Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.
History
In 1970, Martin Rodbell examined the effects of glucagon on a rat's liver cell membrane receptor. He noted that guanosine triphosphate disassociated glucagon from this receptor and stimulated the G-protein, which strongly influenced the cell's metabolism. Thus, he deduced that the G-protein is a transducer that accepts glucagon molecules and affects the cell. For this, he shared the 1994 Nobel Prize in Physiology or Medicine with Alfred G. Gilman.
The earliest MEDLINE entry for "signal transduction" dates from 1972. Some early articles used the terms signal transmission and sensory transduction. In 2007, a total of 48,377 scientific papers—including 11,211 review papers—were published on the subject. The term first appeared in a paper's title in 1979. Widespread use of the term has been traced to a 1980 review article by Rodbell: Research papers focusing on signal transduction first appeared in large numbers in the late 1980s and early 1990s.
Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositide 3-kinases, phosphatidylinositol-3-kinases, PI 3-kinases, PI(3)Ks, PI-3Ks or by the HUGO official stem symbol for the gene family, PI3K(s)) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
The discovery of PI 3-kinases by Lewis Cantley and colleagues began with their identification of a previously unknown phosphoinositide kinase associated with the polyoma middle T protein. They observed unique substrate specificity and chromatographic properties of the products of the lipid kinase, leading to the discovery that this phosphoinositide kinase had the unprecedented ability to phosphorylate phosphoinositides on the 3' position of the inositol ring. Subsequently, Cantley and colleagues demonstrated that in vivo the enzyme prefers PtdIns(4,5)P2 as a substrate, producing the novel phosphoinositide PtdIns(3,4,5)P3.
Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes. Akt1 is also able to induce protein synthesis pathways, and is therefore a key signaling protein in the cellular pathways that lead to skeletal muscle hypertrophy, and general tissue growth. Mouse model with complete deletion of Akt1 manifests growth retardation and increased spontaneous apoptosis in tissues such as testes and thymus. Since it can block apoptosis, and thereby promote cell survival, Akt1 has been implicated as a major factor in many types of cancer. Akt (now also called Akt1) was originally identified as the oncogene in the transforming retrovirus, AKT8.
Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport. In a mouse which is null for Akt1 but normal for Akt2, glucose homeostasis is unperturbed, but the animals are smaller, consistent with a role for Akt1 in growth. In contrast, mice which do not have Akt2, but have normal Akt1, have mild growth deficiency and display a diabetic phenotype (insulin resistance), again consistent with the idea that Akt2 is more specific for the insulin receptor signaling pathway. Akt isoforms are overexpressed in a variety of human tumors, and, at the genomic level, are amplified in gastric adenocarcinomas (Akt1), ovarian (Akt2), pancreatic (Akt2) and breast (Akt2) cancer.
Mount Athos is commonly referred to as the "Holy Mountain" (Greek:Ἅγιον Ὄρος, Agion Oros[ˈaʝ(i)o(n) ˈoros]) and the entity as the "Athonite State" (Greek:Αθωνική Πολιτεία, Athoniki Politia). In the Classical era, while the mountain was called Athos, the peninsula was known as Acté or Akté (Ἀκτὴ).
Mount Athos has been inhabited since the ancient times and is known for its nearly 1,800-year continuous Christian presence and its long historical monastic traditions, which date back to at least 800 A.D. and the Byzantine era. Today, over 2,000 monks from Greece and many other Eastern Orthodox countries, such as Romania, Moldova, Bulgaria, Serbia and Russia, live an ascetic life in Athos, isolated from the rest of the world. The Athonite monasteries feature a rich collection of well-preserved artifacts, rare books, ancient documents, and artworks of immense historical value.
RAC-beta serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT2gene.
Function
This gene is a putative oncogene encoding a protein belonging to the AKT subfamily of serine/threonine kinases that contain SH2-like (Src homology 2-like) domains. The encoded protein is a general protein kinase capable of phosphorylating several known proteins.
Clinical significance
The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers.
Protein Kinase B, otherwise known as AKT, an enzyme that plays a major role in signal transduction
Pacamor Kubar Bearings in Troy, NY domestically manufactures miniature and instrument ball bearings for aerospace, guidance, military, medical, dental, and other high precision applications.
An acid dissociation constant, Ka, (also known as acidity constant, or acid-ionization constant) is a quantitative measure of the strength of an acid in solution. It is the equilibrium constant for a chemical reaction known as dissociation in the context of acid-base reactions. In aqueous solution, the equilibrium of acid dissociation can be written symbolically as:
where HA is a generic acid that dissociates into A−, known as the conjugate base of the acid and a hydrogen ion which combines with a water molecule to make an hydronium ion. In the example shown in the figure, HA represents acetic acid, and A− represents the acetate ion, the conjugate base.
The chemical species HA, A− and H3O+ are said to be in equilibrium when their concentrations do not change with the passing of time. The dissociation constant is usually written as a quotient of the equilibrium concentrations (in mol/L), denoted by [HA], [A−] and [H3O+]
In all but the most concentrated aqueous solutions of an acid the concentration of water can be taken as constant and can be ignored. The definition can then be written more simply
Receptors: Signal Transduction and Phosphorylation Cascade
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it, just like molecular walkie-talkies. Check it out!
Watch the whole Biochemistry playlist: http://bit.ly/ProfDaveBiochem
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biology Tutorials: http://bit.ly/ProfDaveBio
Classical Physics Tutorials: http://bit.ly/ProfDavePhysics1
Modern Physics Tutorials: http://bit.ly/ProfDavePhysics2
Mathematics Tutorials: http://bit.ly/ProfDaveMaths
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/...
published: 06 Sep 2016
Signal Transduction Pathways
038 - Signal Transduction Pathways.mov
Paul Andersen explains how signal transduction pathways are used by cells to convert chemical messages to cellular action. Epinephrine is used as a sample messenger to trigger the release of glucose from cells in the liver. The G-Protein, adenylyl cyclase, cAMP, and protein kinases are all used as illustrative examples of signal transduction. A review of the concepts is also included.
Do you speak another language? Help me translate my videos:
http://www.bozemanscience.com/translations/
Intro Music Atribution
Title: I4dsong_loop_main.wav
Artist: CosmicD
Link to sound: http://www.freesound.org/people/CosmicD/sounds/72556/
Creative Commons Atribution License
All of the images are licensed under creative commons and public domain licensing:
"File...
published: 21 Aug 2011
Cell Signal Transduction — G-Protein, cAMP, JAK-STAT pathway — Endocrinology Series
Cell Signal Transduction | A Preview | Endocrinology Playlist | Medicosis.
🧪Acid-Base Course: https://www.medicosisperfectionalis.com/products/p/acid-base-disturbances-course/
❤️ Cardiac Pharmacology Course: https://www.medicosisperfectionalis.com/
⁉️ Questions and Answers: https://www.medicosisperfectionalis.com/
📝 Notes: https://www.medicosisperfectionalis.com/
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG
💊🦠 Antibiotics Course: https://www.medicosisperfectionalis.com/products/courses/antibiotics/
📊 My favorite Productivity App (Airtable): https://airtable.com/invite/r/2zH40fus/
Anesthesiology Playlist: https://youtube.com/playlist?list=PLYcLrRDaR8_fhRF59m3o4EDwGVDK2UgPh/
🧪Acid-Base Course: https://www.medicosisperfectionalis.com/products/p/acid-base-disturbances-...
published: 04 Nov 2021
Signal Transduction Pathways (G-Protein, Receptor Tyrosine Kinase, cGMP)
SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channel/UCZaDAUF7UEcRXIFvGZu3O9Q/join
My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.
published: 12 May 2021
Common cell signaling pathway
What are common cell signaling pathways? To make a multicellular organism, cells must be able to communicate with one another, and to do it cells often send out tiny chemical signals that act on the receptors on other cells. Signals can be classified according to the distance between the signaling cell and the target cell. Find our full video library only on Osmosis: http://osms.it/more.
Join millions of current and future clinicians who learn by Osmosis, along with hundreds of universities around the world who partner with Osmosis from Elseiver to make medical and health education more engaging and efficient. We have unparalleled tools and materials to prepare you for success in school, on your board exams, and as a future clinician. Sign up for a free trial at http://osms.it/more. If y...
published: 14 Oct 2020
Intro to Cell Signaling
Explore cell signaling with the Amoeba Sisters! This introductory video describes vocabulary such as ligand and receptor. It includes the stages of cell signaling (reception, transduction, and response) and different types of signaling including autocrine, paracrine, and endocrine. This is just an introduction to a series on signaling that we hope to expand on in the future!
Factual References:
OpenStax, Biology. OpenStax CNX. Jun 1, 2018 http://cnx.org/contents/[email protected].
Reece, J. B., & Campbell, N. A. (2011). Campbell biology. Boston: Benjamin Cummings / Pearson.
Further Reading Suggestion:
Want to learn more about autocrine signaling in cancer cells?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1002946/
---------------------------
Biology Video Play...
published: 30 Aug 2018
Signal Transduction AP Biology
4.2 From the AP Biology C.E.D.
published: 17 Aug 2022
Signal Transduction in Immune Cells: Receptor-Ligand Interactions
Now that we know some things about immune cell structure and function, we need to start understanding how these cells interact on the molecular level, and how signals are translated into cellular response. This means looking at receptor-ligand interactions. What is signal transduction?What are kinases? What are GTPases? What are G-proteins? We need to know about these important cellular components if we are going to understand the immune system, so let's take a closer look!
Script by Stephanie Melchor
Select images provided by BioRender.com
Biochemistry tutorial on receptors: https://www.youtube.com/watch?v=VatdTJka3_M
Watch the whole Immunology playlist: http://bit.ly/ProfDaveImmuno
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/P...
published: 10 Jun 2021
Cell Signal Transduction (Biosignaling) - Quick Review - Biochemistry and Physiology
A brief animation explaining signal transduction in cells. Created for AP Biology class, 2010-2011. :)
(Disclaimer: I made this for a project in 11th grade so I apologize for any mistakes/inconsistencies/annoying background music)
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it,...
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it, just like molecular walkie-talkies. Check it out!
Watch the whole Biochemistry playlist: http://bit.ly/ProfDaveBiochem
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biology Tutorials: http://bit.ly/ProfDaveBio
Classical Physics Tutorials: http://bit.ly/ProfDavePhysics1
Modern Physics Tutorials: http://bit.ly/ProfDavePhysics2
Mathematics Tutorials: http://bit.ly/ProfDaveMaths
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it, just like molecular walkie-talkies. Check it out!
Watch the whole Biochemistry playlist: http://bit.ly/ProfDaveBiochem
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biology Tutorials: http://bit.ly/ProfDaveBio
Classical Physics Tutorials: http://bit.ly/ProfDavePhysics1
Modern Physics Tutorials: http://bit.ly/ProfDavePhysics2
Mathematics Tutorials: http://bit.ly/ProfDaveMaths
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
038 - Signal Transduction Pathways.mov
Paul Andersen explains how signal transduction pathways are used by cells to convert chemical messages to cellular actio...
038 - Signal Transduction Pathways.mov
Paul Andersen explains how signal transduction pathways are used by cells to convert chemical messages to cellular action. Epinephrine is used as a sample messenger to trigger the release of glucose from cells in the liver. The G-Protein, adenylyl cyclase, cAMP, and protein kinases are all used as illustrative examples of signal transduction. A review of the concepts is also included.
Do you speak another language? Help me translate my videos:
http://www.bozemanscience.com/translations/
Intro Music Atribution
Title: I4dsong_loop_main.wav
Artist: CosmicD
Link to sound: http://www.freesound.org/people/CosmicD/sounds/72556/
Creative Commons Atribution License
All of the images are licensed under creative commons and public domain licensing:
"File:Dora and Boots.jpg." Wikipedia, the Free Encyclopedia, October 28, 2013. http://en.wikipedia.org/w/index.php?title=File:Dora_and_Boots.jpg&oldid=468219594.
"File:Jimi Hendrix 1967 Uncropped.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:Jimi_Hendrix_1967_uncropped.jpg.
"File:MarshallStack Slayer.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:MarshallStack_Slayer.jpg.
"File:Pickup-SSH.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:Pickup-SSH.jpg.
Juancoronado1974. English: Phospholipid Bilayer, November 23, 2013. Own work. http://commons.wikimedia.org/wiki/File:Bilayer.png.
038 - Signal Transduction Pathways.mov
Paul Andersen explains how signal transduction pathways are used by cells to convert chemical messages to cellular action. Epinephrine is used as a sample messenger to trigger the release of glucose from cells in the liver. The G-Protein, adenylyl cyclase, cAMP, and protein kinases are all used as illustrative examples of signal transduction. A review of the concepts is also included.
Do you speak another language? Help me translate my videos:
http://www.bozemanscience.com/translations/
Intro Music Atribution
Title: I4dsong_loop_main.wav
Artist: CosmicD
Link to sound: http://www.freesound.org/people/CosmicD/sounds/72556/
Creative Commons Atribution License
All of the images are licensed under creative commons and public domain licensing:
"File:Dora and Boots.jpg." Wikipedia, the Free Encyclopedia, October 28, 2013. http://en.wikipedia.org/w/index.php?title=File:Dora_and_Boots.jpg&oldid=468219594.
"File:Jimi Hendrix 1967 Uncropped.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:Jimi_Hendrix_1967_uncropped.jpg.
"File:MarshallStack Slayer.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:MarshallStack_Slayer.jpg.
"File:Pickup-SSH.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:Pickup-SSH.jpg.
Juancoronado1974. English: Phospholipid Bilayer, November 23, 2013. Own work. http://commons.wikimedia.org/wiki/File:Bilayer.png.
Cell Signal Transduction | A Preview | Endocrinology Playlist | Medicosis.
🧪Acid-Base Course: https://www.medicosisperfectionalis.com/products/p/acid-base-dist...
Cell Signal Transduction | A Preview | Endocrinology Playlist | Medicosis.
🧪Acid-Base Course: https://www.medicosisperfectionalis.com/products/p/acid-base-disturbances-course/
❤️ Cardiac Pharmacology Course: https://www.medicosisperfectionalis.com/
⁉️ Questions and Answers: https://www.medicosisperfectionalis.com/
📝 Notes: https://www.medicosisperfectionalis.com/
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG
💊🦠 Antibiotics Course: https://www.medicosisperfectionalis.com/products/courses/antibiotics/
📊 My favorite Productivity App (Airtable): https://airtable.com/invite/r/2zH40fus/
Anesthesiology Playlist: https://youtube.com/playlist?list=PLYcLrRDaR8_fhRF59m3o4EDwGVDK2UgPh/
🧪Acid-Base Course: https://www.medicosisperfectionalis.com/products/p/acid-base-disturbances-course/
🧠Autonomic Pharmacology Course: www.medicosisperfectionalis.com/
🎁Free Stuff: https://www.medicosisperfectionalis.com/
💊 Antibiotics Lectures: https://www.medicosisperfectionalis.com/
📚 Sapira’s Art And Science of Bedside Diagnosis: https://www.amazon.com/shop/medicosisperfectionalis/
🧠 CNS Pharmacology Course: https://www.medicosisperfectionalis.com/
👨🏫 Watch the first lecture of my CNS Pharmacology Course: https://youtu.be/tUShmUX-1IU/
🧪 Electrolytes Videos: https://www.medicosisperfectionalis.com/
💊 Antibiotics Lectures: https://www.medicosisperfectionalis.com/
💊 Pharmacology Lectures: https://www.medicosisperfectionalis.com/
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
► 🧠 Physiology Playlist: https://www.youtube.com/watch?v=6qk_LTVXZ2w&list=PLYcLrRDaR8_eAjmngd289ghWijs2wfqnj&index=2&t=0s
► 🩸 hematology videos: https://www.youtube.com/playlist?list=PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU
► 😍 Support me on Patreon: https://www.patreon.com/medicosis/
► 🥰 Support me on PayPal: https://www.paypal.me/perfectionalis/
► 😚 Join my Channel on YouTube: https://www.youtube.com/channel/UCl-J-ovSJhA3or73Q2uVpow/join
► 👨🏫 All of my premium courses are ON SALE: https://www.medicosisperfectionalis.com/
► ❤️ Cardiac Pharmacology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_e3pM6ifeZDfNPlE3K4KF3J/
📚 Recommended Books: https://www.amazon.com/shop/medicosisperfectionalis/
► ❓If you have any questions, please email me at: [email protected]
► 💪 Rheumatology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_ckdsow-7buX1rIzIEKfxZQ
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG/
🎁 Small gift: here are 2 FREE audiobooks from Audible https://amzn.to/2FQurW0
📖 Try Amazon Kindle unlimited for FREE, they have some good medical books that you can read for FREE. https://amzn.to/2UceoG2
--If you have joined my channel on youtube (the join button that's next to the subscribe button), then go to the "community tab" and you will find some member-only posts.
►Website: www.medicosisperfectionalis.com
►Patreon: https://www.patreon.com/medicosis
►YouTube: https://www.youtube.com/c/MedicosisPerfectionalis or:
► Like my page on Facebook https://www.facebook.com/medicosis/
►Follow us on Instagram here: https://www.instagram.com/medicosisperfectionalis/ or @
►PayPal: https://www.paypal.me/perfectionalis/
►Venmo: @medicosis
►Facebook: https://www.facebook.com/medicosis/
►Twitter: https://www.twitter.com/medicosis
►SoundCloud: https://soundcloud.com/medicosis
►TikTok: www.tiktok.com/@medicosisp/
►LinkedIn: linkedin.com/in/medicosis-perfectionalis-873886197
►Snapchat: https://www.snapchat.com/add/medicosis
►Pinterest: https://www.pinterest.com/medicosisperfectionalis/
►Telegram: https://t.me/medicosisp
►Rumble: https://rumble.com/user/MedicosisPerfectionalis
► Tumblr: https://medicosis.tumblr.com/
Thank you so much for supporting my channel! Love ❤️.
Happy studying!!
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
📱Save on your mobile phone bill: http://fbuy.me/q6bMj
📊 My favorite Productivity Apps: https://airtable.com/invite/r/2zH40fus/ 🏦 Qbank (TrueLearn): https://truelearn.referralrock.com/l/MEDICOSIS/
Cell Signal Transduction | A Preview | Endocrinology Playlist | Medicosis.
🧪Acid-Base Course: https://www.medicosisperfectionalis.com/products/p/acid-base-disturbances-course/
❤️ Cardiac Pharmacology Course: https://www.medicosisperfectionalis.com/
⁉️ Questions and Answers: https://www.medicosisperfectionalis.com/
📝 Notes: https://www.medicosisperfectionalis.com/
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG
💊🦠 Antibiotics Course: https://www.medicosisperfectionalis.com/products/courses/antibiotics/
📊 My favorite Productivity App (Airtable): https://airtable.com/invite/r/2zH40fus/
Anesthesiology Playlist: https://youtube.com/playlist?list=PLYcLrRDaR8_fhRF59m3o4EDwGVDK2UgPh/
🧪Acid-Base Course: https://www.medicosisperfectionalis.com/products/p/acid-base-disturbances-course/
🧠Autonomic Pharmacology Course: www.medicosisperfectionalis.com/
🎁Free Stuff: https://www.medicosisperfectionalis.com/
💊 Antibiotics Lectures: https://www.medicosisperfectionalis.com/
📚 Sapira’s Art And Science of Bedside Diagnosis: https://www.amazon.com/shop/medicosisperfectionalis/
🧠 CNS Pharmacology Course: https://www.medicosisperfectionalis.com/
👨🏫 Watch the first lecture of my CNS Pharmacology Course: https://youtu.be/tUShmUX-1IU/
🧪 Electrolytes Videos: https://www.medicosisperfectionalis.com/
💊 Antibiotics Lectures: https://www.medicosisperfectionalis.com/
💊 Pharmacology Lectures: https://www.medicosisperfectionalis.com/
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
► 🧠 Physiology Playlist: https://www.youtube.com/watch?v=6qk_LTVXZ2w&list=PLYcLrRDaR8_eAjmngd289ghWijs2wfqnj&index=2&t=0s
► 🩸 hematology videos: https://www.youtube.com/playlist?list=PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU
► 😍 Support me on Patreon: https://www.patreon.com/medicosis/
► 🥰 Support me on PayPal: https://www.paypal.me/perfectionalis/
► 😚 Join my Channel on YouTube: https://www.youtube.com/channel/UCl-J-ovSJhA3or73Q2uVpow/join
► 👨🏫 All of my premium courses are ON SALE: https://www.medicosisperfectionalis.com/
► ❤️ Cardiac Pharmacology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_e3pM6ifeZDfNPlE3K4KF3J/
📚 Recommended Books: https://www.amazon.com/shop/medicosisperfectionalis/
► ❓If you have any questions, please email me at: [email protected]
► 💪 Rheumatology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_ckdsow-7buX1rIzIEKfxZQ
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG/
🎁 Small gift: here are 2 FREE audiobooks from Audible https://amzn.to/2FQurW0
📖 Try Amazon Kindle unlimited for FREE, they have some good medical books that you can read for FREE. https://amzn.to/2UceoG2
--If you have joined my channel on youtube (the join button that's next to the subscribe button), then go to the "community tab" and you will find some member-only posts.
►Website: www.medicosisperfectionalis.com
►Patreon: https://www.patreon.com/medicosis
►YouTube: https://www.youtube.com/c/MedicosisPerfectionalis or:
► Like my page on Facebook https://www.facebook.com/medicosis/
►Follow us on Instagram here: https://www.instagram.com/medicosisperfectionalis/ or @
►PayPal: https://www.paypal.me/perfectionalis/
►Venmo: @medicosis
►Facebook: https://www.facebook.com/medicosis/
►Twitter: https://www.twitter.com/medicosis
►SoundCloud: https://soundcloud.com/medicosis
►TikTok: www.tiktok.com/@medicosisp/
►LinkedIn: linkedin.com/in/medicosis-perfectionalis-873886197
►Snapchat: https://www.snapchat.com/add/medicosis
►Pinterest: https://www.pinterest.com/medicosisperfectionalis/
►Telegram: https://t.me/medicosisp
►Rumble: https://rumble.com/user/MedicosisPerfectionalis
► Tumblr: https://medicosis.tumblr.com/
Thank you so much for supporting my channel! Love ❤️.
Happy studying!!
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
📱Save on your mobile phone bill: http://fbuy.me/q6bMj
📊 My favorite Productivity Apps: https://airtable.com/invite/r/2zH40fus/ 🏦 Qbank (TrueLearn): https://truelearn.referralrock.com/l/MEDICOSIS/
SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channel/UCZaDAUF7UEcRXIFvGZu3O9Q/join
My goal is to reduce educational disparities by making education FRE...
SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channel/UCZaDAUF7UEcRXIFvGZu3O9Q/join
My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.
SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channel/UCZaDAUF7UEcRXIFvGZu3O9Q/join
My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.
What are common cell signaling pathways? To make a multicellular organism, cells must be able to communicate with one another, and to do it cells often send out...
Explore cell signaling with the Amoeba Sisters! This introductory video describes vocabulary such as ligand and receptor. It includes the stages of cell signali...
Explore cell signaling with the Amoeba Sisters! This introductory video describes vocabulary such as ligand and receptor. It includes the stages of cell signaling (reception, transduction, and response) and different types of signaling including autocrine, paracrine, and endocrine. This is just an introduction to a series on signaling that we hope to expand on in the future!
Factual References:
OpenStax, Biology. OpenStax CNX. Jun 1, 2018 http://cnx.org/contents/[email protected].
Reece, J. B., & Campbell, N. A. (2011). Campbell biology. Boston: Benjamin Cummings / Pearson.
Further Reading Suggestion:
Want to learn more about autocrine signaling in cancer cells?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1002946/
---------------------------
Biology Video Playlist: https://www.youtube.com/playlist?list=PLwL0Myd7Dk1F0iQPGrjehze3eDpco1eVz
The Amoeba Sisters videos demystify science with humor and relevance. The videos center on Pinky's certification and experience in teaching biology at the high school level. Amoeba Sisters videos only cover concepts that Pinky is certified to teach, and they focus on her specialty: secondary life science. Learn more about our videos here: https://www.amoebasisters.com/our-videos
⭐ Our Linktree: https://linktr.ee/amoebasisters
🗂️ Resources that complement our videos! Visit https://docs.google.com/spreadsheets/d/1b3kmAzFEjWgoMKCrkeNCKFYunWk04IuLY93jI4OY0gY/edit?usp=sharing
❤️ Support Us? https://www.amoebasisters.com/support-us
TIPS FOR VIEWING EDU YOUTUBE VIDEOS:
Want to learn tips for viewing edu YouTube videos including changing the speed, language, viewing the transcript, etc? https://www.amoebasisters.com/pinkys-ed-tech-favorites/10-youtube-tips-from-an-edu-youtuber-duo
MUSIC:
Our intro music designed and performed by Jeremiah Cheshire.
End music in this video is listed free to use/no attribution required from the YouTube audio library https://www.youtube.com/audiolibrary/music?feature=blog
COMMUNITY:
We take pride in our AWESOME community, and we welcome feedback and discussion. However, please remember that this is an education channel. See YouTube's community guidelines and how YouTube handles comments that are reported by the community. We also reserve the right to remove comments.
TRANSLATIONS:
Dutch captions by M. Torn
While we don't allow dubbing of our videos, we do gladly accept subtitle translations from our community. Some translated subtitles on our videos were translated by the community using YouTube's community-contributed subtitle feature. After the feature was discontinued by YouTube, we have another option for submitting translated subtitles here: https://www.amoebasisters.com/pinkys-ed-tech-favorites/community-contributed-subtitles We want to thank our amazing community for the generosity of their time in continuing to create translated subtitles. If you have a concern about community contributed contributions, please contact us.
Explore cell signaling with the Amoeba Sisters! This introductory video describes vocabulary such as ligand and receptor. It includes the stages of cell signaling (reception, transduction, and response) and different types of signaling including autocrine, paracrine, and endocrine. This is just an introduction to a series on signaling that we hope to expand on in the future!
Factual References:
OpenStax, Biology. OpenStax CNX. Jun 1, 2018 http://cnx.org/contents/[email protected].
Reece, J. B., & Campbell, N. A. (2011). Campbell biology. Boston: Benjamin Cummings / Pearson.
Further Reading Suggestion:
Want to learn more about autocrine signaling in cancer cells?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1002946/
---------------------------
Biology Video Playlist: https://www.youtube.com/playlist?list=PLwL0Myd7Dk1F0iQPGrjehze3eDpco1eVz
The Amoeba Sisters videos demystify science with humor and relevance. The videos center on Pinky's certification and experience in teaching biology at the high school level. Amoeba Sisters videos only cover concepts that Pinky is certified to teach, and they focus on her specialty: secondary life science. Learn more about our videos here: https://www.amoebasisters.com/our-videos
⭐ Our Linktree: https://linktr.ee/amoebasisters
🗂️ Resources that complement our videos! Visit https://docs.google.com/spreadsheets/d/1b3kmAzFEjWgoMKCrkeNCKFYunWk04IuLY93jI4OY0gY/edit?usp=sharing
❤️ Support Us? https://www.amoebasisters.com/support-us
TIPS FOR VIEWING EDU YOUTUBE VIDEOS:
Want to learn tips for viewing edu YouTube videos including changing the speed, language, viewing the transcript, etc? https://www.amoebasisters.com/pinkys-ed-tech-favorites/10-youtube-tips-from-an-edu-youtuber-duo
MUSIC:
Our intro music designed and performed by Jeremiah Cheshire.
End music in this video is listed free to use/no attribution required from the YouTube audio library https://www.youtube.com/audiolibrary/music?feature=blog
COMMUNITY:
We take pride in our AWESOME community, and we welcome feedback and discussion. However, please remember that this is an education channel. See YouTube's community guidelines and how YouTube handles comments that are reported by the community. We also reserve the right to remove comments.
TRANSLATIONS:
Dutch captions by M. Torn
While we don't allow dubbing of our videos, we do gladly accept subtitle translations from our community. Some translated subtitles on our videos were translated by the community using YouTube's community-contributed subtitle feature. After the feature was discontinued by YouTube, we have another option for submitting translated subtitles here: https://www.amoebasisters.com/pinkys-ed-tech-favorites/community-contributed-subtitles We want to thank our amazing community for the generosity of their time in continuing to create translated subtitles. If you have a concern about community contributed contributions, please contact us.
Now that we know some things about immune cell structure and function, we need to start understanding how these cells interact on the molecular level, and how s...
Now that we know some things about immune cell structure and function, we need to start understanding how these cells interact on the molecular level, and how signals are translated into cellular response. This means looking at receptor-ligand interactions. What is signal transduction?What are kinases? What are GTPases? What are G-proteins? We need to know about these important cellular components if we are going to understand the immune system, so let's take a closer look!
Script by Stephanie Melchor
Select images provided by BioRender.com
Biochemistry tutorial on receptors: https://www.youtube.com/watch?v=VatdTJka3_M
Watch the whole Immunology playlist: http://bit.ly/ProfDaveImmuno
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem
Biology/Genetics Tutorials: http://bit.ly/ProfDaveBio
Anatomy & Physiology Tutorials: http://bit.ly/ProfDaveAnatPhys
Biopsychology Tutorials: http://bit.ly/ProfDaveBiopsych
Microbiology/Infectious Diseases Tutorials: http://bit.ly/ProfDaveMicrobio
History of Drugs Videos: http://bit.ly/ProfDaveHistoryDrugs
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
Now that we know some things about immune cell structure and function, we need to start understanding how these cells interact on the molecular level, and how signals are translated into cellular response. This means looking at receptor-ligand interactions. What is signal transduction?What are kinases? What are GTPases? What are G-proteins? We need to know about these important cellular components if we are going to understand the immune system, so let's take a closer look!
Script by Stephanie Melchor
Select images provided by BioRender.com
Biochemistry tutorial on receptors: https://www.youtube.com/watch?v=VatdTJka3_M
Watch the whole Immunology playlist: http://bit.ly/ProfDaveImmuno
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem
Biology/Genetics Tutorials: http://bit.ly/ProfDaveBio
Anatomy & Physiology Tutorials: http://bit.ly/ProfDaveAnatPhys
Biopsychology Tutorials: http://bit.ly/ProfDaveBiopsych
Microbiology/Infectious Diseases Tutorials: http://bit.ly/ProfDaveMicrobio
History of Drugs Videos: http://bit.ly/ProfDaveHistoryDrugs
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
Cell Signal Transduction Quick Review (cell signaling).
🍱 Endocrine Pharmacology Course: https://www.medicosisperfectionalis.com/products/
📝 Download my handw...
Cell Signal Transduction Quick Review (cell signaling).
🍱 Endocrine Pharmacology Course: https://www.medicosisperfectionalis.com/products/
📝 Download my handwritten notes: www.medicosisperfectionalis.com/
💦 🐳 Kidney Physiology Course: https://www.medicosisperfectionalis.com/products/
❤️ Cardiac Pharmacology Course: https://www.medicosisperfectionalis.com/
⁉️ Questions and Answers: https://www.medicosisperfectionalis.com/
📝 Notes: https://www.medicosisperfectionalis.com/
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG
💊🦠 Antibiotics Course: https://www.medicosisperfectionalis.com/products/courses/antibiotics/
📊 My favorite Productivity App (Airtable): https://airtable.com/invite/r/2zH40fus/
Anesthesiology Playlist: https://youtube.com/playlist?list=PLYcLrRDaR8_fhRF59m3o4EDwGVDK2UgPh/
🧪Acid-Base Course: https://www.medicosisperfectionalis.com/products/p/acid-base-disturbances-course/
🧠Autonomic Pharmacology Course: www.medicosisperfectionalis.com/
🎁Free Stuff: https://www.medicosisperfectionalis.com/
💊 Antibiotics Lectures: https://www.medicosisperfectionalis.com/
📚 Sapira’s Art And Science of Bedside Diagnosis: https://www.amazon.com/shop/medicosisperfectionalis/
🧠 CNS Pharmacology Course: https://www.medicosisperfectionalis.com/
👨🏫 Watch the first lecture of my CNS Pharmacology Course: https://youtu.be/tUShmUX-1IU/
🧪 Electrolytes Videos: https://www.medicosisperfectionalis.com/
💊 Antibiotics Lectures: https://www.medicosisperfectionalis.com/
💊 Pharmacology Lectures: https://www.medicosisperfectionalis.com/
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
► 🧠 Physiology Playlist: https://www.youtube.com/watch?v=6qk_LTVXZ2w&list=PLYcLrRDaR8_eAjmngd289ghWijs2wfqnj&index=2&t=0s
► 🩸 hematology videos: https://www.youtube.com/playlist?list=PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU
► 🙌 Support me on cash app: https://cash.app/$medicosis/
► 😍 Support me on Patreon: https://www.patreon.com/medicosis/
► 🥰 Support me on PayPal: https://www.paypal.me/perfectionalis/
► ☕️ Buy me a Coffee: https://www.buymeacoffee.com/medicosis/
► 😚 Join my Channel on YouTube: https://www.youtube.com/channel/UCl-J-ovSJhA3or73Q2uVpow/join/
► 👨🏫 All of my premium courses are ON SALE: https://www.medicosisperfectionalis.com/
► ❤️ Cardiac Pharmacology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_e3pM6ifeZDfNPlE3K4KF3J/
📚 Recommended Books: https://www.amazon.com/shop/medicosisperfectionalis/
► ❓If you have any questions, please email me at: [email protected]
► 💪 Rheumatology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_ckdsow-7buX1rIzIEKfxZQ
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG/
🎁 Small gift: here are 2 FREE audiobooks from Audible https://amzn.to/2FQurW0
📖 Try Amazon Kindle unlimited for FREE, they have some good medical books that you can read for FREE. https://amzn.to/2UceoG2
--If you have joined my channel on youtube (the join button that's next to the subscribe button), then go to the "community tab" and you will find some member-only posts.
►Website: www.medicosisperfectionalis.com
►Patreon: https://www.patreon.com/medicosis
►YouTube: https://www.youtube.com/c/MedicosisPerfectionalis or:
► Like my page on Facebook https://www.facebook.com/medicosis/
►Follow us on Instagram here: https://www.instagram.com/medicosisperfectionalis/
►PayPal: https://www.paypal.me/perfectionalis/
►Venmo: @medicosis
►Facebook: https://www.facebook.com/medicosis/
►Twitter: https://www.twitter.com/medicosis
►SoundCloud: https://soundcloud.com/medicosis
►TikTok: www.tiktok.com/@medicosisp/
►LinkedIn: linkedin.com/in/medicosis-perfectionalis-873886197
►Snapchat: https://www.snapchat.com/add/medicosis
►Pinterest: https://www.pinterest.com/medicosisperfectionalis/
►Telegram: https://t.me/medicosisp
►Rumble: https://rumble.com/user/MedicosisPerfectionalis
► Tumblr: https://medicosis.tumblr.com/
Thank you so much for supporting my channel! Love ❤️.
Happy studying!!
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
📱Save on your mobile phone bill: http://fbuy.me/q6bMj
📊 My favorite Productivity Apps: https://airtable.com/invite/r/2zH40fus/ 🏦 Qbank (TrueLearn): https://truelearn.referralrock.com/l/MEDICOSIS/
Cell Signal Transduction Quick Review (cell signaling).
🍱 Endocrine Pharmacology Course: https://www.medicosisperfectionalis.com/products/
📝 Download my handwritten notes: www.medicosisperfectionalis.com/
💦 🐳 Kidney Physiology Course: https://www.medicosisperfectionalis.com/products/
❤️ Cardiac Pharmacology Course: https://www.medicosisperfectionalis.com/
⁉️ Questions and Answers: https://www.medicosisperfectionalis.com/
📝 Notes: https://www.medicosisperfectionalis.com/
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG
💊🦠 Antibiotics Course: https://www.medicosisperfectionalis.com/products/courses/antibiotics/
📊 My favorite Productivity App (Airtable): https://airtable.com/invite/r/2zH40fus/
Anesthesiology Playlist: https://youtube.com/playlist?list=PLYcLrRDaR8_fhRF59m3o4EDwGVDK2UgPh/
🧪Acid-Base Course: https://www.medicosisperfectionalis.com/products/p/acid-base-disturbances-course/
🧠Autonomic Pharmacology Course: www.medicosisperfectionalis.com/
🎁Free Stuff: https://www.medicosisperfectionalis.com/
💊 Antibiotics Lectures: https://www.medicosisperfectionalis.com/
📚 Sapira’s Art And Science of Bedside Diagnosis: https://www.amazon.com/shop/medicosisperfectionalis/
🧠 CNS Pharmacology Course: https://www.medicosisperfectionalis.com/
👨🏫 Watch the first lecture of my CNS Pharmacology Course: https://youtu.be/tUShmUX-1IU/
🧪 Electrolytes Videos: https://www.medicosisperfectionalis.com/
💊 Antibiotics Lectures: https://www.medicosisperfectionalis.com/
💊 Pharmacology Lectures: https://www.medicosisperfectionalis.com/
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
► 🧠 Physiology Playlist: https://www.youtube.com/watch?v=6qk_LTVXZ2w&list=PLYcLrRDaR8_eAjmngd289ghWijs2wfqnj&index=2&t=0s
► 🩸 hematology videos: https://www.youtube.com/playlist?list=PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU
► 🙌 Support me on cash app: https://cash.app/$medicosis/
► 😍 Support me on Patreon: https://www.patreon.com/medicosis/
► 🥰 Support me on PayPal: https://www.paypal.me/perfectionalis/
► ☕️ Buy me a Coffee: https://www.buymeacoffee.com/medicosis/
► 😚 Join my Channel on YouTube: https://www.youtube.com/channel/UCl-J-ovSJhA3or73Q2uVpow/join/
► 👨🏫 All of my premium courses are ON SALE: https://www.medicosisperfectionalis.com/
► ❤️ Cardiac Pharmacology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_e3pM6ifeZDfNPlE3K4KF3J/
📚 Recommended Books: https://www.amazon.com/shop/medicosisperfectionalis/
► ❓If you have any questions, please email me at: [email protected]
► 💪 Rheumatology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_ckdsow-7buX1rIzIEKfxZQ
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG/
🎁 Small gift: here are 2 FREE audiobooks from Audible https://amzn.to/2FQurW0
📖 Try Amazon Kindle unlimited for FREE, they have some good medical books that you can read for FREE. https://amzn.to/2UceoG2
--If you have joined my channel on youtube (the join button that's next to the subscribe button), then go to the "community tab" and you will find some member-only posts.
►Website: www.medicosisperfectionalis.com
►Patreon: https://www.patreon.com/medicosis
►YouTube: https://www.youtube.com/c/MedicosisPerfectionalis or:
► Like my page on Facebook https://www.facebook.com/medicosis/
►Follow us on Instagram here: https://www.instagram.com/medicosisperfectionalis/
►PayPal: https://www.paypal.me/perfectionalis/
►Venmo: @medicosis
►Facebook: https://www.facebook.com/medicosis/
►Twitter: https://www.twitter.com/medicosis
►SoundCloud: https://soundcloud.com/medicosis
►TikTok: www.tiktok.com/@medicosisp/
►LinkedIn: linkedin.com/in/medicosis-perfectionalis-873886197
►Snapchat: https://www.snapchat.com/add/medicosis
►Pinterest: https://www.pinterest.com/medicosisperfectionalis/
►Telegram: https://t.me/medicosisp
►Rumble: https://rumble.com/user/MedicosisPerfectionalis
► Tumblr: https://medicosis.tumblr.com/
Thank you so much for supporting my channel! Love ❤️.
Happy studying!!
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
📱Save on your mobile phone bill: http://fbuy.me/q6bMj
📊 My favorite Productivity Apps: https://airtable.com/invite/r/2zH40fus/ 🏦 Qbank (TrueLearn): https://truelearn.referralrock.com/l/MEDICOSIS/
A brief animation explaining signal transduction in cells. Created for AP Biology class, 2010-2011. :)
(Disclaimer: I made this for a project in 11th grade so ...
A brief animation explaining signal transduction in cells. Created for AP Biology class, 2010-2011. :)
(Disclaimer: I made this for a project in 11th grade so I apologize for any mistakes/inconsistencies/annoying background music)
A brief animation explaining signal transduction in cells. Created for AP Biology class, 2010-2011. :)
(Disclaimer: I made this for a project in 11th grade so I apologize for any mistakes/inconsistencies/annoying background music)
This video will be encompass the AKT/PKB Signaling Pathway .
The Akt Pathway, or PI3K-Akt Pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. Key proteins involved are PI3K (phosphatidylinositol 3-kinase) and Akt (Protein Kinase B).
Initial stimulation by one of the growth factors causes activation of a cell surface receptor and phosphorylation of PI3K. Activated PI3K then phosphorylates lipids on the plasma membrane, forming second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP3). Akt, a serine/threonine kinase, is recruited to the membrane by interaction with these phosphoinositide docking sites, so that it can be fully activated.[1] Activated Akt mediates downstream responses, including cell survival, growth, prolif...
published: 10 Jun 2020
Protein Kinases: Cell Signaling and Phosphorylation
Cells receive signals from outside via receptors. When a ligand binds to its receptor, a signal is transmitted as part of the signaling cascade, which may alter the function of the cell. A central element of these signaling cascades are protein kinases.
Subscribe to AMBOSS YouTube for the latest clinical examination videos, medical student interviews, study tips and tricks, and live webinars!
Free 5-Day Trial: https://go.amboss.com/04g
Instagram: https://www.instagram.com/amboss_med/
Facebook: https://www.facebook.com/AMBOSS.Med/
Twitter: https://twitter.com/ambossmed
#AMBOSSMed
published: 02 Nov 2020
Protein kinase b pathway | PI3k akt mtor pathway animation
Protein kinase b pathway PI3k akt mtor pathway animation - This lecture explains about the Protein kinase b pathway PI3k akt mtor pathway. Learn more about the protein kinaee b pathway also known as the protein kinase b signaling pathway including the role of protein kinase b pathway like Pi3k akt mtor pathway.
Stay tuned to know answers to the following questions -
What is protein kinase b?
Best hat is protein kinase b signaling?
How protein kinase b signaling works?
What are the steps of protein kinase b signaling pathway?
Steps of Pi3k akt mtor pathway?
Join, Shomu's Biology csir net life science online coaching -
http://www.shomusbiology.com/net-coaching
Get Shomu's Biology CSIR NET life science study materials here-
http://www.shomusbiology.com/dvd-store/
Download the study m...
published: 30 Aug 2022
Pronounce Medical Words ― Protein Kinase B
This video shows you how to say Protein Kinase B.
How would you pronounce Protein Kinase B?
published: 07 May 2014
Signal Transduction Pathway (Protein Kinase B Pathway/PKB/P13K Pathway) @BioSeekho
SIT Vodcast: "Clinically Relevant Protein Kinase B" with Sebastian Oeck
An interesting discussion with Sebastian Oeck from the Institute of Cell Biology in Germany. His aim is to aid cancer patients using the Protein Kinase B (PKB) mutation.
published: 14 Jul 2017
PI-3-Kinase Pathway of PKB/Akt (Protein kinase B) activation
Molecular Switching | Protein kinase | Protein phosphatase | GTP binding protein
This video from B for Biology includes molecular switching by protein kinase, protein phosphatase and GTP binding proteins.
published: 13 Mar 2018
Gene Music using Protein Sequence of AURKB "AURORA KINASE B"
Shop AURKB - https://www.redbubble.com/people/genemusic/works/46517752-aurkb?asc=u
Subscribe - https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences)
Gene Music using Protein Sequence of AURKB 'AURORA KINASE B'
This video will be encompass the AKT/PKB Signaling Pathway .
The Akt Pathway, or PI3K-Akt Pathway is a signal transduction pathway that promotes survival and gr...
This video will be encompass the AKT/PKB Signaling Pathway .
The Akt Pathway, or PI3K-Akt Pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. Key proteins involved are PI3K (phosphatidylinositol 3-kinase) and Akt (Protein Kinase B).
Initial stimulation by one of the growth factors causes activation of a cell surface receptor and phosphorylation of PI3K. Activated PI3K then phosphorylates lipids on the plasma membrane, forming second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP3). Akt, a serine/threonine kinase, is recruited to the membrane by interaction with these phosphoinositide docking sites, so that it can be fully activated.[1] Activated Akt mediates downstream responses, including cell survival, growth, proliferation, cell migration and angiogenesis, by phosphorylating a range of intracellular proteins. The pathway is present in all cells of higher eukaryotes and is highly conserved.
There are multiple types of phosphoinositide 3-kinase but only class I are responsible for lipid phosphorylation in response to growth stimuli.
Akt resides in the cytosol in an inactive conformation, until the cell is stimulated and it translocates to the plasma membrane. The Akt PH domain has a high affinity for second messenger PI(3,4,5)P3, binding to it preferentially over other phosphoinositides.[11] Thus PI3K activity is essential for translocation of Akt to the membrane. Interaction with PI(3,4,5)P3 causes conformational changes and exposure of phosphorylation sites Thr308 in the kinase domain and Ser473 in the C-terminal domain. Akt is partially activated by phosphorylation of T308 by PDK1. Full activation requires phosphorylation of S473, which can be catalysed by multiple proteins, including phosphoinositide-dependent kinase 2 (PDK2), integrin-linked kinase (ILK)
This video will be encompass the AKT/PKB Signaling Pathway .
The Akt Pathway, or PI3K-Akt Pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. Key proteins involved are PI3K (phosphatidylinositol 3-kinase) and Akt (Protein Kinase B).
Initial stimulation by one of the growth factors causes activation of a cell surface receptor and phosphorylation of PI3K. Activated PI3K then phosphorylates lipids on the plasma membrane, forming second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP3). Akt, a serine/threonine kinase, is recruited to the membrane by interaction with these phosphoinositide docking sites, so that it can be fully activated.[1] Activated Akt mediates downstream responses, including cell survival, growth, proliferation, cell migration and angiogenesis, by phosphorylating a range of intracellular proteins. The pathway is present in all cells of higher eukaryotes and is highly conserved.
There are multiple types of phosphoinositide 3-kinase but only class I are responsible for lipid phosphorylation in response to growth stimuli.
Akt resides in the cytosol in an inactive conformation, until the cell is stimulated and it translocates to the plasma membrane. The Akt PH domain has a high affinity for second messenger PI(3,4,5)P3, binding to it preferentially over other phosphoinositides.[11] Thus PI3K activity is essential for translocation of Akt to the membrane. Interaction with PI(3,4,5)P3 causes conformational changes and exposure of phosphorylation sites Thr308 in the kinase domain and Ser473 in the C-terminal domain. Akt is partially activated by phosphorylation of T308 by PDK1. Full activation requires phosphorylation of S473, which can be catalysed by multiple proteins, including phosphoinositide-dependent kinase 2 (PDK2), integrin-linked kinase (ILK)
Cells receive signals from outside via receptors. When a ligand binds to its receptor, a signal is transmitted as part of the signaling cascade, which may alter...
Cells receive signals from outside via receptors. When a ligand binds to its receptor, a signal is transmitted as part of the signaling cascade, which may alter the function of the cell. A central element of these signaling cascades are protein kinases.
Subscribe to AMBOSS YouTube for the latest clinical examination videos, medical student interviews, study tips and tricks, and live webinars!
Free 5-Day Trial: https://go.amboss.com/04g
Instagram: https://www.instagram.com/amboss_med/
Facebook: https://www.facebook.com/AMBOSS.Med/
Twitter: https://twitter.com/ambossmed
#AMBOSSMed
Cells receive signals from outside via receptors. When a ligand binds to its receptor, a signal is transmitted as part of the signaling cascade, which may alter the function of the cell. A central element of these signaling cascades are protein kinases.
Subscribe to AMBOSS YouTube for the latest clinical examination videos, medical student interviews, study tips and tricks, and live webinars!
Free 5-Day Trial: https://go.amboss.com/04g
Instagram: https://www.instagram.com/amboss_med/
Facebook: https://www.facebook.com/AMBOSS.Med/
Twitter: https://twitter.com/ambossmed
#AMBOSSMed
Protein kinase b pathway PI3k akt mtor pathway animation - This lecture explains about the Protein kinase b pathway PI3k akt mtor pathway. Learn more about the ...
Protein kinase b pathway PI3k akt mtor pathway animation - This lecture explains about the Protein kinase b pathway PI3k akt mtor pathway. Learn more about the protein kinaee b pathway also known as the protein kinase b signaling pathway including the role of protein kinase b pathway like Pi3k akt mtor pathway.
Stay tuned to know answers to the following questions -
What is protein kinase b?
Best hat is protein kinase b signaling?
How protein kinase b signaling works?
What are the steps of protein kinase b signaling pathway?
Steps of Pi3k akt mtor pathway?
Join, Shomu's Biology csir net life science online coaching -
http://www.shomusbiology.com/net-coaching
Get Shomu's Biology CSIR NET life science study materials here-
http://www.shomusbiology.com/dvd-store/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
Our Website – www.shomusbiology.com
Facebook page- https://www.facebook.com/ShomusBiology/
Twitter - https://twitter.com/shomusbiology
SlideShare- www.slideshare.net/shomusbiology
Google plus- https://plus.google.com/113648584982732129198
LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661
Youtube- https://www.youtube.com/user/TheFunsuman
Thank you for watching the cell signaling lecture on Protein kinase b pathway PI3k akt mtor pathway.
Protein kinase b pathway PI3k akt mtor pathway animation - This lecture explains about the Protein kinase b pathway PI3k akt mtor pathway. Learn more about the protein kinaee b pathway also known as the protein kinase b signaling pathway including the role of protein kinase b pathway like Pi3k akt mtor pathway.
Stay tuned to know answers to the following questions -
What is protein kinase b?
Best hat is protein kinase b signaling?
How protein kinase b signaling works?
What are the steps of protein kinase b signaling pathway?
Steps of Pi3k akt mtor pathway?
Join, Shomu's Biology csir net life science online coaching -
http://www.shomusbiology.com/net-coaching
Get Shomu's Biology CSIR NET life science study materials here-
http://www.shomusbiology.com/dvd-store/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
Our Website – www.shomusbiology.com
Facebook page- https://www.facebook.com/ShomusBiology/
Twitter - https://twitter.com/shomusbiology
SlideShare- www.slideshare.net/shomusbiology
Google plus- https://plus.google.com/113648584982732129198
LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661
Youtube- https://www.youtube.com/user/TheFunsuman
Thank you for watching the cell signaling lecture on Protein kinase b pathway PI3k akt mtor pathway.
An interesting discussion with Sebastian Oeck from the Institute of Cell Biology in Germany. His aim is to aid cancer patients using the Protein Kinase B (PKB)...
An interesting discussion with Sebastian Oeck from the Institute of Cell Biology in Germany. His aim is to aid cancer patients using the Protein Kinase B (PKB) mutation.
An interesting discussion with Sebastian Oeck from the Institute of Cell Biology in Germany. His aim is to aid cancer patients using the Protein Kinase B (PKB) mutation.
Shop AURKB - https://www.redbubble.com/people/genemusic/works/46517752-aurkb?asc=u
Subscribe - https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences)
Gene Music using Protein Sequence of AURKB 'AURORA KINASE B'
Shop AURKB - https://www.redbubble.com/people/genemusic/works/46517752-aurkb?asc=u
Subscribe - https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences)
Gene Music using Protein Sequence of AURKB 'AURORA KINASE B'
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it, just like molecular walkie-talkies. Check it out!
Watch the whole Biochemistry playlist: http://bit.ly/ProfDaveBiochem
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biology Tutorials: http://bit.ly/ProfDaveBio
Classical Physics Tutorials: http://bit.ly/ProfDavePhysics1
Modern Physics Tutorials: http://bit.ly/ProfDavePhysics2
Mathematics Tutorials: http://bit.ly/ProfDaveMaths
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
038 - Signal Transduction Pathways.mov
Paul Andersen explains how signal transduction pathways are used by cells to convert chemical messages to cellular action. Epinephrine is used as a sample messenger to trigger the release of glucose from cells in the liver. The G-Protein, adenylyl cyclase, cAMP, and protein kinases are all used as illustrative examples of signal transduction. A review of the concepts is also included.
Do you speak another language? Help me translate my videos:
http://www.bozemanscience.com/translations/
Intro Music Atribution
Title: I4dsong_loop_main.wav
Artist: CosmicD
Link to sound: http://www.freesound.org/people/CosmicD/sounds/72556/
Creative Commons Atribution License
All of the images are licensed under creative commons and public domain licensing:
"File:Dora and Boots.jpg." Wikipedia, the Free Encyclopedia, October 28, 2013. http://en.wikipedia.org/w/index.php?title=File:Dora_and_Boots.jpg&oldid=468219594.
"File:Jimi Hendrix 1967 Uncropped.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:Jimi_Hendrix_1967_uncropped.jpg.
"File:MarshallStack Slayer.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:MarshallStack_Slayer.jpg.
"File:Pickup-SSH.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:Pickup-SSH.jpg.
Juancoronado1974. English: Phospholipid Bilayer, November 23, 2013. Own work. http://commons.wikimedia.org/wiki/File:Bilayer.png.
Cell Signal Transduction | A Preview | Endocrinology Playlist | Medicosis.
🧪Acid-Base Course: https://www.medicosisperfectionalis.com/products/p/acid-base-disturbances-course/
❤️ Cardiac Pharmacology Course: https://www.medicosisperfectionalis.com/
⁉️ Questions and Answers: https://www.medicosisperfectionalis.com/
📝 Notes: https://www.medicosisperfectionalis.com/
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG
💊🦠 Antibiotics Course: https://www.medicosisperfectionalis.com/products/courses/antibiotics/
📊 My favorite Productivity App (Airtable): https://airtable.com/invite/r/2zH40fus/
Anesthesiology Playlist: https://youtube.com/playlist?list=PLYcLrRDaR8_fhRF59m3o4EDwGVDK2UgPh/
🧪Acid-Base Course: https://www.medicosisperfectionalis.com/products/p/acid-base-disturbances-course/
🧠Autonomic Pharmacology Course: www.medicosisperfectionalis.com/
🎁Free Stuff: https://www.medicosisperfectionalis.com/
💊 Antibiotics Lectures: https://www.medicosisperfectionalis.com/
📚 Sapira’s Art And Science of Bedside Diagnosis: https://www.amazon.com/shop/medicosisperfectionalis/
🧠 CNS Pharmacology Course: https://www.medicosisperfectionalis.com/
👨🏫 Watch the first lecture of my CNS Pharmacology Course: https://youtu.be/tUShmUX-1IU/
🧪 Electrolytes Videos: https://www.medicosisperfectionalis.com/
💊 Antibiotics Lectures: https://www.medicosisperfectionalis.com/
💊 Pharmacology Lectures: https://www.medicosisperfectionalis.com/
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
► 🧠 Physiology Playlist: https://www.youtube.com/watch?v=6qk_LTVXZ2w&list=PLYcLrRDaR8_eAjmngd289ghWijs2wfqnj&index=2&t=0s
► 🩸 hematology videos: https://www.youtube.com/playlist?list=PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU
► 😍 Support me on Patreon: https://www.patreon.com/medicosis/
► 🥰 Support me on PayPal: https://www.paypal.me/perfectionalis/
► 😚 Join my Channel on YouTube: https://www.youtube.com/channel/UCl-J-ovSJhA3or73Q2uVpow/join
► 👨🏫 All of my premium courses are ON SALE: https://www.medicosisperfectionalis.com/
► ❤️ Cardiac Pharmacology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_e3pM6ifeZDfNPlE3K4KF3J/
📚 Recommended Books: https://www.amazon.com/shop/medicosisperfectionalis/
► ❓If you have any questions, please email me at: [email protected]
► 💪 Rheumatology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_ckdsow-7buX1rIzIEKfxZQ
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG/
🎁 Small gift: here are 2 FREE audiobooks from Audible https://amzn.to/2FQurW0
📖 Try Amazon Kindle unlimited for FREE, they have some good medical books that you can read for FREE. https://amzn.to/2UceoG2
--If you have joined my channel on youtube (the join button that's next to the subscribe button), then go to the "community tab" and you will find some member-only posts.
►Website: www.medicosisperfectionalis.com
►Patreon: https://www.patreon.com/medicosis
►YouTube: https://www.youtube.com/c/MedicosisPerfectionalis or:
► Like my page on Facebook https://www.facebook.com/medicosis/
►Follow us on Instagram here: https://www.instagram.com/medicosisperfectionalis/ or @
►PayPal: https://www.paypal.me/perfectionalis/
►Venmo: @medicosis
►Facebook: https://www.facebook.com/medicosis/
►Twitter: https://www.twitter.com/medicosis
►SoundCloud: https://soundcloud.com/medicosis
►TikTok: www.tiktok.com/@medicosisp/
►LinkedIn: linkedin.com/in/medicosis-perfectionalis-873886197
►Snapchat: https://www.snapchat.com/add/medicosis
►Pinterest: https://www.pinterest.com/medicosisperfectionalis/
►Telegram: https://t.me/medicosisp
►Rumble: https://rumble.com/user/MedicosisPerfectionalis
► Tumblr: https://medicosis.tumblr.com/
Thank you so much for supporting my channel! Love ❤️.
Happy studying!!
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
📱Save on your mobile phone bill: http://fbuy.me/q6bMj
📊 My favorite Productivity Apps: https://airtable.com/invite/r/2zH40fus/ 🏦 Qbank (TrueLearn): https://truelearn.referralrock.com/l/MEDICOSIS/
SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channel/UCZaDAUF7UEcRXIFvGZu3O9Q/join
My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.
Explore cell signaling with the Amoeba Sisters! This introductory video describes vocabulary such as ligand and receptor. It includes the stages of cell signaling (reception, transduction, and response) and different types of signaling including autocrine, paracrine, and endocrine. This is just an introduction to a series on signaling that we hope to expand on in the future!
Factual References:
OpenStax, Biology. OpenStax CNX. Jun 1, 2018 http://cnx.org/contents/[email protected].
Reece, J. B., & Campbell, N. A. (2011). Campbell biology. Boston: Benjamin Cummings / Pearson.
Further Reading Suggestion:
Want to learn more about autocrine signaling in cancer cells?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1002946/
---------------------------
Biology Video Playlist: https://www.youtube.com/playlist?list=PLwL0Myd7Dk1F0iQPGrjehze3eDpco1eVz
The Amoeba Sisters videos demystify science with humor and relevance. The videos center on Pinky's certification and experience in teaching biology at the high school level. Amoeba Sisters videos only cover concepts that Pinky is certified to teach, and they focus on her specialty: secondary life science. Learn more about our videos here: https://www.amoebasisters.com/our-videos
⭐ Our Linktree: https://linktr.ee/amoebasisters
🗂️ Resources that complement our videos! Visit https://docs.google.com/spreadsheets/d/1b3kmAzFEjWgoMKCrkeNCKFYunWk04IuLY93jI4OY0gY/edit?usp=sharing
❤️ Support Us? https://www.amoebasisters.com/support-us
TIPS FOR VIEWING EDU YOUTUBE VIDEOS:
Want to learn tips for viewing edu YouTube videos including changing the speed, language, viewing the transcript, etc? https://www.amoebasisters.com/pinkys-ed-tech-favorites/10-youtube-tips-from-an-edu-youtuber-duo
MUSIC:
Our intro music designed and performed by Jeremiah Cheshire.
End music in this video is listed free to use/no attribution required from the YouTube audio library https://www.youtube.com/audiolibrary/music?feature=blog
COMMUNITY:
We take pride in our AWESOME community, and we welcome feedback and discussion. However, please remember that this is an education channel. See YouTube's community guidelines and how YouTube handles comments that are reported by the community. We also reserve the right to remove comments.
TRANSLATIONS:
Dutch captions by M. Torn
While we don't allow dubbing of our videos, we do gladly accept subtitle translations from our community. Some translated subtitles on our videos were translated by the community using YouTube's community-contributed subtitle feature. After the feature was discontinued by YouTube, we have another option for submitting translated subtitles here: https://www.amoebasisters.com/pinkys-ed-tech-favorites/community-contributed-subtitles We want to thank our amazing community for the generosity of their time in continuing to create translated subtitles. If you have a concern about community contributed contributions, please contact us.
Now that we know some things about immune cell structure and function, we need to start understanding how these cells interact on the molecular level, and how signals are translated into cellular response. This means looking at receptor-ligand interactions. What is signal transduction?What are kinases? What are GTPases? What are G-proteins? We need to know about these important cellular components if we are going to understand the immune system, so let's take a closer look!
Script by Stephanie Melchor
Select images provided by BioRender.com
Biochemistry tutorial on receptors: https://www.youtube.com/watch?v=VatdTJka3_M
Watch the whole Immunology playlist: http://bit.ly/ProfDaveImmuno
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem
Biology/Genetics Tutorials: http://bit.ly/ProfDaveBio
Anatomy & Physiology Tutorials: http://bit.ly/ProfDaveAnatPhys
Biopsychology Tutorials: http://bit.ly/ProfDaveBiopsych
Microbiology/Infectious Diseases Tutorials: http://bit.ly/ProfDaveMicrobio
History of Drugs Videos: http://bit.ly/ProfDaveHistoryDrugs
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
Cell Signal Transduction Quick Review (cell signaling).
🍱 Endocrine Pharmacology Course: https://www.medicosisperfectionalis.com/products/
📝 Download my handwritten notes: www.medicosisperfectionalis.com/
💦 🐳 Kidney Physiology Course: https://www.medicosisperfectionalis.com/products/
❤️ Cardiac Pharmacology Course: https://www.medicosisperfectionalis.com/
⁉️ Questions and Answers: https://www.medicosisperfectionalis.com/
📝 Notes: https://www.medicosisperfectionalis.com/
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG
💊🦠 Antibiotics Course: https://www.medicosisperfectionalis.com/products/courses/antibiotics/
📊 My favorite Productivity App (Airtable): https://airtable.com/invite/r/2zH40fus/
Anesthesiology Playlist: https://youtube.com/playlist?list=PLYcLrRDaR8_fhRF59m3o4EDwGVDK2UgPh/
🧪Acid-Base Course: https://www.medicosisperfectionalis.com/products/p/acid-base-disturbances-course/
🧠Autonomic Pharmacology Course: www.medicosisperfectionalis.com/
🎁Free Stuff: https://www.medicosisperfectionalis.com/
💊 Antibiotics Lectures: https://www.medicosisperfectionalis.com/
📚 Sapira’s Art And Science of Bedside Diagnosis: https://www.amazon.com/shop/medicosisperfectionalis/
🧠 CNS Pharmacology Course: https://www.medicosisperfectionalis.com/
👨🏫 Watch the first lecture of my CNS Pharmacology Course: https://youtu.be/tUShmUX-1IU/
🧪 Electrolytes Videos: https://www.medicosisperfectionalis.com/
💊 Antibiotics Lectures: https://www.medicosisperfectionalis.com/
💊 Pharmacology Lectures: https://www.medicosisperfectionalis.com/
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
► 🧠 Physiology Playlist: https://www.youtube.com/watch?v=6qk_LTVXZ2w&list=PLYcLrRDaR8_eAjmngd289ghWijs2wfqnj&index=2&t=0s
► 🩸 hematology videos: https://www.youtube.com/playlist?list=PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU
► 🙌 Support me on cash app: https://cash.app/$medicosis/
► 😍 Support me on Patreon: https://www.patreon.com/medicosis/
► 🥰 Support me on PayPal: https://www.paypal.me/perfectionalis/
► ☕️ Buy me a Coffee: https://www.buymeacoffee.com/medicosis/
► 😚 Join my Channel on YouTube: https://www.youtube.com/channel/UCl-J-ovSJhA3or73Q2uVpow/join/
► 👨🏫 All of my premium courses are ON SALE: https://www.medicosisperfectionalis.com/
► ❤️ Cardiac Pharmacology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_e3pM6ifeZDfNPlE3K4KF3J/
📚 Recommended Books: https://www.amazon.com/shop/medicosisperfectionalis/
► ❓If you have any questions, please email me at: [email protected]
► 💪 Rheumatology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_ckdsow-7buX1rIzIEKfxZQ
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG/
🎁 Small gift: here are 2 FREE audiobooks from Audible https://amzn.to/2FQurW0
📖 Try Amazon Kindle unlimited for FREE, they have some good medical books that you can read for FREE. https://amzn.to/2UceoG2
--If you have joined my channel on youtube (the join button that's next to the subscribe button), then go to the "community tab" and you will find some member-only posts.
►Website: www.medicosisperfectionalis.com
►Patreon: https://www.patreon.com/medicosis
►YouTube: https://www.youtube.com/c/MedicosisPerfectionalis or:
► Like my page on Facebook https://www.facebook.com/medicosis/
►Follow us on Instagram here: https://www.instagram.com/medicosisperfectionalis/
►PayPal: https://www.paypal.me/perfectionalis/
►Venmo: @medicosis
►Facebook: https://www.facebook.com/medicosis/
►Twitter: https://www.twitter.com/medicosis
►SoundCloud: https://soundcloud.com/medicosis
►TikTok: www.tiktok.com/@medicosisp/
►LinkedIn: linkedin.com/in/medicosis-perfectionalis-873886197
►Snapchat: https://www.snapchat.com/add/medicosis
►Pinterest: https://www.pinterest.com/medicosisperfectionalis/
►Telegram: https://t.me/medicosisp
►Rumble: https://rumble.com/user/MedicosisPerfectionalis
► Tumblr: https://medicosis.tumblr.com/
Thank you so much for supporting my channel! Love ❤️.
Happy studying!!
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
📱Save on your mobile phone bill: http://fbuy.me/q6bMj
📊 My favorite Productivity Apps: https://airtable.com/invite/r/2zH40fus/ 🏦 Qbank (TrueLearn): https://truelearn.referralrock.com/l/MEDICOSIS/
A brief animation explaining signal transduction in cells. Created for AP Biology class, 2010-2011. :)
(Disclaimer: I made this for a project in 11th grade so I apologize for any mistakes/inconsistencies/annoying background music)
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.
History
In 1970, Martin Rodbell examined the effects of glucagon on a rat's liver cell membrane receptor. He noted that guanosine triphosphate disassociated glucagon from this receptor and stimulated the G-protein, which strongly influenced the cell's metabolism. Thus, he deduced that the G-protein is a transducer that accepts glucagon molecules and affects the cell. For this, he shared the 1994 Nobel Prize in Physiology or Medicine with Alfred G. Gilman.
The earliest MEDLINE entry for "signal transduction" dates from 1972. Some early articles used the terms signal transmission and sensory transduction. In 2007, a total of 48,377 scientific papers—including 11,211 review papers—were published on the subject. The term first appeared in a paper's title in 1979. Widespread use of the term has been traced to a 1980 review article by Rodbell: Research papers focusing on signal transduction first appeared in large numbers in the late 1980s and early 1990s.
This video will be encompass the AKT/PKB Signaling Pathway .
The Akt Pathway, or PI3K-Akt Pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. Key proteins involved are PI3K (phosphatidylinositol 3-kinase) and Akt (Protein Kinase B).
Initial stimulation by one of the growth factors causes activation of a cell surface receptor and phosphorylation of PI3K. Activated PI3K then phosphorylates lipids on the plasma membrane, forming second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP3). Akt, a serine/threonine kinase, is recruited to the membrane by interaction with these phosphoinositide docking sites, so that it can be fully activated.[1] Activated Akt mediates downstream responses, including cell survival, growth, proliferation, cell migration and angiogenesis, by phosphorylating a range of intracellular proteins. The pathway is present in all cells of higher eukaryotes and is highly conserved.
There are multiple types of phosphoinositide 3-kinase but only class I are responsible for lipid phosphorylation in response to growth stimuli.
Akt resides in the cytosol in an inactive conformation, until the cell is stimulated and it translocates to the plasma membrane. The Akt PH domain has a high affinity for second messenger PI(3,4,5)P3, binding to it preferentially over other phosphoinositides.[11] Thus PI3K activity is essential for translocation of Akt to the membrane. Interaction with PI(3,4,5)P3 causes conformational changes and exposure of phosphorylation sites Thr308 in the kinase domain and Ser473 in the C-terminal domain. Akt is partially activated by phosphorylation of T308 by PDK1. Full activation requires phosphorylation of S473, which can be catalysed by multiple proteins, including phosphoinositide-dependent kinase 2 (PDK2), integrin-linked kinase (ILK)
Cells receive signals from outside via receptors. When a ligand binds to its receptor, a signal is transmitted as part of the signaling cascade, which may alter the function of the cell. A central element of these signaling cascades are protein kinases.
Subscribe to AMBOSS YouTube for the latest clinical examination videos, medical student interviews, study tips and tricks, and live webinars!
Free 5-Day Trial: https://go.amboss.com/04g
Instagram: https://www.instagram.com/amboss_med/
Facebook: https://www.facebook.com/AMBOSS.Med/
Twitter: https://twitter.com/ambossmed
#AMBOSSMed
Protein kinase b pathway PI3k akt mtor pathway animation - This lecture explains about the Protein kinase b pathway PI3k akt mtor pathway. Learn more about the protein kinaee b pathway also known as the protein kinase b signaling pathway including the role of protein kinase b pathway like Pi3k akt mtor pathway.
Stay tuned to know answers to the following questions -
What is protein kinase b?
Best hat is protein kinase b signaling?
How protein kinase b signaling works?
What are the steps of protein kinase b signaling pathway?
Steps of Pi3k akt mtor pathway?
Join, Shomu's Biology csir net life science online coaching -
http://www.shomusbiology.com/net-coaching
Get Shomu's Biology CSIR NET life science study materials here-
http://www.shomusbiology.com/dvd-store/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
Our Website – www.shomusbiology.com
Facebook page- https://www.facebook.com/ShomusBiology/
Twitter - https://twitter.com/shomusbiology
SlideShare- www.slideshare.net/shomusbiology
Google plus- https://plus.google.com/113648584982732129198
LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661
Youtube- https://www.youtube.com/user/TheFunsuman
Thank you for watching the cell signaling lecture on Protein kinase b pathway PI3k akt mtor pathway.
An interesting discussion with Sebastian Oeck from the Institute of Cell Biology in Germany. His aim is to aid cancer patients using the Protein Kinase B (PKB) mutation.
Shop AURKB - https://www.redbubble.com/people/genemusic/works/46517752-aurkb?asc=u
Subscribe - https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences)
Gene Music using Protein Sequence of AURKB 'AURORA KINASE B'