Effect of zonisamide on essential tremor: a pilot crossover study in comparison with arotinolol - PubMed
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A multicenter randomized crossover multiple-dose comparison study of arotinolol and propranolol in essential tremor - PubMed
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æºå¸¯åž‹è‡ªå‹•è¡€åœ§è¨ˆ(ABPM)を用ã„ãŸ24時間血圧ã®æ¸¬å®šãŒå¯èƒ½ã¨ãªã‚Š, 従æ¥ã®éšæ™‚血圧ã®æ¸¬å®šã§ã¯ã‚ã‹ã‚‰ãªã‹ã£ãŸç™½è¡£é«˜è¡€åœ§, æ—©æœã®æ€¥æ¿€ãªè¡€åœ§ä¸Šæ˜‡(morning surge)や夜間血圧ã«ãŠã‘ã‚‹dipperåž‹ãŠã‚ˆã³non-dipPeråž‹ã®å˜åœ¨ãŒæ˜Žã‚‰ã‹ã«ãªã£ãŸ. ã¾ãŸ, 24時間血圧ã¯å¿ƒè¡€ç®¡ç³»ç–¾æ‚£ã‚„臓器障害ã®ç™ºç—‡ãƒ»é€²å±•ã¨å¯†æŽ¥ãªé–¢ä¿‚ã«ã‚ã‚‹ã“ã¨ãŒã‚ã‹ã£ã¦ããŸ. 今回, 本態性高血圧症患者21例(å¹³å‡å¹´é½¢63.6æ³)を対象ã¨ã—, αβé®æ–薬塩酸アãƒãƒãƒŽãƒãƒ¼ãƒ«ã®è¡€åœ§æ—¥å†…変動ã«ãŠã‚ˆã¼ã™å½±éŸ¿ã‚’ABPMを用ã„検討ã—ãŸ. 本剤ã®æœç”¨ã«ã‚ˆã‚Š, 24時間を通ã˜æ—¥å†…変動リズムã®ãƒ‘ターンã«å½±éŸ¿ã‚’ãŠã‚ˆã¼ã™ã“ã¨ãªã良好ãªé™åœ§åŠ¹æžœãŒèªã‚られãŸ. ã¾ãŸ, dipperåž‹ã¨non-dipPeråž‹ã«åˆ†ã‘ãŸæ¤œè¨Žã«ãŠã„ã¦, non-dipperåž‹ã§ã‚ˆã‚Šè‰¯å¥½ãªé™åœ§åŠ¹æžœãŒç¢ºèªã•ã‚ŒãŸ. ã“れより, 本剤ã¯è¡€åœ§æ—¥å†…変動ã«æ‚ªå½±éŸ¿ã‚’ãŠã‚ˆã¼ã•ãšå®‰å®š
Treatment of essential tremor with arotinolol - PubMed
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