'+pages+'');
$('.stream > div:odd').addClass('bgr_color');
updateHeight('#history');
});
window.activateTabArea = ensure(function(tab, areas){
var parsed = false;
var parts = (areas || '').split('/');
window.fsonload = $.inArray('fs', parts) >= 0;
if(fsonload){
parts.splice(parts.indexOf('fs'), 1);
}
var replayMode = false;
if($.inArray('replay', parts)>=0){
replayMode = 'replay';
}
var noSoundMode = false;
if($.inArray('nosound', parts)>=0){
noSoundMode = 'nosound';
}
if($.inArray('ns', parts)>=0){
noSoundMode = 'ns';
}
var previewMode = null;
if($.inArray('p', parts)>=0){
previewMode = 'p';
}
if($.inArray('preview', parts)>=0){
previewMode = 'preview';
}
if($.inArray('repeat', parts)>=0){
replayMode = 'repeat';
}
if($.inArray('r', parts)>=0 || $.inArray('ro', parts)>=0){
replayMode = 'r';
}
if(replayMode){
parts.splice(parts.indexOf(replayMode), 1);
}
if(noSoundMode){
parts.splice(parts.indexOf(noSoundMode), 1);
}
if(previewMode){
parts.splice(parts.indexOf(previewMode), 1);
}
if(previewMode){
if(!parts.length){
parts = ['1-14', '999:59'];
}
}
var area = parts[0];
if(tab == 'history' && false){
var page = parseInt(area || '1') || 1;
$.ajax({
url: 'https://login.wn.com/recent/json/?pp='+history_pp+'&skip='+history_pp*(page-1),
dataType: 'jsonp',
success: function(response){
$ensure(function(){
renderHistory(response, page);
});
}
});
return true;
}
if(tab == 'global_history' && false){
var page = parseInt(area || '1') || 1;
globalHistory.fetchStream(page, '', function(){
updateHeight('#global_history');
});
return true;
}
if(tab == 'my_playlists' && false){
var page = parseInt(area || '1') || 1;
myPlaylists.fetchStream(page, '', function(){
updateHeight('#my_playlists');
});
return true;
}
if(tab == 'my_videos' && false){
var page = parseInt(area || '1') || 1;
myVideos.fetchStream(page, '', function(){
updateHeight('#my_videos');
});
return true;
}
if(tab == 'related_sites' && areas && matchPosition(areas)){
var seconds = parsePosition(areas);
scrollRelated(seconds);
return false;
}
if(matchPosition(area) || matchAction(area)){
parts.unshift('1');
area = parts[0];
}
if(tab == 'expand' && area && area.match(/\d+/)) {
var num = parseInt(area);
if(num < 100){
//FIX ME. Load news page with ajax here
}
else if(num > 1900){
//FIX ME. Load timeline page with ajax here
}
}
else if(tab.match(/^playlist\d+$/)){
var playerId = parseInt(tab.substring(8));
var vp = videoplayers[playerId];
window.descriptionsholder = $('.descriptionsplace');
if(!vp) return; // why? no player?
if(replayMode){
$('.replaycurrent'+playerId).attr('checked', true);
vp.setReplayCurrent(true);
}
var playQueue = [];
window.playQueue = playQueue;
var playQueuePosition = 0;
var playShouldStart = null;
var playShouldStop = null;
var parseList = function(x){
var items = x.split(/;|,/g);
var results = [];
for (i in items){
try{
var action = parseAction(vp, items[i]);
if(!action.video){
if(window.console && console.log) console.log("Warning: No video for queued entry: " + items[i]);
}else{
results.push(action);
}
}catch(e){
if(window.console && console.log) console.log("Warning: Can''t parse queue entry: " + items[i]);
}
}
return results;
};
var scrollToPlaylistPosition = function(vp){
var ppos = vp.getPlaylistPosition();
var el = vp.playlistContainer.find('>li').eq(ppos);
var par = el.closest('.playlist_scrollarea');
par.scrollTop(el.offset().top-par.height()/2);
}
var updateVolumeState = function(){
if(noSoundMode){
if(noSoundMode == 'turn-on'){
clog("Sound is on, vsid="+vp.vsid);
vp.setVolumeUnMute();
noSoundMode = false;
}else{
clog("Sound is off, vsid="+vp.vsid);
vp.setVolumeMute();
noSoundMode = 'turn-on';
}
}
}
var playQueueUpdate = function(){
var playPosition = playQueue[playQueuePosition];
vp.playFromPlaylist(playPosition.video);
scrollToPlaylistPosition(vp);
playShouldStart = playPosition.start;
playShouldStop = playPosition.stop;
};
var playQueueAdvancePosition = function(){
clog("Advancing play position...");
playQueuePosition ++;
while(playQueuePosition < playQueue.length && !playQueue[playQueuePosition].video){
playQueuePosition ++;
}
if(playQueuePosition < playQueue.length){
playQueueUpdate();
}else if(vp.getReplayCurrent()){
playQueuePosition = 0;
playQueueUpdate();
vp.seekTo(playShouldStart);
vp.playVideo();
}else{
vp.pauseVideo();
playShouldStop = null;
playShouldStart = null;
}
};
function loadMoreVideos(playerId, vp, start, finish, callback){
var playlistInfo = playlists[playerId-1];
if(playlistInfo.loading >= finish) return;
playlistInfo.loading = finish;
$.ajax({
url: '/api/upge/cheetah-photo-search/query_videos2',
dataType: 'json',
data: {
query: playlistInfo.query,
orderby: playlistInfo.orderby,
start: start,
count: finish-start
},
success: function(response){
var pl = vp.getPlaylist().slice(0);
pl.push.apply(pl, response);
vp.setPlaylist(pl);
callback();
}
});
}
if(parts.length == 1 && matchDash(parts[0])){
var pl = vp.getActualPlaylist();
var vids = parseDash(parts[0]);
parts = [];
for(var i = 0; i < vids.length; i++){
playQueue.push({
'video': pl[vids[i]-1],
'start': 0,
'stop': null
})
}
if(vids.length){
if(vids[vids.length-1]-1>=pl.length){
loadMoreVideos(playerId, vp, pl.length, vids[vids.length-1], function(){
if(fsonload){
activateTabArea(tab, parts[0]+'/fs');
}else{
activateTabArea(tab, parts[0]);
}
var pls = vp.getPlaylist();
vp.playFromPlaylist(pls[pls.length-1]);
vp.playVideo();
scrollToPlaylistPosition(vp);
});
return true;
}
}
if(playQueue){
playQueueUpdate();
vp.playVideo();
parsed = true;
playShouldStart = 0;
}
}
if(previewMode){
var vids = [];
var dur = 0;
var pl = vp.getActualPlaylist();
area = parts[0];
if(parts.length == 1 && matchPosition(parts[0])){
vids = parseDash('1-'+pl.length);
dur = parsePosition(parts[0]);
parts = [];
}else
if(parts.length == 1 && matchDash(parts[0])){
vids = parseDash(parts[0]);
dur = parsePosition("999:59");
parts = [];
}
if(parts.length == 2 && matchDash(parts[0]) && matchPosition(parts[1])){
vids = parseDash(parts[0]);
dur = parsePosition(parts[1]);
parts = [];
}
for(var i = 0; i < vids.length; i++){
playQueue.push({
'video': pl[vids[i]-1],
'start': 0,
'stop': dur
})
}
if(playQueue){
playQueueUpdate();
vp.playVideo();
parsed = true;
}
}
if(parts.length>1){
for(var i = 0; i < parts.length; i++){
var sel = findMatchingVideo(vp, parts[i]);
if(sel){
playQueue.push({
'video': sel,
'start': 0,
'stop': null
})
}
}
if(playQueue){
playQueueUpdate();
vp.playVideo();
parsed = true;
}
}else if(area){
var sel = findMatchingVideo(vp, area);
if(sel){
vp.playFromPlaylist(sel);
playShouldStart = 0;
parsed = true;
}
}
if(fsonload || replayMode){
playShouldStart = 0;
}
if(document.location.search.match('at=|queue=')){
var opts = document.location.search.replace(/^\?/,'').split(/&/g);
for(var o in opts){
if(opts[o].match(/^at=(\d+:)?(\d+:)?\d+$/)){
playShouldStart = parsePosition(opts[o].substr(3))
}
if(opts[o].match(/^queue=/)){
playQueue = parseList(opts[o].substr(6));
if(playQueue){
playQueuePosition = 0;
playQueueUpdate();
}
}
}
}
if(matchPosition(parts[1])){
playShouldStart = parsePosition(parts[1]);
parsed = true;
}
if(matchAction(parts[1])){
var action = parseAction(vp, area+'/'+parts[1]);
playShouldStart = action.start;
playShouldStop = action.stop;
parsed = true;
}
if(playShouldStart !== null && !playQueue.length){
playQueue.push({
video: vp.getCurrentVideo(),
start: playShouldStart,
stop: playShouldStop
});
}
if(playShouldStart != null){
setInterval(function(){
if(playShouldStop && vp.currentPlayer && vp.currentPlayer.getCurrentTime() > playShouldStop){
playShouldStop = null;
if(vp.getCurrentVideo() == playQueue[playQueuePosition].video){
playQueueAdvancePosition();
}else{
playShouldStart = null;
}
}
}, 500);
vp.playerContainer.bind('videoplayer.player.statechange', function(e, state){
if(state == 'ended'){ // advance to the next video
playQueueAdvancePosition();
}
});
vp.playerContainer.bind('videoplayer.player.readychange', function(e, state){
if(state){
updateVolumeState();
if(playShouldStart !== null){
vp.seekTo(playShouldStart);
playShouldStart = null;
}else{
playShouldStop = null; // someone started other video, stop playing from playQueue
}
}
if(fsonload) {
triggerFullscreen(playerId); fsonload = false;
}
});
}
}
else if(tab.match(/^wiki\d+$/)){
if(firstTimeActivate){
load_wiki($('#'+tab), function(){
if(area){
var areaNode = $('#'+area);
if(areaNode.length>0){
$('html, body').scrollTop(areaNode.offset().top + 10);
return true;
}
}
});
}
}
return parsed;
})
window.activateTab = ensure(function(tab, area){
window.activeArea = null;
if(tab == 'import_videos'){
if(area){
import_videos(area);
}else{
start_import();
}
return true;
}
if(tab == 'chat'){
update_chat_position($('.chat').eq(0));
window.activeArea = 'chat';
jQuery('.tabtrigger').offscreentabs('activateTab', 'chat');
return true;
}
if(tab in rev_names){
tab = rev_names[tab];
}
if(tab.match(':')){ return false; }
var sup = $('ul li a[id=#'+tab+']');
if(sup && sup.length>0){
window.activeArea = area;
sup.first().click();
if(!window.activateTabArea(tab, area)){
window.activeArea = null;
}
window.activeArea = null;
return true;
}else{
var have_tabs = $('#playlist_menu li').length;
if(tab.match(/^playlists?\d+$/)){
var to_add = +tab.substring(8).replace(/^s/,'')-have_tabs;
if(to_add>0 && have_tabs){
add_more_videos(to_add);
return true;
}
}
}
return false;
});
window.currentPath = ensure(function(){
return window.lastHistory.replace(basepath, '').split('?')[0];
});
window.main_tab = window.main_tab || 'videos';
window.addHistory = ensure(function(path){
if(window.console && console.log) console.log("Adding to history: "+path);
if(window.history && history.replaceState && document.location.hostname.match(/^(youtube\.)?(\w{2,3}\.)?wn\.com$/)){
if(path == main_tab || path == main_tab+'/' || path == '' || path == '/') {
path = basepath;
} else if( path.match('^'+main_tab+'/') ){
path = basepath + '/' + path.replace(main_tab+'/', '').replace('--','/');
} else {
path = basepath + '/' + path.replace('--','/');
}
if(document.location.search){
path += document.location.search;
}
if(window.lastHistory) {
history.pushState(null, null, path);
}
else if(window.lastHistory != path){
history.replaceState(null, null, path);
window.lastHistory = path;
}
}
else{
path = path.replace('--','/');
if(path == main_tab || path == main_tab+'/' || path == '' || path == '/') {
path = '';
}
if(window.lastHistory != '/'+path){
window.location.hash = path? '/'+path : '';
window.lastHistory = '/'+path;
}
}
});
$('.tabtrigger li a').live('click', ensure(function() {
var tab = $(this).attr('id');
if(tab.substring(0,1) == '#'){
var name = tab.substring(1);
if(name in menu_names){
name = menu_names[name][0];
}
realTab = rev_names[name];
$('#'+realTab).show();
if(window.console && console.log) console.log("Triggering tab: "+name+(window.activeArea?" activeArea="+window.activeArea:''));
var path = name;
if(window.activeArea){
path = path + '/' + window.activeArea;
}
if(tab.match(/#playlist\d+/) || tab.match(/#details\d+/)){
$('.multiple-playlists').show();
$('.related_playlist').show();
$('.longest_videos_playlist').show();
}else {
$('.multiple-playlists').hide();
$('.related_playlist').hide();
$('.longest_videos_playlist').hide();
}
// start the related script only when the tab is on screen showing
if (tab.match(/related_sites/)) {
if (mc) {
mc.startCredits();
}
}
window.activeTab = realTab;
addHistory(path);
setTimeout(ensure(function(){
if(tab.match(/language--/)){
$('.tabtrigger').offscreentabs('activateTab', 'language');
}
if(tab.match(/weather/)) {
$('.tabtrigger').offscreentabs('activateTab', 'weather');
loadContinent();
}
updateMenus(tab);
updateHeight();
}), 10);
}
return false;
}));
});
-->
');
} else {
var query = elem.find('.keywords').html();
$.ajax({
context: elem,
url: 'https://wn.com/api/upge/cheetah-search-adv/video',
cache: true,
data: {
'query': query
},
dataType: 'jsonp',
success: function(text) {
if (text.length > 0) {
video_id = text[0].id;
elem.find('.player').html('
VIDEO
');
}
}
});
}
}
var stopAllYouTubeVideos = function() {
var iframes = document.querySelectorAll('iframe');
Array.prototype.forEach.call(iframes, function(iframe) {
iframe.contentWindow.postMessage(JSON.stringify({ event: 'command', func: 'pauseVideo' }), '*');
});
}
jQuery(function() {
jQuery(".playVideo").live("click", function() {
if(!$(this).hasClass("played")){
stopAllYouTubeVideos();
var elem = $(this);
setTimeout(function(){
mouseOverMe(elem);
}, 1000);
}
});
jQuery(".description_box .expandContent").live("click", function() {
elem = $(this).parent().parent().parent().find('.descContent');
if(elem.height() > 51) {
elem.css('height', '44px');
$(this).html('Show More
');
}else{
elem.css('height', 'auto');
$(this).html('Hide
');
}
});
jQuery('.interview-play-off').click(function() {
$(".interview-play-off").hide();
$(".interview-play").show();
$(".videoplayer-control-pause").click();
});
jQuery(".video-desc .show_author_videos").live("click", function() {
query = $(this).attr('title');
container = $(this).parent().parent().parent().find('.video-author-thumbs');
$(this).parent().parent().parent().find('.video-author-thumbs').css('height', '220px');
jQuery.ajax({
url: '/api/upge/cheetah-photo-search/videoresults',
data: {'query': query},
success: function(text) {
if(!text) { text = i18n("No results"); }
container.html(jQuery(text));
}
});
});
});
// -->
Work Things Out
by:
Cubic U
CHORUS 1
Latest News for: gpc3
Edit
The Eagle-Tribune
08 Nov 2024
New findings showcase the potential of in vivo CAR-M technology as an effective, off-the-shelf treatment for hepatocellular carcinoma (HCC ) ... .
Edit
Victoria Advocate
08 Nov 2024
- MT-303 programs immune cells directly in patients; the first time an in vivo CAR has been evaluated clinically in HCC - ... .
Edit
PR Newswire
08 Nov 2024
MT-303 is a first-in-class Glypican-3 (GPC3 ) targeting CAR encoded from  ;mRNA and encapsulated in lipid nanoparticles ... GPC3 expression has been linked to aggressive tumor behavior and poor prognosis.
Edit
Victoria Advocate
05 Nov 2024
Pre-clinical data demonstrate robust anti-tumor activity and a novel off-the-shelf approach for GPC3 + solid tumors ... .
Edit
PR Newswire
05 Nov 2024
Pre-clinical data demonstrate robust anti-tumor activity and a novel off-the-shelf approach for GPC3 + solid tumors ... The data show that this in vivo CAR-M therapy has significant potential as a treatment for GPC3+ solid tumors, including HCC .
Edit
Nasdaq Globe Newswire
31 Oct 2024
Abstracts demonstrate reversal of resistance to PD1 checkpoint blockade and predictive AI model of HCC survival rate. Abstracts demonstrate reversal of resistance to PD1 checkpoint blockade and predictive AI model of HCC survival rate ... .
Edit
The Facts
31 Jul 2024
- MT-303 is Myeloid's second clinical in vivo mRNA CAR program; it incorporates proprietary next-generation mRNA innovations - ... .
Edit
PR Newswire
31 Jul 2024
Matthew Maurer, Chief Medical Officer of Myeloid, commented, "We are thrilled to have swiftly advanced MT-303 into the clinic as the first in vivo CAR therapy applicable to the majority of liver cancers, and other cancers expressing GPC3 .
Edit
MENA FN
04 Jun 2024
(MENAFN - PR Newswire ). CAR031 study at 9.03-mo median follow up achieves disease control rate (DCR ) of 91.3% and objective response rate (ORR ) of 56.5% for patients across all dose levels (DLs) ... .
Edit
PR Newswire
04 Jun 2024
C-CAR031 is based on a novel GPC3 -targeting CAR-T designed by AstraZeneca (LSE /STO /Nasdaq ... C-CAR031 is an autologous, armored GPC3-targeting chimeric antigen receptor T-Cell (CAR-T) therapy, being studied for the treatment of HCC .
Edit
PR Newswire
15 Jan 2024
We initially identified GPC3 as a viable target for CAR T-cell therapy and subsequently progressed it to clinical trials for the treatment of HCC ... CT011 is an autologous GPC3 CAR T-cell product ...
Edit
Pharmiweb
15 Dec 2023
The Structure of GPC3 . GPC3, or Glypican-3, is an oncofetal glycoprotein tethered to the cell membrane via a glycophosphatidylinositol (GPI) anchor [1-2] ... However, in most adult organs, GPC3 is scarcely detectable ... Function of GPC3 ... GPC3 Protein.
Edit
Victoria Advocate
07 Dec 2023
C-CAR031 is based on a novel GPC3 -targeting CAR-T (AZD5851) designed by AstraZeneca using their transforming growth factor-beta receptor II (TGFβRII) dominant negative armoring discovery platform, and is manufactured by AbelZeta in China .
Loading...');
var query = jQuery('.radio_query').val();
jQuery.ajax({
data: { query: query },
url: '/api/upge/cheetah-photo-search/radio',
success: function(text) {
jQuery('.radio-search-results').html(jQuery(text));
updateHeight();
$('#RadioSearchTable').tablesorter();
$('#RadioSearchTable').trigger("update");
}
});
return false; // do not submit the form
});
$(".search-tools-btn").click(function () {
header = $(this);
content = $(".search-tools-content");
if(content.is(':visible')) {
content.hide('slow');
header.html('Tools ');
}else{
content.show('slow');
header.html('Hide ');
}
});
});
The Eagle-Tribune
08 Nov 2024
The Eagle-Tribune
08 Nov 2024