'+pages+''); $('.stream > div:odd').addClass('bgr_color'); updateHeight('#history'); }); window.activateTabArea = ensure(function(tab, areas){ var parsed = false; var parts = (areas || '').split('/'); window.fsonload = $.inArray('fs', parts) >= 0; if(fsonload){ parts.splice(parts.indexOf('fs'), 1); } var replayMode = false; if($.inArray('replay', parts)>=0){ replayMode = 'replay'; } var noSoundMode = false; if($.inArray('nosound', parts)>=0){ noSoundMode = 'nosound'; } if($.inArray('ns', parts)>=0){ noSoundMode = 'ns'; } var previewMode = null; if($.inArray('p', parts)>=0){ previewMode = 'p'; } if($.inArray('preview', parts)>=0){ previewMode = 'preview'; } if($.inArray('repeat', parts)>=0){ replayMode = 'repeat'; } if($.inArray('r', parts)>=0 || $.inArray('ro', parts)>=0){ replayMode = 'r'; } if(replayMode){ parts.splice(parts.indexOf(replayMode), 1); } if(noSoundMode){ parts.splice(parts.indexOf(noSoundMode), 1); } if(previewMode){ parts.splice(parts.indexOf(previewMode), 1); } if(previewMode){ if(!parts.length){ parts = ['1-14', '999:59']; } } var area = parts[0]; if(tab == 'history' && false){ var page = parseInt(area || '1') || 1; $.ajax({ url: 'https://login.wn.com/recent/json/?pp='+history_pp+'&skip='+history_pp*(page-1), dataType: 'jsonp', success: function(response){ $ensure(function(){ renderHistory(response, page); }); } }); return true; } if(tab == 'global_history' && false){ var page = parseInt(area || '1') || 1; globalHistory.fetchStream(page, '', function(){ updateHeight('#global_history'); }); return true; } if(tab == 'my_playlists' && false){ var page = parseInt(area || '1') || 1; myPlaylists.fetchStream(page, '', function(){ updateHeight('#my_playlists'); }); return true; } if(tab == 'my_videos' && false){ var page = parseInt(area || '1') || 1; myVideos.fetchStream(page, '', function(){ updateHeight('#my_videos'); }); return true; } if(tab == 'related_sites' && areas && matchPosition(areas)){ var seconds = parsePosition(areas); scrollRelated(seconds); return false; } if(matchPosition(area) || matchAction(area)){ parts.unshift('1'); area = parts[0]; } if(tab == 'expand' && area && area.match(/\d+/)) { var num = parseInt(area); if(num < 100){ //FIX ME. Load news page with ajax here } else if(num > 1900){ //FIX ME. Load timeline page with ajax here } } else if(tab.match(/^playlist\d+$/)){ var playerId = parseInt(tab.substring(8)); var vp = videoplayers[playerId]; window.descriptionsholder = $('.descriptionsplace'); if(!vp) return; // why? no player? if(replayMode){ $('.replaycurrent'+playerId).attr('checked', true); vp.setReplayCurrent(true); } var playQueue = []; window.playQueue = playQueue; var playQueuePosition = 0; var playShouldStart = null; var playShouldStop = null; var parseList = function(x){ var items = x.split(/;|,/g); var results = []; for (i in items){ try{ var action = parseAction(vp, items[i]); if(!action.video){ if(window.console && console.log) console.log("Warning: No video for queued entry: " + items[i]); }else{ results.push(action); } }catch(e){ if(window.console && console.log) console.log("Warning: Can''t parse queue entry: " + items[i]); } } return results; }; var scrollToPlaylistPosition = function(vp){ var ppos = vp.getPlaylistPosition(); var el = vp.playlistContainer.find('>li').eq(ppos); var par = el.closest('.playlist_scrollarea'); par.scrollTop(el.offset().top-par.height()/2); } var updateVolumeState = function(){ if(noSoundMode){ if(noSoundMode == 'turn-on'){ clog("Sound is on, vsid="+vp.vsid); vp.setVolumeUnMute(); noSoundMode = false; }else{ clog("Sound is off, vsid="+vp.vsid); vp.setVolumeMute(); noSoundMode = 'turn-on'; } } } var playQueueUpdate = function(){ var playPosition = playQueue[playQueuePosition]; vp.playFromPlaylist(playPosition.video); scrollToPlaylistPosition(vp); playShouldStart = playPosition.start; playShouldStop = playPosition.stop; }; var playQueueAdvancePosition = function(){ clog("Advancing play position..."); playQueuePosition ++; while(playQueuePosition < playQueue.length && !playQueue[playQueuePosition].video){ playQueuePosition ++; } if(playQueuePosition < playQueue.length){ playQueueUpdate(); }else if(vp.getReplayCurrent()){ playQueuePosition = 0; playQueueUpdate(); vp.seekTo(playShouldStart); vp.playVideo(); }else{ vp.pauseVideo(); playShouldStop = null; playShouldStart = null; } }; function loadMoreVideos(playerId, vp, start, finish, callback){ var playlistInfo = playlists[playerId-1]; if(playlistInfo.loading >= finish) return; playlistInfo.loading = finish; $.ajax({ url: '/api/upge/cheetah-photo-search/query_videos2', dataType: 'json', data: { query: playlistInfo.query, orderby: playlistInfo.orderby, start: start, count: finish-start }, success: function(response){ var pl = vp.getPlaylist().slice(0); pl.push.apply(pl, response); vp.setPlaylist(pl); callback(); } }); } if(parts.length == 1 && matchDash(parts[0])){ var pl = vp.getActualPlaylist(); var vids = parseDash(parts[0]); parts = []; for(var i = 0; i < vids.length; i++){ playQueue.push({ 'video': pl[vids[i]-1], 'start': 0, 'stop': null }) } if(vids.length){ if(vids[vids.length-1]-1>=pl.length){ loadMoreVideos(playerId, vp, pl.length, vids[vids.length-1], function(){ if(fsonload){ activateTabArea(tab, parts[0]+'/fs'); }else{ activateTabArea(tab, parts[0]); } var pls = vp.getPlaylist(); vp.playFromPlaylist(pls[pls.length-1]); vp.playVideo(); scrollToPlaylistPosition(vp); }); return true; } } if(playQueue){ playQueueUpdate(); vp.playVideo(); parsed = true; playShouldStart = 0; } } if(previewMode){ var vids = []; var dur = 0; var pl = vp.getActualPlaylist(); area = parts[0]; if(parts.length == 1 && matchPosition(parts[0])){ vids = parseDash('1-'+pl.length); dur = parsePosition(parts[0]); parts = []; }else if(parts.length == 1 && matchDash(parts[0])){ vids = parseDash(parts[0]); dur = parsePosition("999:59"); parts = []; } if(parts.length == 2 && matchDash(parts[0]) && matchPosition(parts[1])){ vids = parseDash(parts[0]); dur = parsePosition(parts[1]); parts = []; } for(var i = 0; i < vids.length; i++){ playQueue.push({ 'video': pl[vids[i]-1], 'start': 0, 'stop': dur }) } if(playQueue){ playQueueUpdate(); vp.playVideo(); parsed = true; } } if(parts.length>1){ for(var i = 0; i < parts.length; i++){ var sel = findMatchingVideo(vp, parts[i]); if(sel){ playQueue.push({ 'video': sel, 'start': 0, 'stop': null }) } } if(playQueue){ playQueueUpdate(); vp.playVideo(); parsed = true; } }else if(area){ var sel = findMatchingVideo(vp, area); if(sel){ vp.playFromPlaylist(sel); playShouldStart = 0; parsed = true; } } if(fsonload || replayMode){ playShouldStart = 0; } if(document.location.search.match('at=|queue=')){ var opts = document.location.search.replace(/^\?/,'').split(/&/g); for(var o in opts){ if(opts[o].match(/^at=(\d+:)?(\d+:)?\d+$/)){ playShouldStart = parsePosition(opts[o].substr(3)) } if(opts[o].match(/^queue=/)){ playQueue = parseList(opts[o].substr(6)); if(playQueue){ playQueuePosition = 0; playQueueUpdate(); } } } } if(matchPosition(parts[1])){ playShouldStart = parsePosition(parts[1]); parsed = true; } if(matchAction(parts[1])){ var action = parseAction(vp, area+'/'+parts[1]); playShouldStart = action.start; playShouldStop = action.stop; parsed = true; } if(playShouldStart !== null && !playQueue.length){ playQueue.push({ video: vp.getCurrentVideo(), start: playShouldStart, stop: playShouldStop }); } if(playShouldStart != null){ setInterval(function(){ if(playShouldStop && vp.currentPlayer && vp.currentPlayer.getCurrentTime() > playShouldStop){ playShouldStop = null; if(vp.getCurrentVideo() == playQueue[playQueuePosition].video){ playQueueAdvancePosition(); }else{ playShouldStart = null; } } }, 500); vp.playerContainer.bind('videoplayer.player.statechange', function(e, state){ if(state == 'ended'){ // advance to the next video playQueueAdvancePosition(); } }); vp.playerContainer.bind('videoplayer.player.readychange', function(e, state){ if(state){ updateVolumeState(); if(playShouldStart !== null){ vp.seekTo(playShouldStart); playShouldStart = null; }else{ playShouldStop = null; // someone started other video, stop playing from playQueue } } if(fsonload) { triggerFullscreen(playerId); fsonload = false; } }); } } else if(tab.match(/^wiki\d+$/)){ if(firstTimeActivate){ load_wiki($('#'+tab), function(){ if(area){ var areaNode = $('#'+area); if(areaNode.length>0){ $('html, body').scrollTop(areaNode.offset().top + 10); return true; } } }); } } return parsed; }) window.activateTab = ensure(function(tab, area){ window.activeArea = null; if(tab == 'import_videos'){ if(area){ import_videos(area); }else{ start_import(); } return true; } if(tab == 'chat'){ update_chat_position($('.chat').eq(0)); window.activeArea = 'chat'; jQuery('.tabtrigger').offscreentabs('activateTab', 'chat'); return true; } if(tab in rev_names){ tab = rev_names[tab]; } if(tab.match(':')){ return false; } var sup = $('ul li a[id=#'+tab+']'); if(sup && sup.length>0){ window.activeArea = area; sup.first().click(); if(!window.activateTabArea(tab, area)){ window.activeArea = null; } window.activeArea = null; return true; }else{ var have_tabs = $('#playlist_menu li').length; if(tab.match(/^playlists?\d+$/)){ var to_add = +tab.substring(8).replace(/^s/,'')-have_tabs; if(to_add>0 && have_tabs){ add_more_videos(to_add); return true; } } } return false; }); window.currentPath = ensure(function(){ return window.lastHistory.replace(basepath, '').split('?')[0]; }); window.main_tab = window.main_tab || 'videos'; window.addHistory = ensure(function(path){ if(window.console && console.log) console.log("Adding to history: "+path); if(window.history && history.replaceState && document.location.hostname.match(/^(youtube\.)?(\w{2,3}\.)?wn\.com$/)){ if(path == main_tab || path == main_tab+'/' || path == '' || path == '/') { path = basepath; } else if( path.match('^'+main_tab+'/') ){ path = basepath + '/' + path.replace(main_tab+'/', '').replace('--','/'); } else { path = basepath + '/' + path.replace('--','/'); } if(document.location.search){ path += document.location.search; } if(window.lastHistory) { history.pushState(null, null, path); } else if(window.lastHistory != path){ history.replaceState(null, null, path); window.lastHistory = path; } } else{ path = path.replace('--','/'); if(path == main_tab || path == main_tab+'/' || path == '' || path == '/') { path = ''; } if(window.lastHistory != '/'+path){ window.location.hash = path? '/'+path : ''; window.lastHistory = '/'+path; } } }); $('.tabtrigger li a').live('click', ensure(function() { var tab = $(this).attr('id'); if(tab.substring(0,1) == '#'){ var name = tab.substring(1); if(name in menu_names){ name = menu_names[name][0]; } realTab = rev_names[name]; $('#'+realTab).show(); if(window.console && console.log) console.log("Triggering tab: "+name+(window.activeArea?" activeArea="+window.activeArea:'')); var path = name; if(window.activeArea){ path = path + '/' + window.activeArea; } if(tab.match(/#playlist\d+/) || tab.match(/#details\d+/)){ $('.multiple-playlists').show(); $('.related_playlist').show(); $('.longest_videos_playlist').show(); }else { $('.multiple-playlists').hide(); $('.related_playlist').hide(); $('.longest_videos_playlist').hide(); } // start the related script only when the tab is on screen showing if (tab.match(/related_sites/)) { if (mc) { mc.startCredits(); } } window.activeTab = realTab; addHistory(path); setTimeout(ensure(function(){ if(tab.match(/language--/)){ $('.tabtrigger').offscreentabs('activateTab', 'language'); } if(tab.match(/weather/)) { $('.tabtrigger').offscreentabs('activateTab', 'weather'); loadContinent(); } updateMenus(tab); updateHeight(); }), 10); } return false; })); }); -->

'); } else { var query = elem.find('.keywords').html(); $.ajax({ context: elem, url: 'https://wn.com/api/upge/cheetah-search-adv/video', cache: true, data: { 'query': query }, dataType: 'jsonp', success: function(text) { if (text.length > 0) { video_id = text[0].id; elem.find('.player').html(''); } } }); } } var stopAllYouTubeVideos = function() { var iframes = document.querySelectorAll('iframe'); Array.prototype.forEach.call(iframes, function(iframe) { iframe.contentWindow.postMessage(JSON.stringify({ event: 'command', func: 'pauseVideo' }), '*'); }); } jQuery(function() { jQuery(".playVideo").live("click", function() { if(!$(this).hasClass("played")){ stopAllYouTubeVideos(); var elem = $(this); setTimeout(function(){ mouseOverMe(elem); }, 1000); } }); jQuery(".description_box .expandContent").live("click", function() { elem = $(this).parent().parent().parent().find('.descContent'); if(elem.height() > 51) { elem.css('height', '44px'); $(this).html('Show More '); }else{ elem.css('height', 'auto'); $(this).html('Hide '); } }); jQuery('.interview-play-off').click(function() { $(".interview-play-off").hide(); $(".interview-play").show(); $(".videoplayer-control-pause").click(); }); jQuery(".video-desc .show_author_videos").live("click", function() { query = $(this).attr('title'); container = $(this).parent().parent().parent().find('.video-author-thumbs'); $(this).parent().parent().parent().find('.video-author-thumbs').css('height', '220px'); jQuery.ajax({ url: '/api/upge/cheetah-photo-search/videoresults', data: {'query': query}, success: function(text) { if(!text) { text = i18n("No results"); } container.html(jQuery(text)); } }); }); }); // -->

Latest News for: hedgehog signaling pathway

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Aging Mechanism Analysis Paves the Way for Anti-Aging Research

GetNews 01 Apr 2024
Through the analysis of key regulatory pathways, such as Notch, Wnt, and Hedgehog signaling, researchers can unravel the molecular mechanisms underlying stem cell exhaustion.
Edit

Nathaniel A. Dyment, PhD, Presented With 2024 Kappa Delta Young Investigator Award for Research on ...

Victoria Advocate 02 Feb 2024
While more disorganized, the zonal attachments shared common features with native entheses.Activating the Hedgehog (Hh) signaling pathway—a key regulator of enthesis formation during growth and ...
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Endeavor BioMedicines Successfully Completes Phase 2a Trial of ENV-101 in Patients with Idiopathic Pulmonary Fibrosis

The Eagle-Tribune 24 Jan 2024
ENV-101 is an oral small molecule inhibitor of the Hedgehog (Hh) signaling pathway that offers a novel approach to treating the underlying pathologic mechanisms that cause fibrotic lung diseases.
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Targeting GPC3: Strategies for Therapeutic Intervention in Cancer

Pharmiweb 15 Dec 2023
Mechanistically, GPC3 likely participates in the regulation of signaling pathways such as Wnt, hedgehog, bone morphogenic protein, and FGF ... This, in turn, activates signaling pathways mediated by their specific receptors[20-21].
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Hedgehog Pathway Inhibitors Market Size, Share | Growth Report 2031

MENA FN 06 Dec 2023
(MENAFN - Straits Research) Hedgehog pathway Inhibitors are medications that selectively target and impede the Hedgehog signaling mechanism. This pathway requires various cellular processes during ... .
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Scientists transform scales on chicken feet into feathers by simply tweaking a gene

Interesting Engineering 29 May 2023
The team achieved this ...
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Scientists turn scales into feathers by tinkering with chicken genes

Killeen Daily Herald 24 May 2023
One of these genes, called Sonic hedgehog (Shh), controls a signaling pathway - a communication system that allows the transmission of messages within and between cells ... As the signaling pathways ...
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Scales or feathers? It all comes down to a few genes

Phys Dot Org 17 May 2023
One of these genes, called Sonic hedgehog (Shh), controls a signaling pathway—a communication system that allows the transmission of messages within and between cells ... As the signaling pathways ...
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Precision Cancer Therapeutics Markets, 2022 - Focus on Monoclonal Antibodies, Kinase Inhibitors, Angiogenesis Inhibitors, Proteasome ...

Eagle-Tribune 27 Dec 2022
... are covered including mTOR inhibitors, PI3K inhibitors, PARP inhibitors, apoptosis inhibitors, histone deacetylase inhibitors, CDK inhibitors, hedgehog signaling pathway inhibitors and several others.
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How a protein breaks free to cause deadly cancers

Phys Dot Org 18 Jul 2022
GLI1 is typically activated by the Hedgehog signaling pathway, known as HH. However, scientists have known for about a decade that crosstalk (interaction) between HH and the mitogen-activated protein kinase pathway has a role in cancers.
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Endeavor BioMedicines Partners with xCures to Identify Patients with PTCH1 mutations for Phase 2 Trial ...

Eagle-Tribune 31 May 2022
“We recently dosed the first patient in a Phase 2 study evaluating ENV-101 (taladegib), a small molecule inhibitor of the Hedgehog signaling pathway, in patients with advanced solid tumors harboring PTCH1 loss of function mutations.
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Endeavor Doses First Patient in Phase 2 Oncology Study Evaluating the Safety and Efficacy of ...

The Facts 25 May 2022
“The clinical effects of ENV-101, a small molecule inhibitor of the Hedgehog signaling pathway for the treatment of cancer have been evaluated in nearly 200 participants so far ... Targeting the Hedgehog Signaling Pathway in Oncology and Fibrosis.
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Scientists discover a gene that plays a critical role in embryo development

Phys Dot Org 24 May 2022
For this study, investigators sought to better understand the so-called Hedgehog signaling pathway, which regulates growth of the human embryo but also is active in adulthood ... to Hedgehog signaling.".
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A novel molecular mechanism that regulates secretion of the sonic hedgehog signaling molecule

Phys Dot Org 09 May 2022
... (Shh), a key signaling molecule that plays an important role in cancer progression in mammals, opening the door to novel therapeutic strategies for cancer induced by the hedgehog signaling pathway.
Edit

Endeavor BioMedicines Closes $101M Series B Financing to Advance Clinical-Stage Precision Medicine Pipeline

The Facts 07 Feb 2022
Targeting the Hedgehog Signaling Pathway in Oncology and Pulmonary Disease ... PTCH1, an oncogenic driver mutation in the Hedgehog signaling pathway is found in approximately 2% of all cancers.

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