-
Cell signalling: kinases & phosphorylation
The way in which the proteins in a cell transmit signals to one another is hugely important for controlling cell division, cell migration and even cell death. If this process goes wrong, it can lead to the onset of diseases such as cancer.
This is the first part of a series of animations exploring cell signalling, this time focusing on kinases and phosphorylations. Within a cell, phosphorylations are a major way in which proteins can transmit chemical signals to one another. In this video, we're exploring what you need in order to perform a phosphorylation, how it works and what happens when proteins are phosphorylated.
Below are some references of seminal papers in the field. Early sequence alignments of ~100 protein kinases showed remarkable conservation of particular amino acid motifs...
published: 21 May 2015
-
Signal Transduction Pathways (G-Protein, Receptor Tyrosine Kinase, cGMP)
SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channel/UCZaDAUF7UEcRXIFvGZu3O9Q/join
My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.
published: 12 May 2021
-
Protein kinase A activation by cAMP
GPCRs step by step in following videos
GPCRs (G protein linked cell signaling)
https://youtu.be/GSjVKVGK_1o
GPCRs (Activation of G protein receptor)
https://youtu.be/Le_f5cxpD4w
GPCRs (phospholipase C activation IP3 & DAG, Diacyl Glycerol)
https://youtu.be/2bbBrpgeheY
GPCRs - (Inositol triphosphate (IP3) Calcium release)
https://youtu.be/lsYBeFqEwzk
GPCRs- (Di acyl glycerol (DAG) activates protein Kinase C (PKC)
https://youtu.be/larIxw_9ePU
GPCRs- (Adenyl Cyclase and cAMP)
https://youtu.be/0nA2xhNiAow
GPCRs- (Protein kinase A activation by cAMP )
https://youtu.be/NaOBRvAFiJQ
#BiotechReview #GPCRs #GProtein #CellSignaling #SignalTransduction #cAMP
published: 18 Aug 2011
-
Protein Kinase A (PKA)
Donate here: http://www.aklectures.com/donate.php
Website video link: http://www.aklectures.com/lecture/protein-kinase-a-pka
Facebook link: https://www.facebook.com/aklectures
Website link: http://www.aklectures.com
published: 01 Apr 2015
-
Receptor Tyrosine Kinases (Newer Version)
published: 29 Sep 2017
-
Protein kinase a
This cell signaling lecture explains about the protein kinase a pathway. http://shomusbiology.com/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
We are social. Find us ...
published: 06 Dec 2012
-
Ras-MAPK pathway | Ras-MAPK in cancer | The MAP Kinase (MAPK) signalling pathway
This video talks about The MAP Kinase (MAPK) signalling pathway. It also talk about how this pathway goes wrong in cancer.
this video will answer the following questions:
What does the MAPK signaling pathway do?
What type of signaling is MAPK?
What kind of kinase is MAPK?
What kind of MAP kinase mutation might cause cancer?
What does the MAPK signaling pathway do?
Does ERK cause cancer?
What type of signaling is MAPK?
published: 11 Jan 2022
-
Protein Kinase A
Protein kinase A is an enzyme that plays an important role in transfer of cell signal inside the cell. It is also known as cyclic AMP dependent protein kinase A.
published: 08 Oct 2023
-
Receptors: Signal Transduction and Phosphorylation Cascade
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it, just like molecular walkie-talkies. Check it out!
Watch the whole Biochemistry playlist: http://bit.ly/ProfDaveBiochem
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biology Tutorials: http://bit.ly/ProfDaveBio
Classical Physics Tutorials: http://bit.ly/ProfDavePhysics1
Modern Physics Tutorials: http://bit.ly/ProfDavePhysics2
Mathematics Tutorials: http://bit.ly/ProfDaveMaths
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/...
published: 06 Sep 2016
-
Kinases, its function and different types
#biotechnology #cellsignaling #kinases #phosphorylation
Protein kinases (PTKs) are enzymes that regulate the biological activity of proteins by phosphorylation of specific amino acids with ATP as the source of phosphate, thereby inducing a conformational change from an inactive to an active form of the protein or vice versa.
The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes. Protein kinases are also found in bacteria and plants. Up to 30% of all human proteins may be modified by kinase activity, and kinases are known to regulate the majority of cellular pathways, especially those involved in signal transduction.
Types of kinases
1. Serine/threonine kinases
2. Tyrosine Kinases
3. Dual specificity ...
published: 02 Sep 2020
5:20
Cell signalling: kinases & phosphorylation
The way in which the proteins in a cell transmit signals to one another is hugely important for controlling cell division, cell migration and even cell death. I...
The way in which the proteins in a cell transmit signals to one another is hugely important for controlling cell division, cell migration and even cell death. If this process goes wrong, it can lead to the onset of diseases such as cancer.
This is the first part of a series of animations exploring cell signalling, this time focusing on kinases and phosphorylations. Within a cell, phosphorylations are a major way in which proteins can transmit chemical signals to one another. In this video, we're exploring what you need in order to perform a phosphorylation, how it works and what happens when proteins are phosphorylated.
Below are some references of seminal papers in the field. Early sequence alignments of ~100 protein kinases showed remarkable conservation of particular amino acid motifs (1), and these same residues were found to be important to activity when scanning mutagenesis experiments tested activity after sequentially mutating kinase residues (2). While these conserved motifs are far apart in the amino acid sequence, the first structures of a kinase (3, 4) showed that they are all close to ATP and the substrate in three dimensional space. The original list of kinases was massively expanded to 518 members using data gathered from the Human Genome Project (5).
References:
(1) Hanks, S.K., Quinn, A.M., and Hunter, T. (1988) ‘The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains’. Science (New York, NY) 241 (4861), 42–52
(2) Gibbs, C.S. and Zoller, M.J. (1991) ‘Rational Scanning Mutagenesis of a Protein Kinase Identifies Functional Regions Involved in Catalysis and Substrate Interactions.’. The Journal of biological chemistry 266 (14), 8923–8931
(3) Knighton, D.R., Zheng, J.H., Eyck, Ten, L.F., Ashford, V.A., Xuong, N.H., Taylor, S.S., and Sowadski, J.M. (1991a) ‘Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase.’. Science (New York, NY) 253 (5018), 407–414
(4) Knighton, D.R., Zheng, J.H., Eyck, Ten, L.F., Xuong, N.H., Taylor, S.S., and Sowadski, J.M. (1991b) ‘Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase’. Science (New York, NY) 253 (5018), 414–420
(5) Manning, G., Whyte, D.B., Martinez, R., Hunter, T., and Sudarsanam, S. (2002b) ‘The Protein Kinase Complement of the Human Genome.’. Science (New York, NY) 298 (5600), 1912–1934
https://wn.com/Cell_Signalling_Kinases_Phosphorylation
The way in which the proteins in a cell transmit signals to one another is hugely important for controlling cell division, cell migration and even cell death. If this process goes wrong, it can lead to the onset of diseases such as cancer.
This is the first part of a series of animations exploring cell signalling, this time focusing on kinases and phosphorylations. Within a cell, phosphorylations are a major way in which proteins can transmit chemical signals to one another. In this video, we're exploring what you need in order to perform a phosphorylation, how it works and what happens when proteins are phosphorylated.
Below are some references of seminal papers in the field. Early sequence alignments of ~100 protein kinases showed remarkable conservation of particular amino acid motifs (1), and these same residues were found to be important to activity when scanning mutagenesis experiments tested activity after sequentially mutating kinase residues (2). While these conserved motifs are far apart in the amino acid sequence, the first structures of a kinase (3, 4) showed that they are all close to ATP and the substrate in three dimensional space. The original list of kinases was massively expanded to 518 members using data gathered from the Human Genome Project (5).
References:
(1) Hanks, S.K., Quinn, A.M., and Hunter, T. (1988) ‘The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains’. Science (New York, NY) 241 (4861), 42–52
(2) Gibbs, C.S. and Zoller, M.J. (1991) ‘Rational Scanning Mutagenesis of a Protein Kinase Identifies Functional Regions Involved in Catalysis and Substrate Interactions.’. The Journal of biological chemistry 266 (14), 8923–8931
(3) Knighton, D.R., Zheng, J.H., Eyck, Ten, L.F., Ashford, V.A., Xuong, N.H., Taylor, S.S., and Sowadski, J.M. (1991a) ‘Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase.’. Science (New York, NY) 253 (5018), 407–414
(4) Knighton, D.R., Zheng, J.H., Eyck, Ten, L.F., Xuong, N.H., Taylor, S.S., and Sowadski, J.M. (1991b) ‘Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase’. Science (New York, NY) 253 (5018), 414–420
(5) Manning, G., Whyte, D.B., Martinez, R., Hunter, T., and Sudarsanam, S. (2002b) ‘The Protein Kinase Complement of the Human Genome.’. Science (New York, NY) 298 (5600), 1912–1934
- published: 21 May 2015
- views: 197112
17:26
Signal Transduction Pathways (G-Protein, Receptor Tyrosine Kinase, cGMP)
SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channel/UCZaDAUF7UEcRXIFvGZu3O9Q/join
My goal is to reduce educational disparities by making education FRE...
SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channel/UCZaDAUF7UEcRXIFvGZu3O9Q/join
My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.
https://wn.com/Signal_Transduction_Pathways_(G_Protein,_Receptor_Tyrosine_Kinase,_Cgmp)
SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channel/UCZaDAUF7UEcRXIFvGZu3O9Q/join
My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.
- published: 12 May 2021
- views: 488769
0:38
Protein kinase A activation by cAMP
GPCRs step by step in following videos
GPCRs (G protein linked cell signaling)
https://youtu.be/GSjVKVGK_1o
GPCRs (Activation of G protein receptor)
https://you...
GPCRs step by step in following videos
GPCRs (G protein linked cell signaling)
https://youtu.be/GSjVKVGK_1o
GPCRs (Activation of G protein receptor)
https://youtu.be/Le_f5cxpD4w
GPCRs (phospholipase C activation IP3 & DAG, Diacyl Glycerol)
https://youtu.be/2bbBrpgeheY
GPCRs - (Inositol triphosphate (IP3) Calcium release)
https://youtu.be/lsYBeFqEwzk
GPCRs- (Di acyl glycerol (DAG) activates protein Kinase C (PKC)
https://youtu.be/larIxw_9ePU
GPCRs- (Adenyl Cyclase and cAMP)
https://youtu.be/0nA2xhNiAow
GPCRs- (Protein kinase A activation by cAMP )
https://youtu.be/NaOBRvAFiJQ
#BiotechReview #GPCRs #GProtein #CellSignaling #SignalTransduction #cAMP
https://wn.com/Protein_Kinase_A_Activation_By_Camp
GPCRs step by step in following videos
GPCRs (G protein linked cell signaling)
https://youtu.be/GSjVKVGK_1o
GPCRs (Activation of G protein receptor)
https://youtu.be/Le_f5cxpD4w
GPCRs (phospholipase C activation IP3 & DAG, Diacyl Glycerol)
https://youtu.be/2bbBrpgeheY
GPCRs - (Inositol triphosphate (IP3) Calcium release)
https://youtu.be/lsYBeFqEwzk
GPCRs- (Di acyl glycerol (DAG) activates protein Kinase C (PKC)
https://youtu.be/larIxw_9ePU
GPCRs- (Adenyl Cyclase and cAMP)
https://youtu.be/0nA2xhNiAow
GPCRs- (Protein kinase A activation by cAMP )
https://youtu.be/NaOBRvAFiJQ
#BiotechReview #GPCRs #GProtein #CellSignaling #SignalTransduction #cAMP
- published: 18 Aug 2011
- views: 85190
13:04
Protein Kinase A (PKA)
Donate here: http://www.aklectures.com/donate.php
Website video link: http://www.aklectures.com/lecture/protein-kinase-a-pka
Facebook link: https://www.facebook...
Donate here: http://www.aklectures.com/donate.php
Website video link: http://www.aklectures.com/lecture/protein-kinase-a-pka
Facebook link: https://www.facebook.com/aklectures
Website link: http://www.aklectures.com
https://wn.com/Protein_Kinase_A_(Pka)
Donate here: http://www.aklectures.com/donate.php
Website video link: http://www.aklectures.com/lecture/protein-kinase-a-pka
Facebook link: https://www.facebook.com/aklectures
Website link: http://www.aklectures.com
- published: 01 Apr 2015
- views: 59525
12:03
Protein kinase a
This cell signaling lecture explains about the protein kinase a pathway. http://shomusbiology.com/
Download the study materials here-
http://shomusbiology.com/b...
This cell signaling lecture explains about the protein kinase a pathway. http://shomusbiology.com/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
Our Website – www.shomusbiology.com
Facebook page- https://www.facebook.com/ShomusBiology/
Twitter - https://twitter.com/shomusbiology
SlideShare- www.slideshare.net/shomusbiology
Google plus- https://plus.google.com/113648584982732129198
LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661
Youtube- https://www.youtube.com/user/TheFunsuman
Thank you for watching
In cell biology, Protein kinase A (PKA) refers to a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase (EC 2.7.11.11). Protein kinase A has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.
It should not be confused with AMP-activated protein kinase - which, although being of similar nature, may have opposite effects - [1] nor with cyclin-dependent kinases (Cdks), nor with the acid dissociation constant, pKa.
Activation
Each PKA is a holoenzyme that consists of a regulatory subunit dimer with each regulatory subunit being bound to a catalytic subunit. Under low levels of cAMP, the holoenzyme remains intact and is catalytically inactive. When the concentration of cAMP rises (e.g., activation of adenylate cyclases by G protein-coupled receptors coupled to Gs, inhibition of phosphodiesterases that degrade cAMP), cAMP binds to the two binding sites on the regulatory subunits, which leads to the release of the catalytic subunits. For maximal function, each catalytic subunit must also be phosphorylated, which occurs on Thr 197 and helps orientate catalytic residues in the active site.[2]
1. Cytosolic cAMP increases. 2. Two cAMP molecules bind to each PKA regulatory subunit. 3. The regulatory subunits move out of the active sites of the catalytic subunits and the R2C2 complex dissociates 4. The free catalytic subunits interact with proteins to phosphorylate Ser or Thr residues. Source of the article published in description is Wikipedia. I am sharing their material. © by original content developers of Wikipedia.
Link- http://en.wikipedia.org/wiki/Main_Page
https://wn.com/Protein_Kinase_A
This cell signaling lecture explains about the protein kinase a pathway. http://shomusbiology.com/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
Our Website – www.shomusbiology.com
Facebook page- https://www.facebook.com/ShomusBiology/
Twitter - https://twitter.com/shomusbiology
SlideShare- www.slideshare.net/shomusbiology
Google plus- https://plus.google.com/113648584982732129198
LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661
Youtube- https://www.youtube.com/user/TheFunsuman
Thank you for watching
In cell biology, Protein kinase A (PKA) refers to a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase (EC 2.7.11.11). Protein kinase A has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.
It should not be confused with AMP-activated protein kinase - which, although being of similar nature, may have opposite effects - [1] nor with cyclin-dependent kinases (Cdks), nor with the acid dissociation constant, pKa.
Activation
Each PKA is a holoenzyme that consists of a regulatory subunit dimer with each regulatory subunit being bound to a catalytic subunit. Under low levels of cAMP, the holoenzyme remains intact and is catalytically inactive. When the concentration of cAMP rises (e.g., activation of adenylate cyclases by G protein-coupled receptors coupled to Gs, inhibition of phosphodiesterases that degrade cAMP), cAMP binds to the two binding sites on the regulatory subunits, which leads to the release of the catalytic subunits. For maximal function, each catalytic subunit must also be phosphorylated, which occurs on Thr 197 and helps orientate catalytic residues in the active site.[2]
1. Cytosolic cAMP increases. 2. Two cAMP molecules bind to each PKA regulatory subunit. 3. The regulatory subunits move out of the active sites of the catalytic subunits and the R2C2 complex dissociates 4. The free catalytic subunits interact with proteins to phosphorylate Ser or Thr residues. Source of the article published in description is Wikipedia. I am sharing their material. © by original content developers of Wikipedia.
Link- http://en.wikipedia.org/wiki/Main_Page
- published: 06 Dec 2012
- views: 30807
7:34
Ras-MAPK pathway | Ras-MAPK in cancer | The MAP Kinase (MAPK) signalling pathway
This video talks about The MAP Kinase (MAPK) signalling pathway. It also talk about how this pathway goes wrong in cancer.
this video will answer the following ...
This video talks about The MAP Kinase (MAPK) signalling pathway. It also talk about how this pathway goes wrong in cancer.
this video will answer the following questions:
What does the MAPK signaling pathway do?
What type of signaling is MAPK?
What kind of kinase is MAPK?
What kind of MAP kinase mutation might cause cancer?
What does the MAPK signaling pathway do?
Does ERK cause cancer?
What type of signaling is MAPK?
https://wn.com/Ras_Mapk_Pathway_|_Ras_Mapk_In_Cancer_|_The_Map_Kinase_(Mapk)_Signalling_Pathway
This video talks about The MAP Kinase (MAPK) signalling pathway. It also talk about how this pathway goes wrong in cancer.
this video will answer the following questions:
What does the MAPK signaling pathway do?
What type of signaling is MAPK?
What kind of kinase is MAPK?
What kind of MAP kinase mutation might cause cancer?
What does the MAPK signaling pathway do?
Does ERK cause cancer?
What type of signaling is MAPK?
- published: 11 Jan 2022
- views: 102303
2:30
Protein Kinase A
Protein kinase A is an enzyme that plays an important role in transfer of cell signal inside the cell. It is also known as cyclic AMP dependent protein kinase A...
Protein kinase A is an enzyme that plays an important role in transfer of cell signal inside the cell. It is also known as cyclic AMP dependent protein kinase A.
https://wn.com/Protein_Kinase_A
Protein kinase A is an enzyme that plays an important role in transfer of cell signal inside the cell. It is also known as cyclic AMP dependent protein kinase A.
- published: 08 Oct 2023
- views: 406
6:26
Receptors: Signal Transduction and Phosphorylation Cascade
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it,...
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it, just like molecular walkie-talkies. Check it out!
Watch the whole Biochemistry playlist: http://bit.ly/ProfDaveBiochem
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biology Tutorials: http://bit.ly/ProfDaveBio
Classical Physics Tutorials: http://bit.ly/ProfDavePhysics1
Modern Physics Tutorials: http://bit.ly/ProfDavePhysics2
Mathematics Tutorials: http://bit.ly/ProfDaveMaths
EMAIL►
[email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
https://wn.com/Receptors_Signal_Transduction_And_Phosphorylation_Cascade
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it, just like molecular walkie-talkies. Check it out!
Watch the whole Biochemistry playlist: http://bit.ly/ProfDaveBiochem
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biology Tutorials: http://bit.ly/ProfDaveBio
Classical Physics Tutorials: http://bit.ly/ProfDavePhysics1
Modern Physics Tutorials: http://bit.ly/ProfDavePhysics2
Mathematics Tutorials: http://bit.ly/ProfDaveMaths
EMAIL►
[email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
- published: 06 Sep 2016
- views: 452542
16:28
Kinases, its function and different types
#biotechnology #cellsignaling #kinases #phosphorylation
Protein kinases (PTKs) are enzymes that regulate the biological activity of proteins by phosphorylation...
#biotechnology #cellsignaling #kinases #phosphorylation
Protein kinases (PTKs) are enzymes that regulate the biological activity of proteins by phosphorylation of specific amino acids with ATP as the source of phosphate, thereby inducing a conformational change from an inactive to an active form of the protein or vice versa.
The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes. Protein kinases are also found in bacteria and plants. Up to 30% of all human proteins may be modified by kinase activity, and kinases are known to regulate the majority of cellular pathways, especially those involved in signal transduction.
Types of kinases
1. Serine/threonine kinases
2. Tyrosine Kinases
3. Dual specificity kinases
4. Histidine kinases
Serine/threonine kinases
A serine/threonine-protein kinase is a kinase enzyme that phosphorylates the OH group of serine or threonine (which have similar sidechains). At least 125 of the 500+ human protein kinases are serine/threonine kinases (STK).
The chemical reaction performed by these enzymes can be written as
ATP + a protein ----------- ADP + a phosphoprotein
Thus, the two substrates of this enzyme are ATP and a protein, whereas its two products are ADP and phosphoprotein.
Raf (Rapidly accelerated fibrosarcoma) or (MAPKKK)
Tyrosine kinases
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to the tyrosine amino acid of specific proteins inside a cell. It functions as an "on" or "off" switch in many cellular functions. Examples are SRC, ABL, FAK and Janus kinase
Dual specificity kinases
A dual-specificity kinase is a kinase that can act as both tyrosine and serine/threonine kinase. MEKs, involved in MAP kinase pathway, is an example of dual-specificity kinases.
Histidine kinase
A histidine kinase is an enzyme that can transfer a phosphate group from ATP to the histidine amino acid of specific proteins inside a cell.
MAPK signaling pathway: https://youtu.be/jxeBuxZUhkk
https://wn.com/Kinases,_Its_Function_And_Different_Types
#biotechnology #cellsignaling #kinases #phosphorylation
Protein kinases (PTKs) are enzymes that regulate the biological activity of proteins by phosphorylation of specific amino acids with ATP as the source of phosphate, thereby inducing a conformational change from an inactive to an active form of the protein or vice versa.
The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes. Protein kinases are also found in bacteria and plants. Up to 30% of all human proteins may be modified by kinase activity, and kinases are known to regulate the majority of cellular pathways, especially those involved in signal transduction.
Types of kinases
1. Serine/threonine kinases
2. Tyrosine Kinases
3. Dual specificity kinases
4. Histidine kinases
Serine/threonine kinases
A serine/threonine-protein kinase is a kinase enzyme that phosphorylates the OH group of serine or threonine (which have similar sidechains). At least 125 of the 500+ human protein kinases are serine/threonine kinases (STK).
The chemical reaction performed by these enzymes can be written as
ATP + a protein ----------- ADP + a phosphoprotein
Thus, the two substrates of this enzyme are ATP and a protein, whereas its two products are ADP and phosphoprotein.
Raf (Rapidly accelerated fibrosarcoma) or (MAPKKK)
Tyrosine kinases
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to the tyrosine amino acid of specific proteins inside a cell. It functions as an "on" or "off" switch in many cellular functions. Examples are SRC, ABL, FAK and Janus kinase
Dual specificity kinases
A dual-specificity kinase is a kinase that can act as both tyrosine and serine/threonine kinase. MEKs, involved in MAP kinase pathway, is an example of dual-specificity kinases.
Histidine kinase
A histidine kinase is an enzyme that can transfer a phosphate group from ATP to the histidine amino acid of specific proteins inside a cell.
MAPK signaling pathway: https://youtu.be/jxeBuxZUhkk
- published: 02 Sep 2020
- views: 8803