inherited disorders of cornification, Part 4. Syndromic keratodermas. Rook's chapter 65.

  • Order:
  • Duration: 47:25
  • Uploaded Date: 03 Jan 2021
  • views: 5597
Also includes Porokeratosis and perforating disorders.
https://wn.com/Lecture_58_Inherited_Disorders_Of_Cornification,_Part_4._Syndromic_Keratodermas._Rook's_Chapter_65.
Detecting Gene Ontology misannotations using... - Chengxin Zhang - Bio-Ontologies - ISMB 2020
15:19

Detecting Gene Ontology misannotations using... - Chengxin Zhang - Bio-Ontologies - ISMB 2020

  • Order:
  • Duration: 15:19
  • Uploaded Date: 13 Jan 2021
  • views: 130
Detecting Gene Ontology misannotations using taxon-specific rate ratio comparisons - Chengxin Zhang - Bio-Ontologies - ISMB 2020
https://wn.com/Detecting_Gene_Ontology_Misannotations_Using..._Chengxin_Zhang_Bio_Ontologies_Ismb_2020
Induction of Adherens Junctions within Granuloma Macrophages
0:20

Induction of Adherens Junctions within Granuloma Macrophages

  • Order:
  • Duration: 0:20
  • Uploaded Date: 05 Oct 2017
  • views: 392
Movie of Tg(mfap4:tomato-caax); Gt(jup-citrine)ct520a animal shown in Figure 2. Magenta: macrophages, M. marinum: cyan, and green: plakoglobin. Individual frames display maximum projection images of 70 μm. Read more from Cronan et al. (2016) in Immunity: http://www.cell.com/immunity/fulltext/S1074-7613(16)30383-1
https://wn.com/Induction_Of_Adherens_Junctions_Within_Granuloma_Macrophages
Death 2 Pathways_pt2_Biological information available for correlations
7:10

Death 2 Pathways_pt2_Biological information available for correlations

  • Order:
  • Duration: 7:10
  • Uploaded Date: 20 Jun 2017
  • views: 92
“Death to Pathways! A Case for Data-Driven, Cell-Specific Networks”. Lecture given on June 19, 2017, at the University of Colorado Anschutz Medical Campus to members of the Gates Center Summer Internship Program (GSIP). Videos provide support for data-driven, cell-specific methods for identifying gene-centered signaling networks using transcriptome data. Pearson correlations are used to find related genes to a target of interest in two large lung cancer cell line datasets. The intersection of correlated genes between the two datasets is used to vastly reduce the number of false positives and to construct the target-specific network. The target genes Junction Plakoglobin (JUP) and Glycogen Synthase Kinase 3 Beta (GSK3B) are used as examples in the presentation (references given below). Sechler M, Borowicz S, Van Scoyk M, Avasarala S, Zerayesus S, Edwards MG, et al. Novel role for γ-catenin in the regulation of cancer cell migration via the induction of hepatocyte growth factor activator inhibitor type 1 (HAI-1). Journal of Biological Chemistry. 2015 Jun 19;290(25): 15610–20. Hoffman O, Burns N, Vadász I, Eltzschig HK, Edwards MG, Vohwinkel CU (2017) Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome. PLoS ONE 12(2): e0172116. pmid:28196122 For all business or lecture requests, you can contact me, Dr. Michael Edwards from Bioinfo Solutions, at this email address: michael.edwards@bioinfosolutions.com.
https://wn.com/Death_2_Pathways_Pt2_Biological_Information_Available_For_Correlations
Understanding Bioinformatics_Part 4_Using the crowd to find genes related to JUP
12:07

Understanding Bioinformatics_Part 4_Using the crowd to find genes related to JUP

  • Order:
  • Duration: 12:07
  • Uploaded Date: 18 Sep 2015
  • views: 411
This video is part 4 of a guest lecture on bioinformatics given to bioengineering graduate students in the Analytic Methods for Engineering Analysis class on Sept.17, 2015. Part 4 of the lecture gives a demonstration on how we can use correlation and different datasets to find connected genes. In this example, I use two different lung cancer cell line gene expression datasets to find common genes correlated to Junction Plakoglobin (JUP).
https://wn.com/Understanding_Bioinformatics_Part_4_Using_The_Crowd_To_Find_Genes_Related_To_Jup
developed with YouTube
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developed with YouTube
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What does plakoglobin mean?

What does plakoglobin mean? A spoken definition of plakoglobin. Intro Sound: Typewriter - Tamskp Licensed under CC:BA 3.0 Outro Music: Groove Groove - Kevin MacLeod (incompetech.com) Licensed under CC:BA 3.0 Intro/Outro Photo: The best days are not planned - Marcus Hansson Licensed under CC-BY-2.0 Book Image: Open Book template PSD - DougitDesign Licensed under CC:BA 3.0 Text derived from: http://en.wiktionary.org/wiki/plakoglobin
0:37
What does plakoglobin mean?
What does plakoglobin mean? A spoken definition of plakoglobin. Intro Sound: Typewrit...
published: 17 Oct 2017
Play in Full Screen
6:07
Desmosomes: Structure and Functions
¿What are desmosomes? ¿What do they do? ¿What proteins are they made of? Here we talk abou...
published: 31 May 2021
Play in Full Screen
0:19
How to Pronounce Plakoglobin
This video shows you how to pronounce Plakoglobin
published: 01 Jun 2015
Play in Full Screen
3:29
Transcription in Myc-Related Cancers
Healthy cells regulate gene transcription as an essential checkpoint to prevent uncontroll...
published: 02 Oct 2019
Play in Full Screen
1:30
Desmosomes
In this video we have discussed about the desmosomes .
published: 12 Dec 2023
Play in Full Screen
47:25
Lecture-58: Inherited disorders of cornification, Part 4. Syndromic keratodermas. Rook's chapter 65.
Also includes Porokeratosis and perforating disorders.
published: 03 Jan 2021
Play in Full Screen
15:19
Detecting Gene Ontology misannotations using... - Chengxin Zhang - Bio-Ontologies - ISMB 2020
Detecting Gene Ontology misannotations using taxon-specific rate ratio comparisons - Cheng...
published: 13 Jan 2021
Play in Full Screen
0:20
Induction of Adherens Junctions within Granuloma Macrophages
Movie of Tg(mfap4:tomato-caax); Gt(jup-citrine)ct520a animal shown in Figure 2. Magenta: m...
published: 05 Oct 2017
Play in Full Screen
7:10
Death 2 Pathways_pt2_Biological information available for correlations
“Death to Pathways! A Case for Data-Driven, Cell-Specific Networks”. Lecture given on June...
published: 20 Jun 2017
Play in Full Screen
12:07
Understanding Bioinformatics_Part 4_Using the crowd to find genes related to JUP
This video is part 4 of a guest lecture on bioinformatics given to bioengineering graduate...
published: 18 Sep 2015
Play in Full Screen

Plakoglobin

Plakoglobin, also known as junction plakoglobin or gamma-catenin, is a protein that in humans is encoded by the JUP gene. Plakoglobin is a member of the catenin protein family and homologous to β-catenin. Plakoglobin is a cytoplasmic component of desmosomes and adherens junctions structures located within intercalated discs of cardiac muscle that function to anchor sarcomeres and join adjacent cells in cardiac muscle. Mutations in plakoglobin are associated with arrhythmogenic right ventricular dysplasia and Pemphigus vulgaris.

Structure

Human plakoglobin is 81.7 kDa in molecular weight and 745 amino acids long. The JUP gene contains 13 exons spanning 17 kb on chromosome 17q21. Plakoglobin is a member of the catenin family, since it contains a distinct repeating amino acid motif called the armadillo repeat. Plakoglobin is highly homologous to β-catenin; both have 12 armadillo repeats as well as N-terminal and C-terminal globular domains of unknown structure. Plakoglobin was originally identified as a component of desmosomes, where it can bind to the cadherin family member desmoglein I. Plakoglobin also associates with classical cadherins such as E-cadherin; in that context, it was called gamma-catenin. Plakoglobin forms distinct complexes with cadherins and desmosomal cadherins.

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