Re: The uncertainty is the key issue
to set up an extra office elsewhere in the EU like Netherlands, Belgium or Germany
Not Belgium. Having worked there for the European HQ of a German multi-national, I wouldn't recommend it. Loved living there, but we opened our head office with the plan of openining a bunch of stores there - 3 years later the first one was still in the planning and permits stage, and the Belgian subsidiary was still not off the ground.
Germany has some complex and annoying labour laws, but it's nothing on Belgium. I'd suggest the Netherlands, except, can you really be certain they'll still be in the EU in ten years time? I think it's a high probability that they will, but it would be a brave man who called it a certainty.
If the UK market is important, Ireland has got to look attractive. Low taxes, easy to start companies. If there's space. They'll do well out of Brexit, unless it goes wrong, in which case they could suffer badly.
At the moment serious European politicians are talking about giving Britain a "worse" deal simply because they don't want to make leaving the EU look attractive. And they're saying this out loud, in public and deliberately! What the hell does that say about the EU and how it's viewed? Voters will not put up with that kind of shit forever.
For me, the Eurocrisis is the central issue. Until that can be solved, the EU has no long-term certainty itself. It could implode tomorrow, it could limp along in a disastrous economic slump for another ten years, or the problems might magically go away. But that last seems unlikely, as the solutions are breaking up the Euro (currently unacceptable), or closer union (also currently unacceptable). I wouldn't have voted for Brexit without it (the treatment of Greece was the final straw for me) - and I suspect the referendum would have been won without it. Italy's banking system could implode tomorrow and take the Euro with it. Or not. Greece is economically unimportant, but politically makes the Eurozone look awful - incomptenent, indecisive and cruel. As well as being a moral stain for which many politicians will need to atone.
Unfortunately because nobody agrees what to do, and there's so many competing interests, it's really hard to change the EU. But I think almost everyone now agrees that urgent change is needed. That creates its own uncertainty.