-
Vasodilators (Treating Hypertension)
We just learned about vasoconstrictors, which treat low blood pressure, or hypotension, by constricting the blood vessels. Now let's look at the precise opposite, vasodilators, which treat high blood pressure, or hypertension, by dilating the blood vessels. Let's learn more about hypertension and the mechanisms by which vasodilators address this issue!
Script by Michael Keith
Watch the whole Pharmacology playlist: http://bit.ly/ProfDavePharma
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem
Biology/Genetics Tutorials: http://bit.ly/ProfDaveBio
Anatomy & Physiology Tutorials: http://bit.ly/ProfDaveAnatPhys
Biopsychology Tutorials: http://bit.ly/ProfDaveBiopsych
Micro...
published: 28 Feb 2024
-
Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin...
Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments. Scott D Hansen and Dyche Mullins (2015), eLIFE http://dx.doi.org/10.7554/eLife.06585
Enabled/Vasodilator (Ena/VASP) proteins promote actin filament assembly at multiple locations, including: leading edge membranes, focal adhesions, and the surface of intracellular pathogens. One important Ena/VASP regulator is the mig-10/Lamellipodin/RIAM family of adaptors that promote lamellipod formation in fibroblasts and drive neurite outgrowth and axon guidance in neurons. To better understand how MRL proteins promote actin network formation we studied the interactions between Lamellipodin (Lpd), actin, and VASP, both in vivo and in vitro. We find that Lpd binds directly to actin filaments and...
published: 23 Aug 2015
-
Profilin
Profilin is a G-actin binding protein. Profilin also recognizes proline rich motif of VASP and mDia1 at the opposite side of its actin binding site. WASP Homology 2 (WH2) domain, also called globular actin binding site (GAB) follows the proline-rich motif of VASP, and binds to the cleft of subdomains of actin, and extends toward its pointed end.
published: 21 Aug 2012
-
VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent
VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent of the α-catenin-vinculin module. Joppe Oldenburg et al (2015), Scientific Reports http://dx.doi.org/10.1038/srep17225
Mechanical forces are integrated at cadherin-based adhesion complexes to regulate morphology and strength of cell-cell junctions and organization of associated F-actin. A central mechanosensor at the cadherin complex is α-catenin, whose stretching recruits vinculin to regulate adhesion strength. The identity of the F-actin regulating signals that are also activated by mechanical forces at cadherin-based junctions has remained elusive. Here we identify the actin-regulators VASP, zyxin and TES as members of punctate, tensile cadherin-based junctions called Focal Adherens Junctions (FAJ...
published: 27 Nov 2015
-
VASP Acting workshop.
published: 25 Aug 2018
-
Clopidogrel | Pharmacology Animation Video | Student Online Education | V-Learning™
Clopidogrel is an antiplatelet drug that is inactive and converted by cytochrome enzymes into active metabolite.
Clopidogrel prevents binding of ADP to receptor by binding itself and cause activation of adenylyl cyclase which converts ATP to cAMP and phosphorylate vasodilator stimulated phosphoprotein.
----------------------------------------
Pharmacology Lectures Collection -
https://www.sqadia.com/categories/pharmacology
----------------------------------------
This phosphorylated form is unable to activate GP IIb/IIIa receptors, preventing the platelet aggregation.
----------------------------------------
5500+ Medical Videos
Try for FREE! - https://www.sqadia.com/categories/free
----------------------------------------
published: 01 Sep 2020
-
Impact of Prasugrel and Ticagrelor on Platelet Reactivity in Patients With Acute Coronary Syndrom...
Abstract
Background: This meta-analysis mainly aimed to compare the impact of prasugrel and ticagrelor on platelet reactivity (PR) in patients with acute coronary syndrome (ACS).
Methods: We searched four electronic databases to identify randomized controlled trials and cohort studies comparing the impact of prasugrel and ticagrelor on PR in patients with ACS. We performed group analyses according to three detection methods, drug dose [loading dose (LD) and maintenance dose (MTD)] and LD effect time, and assessed the robustness of the results through sensitivity analysis.
Results: Twenty-five studies with 5,098 patients were eligible. After LD, the incidence of high on-treatment platelet reactivity (HTPR) of ticagrelor was significantly lower than that of prasugrel within 6-18 h b...
published: 27 May 2024
-
血管拡張因子刺激リン酸化タンパク質
血管拡張因子刺激リン酸化タンパク質, by Wikipedia https://ja.wikipedia.org/wiki?curid=3823771 / CC BY SA 3.0
#タンパク質
#シグナル伝達
血管拡張因子刺激リン酸化タンパク質(Vasodilator-stimulated phosphoprotein)とは、ヒトのVASP遺伝子にコードされているタンパク質である。
血管拡張因子刺激リン酸化タンパク質(VASP)はEna-VASPタンパク質ファミリーのメンバーの一つである。
Ena-VASPファミリーのメンバーはN末端にEVH1ドメインを有し、このドメインはE/DFPPPPD/Eモチーフを有するタンパク質に結合し、Ena-VASPタンパク質が焦点接着細胞膜を標的とするように仕向ける。
中間領域には、SH3およびWWドメイン含有タンパク質に結合するプロリンリッチ領域を持つ。
C末端のEVH2ドメインは四量体化を媒介し、GアクチンおよびFアクチンの両方に結合する。
VASPは糸状アクチン形成に関連し、細胞接着や運動性において広範な役割を果たすと思われている。
また、インテグリンと細胞外マトリックスとの相互作用を調節する細胞内シグナル伝達経路に関与している可能性がある。
VASPは、環状ヌクレオチド依存性キナーゼのPKAおよびPKGによって調節される。
血管拡張因子刺激リン酸化タンパク質はZyxin、プロフィリン1、 PFN2と相互作用することが確認されている。
published: 21 Oct 2021
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Receptors and Intracellular Signaling Free Webinar
Hello Everyone!
Welcome! I am Dr Sina Alam, MD; I have been tutoring USMLE Step 1 since 2016; I have a new WhatsApp Based Tutoring program for USMLE Step 1; I talked about this program in this video with my Clone!
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If you want to join my upcoming WhatsApp based BootCamp for 5 Free trial days; Join with one (just any one, not every group) link from the following!
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Only For Bangladeshis (Videos will be in Bangla here!)
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And, if you are still reading, please subscribe to my channel.
published: 27 Oct 2018
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Clopidogrel (PLAVIX) - Mechanism, side effects, precautions & uses
Clopidogrel (PLAVIX) is a thienopyridine derivative that acts as antiplatelet agent. This drug blocks ADP dependent platelet aggregation by acting as antagonist on P2Y12 receptors.
0:00 Introduction
0:29 CLOPIDOGREL - Antiplatelet
1:52 Chemical nature of CLOPIDOGREL
3:11 Structure of CLOPIDOGREL
4:53 Bio-activation of CLOPIDOGREL
10:26 Precautions
13:14 Side effects
14:49 Drug interactions WARFARIN
15:46 How it is given?
published: 02 Jul 2021
8:07
Vasodilators (Treating Hypertension)
We just learned about vasoconstrictors, which treat low blood pressure, or hypotension, by constricting the blood vessels. Now let's look at the precise opposit...
We just learned about vasoconstrictors, which treat low blood pressure, or hypotension, by constricting the blood vessels. Now let's look at the precise opposite, vasodilators, which treat high blood pressure, or hypertension, by dilating the blood vessels. Let's learn more about hypertension and the mechanisms by which vasodilators address this issue!
Script by Michael Keith
Watch the whole Pharmacology playlist: http://bit.ly/ProfDavePharma
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem
Biology/Genetics Tutorials: http://bit.ly/ProfDaveBio
Anatomy & Physiology Tutorials: http://bit.ly/ProfDaveAnatPhys
Biopsychology Tutorials: http://bit.ly/ProfDaveBiopsych
Microbiology/Infectious Diseases Tutorials: http://bit.ly/ProfDaveMicrobio
History of Drugs Videos: http://bit.ly/ProfDaveHistoryDrugs
Immunology Tutorials: http://bit.ly/ProfDaveImmuno
EMAIL►
[email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
https://wn.com/Vasodilators_(Treating_Hypertension)
We just learned about vasoconstrictors, which treat low blood pressure, or hypotension, by constricting the blood vessels. Now let's look at the precise opposite, vasodilators, which treat high blood pressure, or hypertension, by dilating the blood vessels. Let's learn more about hypertension and the mechanisms by which vasodilators address this issue!
Script by Michael Keith
Watch the whole Pharmacology playlist: http://bit.ly/ProfDavePharma
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem
Biology/Genetics Tutorials: http://bit.ly/ProfDaveBio
Anatomy & Physiology Tutorials: http://bit.ly/ProfDaveAnatPhys
Biopsychology Tutorials: http://bit.ly/ProfDaveBiopsych
Microbiology/Infectious Diseases Tutorials: http://bit.ly/ProfDaveMicrobio
History of Drugs Videos: http://bit.ly/ProfDaveHistoryDrugs
Immunology Tutorials: http://bit.ly/ProfDaveImmuno
EMAIL►
[email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
- published: 28 Feb 2024
- views: 9511
1:15
Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin...
Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments. Scott D Hansen and Dyche Mullins (2015), eLIFE http:...
Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments. Scott D Hansen and Dyche Mullins (2015), eLIFE http://dx.doi.org/10.7554/eLife.06585
Enabled/Vasodilator (Ena/VASP) proteins promote actin filament assembly at multiple locations, including: leading edge membranes, focal adhesions, and the surface of intracellular pathogens. One important Ena/VASP regulator is the mig-10/Lamellipodin/RIAM family of adaptors that promote lamellipod formation in fibroblasts and drive neurite outgrowth and axon guidance in neurons. To better understand how MRL proteins promote actin network formation we studied the interactions between Lamellipodin (Lpd), actin, and VASP, both in vivo and in vitro. We find that Lpd binds directly to actin filaments and that this interaction regulates its subcellular localization and enhances its effect on VASP polymerase activity. We propose that Lpd delivers Ena/VASP proteins to growing barbed ends and increases their polymerase activity by tethering them to filaments. This interaction represents one more pathway by which growing actin filaments produce positive feedback to control localization and activity of proteins that regulate their assembly.
Good channel: https://www.youtube.com/Dlium
Subscribe, like and comment.
Good website: https://www.dlium.com
Bookmark, subscribe and comment.
https://wn.com/Lamellipodin_Promotes_Actin_Assembly_By_Clustering_Ena_Vasp_Proteins_And_Tethering_Them_To_Actin...
Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments. Scott D Hansen and Dyche Mullins (2015), eLIFE http://dx.doi.org/10.7554/eLife.06585
Enabled/Vasodilator (Ena/VASP) proteins promote actin filament assembly at multiple locations, including: leading edge membranes, focal adhesions, and the surface of intracellular pathogens. One important Ena/VASP regulator is the mig-10/Lamellipodin/RIAM family of adaptors that promote lamellipod formation in fibroblasts and drive neurite outgrowth and axon guidance in neurons. To better understand how MRL proteins promote actin network formation we studied the interactions between Lamellipodin (Lpd), actin, and VASP, both in vivo and in vitro. We find that Lpd binds directly to actin filaments and that this interaction regulates its subcellular localization and enhances its effect on VASP polymerase activity. We propose that Lpd delivers Ena/VASP proteins to growing barbed ends and increases their polymerase activity by tethering them to filaments. This interaction represents one more pathway by which growing actin filaments produce positive feedback to control localization and activity of proteins that regulate their assembly.
Good channel: https://www.youtube.com/Dlium
Subscribe, like and comment.
Good website: https://www.dlium.com
Bookmark, subscribe and comment.
- published: 23 Aug 2015
- views: 407
2:47
Profilin
Profilin is a G-actin binding protein. Profilin also recognizes proline rich motif of VASP and mDia1 at the opposite side of its actin binding site. WASP Homolo...
Profilin is a G-actin binding protein. Profilin also recognizes proline rich motif of VASP and mDia1 at the opposite side of its actin binding site. WASP Homology 2 (WH2) domain, also called globular actin binding site (GAB) follows the proline-rich motif of VASP, and binds to the cleft of subdomains of actin, and extends toward its pointed end.
https://wn.com/Profilin
Profilin is a G-actin binding protein. Profilin also recognizes proline rich motif of VASP and mDia1 at the opposite side of its actin binding site. WASP Homology 2 (WH2) domain, also called globular actin binding site (GAB) follows the proline-rich motif of VASP, and binds to the cleft of subdomains of actin, and extends toward its pointed end.
- published: 21 Aug 2012
- views: 2210
1:31
VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent
VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent of the α-catenin-vinculin module. Joppe Oldenburg et al (2015), Scient...
VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent of the α-catenin-vinculin module. Joppe Oldenburg et al (2015), Scientific Reports http://dx.doi.org/10.1038/srep17225
Mechanical forces are integrated at cadherin-based adhesion complexes to regulate morphology and strength of cell-cell junctions and organization of associated F-actin. A central mechanosensor at the cadherin complex is α-catenin, whose stretching recruits vinculin to regulate adhesion strength. The identity of the F-actin regulating signals that are also activated by mechanical forces at cadherin-based junctions has remained elusive. Here we identify the actin-regulators VASP, zyxin and TES as members of punctate, tensile cadherin-based junctions called Focal Adherens Junctions (FAJ) and show that they display mechanosensitive recruitment similar to that of vinculin. However, this recruitment is not altered by destroying or over-activating the α-catenin/vinculin module. Structured Illumination Microscopy (SIM) indicates that these tension sensitive proteins concentrate at locations within FAJs that are distinct from the core cadherin complex proteins. Furthermore, localization studies using mutated versions of VASP and zyxin indicate that these two proteins require binding to each other in order to localize to the FAJs. We conclude that there are multiple force sensitive modules present at the FAJ that are activated at distinct locations along the cadherin-F-actin axis and regulate specific aspects of junction dynamics.
Good channel: https://www.youtube.com/Dlium
Subscribe, like and comment.
Good website: https://www.dlium.com
Bookmark, subscribe and comment.
https://wn.com/Vasp,_Zyxin_And_Tes_Are_Tension_Dependent_Members_Of_Focal_Adherens_Junctions_Independent
VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent of the α-catenin-vinculin module. Joppe Oldenburg et al (2015), Scientific Reports http://dx.doi.org/10.1038/srep17225
Mechanical forces are integrated at cadherin-based adhesion complexes to regulate morphology and strength of cell-cell junctions and organization of associated F-actin. A central mechanosensor at the cadherin complex is α-catenin, whose stretching recruits vinculin to regulate adhesion strength. The identity of the F-actin regulating signals that are also activated by mechanical forces at cadherin-based junctions has remained elusive. Here we identify the actin-regulators VASP, zyxin and TES as members of punctate, tensile cadherin-based junctions called Focal Adherens Junctions (FAJ) and show that they display mechanosensitive recruitment similar to that of vinculin. However, this recruitment is not altered by destroying or over-activating the α-catenin/vinculin module. Structured Illumination Microscopy (SIM) indicates that these tension sensitive proteins concentrate at locations within FAJs that are distinct from the core cadherin complex proteins. Furthermore, localization studies using mutated versions of VASP and zyxin indicate that these two proteins require binding to each other in order to localize to the FAJs. We conclude that there are multiple force sensitive modules present at the FAJ that are activated at distinct locations along the cadherin-F-actin axis and regulate specific aspects of junction dynamics.
Good channel: https://www.youtube.com/Dlium
Subscribe, like and comment.
Good website: https://www.dlium.com
Bookmark, subscribe and comment.
- published: 27 Nov 2015
- views: 145
1:21
Clopidogrel | Pharmacology Animation Video | Student Online Education | V-Learning™
Clopidogrel is an antiplatelet drug that is inactive and converted by cytochrome enzymes into active metabolite.
Clopidogrel prevents binding of ADP to recepto...
Clopidogrel is an antiplatelet drug that is inactive and converted by cytochrome enzymes into active metabolite.
Clopidogrel prevents binding of ADP to receptor by binding itself and cause activation of adenylyl cyclase which converts ATP to cAMP and phosphorylate vasodilator stimulated phosphoprotein.
----------------------------------------
Pharmacology Lectures Collection -
https://www.sqadia.com/categories/pharmacology
----------------------------------------
This phosphorylated form is unable to activate GP IIb/IIIa receptors, preventing the platelet aggregation.
----------------------------------------
5500+ Medical Videos
Try for FREE! - https://www.sqadia.com/categories/free
----------------------------------------
https://wn.com/Clopidogrel_|_Pharmacology_Animation_Video_|_Student_Online_Education_|_V_Learning™
Clopidogrel is an antiplatelet drug that is inactive and converted by cytochrome enzymes into active metabolite.
Clopidogrel prevents binding of ADP to receptor by binding itself and cause activation of adenylyl cyclase which converts ATP to cAMP and phosphorylate vasodilator stimulated phosphoprotein.
----------------------------------------
Pharmacology Lectures Collection -
https://www.sqadia.com/categories/pharmacology
----------------------------------------
This phosphorylated form is unable to activate GP IIb/IIIa receptors, preventing the platelet aggregation.
----------------------------------------
5500+ Medical Videos
Try for FREE! - https://www.sqadia.com/categories/free
----------------------------------------
- published: 01 Sep 2020
- views: 2774
2:20
Impact of Prasugrel and Ticagrelor on Platelet Reactivity in Patients With Acute Coronary Syndrom...
Abstract
Background: This meta-analysis mainly aimed to compare the impact of prasugrel and ticagrelor on platelet reactivity (PR) in patients with acute cor...
Abstract
Background: This meta-analysis mainly aimed to compare the impact of prasugrel and ticagrelor on platelet reactivity (PR) in patients with acute coronary syndrome (ACS).
Methods: We searched four electronic databases to identify randomized controlled trials and cohort studies comparing the impact of prasugrel and ticagrelor on PR in patients with ACS. We performed group analyses according to three detection methods, drug dose [loading dose (LD) and maintenance dose (MTD)] and LD effect time, and assessed the robustness of the results through sensitivity analysis.
Results: Twenty-five studies with 5,098 patients were eligible. After LD, the incidence of high on-treatment platelet reactivity (HTPR) of ticagrelor was significantly lower than that of prasugrel within 6-18 h based on vasodilator-stimulated phosphoprotein (VASP) test [RR = 0.25 (0.07, 0.85), P = 0.03], there was no significant difference between ticagrelor and prasugrel in the following results: platelets inhibitory effect within 24-48 h based on VerifyNow P2Y12 (VN) assay (P = 0.11) and VASP test (P = 0.20), and the incidence of HTPR within 2-6 h based on VN assay (P = 0.57) and within 24-48 h based on VN assay (P = 0.46) and VASP test (P = 0.72), the incidence of low on-treatment platelet reactivity (LTPR) within 6-18 h based on VASP test (P = 0.46) and 48 h based on VN assay (P = 0.97) and VASP test (P = 0.73). After MTD, the platelet inhibitory effect of ticagrelor was stronger than that of prasugrel based on VN assay [WMD = -41.64 (-47.16, -36.11), P < 0.00001]and VASP test [WMD = -9.10 (-13.88, -4.32), P = 0.0002], the incidence of HTPR of ticagrelor was significantly lower than that of prasugrel based on VN assay [RR = 0.05 (0.02, 0.16), P < 0.00001], the incidence of LTPR of ticagrelor was significantly higher than prasugrel based on VN assay [RR = 6.54 (4.21, 10.14), P < 0.00001] and VASP test [RR = 2.65 (1.78, 3.96), P < 0.00001], the results of Multiple Electrode Aggregometry (MEA) test was inconsistent with the other two detection methods in platelet inhibitory effect and the incidence of HTPR and LTPR. There was no significant difference between ticagrelor and prasugrel in the following clinical outcomes: all-cause death (P = 0.86), cardiovascular death (P = 0.49), myocardial infarction (P = 0.67), stroke (P = 0.51), target vessel revascularization (P = 0.51), stent thrombosis (P = 0.90), TIMI major bleeding (P = 0.86) and bleeding BARC type ≥ 2 (P = 0.77). The risk of bleeding BARC type 1 of ticagrelor was significantly higher than prasugrel [RR = 1.44 (1.03, 2.02), P = 0.03].
Conclusions: Compared with prasugrel, ticagrelor might have a stronger platelet inhibition effect, with a lower incidence of HTPR and a higher incidence of LTPR and bleeding BARC type 1, while there might be no significant difference in the risk of thrombosis/ischemic, bleeding BARC Type ≥ 2 and TIMI major bleeding. A higher incidence of LTPR might indicate a higher risk of bleeding BARC type 1. The results of VN assay were consistent with that of VASP test, and not with the MEA test.
Front Cardiovasc Med. 2022 Jun 9; 9:905607
Disclaimer: Lupin makes no representation or warranty of any kind, expressed or implied, regarding the accuracy, adequacy, validity, reliability, availability, or completeness of any scientific information shared by the HCP on the STAR UPDATE podcast. You should not allow the contents of this to substitute for your own medical judgment, which you should exercise in evaluating the information on this website.
https://wn.com/Impact_Of_Prasugrel_And_Ticagrelor_On_Platelet_Reactivity_In_Patients_With_Acute_Coronary_Syndrom...
Abstract
Background: This meta-analysis mainly aimed to compare the impact of prasugrel and ticagrelor on platelet reactivity (PR) in patients with acute coronary syndrome (ACS).
Methods: We searched four electronic databases to identify randomized controlled trials and cohort studies comparing the impact of prasugrel and ticagrelor on PR in patients with ACS. We performed group analyses according to three detection methods, drug dose [loading dose (LD) and maintenance dose (MTD)] and LD effect time, and assessed the robustness of the results through sensitivity analysis.
Results: Twenty-five studies with 5,098 patients were eligible. After LD, the incidence of high on-treatment platelet reactivity (HTPR) of ticagrelor was significantly lower than that of prasugrel within 6-18 h based on vasodilator-stimulated phosphoprotein (VASP) test [RR = 0.25 (0.07, 0.85), P = 0.03], there was no significant difference between ticagrelor and prasugrel in the following results: platelets inhibitory effect within 24-48 h based on VerifyNow P2Y12 (VN) assay (P = 0.11) and VASP test (P = 0.20), and the incidence of HTPR within 2-6 h based on VN assay (P = 0.57) and within 24-48 h based on VN assay (P = 0.46) and VASP test (P = 0.72), the incidence of low on-treatment platelet reactivity (LTPR) within 6-18 h based on VASP test (P = 0.46) and 48 h based on VN assay (P = 0.97) and VASP test (P = 0.73). After MTD, the platelet inhibitory effect of ticagrelor was stronger than that of prasugrel based on VN assay [WMD = -41.64 (-47.16, -36.11), P < 0.00001]and VASP test [WMD = -9.10 (-13.88, -4.32), P = 0.0002], the incidence of HTPR of ticagrelor was significantly lower than that of prasugrel based on VN assay [RR = 0.05 (0.02, 0.16), P < 0.00001], the incidence of LTPR of ticagrelor was significantly higher than prasugrel based on VN assay [RR = 6.54 (4.21, 10.14), P < 0.00001] and VASP test [RR = 2.65 (1.78, 3.96), P < 0.00001], the results of Multiple Electrode Aggregometry (MEA) test was inconsistent with the other two detection methods in platelet inhibitory effect and the incidence of HTPR and LTPR. There was no significant difference between ticagrelor and prasugrel in the following clinical outcomes: all-cause death (P = 0.86), cardiovascular death (P = 0.49), myocardial infarction (P = 0.67), stroke (P = 0.51), target vessel revascularization (P = 0.51), stent thrombosis (P = 0.90), TIMI major bleeding (P = 0.86) and bleeding BARC type ≥ 2 (P = 0.77). The risk of bleeding BARC type 1 of ticagrelor was significantly higher than prasugrel [RR = 1.44 (1.03, 2.02), P = 0.03].
Conclusions: Compared with prasugrel, ticagrelor might have a stronger platelet inhibition effect, with a lower incidence of HTPR and a higher incidence of LTPR and bleeding BARC type 1, while there might be no significant difference in the risk of thrombosis/ischemic, bleeding BARC Type ≥ 2 and TIMI major bleeding. A higher incidence of LTPR might indicate a higher risk of bleeding BARC type 1. The results of VN assay were consistent with that of VASP test, and not with the MEA test.
Front Cardiovasc Med. 2022 Jun 9; 9:905607
Disclaimer: Lupin makes no representation or warranty of any kind, expressed or implied, regarding the accuracy, adequacy, validity, reliability, availability, or completeness of any scientific information shared by the HCP on the STAR UPDATE podcast. You should not allow the contents of this to substitute for your own medical judgment, which you should exercise in evaluating the information on this website.
- published: 27 May 2024
- views: 3
1:41
血管拡張因子刺激リン酸化タンパク質
血管拡張因子刺激リン酸化タンパク質, by Wikipedia https://ja.wikipedia.org/wiki?curid=3823771 / CC BY SA 3.0
#タンパク質
#シグナル伝達
血管拡張因子刺激リン酸化タンパク質(Vasodilator-stimulated phosphoprote...
血管拡張因子刺激リン酸化タンパク質, by Wikipedia https://ja.wikipedia.org/wiki?curid=3823771 / CC BY SA 3.0
#タンパク質
#シグナル伝達
血管拡張因子刺激リン酸化タンパク質(Vasodilator-stimulated phosphoprotein)とは、ヒトのVASP遺伝子にコードされているタンパク質である。
血管拡張因子刺激リン酸化タンパク質(VASP)はEna-VASPタンパク質ファミリーのメンバーの一つである。
Ena-VASPファミリーのメンバーはN末端にEVH1ドメインを有し、このドメインはE/DFPPPPD/Eモチーフを有するタンパク質に結合し、Ena-VASPタンパク質が焦点接着細胞膜を標的とするように仕向ける。
中間領域には、SH3およびWWドメイン含有タンパク質に結合するプロリンリッチ領域を持つ。
C末端のEVH2ドメインは四量体化を媒介し、GアクチンおよびFアクチンの両方に結合する。
VASPは糸状アクチン形成に関連し、細胞接着や運動性において広範な役割を果たすと思われている。
また、インテグリンと細胞外マトリックスとの相互作用を調節する細胞内シグナル伝達経路に関与している可能性がある。
VASPは、環状ヌクレオチド依存性キナーゼのPKAおよびPKGによって調節される。
血管拡張因子刺激リン酸化タンパク質はZyxin、プロフィリン1、 PFN2と相互作用することが確認されている。
https://wn.com/血管拡張因子刺激リン酸化タンパク質
血管拡張因子刺激リン酸化タンパク質, by Wikipedia https://ja.wikipedia.org/wiki?curid=3823771 / CC BY SA 3.0
#タンパク質
#シグナル伝達
血管拡張因子刺激リン酸化タンパク質(Vasodilator-stimulated phosphoprotein)とは、ヒトのVASP遺伝子にコードされているタンパク質である。
血管拡張因子刺激リン酸化タンパク質(VASP)はEna-VASPタンパク質ファミリーのメンバーの一つである。
Ena-VASPファミリーのメンバーはN末端にEVH1ドメインを有し、このドメインはE/DFPPPPD/Eモチーフを有するタンパク質に結合し、Ena-VASPタンパク質が焦点接着細胞膜を標的とするように仕向ける。
中間領域には、SH3およびWWドメイン含有タンパク質に結合するプロリンリッチ領域を持つ。
C末端のEVH2ドメインは四量体化を媒介し、GアクチンおよびFアクチンの両方に結合する。
VASPは糸状アクチン形成に関連し、細胞接着や運動性において広範な役割を果たすと思われている。
また、インテグリンと細胞外マトリックスとの相互作用を調節する細胞内シグナル伝達経路に関与している可能性がある。
VASPは、環状ヌクレオチド依存性キナーゼのPKAおよびPKGによって調節される。
血管拡張因子刺激リン酸化タンパク質はZyxin、プロフィリン1、 PFN2と相互作用することが確認されている。
- published: 21 Oct 2021
- views: 5
1:26:37
Receptors and Intracellular Signaling Free Webinar
Hello Everyone!
Welcome! I am Dr Sina Alam, MD; I have been tutoring USMLE Step 1 since 2016; I have a new WhatsApp Based Tutoring program for USMLE Step 1; I t...
Hello Everyone!
Welcome! I am Dr Sina Alam, MD; I have been tutoring USMLE Step 1 since 2016; I have a new WhatsApp Based Tutoring program for USMLE Step 1; I talked about this program in this video with my Clone!
.
If you want to join my upcoming WhatsApp based BootCamp for 5 Free trial days; Join with one (just any one, not every group) link from the following!
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Only For Bangladeshis (Videos will be in Bangla here!)
WhatsApp Group Link:
https://chat.whatsapp.com/Dm6mXp3xomh6Y6De6L1xIz
.
And, if you are still reading, please subscribe to my channel.
https://wn.com/Receptors_And_Intracellular_Signaling_Free_Webinar
Hello Everyone!
Welcome! I am Dr Sina Alam, MD; I have been tutoring USMLE Step 1 since 2016; I have a new WhatsApp Based Tutoring program for USMLE Step 1; I talked about this program in this video with my Clone!
.
If you want to join my upcoming WhatsApp based BootCamp for 5 Free trial days; Join with one (just any one, not every group) link from the following!
.
Only For Bangladeshis (Videos will be in Bangla here!)
WhatsApp Group Link:
https://chat.whatsapp.com/Dm6mXp3xomh6Y6De6L1xIz
.
And, if you are still reading, please subscribe to my channel.
- published: 27 Oct 2018
- views: 1066
17:47
Clopidogrel (PLAVIX) - Mechanism, side effects, precautions & uses
Clopidogrel (PLAVIX) is a thienopyridine derivative that acts as antiplatelet agent. This drug blocks ADP dependent platelet aggregation by acting as antagonist...
Clopidogrel (PLAVIX) is a thienopyridine derivative that acts as antiplatelet agent. This drug blocks ADP dependent platelet aggregation by acting as antagonist on P2Y12 receptors.
0:00 Introduction
0:29 CLOPIDOGREL - Antiplatelet
1:52 Chemical nature of CLOPIDOGREL
3:11 Structure of CLOPIDOGREL
4:53 Bio-activation of CLOPIDOGREL
10:26 Precautions
13:14 Side effects
14:49 Drug interactions WARFARIN
15:46 How it is given?
https://wn.com/Clopidogrel_(Plavix)_Mechanism,_Side_Effects,_Precautions_Uses
Clopidogrel (PLAVIX) is a thienopyridine derivative that acts as antiplatelet agent. This drug blocks ADP dependent platelet aggregation by acting as antagonist on P2Y12 receptors.
0:00 Introduction
0:29 CLOPIDOGREL - Antiplatelet
1:52 Chemical nature of CLOPIDOGREL
3:11 Structure of CLOPIDOGREL
4:53 Bio-activation of CLOPIDOGREL
10:26 Precautions
13:14 Side effects
14:49 Drug interactions WARFARIN
15:46 How it is given?
- published: 02 Jul 2021
- views: 17268
-
Introduction to ab-initio simulation in VASP | VASP Lecture
In this lecture, Martijn Marsman gives an introduction to density-functional theory (DFT) and the projector-augmented-wave (PAW) method.
0:00 Introduction of the speaker
0:00:54 Beginning of the presentation
0:05:19 DFT
0:09:40 Exchange-correlation energy
0:12:08 Bloch functions
0:18:58 Free molecules, surfaces, slabs
0:20:58 Total energy, kinetic energy, Hartree energy, Kohn-Sham equations
0:22:59 Representation of Kohn-Sham orbitals, plane-wave-basis set
0:26:34 Concept of real space and reciprocal space (Fast-Fourier transformation, cutoff energy)
0:36:16 PAW method
0:52:15 Quality of PAW potentials, transferability of pseudopotentials
0:55:27 Local basis set
1:00:00 Decomposition into pseudo, pseudo-on-site and all-electron-on-site contributions, examples: Kohn-Sham orbitals, kinetic ...
published: 09 Dec 2021
-
DOS and Band Structure Calculation using VASP
Kindly Click Here: https://bit.ly/2UtvbHE
DOS and Band Structure Calculation using VASP.
In this video, I talk about the step by step process of accurate DOS and band structure calculations using VASP and some ways of plotting the band structure and DOS of our system.
So, by listening to this video, we will learn how to perform DOS and band structure calculations for our target systems and then how to plot these properties. Also, we will understand the main reason for inconsistency between DOS and band structure and what points we need to take into consideration in order to take a more accurate result and remove the inconsistency between DOS and band structure calculations that is very important. Indeed, we may face this problem that our DOS and band structure calculations are not consist...
published: 03 May 2020
-
How to perform geometry optimization in VASP
Hello, Friends,
In this video, I have provided a comprehensive explanation of how to conduct geometry optimization using VASP. Additionally, you can find a link to download the INCAR file in the description section below, which you are welcome to utilize.
If you find the video helpful, please consider:
Subscribing to my channel
Liking the video
Sharing it with others
Leaving a comment with your thoughts or questions
Your support is greatly appreciated.
Thank you,
SB
File Link: https://drive.google.com/file/d/13LRonPoglaiuWYl9UtD8S0Oy0d5lI4W6/view?usp=sharing
published: 15 Jul 2023
-
The basics of VASP for materials science
In this tutorial, Dr Sherif Abbas of RMIT will introduce you to VASP, one of the most famous software programmes for performing Density Functional Theory (DFT) calculations.
It's particularly famous for its versatility and accuracy in dealing with crystal systems.
In this tutorial you will learn how to perform basic VASP calculations for simple crystals (diamond and gold) by setting up the four VASP input files and submitting a calculation to a supercomputer.
We will retrieve the crystal structures from MaterialsProject.org - a database of materials that include their VASP-calculated properties.
You will visualize your crystals using VESTA, an open-source visualization software.
To access Sherif's VASP for DFT tutorial files via GitHub, click here: https://github.com/sheriftawfikabbas...
published: 03 May 2021
-
VASP Input and output files (Dr. Anchalee and Dr. Pussana)
published: 21 Feb 2019
-
Introduction to Density Functional Theory [Part Two] Setting up a VASP Calculation
An introductory course to performing DFT Calculations. This video should provide the necessary information to set up a VASP calculation to determine the lattice constant of an FCC crystal.
References:
Scholl, D. S.; Steckel, J. A. Density Functional Theory: A practical Introduction; John Wiley & Sons, Inc., 2009; pp 35-41, 50-61, 63-65.
Monkhorst-Pack k points method:
Monkhorst, H. J.; Pack, J. D. Special points for Brillouin-zone integrations. Phys. Rev. B 1976, 13, 5188-5192.
Projector augmented wave method:
Blöchl, P. E. Projector augmented-wave method. Phys. Rev. B 1994, 50, 17953-17979.
Kresse, G.; Joubert, D. From ultrasoft pseudopotentials to the projector augmented-wave method. Phys. Rev. B 1999, 59, 1758-1775.
Vienna Ab Initio Simulation Package:
https://www.vasp.at/wiki/inde...
published: 05 Nov 2021
-
VASP Workshop at NERSC: Basics: DFT, plane waves, PAW method, electronic minimization, Part 1
Presented by Martijn Marsman, University of Vienna
Published on December 18, 2016
Slides are available here http://www.nersc.gov/assets/Uploads/VASP-lecture-Basics.pdf
Presented at the 3-day VASP workshop at NERSC, November 9-11, 2016
published: 21 Dec 2016
-
VASP | ATENÇÃO, VOCÊ COM ESSA FICHA NA MÃO EP. 357
A história da VASP, Viação Aérea São Paulo, do nascimento até o desmanche. Parte 1 de 2.
✈ Contato Comercial: [email protected]
✈ Produtos exclusivos Aviões e Músicas: https://www.lojadoavioesemusicas.com.br/
✈ Seu vídeo na abertura: Suspenso por enquanto
✈ Facebook: http://facebook.com/avioesemusicas
✈ Instagram: @ lito
✈ Twitter: @avioesemusicas
✈ Vinheta de abertura: Ivo Duran (@ivoduran)
✈ Aviões e Músicas é um canal para descomplicar a aviação e complementar as informações do blog http://www.avioesemusicas.com
Vídeos novos toda Quinta e Domingo às 12h00. Ou um Extra a qualquer dia.
Disclaimer: “The views expressed in this video are my own. They have not been reviewed or approved by United. I do not speak for United.”
"Os pontos de vistas aqui apresentados são apenas m...
published: 14 Oct 2018
-
Symmetry and sampling in reciprocal space | VASP Lecture
Martin Schlipf gives a beginner-friendly introduction to symmetry and how it affects sampling in reciprocal space. Then, he elaborates on specific considerations when using VASP, e.g., how to do a band-structure calculation, converging with respect to the number of k points, setting up k-point sampling for hybrid functionals, and more.
0:00:00 Introduction
0:01:03 Construct reciprocal lattice
0:02:50 Translational invariance
0:05:56 Computational advantage of reciprocal space
0:07:10 Outline of the lecture
0:07:40 K-point sampling: converging with respect to the number of k points
0:10:50 Surfaces/slabs, wires, isolated molecules
0:13:30 Symmetry considerations:
0:24:30 Format of the KPOINTS file
0:28:38 Density of states, type of smearning
0:41:49 Band-structure calculations
0:48:43 Hybr...
published: 13 Apr 2022
-
VASP教學課程
時間:2018/9/28
地點:材料系12F會議室
講師:蘇立揚
published: 28 Sep 2018
1:10:22
Introduction to ab-initio simulation in VASP | VASP Lecture
In this lecture, Martijn Marsman gives an introduction to density-functional theory (DFT) and the projector-augmented-wave (PAW) method.
0:00 Introduction of t...
In this lecture, Martijn Marsman gives an introduction to density-functional theory (DFT) and the projector-augmented-wave (PAW) method.
0:00 Introduction of the speaker
0:00:54 Beginning of the presentation
0:05:19 DFT
0:09:40 Exchange-correlation energy
0:12:08 Bloch functions
0:18:58 Free molecules, surfaces, slabs
0:20:58 Total energy, kinetic energy, Hartree energy, Kohn-Sham equations
0:22:59 Representation of Kohn-Sham orbitals, plane-wave-basis set
0:26:34 Concept of real space and reciprocal space (Fast-Fourier transformation, cutoff energy)
0:36:16 PAW method
0:52:15 Quality of PAW potentials, transferability of pseudopotentials
0:55:27 Local basis set
1:00:00 Decomposition into pseudo, pseudo-on-site and all-electron-on-site contributions, examples: Kohn-Sham orbitals, kinetic energy
1:03:08 Local operators
1:04:37 Q&A
1:04:56 What is the difference between norm-conserving pseudopotentials and ultra-soft pseudopotentials?
1:07:28 How is the relationship between pseudo-basis and real-basis functions defined?
1:09:02 How large should the cell size be in a calculation considering defects, vacancies, etc.
https://wn.com/Introduction_To_Ab_Initio_Simulation_In_Vasp_|_Vasp_Lecture
In this lecture, Martijn Marsman gives an introduction to density-functional theory (DFT) and the projector-augmented-wave (PAW) method.
0:00 Introduction of the speaker
0:00:54 Beginning of the presentation
0:05:19 DFT
0:09:40 Exchange-correlation energy
0:12:08 Bloch functions
0:18:58 Free molecules, surfaces, slabs
0:20:58 Total energy, kinetic energy, Hartree energy, Kohn-Sham equations
0:22:59 Representation of Kohn-Sham orbitals, plane-wave-basis set
0:26:34 Concept of real space and reciprocal space (Fast-Fourier transformation, cutoff energy)
0:36:16 PAW method
0:52:15 Quality of PAW potentials, transferability of pseudopotentials
0:55:27 Local basis set
1:00:00 Decomposition into pseudo, pseudo-on-site and all-electron-on-site contributions, examples: Kohn-Sham orbitals, kinetic energy
1:03:08 Local operators
1:04:37 Q&A
1:04:56 What is the difference between norm-conserving pseudopotentials and ultra-soft pseudopotentials?
1:07:28 How is the relationship between pseudo-basis and real-basis functions defined?
1:09:02 How large should the cell size be in a calculation considering defects, vacancies, etc.
- published: 09 Dec 2021
- views: 13942
48:20
DOS and Band Structure Calculation using VASP
Kindly Click Here: https://bit.ly/2UtvbHE
DOS and Band Structure Calculation using VASP.
In this video, I talk about the step by step process of accurate DOS an...
Kindly Click Here: https://bit.ly/2UtvbHE
DOS and Band Structure Calculation using VASP.
In this video, I talk about the step by step process of accurate DOS and band structure calculations using VASP and some ways of plotting the band structure and DOS of our system.
So, by listening to this video, we will learn how to perform DOS and band structure calculations for our target systems and then how to plot these properties. Also, we will understand the main reason for inconsistency between DOS and band structure and what points we need to take into consideration in order to take a more accurate result and remove the inconsistency between DOS and band structure calculations that is very important. Indeed, we may face this problem that our DOS and band structure calculations are not consistent. For example, the bandgap in our DOS calculations is larger than the results in the bandstructure calculations or our band structure calculations show a metallic system (for example); however, our band structure calculations show a semiconducting system with a bandgap. In this video, I tried to cover all these points to obtain a more accurate calculation and remove this inconsistency.
https://wn.com/Dos_And_Band_Structure_Calculation_Using_Vasp
Kindly Click Here: https://bit.ly/2UtvbHE
DOS and Band Structure Calculation using VASP.
In this video, I talk about the step by step process of accurate DOS and band structure calculations using VASP and some ways of plotting the band structure and DOS of our system.
So, by listening to this video, we will learn how to perform DOS and band structure calculations for our target systems and then how to plot these properties. Also, we will understand the main reason for inconsistency between DOS and band structure and what points we need to take into consideration in order to take a more accurate result and remove the inconsistency between DOS and band structure calculations that is very important. Indeed, we may face this problem that our DOS and band structure calculations are not consistent. For example, the bandgap in our DOS calculations is larger than the results in the bandstructure calculations or our band structure calculations show a metallic system (for example); however, our band structure calculations show a semiconducting system with a bandgap. In this video, I tried to cover all these points to obtain a more accurate calculation and remove this inconsistency.
- published: 03 May 2020
- views: 73201
14:33
How to perform geometry optimization in VASP
Hello, Friends,
In this video, I have provided a comprehensive explanation of how to conduct geometry optimization using VASP. Additionally, you can find a link...
Hello, Friends,
In this video, I have provided a comprehensive explanation of how to conduct geometry optimization using VASP. Additionally, you can find a link to download the INCAR file in the description section below, which you are welcome to utilize.
If you find the video helpful, please consider:
Subscribing to my channel
Liking the video
Sharing it with others
Leaving a comment with your thoughts or questions
Your support is greatly appreciated.
Thank you,
SB
File Link: https://drive.google.com/file/d/13LRonPoglaiuWYl9UtD8S0Oy0d5lI4W6/view?usp=sharing
https://wn.com/How_To_Perform_Geometry_Optimization_In_Vasp
Hello, Friends,
In this video, I have provided a comprehensive explanation of how to conduct geometry optimization using VASP. Additionally, you can find a link to download the INCAR file in the description section below, which you are welcome to utilize.
If you find the video helpful, please consider:
Subscribing to my channel
Liking the video
Sharing it with others
Leaving a comment with your thoughts or questions
Your support is greatly appreciated.
Thank you,
SB
File Link: https://drive.google.com/file/d/13LRonPoglaiuWYl9UtD8S0Oy0d5lI4W6/view?usp=sharing
- published: 15 Jul 2023
- views: 918
1:02:55
The basics of VASP for materials science
In this tutorial, Dr Sherif Abbas of RMIT will introduce you to VASP, one of the most famous software programmes for performing Density Functional Theory (DFT) ...
In this tutorial, Dr Sherif Abbas of RMIT will introduce you to VASP, one of the most famous software programmes for performing Density Functional Theory (DFT) calculations.
It's particularly famous for its versatility and accuracy in dealing with crystal systems.
In this tutorial you will learn how to perform basic VASP calculations for simple crystals (diamond and gold) by setting up the four VASP input files and submitting a calculation to a supercomputer.
We will retrieve the crystal structures from MaterialsProject.org - a database of materials that include their VASP-calculated properties.
You will visualize your crystals using VESTA, an open-source visualization software.
To access Sherif's VASP for DFT tutorial files via GitHub, click here: https://github.com/sheriftawfikabbas/dft_tutorial/tree/master/VASP
https://wn.com/The_Basics_Of_Vasp_For_Materials_Science
In this tutorial, Dr Sherif Abbas of RMIT will introduce you to VASP, one of the most famous software programmes for performing Density Functional Theory (DFT) calculations.
It's particularly famous for its versatility and accuracy in dealing with crystal systems.
In this tutorial you will learn how to perform basic VASP calculations for simple crystals (diamond and gold) by setting up the four VASP input files and submitting a calculation to a supercomputer.
We will retrieve the crystal structures from MaterialsProject.org - a database of materials that include their VASP-calculated properties.
You will visualize your crystals using VESTA, an open-source visualization software.
To access Sherif's VASP for DFT tutorial files via GitHub, click here: https://github.com/sheriftawfikabbas/dft_tutorial/tree/master/VASP
- published: 03 May 2021
- views: 20719
23:19
Introduction to Density Functional Theory [Part Two] Setting up a VASP Calculation
An introductory course to performing DFT Calculations. This video should provide the necessary information to set up a VASP calculation to determine the lattice...
An introductory course to performing DFT Calculations. This video should provide the necessary information to set up a VASP calculation to determine the lattice constant of an FCC crystal.
References:
Scholl, D. S.; Steckel, J. A. Density Functional Theory: A practical Introduction; John Wiley & Sons, Inc., 2009; pp 35-41, 50-61, 63-65.
Monkhorst-Pack k points method:
Monkhorst, H. J.; Pack, J. D. Special points for Brillouin-zone integrations. Phys. Rev. B 1976, 13, 5188-5192.
Projector augmented wave method:
Blöchl, P. E. Projector augmented-wave method. Phys. Rev. B 1994, 50, 17953-17979.
Kresse, G.; Joubert, D. From ultrasoft pseudopotentials to the projector augmented-wave method. Phys. Rev. B 1999, 59, 1758-1775.
Vienna Ab Initio Simulation Package:
https://www.vasp.at/wiki/index.php/The_VASP_Manual
https://www.vasp.at/wiki/index.php/INCAR
https://www.vasp.at/wiki/index.php/KPOINTS
https://www.vasp.at/wiki/index.php/POSCAR
https://www.vasp.at/wiki/index.php/POTCAR
https://www.vasp.at/wiki/index.php/PAW_method
SciNet Job Submission:
https://docs.scinet.utoronto.ca/index.php/Slurm
https://wn.com/Introduction_To_Density_Functional_Theory_Part_Two_Setting_Up_A_Vasp_Calculation
An introductory course to performing DFT Calculations. This video should provide the necessary information to set up a VASP calculation to determine the lattice constant of an FCC crystal.
References:
Scholl, D. S.; Steckel, J. A. Density Functional Theory: A practical Introduction; John Wiley & Sons, Inc., 2009; pp 35-41, 50-61, 63-65.
Monkhorst-Pack k points method:
Monkhorst, H. J.; Pack, J. D. Special points for Brillouin-zone integrations. Phys. Rev. B 1976, 13, 5188-5192.
Projector augmented wave method:
Blöchl, P. E. Projector augmented-wave method. Phys. Rev. B 1994, 50, 17953-17979.
Kresse, G.; Joubert, D. From ultrasoft pseudopotentials to the projector augmented-wave method. Phys. Rev. B 1999, 59, 1758-1775.
Vienna Ab Initio Simulation Package:
https://www.vasp.at/wiki/index.php/The_VASP_Manual
https://www.vasp.at/wiki/index.php/INCAR
https://www.vasp.at/wiki/index.php/KPOINTS
https://www.vasp.at/wiki/index.php/POSCAR
https://www.vasp.at/wiki/index.php/POTCAR
https://www.vasp.at/wiki/index.php/PAW_method
SciNet Job Submission:
https://docs.scinet.utoronto.ca/index.php/Slurm
- published: 05 Nov 2021
- views: 17484
1:35:18
VASP Workshop at NERSC: Basics: DFT, plane waves, PAW method, electronic minimization, Part 1
Presented by Martijn Marsman, University of Vienna
Published on December 18, 2016
Slides are available here http://www.nersc.gov/assets/Uploads/VASP-lecture-B...
Presented by Martijn Marsman, University of Vienna
Published on December 18, 2016
Slides are available here http://www.nersc.gov/assets/Uploads/VASP-lecture-Basics.pdf
Presented at the 3-day VASP workshop at NERSC, November 9-11, 2016
https://wn.com/Vasp_Workshop_At_Nersc_Basics_Dft,_Plane_Waves,_Paw_Method,_Electronic_Minimization,_Part_1
Presented by Martijn Marsman, University of Vienna
Published on December 18, 2016
Slides are available here http://www.nersc.gov/assets/Uploads/VASP-lecture-Basics.pdf
Presented at the 3-day VASP workshop at NERSC, November 9-11, 2016
- published: 21 Dec 2016
- views: 59306
18:42
VASP | ATENÇÃO, VOCÊ COM ESSA FICHA NA MÃO EP. 357
A história da VASP, Viação Aérea São Paulo, do nascimento até o desmanche. Parte 1 de 2.
✈ Contato Comercial:
[email protected]
✈ Produtos exclusivos...
A história da VASP, Viação Aérea São Paulo, do nascimento até o desmanche. Parte 1 de 2.
✈ Contato Comercial:
[email protected]
✈ Produtos exclusivos Aviões e Músicas: https://www.lojadoavioesemusicas.com.br/
✈ Seu vídeo na abertura: Suspenso por enquanto
✈ Facebook: http://facebook.com/avioesemusicas
✈ Instagram: @ lito
✈ Twitter: @avioesemusicas
✈ Vinheta de abertura: Ivo Duran (@ivoduran)
✈ Aviões e Músicas é um canal para descomplicar a aviação e complementar as informações do blog http://www.avioesemusicas.com
Vídeos novos toda Quinta e Domingo às 12h00. Ou um Extra a qualquer dia.
Disclaimer: “The views expressed in this video are my own. They have not been reviewed or approved by United. I do not speak for United.”
"Os pontos de vistas aqui apresentados são apenas meus e não foram revistos ou aprovados pela United. Eu não falo em nome da United."
Joselito Souza / Joselito Sousa
https://wn.com/Vasp_|_Atenção,_Você_Com_Essa_Ficha_Na_Mão_Ep._357
A história da VASP, Viação Aérea São Paulo, do nascimento até o desmanche. Parte 1 de 2.
✈ Contato Comercial:
[email protected]
✈ Produtos exclusivos Aviões e Músicas: https://www.lojadoavioesemusicas.com.br/
✈ Seu vídeo na abertura: Suspenso por enquanto
✈ Facebook: http://facebook.com/avioesemusicas
✈ Instagram: @ lito
✈ Twitter: @avioesemusicas
✈ Vinheta de abertura: Ivo Duran (@ivoduran)
✈ Aviões e Músicas é um canal para descomplicar a aviação e complementar as informações do blog http://www.avioesemusicas.com
Vídeos novos toda Quinta e Domingo às 12h00. Ou um Extra a qualquer dia.
Disclaimer: “The views expressed in this video are my own. They have not been reviewed or approved by United. I do not speak for United.”
"Os pontos de vistas aqui apresentados são apenas meus e não foram revistos ou aprovados pela United. Eu não falo em nome da United."
Joselito Souza / Joselito Sousa
- published: 14 Oct 2018
- views: 754063
1:06:22
Symmetry and sampling in reciprocal space | VASP Lecture
Martin Schlipf gives a beginner-friendly introduction to symmetry and how it affects sampling in reciprocal space. Then, he elaborates on specific consideration...
Martin Schlipf gives a beginner-friendly introduction to symmetry and how it affects sampling in reciprocal space. Then, he elaborates on specific considerations when using VASP, e.g., how to do a band-structure calculation, converging with respect to the number of k points, setting up k-point sampling for hybrid functionals, and more.
0:00:00 Introduction
0:01:03 Construct reciprocal lattice
0:02:50 Translational invariance
0:05:56 Computational advantage of reciprocal space
0:07:10 Outline of the lecture
0:07:40 K-point sampling: converging with respect to the number of k points
0:10:50 Surfaces/slabs, wires, isolated molecules
0:13:30 Symmetry considerations:
0:24:30 Format of the KPOINTS file
0:28:38 Density of states, type of smearning
0:41:49 Band-structure calculations
0:48:43 Hybrid functionals
0:49:28 KPOINTS_OPT
0:51:47 Q&A
0:52:08 Does it suffice to use vasp_gam to compute the band gap at the Gamma point for a bulk semiconductor?
0:53:33 For k meshes generation with the Monkhorst-Pack method, is it "saver" to use even or odd number of k points?
0:55:55 What is the difference between the KPOINTS_OPT file and the IBZKPT file?
0:59:05 How to set up the k points for a band-structure calculation using a hybrid functional?
1:02:42 What is downsampling in the context of hybrid functionals?
https://wn.com/Symmetry_And_Sampling_In_Reciprocal_Space_|_Vasp_Lecture
Martin Schlipf gives a beginner-friendly introduction to symmetry and how it affects sampling in reciprocal space. Then, he elaborates on specific considerations when using VASP, e.g., how to do a band-structure calculation, converging with respect to the number of k points, setting up k-point sampling for hybrid functionals, and more.
0:00:00 Introduction
0:01:03 Construct reciprocal lattice
0:02:50 Translational invariance
0:05:56 Computational advantage of reciprocal space
0:07:10 Outline of the lecture
0:07:40 K-point sampling: converging with respect to the number of k points
0:10:50 Surfaces/slabs, wires, isolated molecules
0:13:30 Symmetry considerations:
0:24:30 Format of the KPOINTS file
0:28:38 Density of states, type of smearning
0:41:49 Band-structure calculations
0:48:43 Hybrid functionals
0:49:28 KPOINTS_OPT
0:51:47 Q&A
0:52:08 Does it suffice to use vasp_gam to compute the band gap at the Gamma point for a bulk semiconductor?
0:53:33 For k meshes generation with the Monkhorst-Pack method, is it "saver" to use even or odd number of k points?
0:55:55 What is the difference between the KPOINTS_OPT file and the IBZKPT file?
0:59:05 How to set up the k points for a band-structure calculation using a hybrid functional?
1:02:42 What is downsampling in the context of hybrid functionals?
- published: 13 Apr 2022
- views: 3505
1:19:46
VASP教學課程
時間:2018/9/28
地點:材料系12F會議室
講師:蘇立揚
時間:2018/9/28
地點:材料系12F會議室
講師:蘇立揚
https://wn.com/Vasp教學課程
時間:2018/9/28
地點:材料系12F會議室
講師:蘇立揚
- published: 28 Sep 2018
- views: 6381