Course Curriculam
Course Code: CHM102 Credit Units L T P/S SW AS/DS FW No. of PSDA Total Credit Unit
Course Level UG 3 0 4 2 0 0 0 6
Course Title Bioorganic and Medicinal Chemistry
Course This course gives a description of biomolecules like carbohydrates, amino acids and nucleic acids. A basic introduction to medicinal
Description : chemistry and polymers is provide along with its reaction mechanism is also covered.
Course Objectives :
SN. Objectives
1 Understand the role of biomolecules in the growth and development of living organisms
2 • Grasp the significance of basic experimental understanding of carbohydrates, amino acids, proteins, nucleic acids and medicinal chemistry
3 Build on their knowledge of polymers along with its kinetics and mechanisms
4 Appreciate the relevance of the content in food, beverage and pharmaceutical industries
Pre-Requisites : General
SN. Course Code Course Name
Course Contents / Syllabus :
SN. Module Descriptors / Topics Weightage
Classification of carbohydrates, reducing and non-reducing sugars, General Properties of Glucose and Fructose,
their open chain structure. Epimers, mutarotation and anomers. Mechanism of mutarotation Determination of
Chemistry of configuration of Glucose (Fischer’s proof). Cyclic structure of glucose. Haworth projections. Cyclic structure of
1 Carbohydrate fructose. Inter conversions of sugars (ascending and descending of sugar series, conversion of aldoses to ketoses). 15.00
s Lobry de Bruyn-van Ekenstein rearrangement; stepping–up (Kiliani Fischer method) and stepping–down (Ruff’s
&Wohl’s methods) of aldoses; end-group interchange of aldoses Linkage between monosachharides, structure of
disacharrides (sucrose, maltose, lactose.)
Classification of amino acids, zwitter ion structure and Isoelectric point. Overview of primary, secondary, tertiary and
quaternary structure of proteins. Determination of primary structure of peptides, determination of N-terminal amino
Chemistry of acid (by DNFB and Edman method) and C–terminal amino acid (by thiohydantoin and with carboxypeptidase
2 15.00
Proteins enzyme). Synthesis of simple peptides (upto dipeptides) by N-protection & C-activating groups and Merrifield solid
phase synthesis. Protein denaturation/ renaturation Mechanism of enzyme action, factors affecting enzyme action,
Coenzymes and cofactors and their role in biological reactions)
Constituents of Nucleic acids: Adenine, guanine, thymine and Cytosine (Structure only), Nucleosides and
Chemistry of nucleotides (nomenclature), Synthesis of nucleic 05 17 acids, Structure of polynucleotides; Structure of DNA
3 10.00
Nucleic Acids (Watson-Crick model) and RNA (types of RNA), Genetic Code, Biological roles of DNA and RNA: Replication,
Transcription and Translation
Drug discovery, design and development; Basic Retrosynthetic approach. Drug action-receptor theory. Structure
–activity relationships of drug molecules, binding role of –OH group,-NH2 group, double bond and aromatic ring.
Introductory
Mechanism of action of the representative drugs of the following classes: analgesics agents, antipyretic agents,
4 Medicinal 15.00
anti-inflammatory agents (Aspirin, paracetamol); antibiotics (Chloramphenicol); antibacterial and antifungal agents
Chemistry
(Sulphonamides; Sulphanethoxazol, Sulphacetamide); antiviral agents (Acyclovir), Central Nervous System agents
(Phenobarbital, Diazepam),Cardiovascular (Glyceryl trinitrate), HIV-AIDS related drugs (AZT- Zidovudine)
Definition of space lattice, unit cell. Laws of crystallography – (i) Law of constancy of interfacial angles, (ii) Law of
5 Solid State rationality of indices and iii) Symmetry elements in crystals and law of symmetry .X-ray diffraction by crystals. 10.00
Derivation of Bragg equation. Determination of crystal structure of NaCl, KCl and CsCl (powder method).
Monomers, Oligomers, Polymers and their characteristics, Classification of polymers: Natural synthetic, linear,
cross linked and network; plastics, elastomers, fibres, Homopolymers and Co-polymers, Bonding in polymers:
Introduction to
6 Primary and secondary bond forces in polymers ; cohesive energy, and decomposition of polymers. Determination 15.00
Polymer
of Molecular mass of polymers: Number Average molecular mass (Mn) and Weight average molecular mass (Mw)
of polymers and determination by (i) Viscosity (ii) Light scattering method (iii) Gel permeation chromatography (iv)
Osmometry and Ultracentrifuging. Silicones and Phosphazenes –Silicones and phosphazenes as examples of
inorganic polymers, nature of bonding in triphosphazenes.
Kinetics and Polymerization techniques, Mechanism and kinetics of copolymerization,Addition or chaingrowth polymerization,
Mechanism of Free radical vinyl polymerization, ionic vinyl polymerization, ZieglerNatta polymerization and vinyl polymers,
7 10.00
Polymerizatio Condensation or step growth-polymerization, Polyesters, polyamides, phenol formaldehyde resins, urea
n formaldehyde resins, epoxy resins and polyurethanes.
Synthetic Colour and constitution (electronic Concept), Classification of dyes, Chemistry and synthesis of Methyl orange,
8 10.00
Dyes Congo red, Malachite green, crystal violet, phenolphthalein, fluorescein, Alizarin and Indigo.
Course Learning Outcomes :
SN. Course Learning Outcomes
1 1) Recall the mechanistic aspects of enzyme reactions and relate it to its role in biological reactions.
2) Demonstrate knowledge of skills and techniques which prove to be highly beneficial for studies the Organic chemistry and apply them for future
2
research in these and allied areas.
3 3) Identify the significance of course and applications in real life.
4 4) Analyse the aspects of drugs, its action and mechanism.
5 5) Explain the Concepts of Bioorganic Chemistry in the development of Science and Technology.
6 6) Formulate Qualitative and quantitative analysis of carbohydrates, proteins and synthesis of drug molecules (Practical based)
7) Applying the knowledge gained in the design and preparation of safe drug, safe dye, ecofriendly polymer thorough practical approach in the
7
integrated assignment
Pedagogy for Course Delivery :
SN. Pedagogy Methods
• The course pedagogy will include lectures, discussion, applications, presentations, reading review papers and individual. • The course pedagogy
will follow the four-quadrant approach i.e. using e-content like audio visual aids, video lectures, presentations, open source reference materials,
1
discussions on applications of topics covered. • Assessment will be done through assignments and quiz on topics covered after completion of
modules.
Theory /VAC / Architecture Assessment (L,T & Self Work): 66.70 Max : 100
Attendance+CE+EE : 5+35+60
SN. Type Component Name Marks
1 Attendance 5.00
2 End Term Examination (OMR) 60.00
3 Internal CLASS TEST 10.00
4 Internal HOME ASSIGNMENT 10.00
5 Internal INTEGRATED ASSIGNMENT 15.00
Lab/ Practical/ Studio/Arch. Studio/ Field Work Assessment : 33.30 Max : 100
Attendance+CE+EE : 5+35+60
SN. Type Component Name Marks
1 Attendance 5.00
2 External EXPERIMENT 30.00
3 External VIVA VOCE 30.00
4 Internal PRACTICAL / LAB RECORDS 10.00
5 Internal VIVA VOCE 15.00
6 Internal PERFORMANCE 10.00
Lab/ Practical details, if applicable :
SN
Lab / Practical Details
.
a) Separation of a mixture of two sugars by ascending paper chromatography b) Differentiate between a reducing/ nonreducing sugar c) Synthesis of
1
Osazones.
a. Isolation of protein. b. Determination of protein by the Biuret reaction. c. TLC separation of a mixture containing 2/3 amino acids d. Paper
2 chromatographic separation of a mixture containing 2/3 amino acids e. Action of salivary amylase on starch f. To determine the concentration of
glycine solution by formylation method. g. To determine the saponification value of an oil/fat. h. To determine the iodine value of an oil/fat
3 a. Determination of nucleic acids b. Extraction of DNA from onion/cauliflower
a. To synthesize aspirin by acetylation of salicylic acid and compare it with the ingredient of an aspirin tablet by TLC. b. Synthesis of barbituric acid c.
4
Synthesis of propranolol
List of Professional skill development activities :
[Link] PSDA : 0
SN. PSDA Point
Text & References :
SN. Type Title/Name Description ISBN/ URL
Furniss, B.S.; Hannaford, A.J.; Smith,
1 Book P.W.G.; Tatchell, A.R. Practical Organic
Chemistry, 5th Ed
Vogel’s Qualitative Inorganic Analysis,
2 Book
Revised by G. Svehla., 1989
Vogel, A.I. A Textbook of Quantitative
3 Book
Analysis, ELBS. 1986
Furniss, B.S.; Hannaford, A.J.; Rogers, V.;
4 Book Smith, P.W.G.; Tatchell, A.R. Vogel’s
Textbook of Pra
Ahluwalia, V.K. & Aggarwal, R.
5 Book Comprehensive Practical Organic
Chemistry, Universities Press, 200
Cooper, T.G. Tool of Biochemistry. Wiley-
6 Book
Blackwell, 1977
Wilson, K. & Walker, J. Practical
7 Book Biochemistry. Cambridge University Press,
2009
Varley, H., Gowenlock, A.H & Bell, M.:
8 Book Practical Clinical Biochemistry, Heinemann,
1980
Mann, F.G. & Saunders, B.C. Practical
9 Book Organic Chemistry, Pearson Education.
1936
