Long-chain fatty acid transport protein 1

SLC27A1
Identifiers
Aliases	SLC27A1, ACSVL5, FATP, FATP1, FATP-1, solute carrier family 27 member 1
External IDs	OMIM: 600691; MGI: 1347098; HomoloGene: 8063; GeneCards: SLC27A1; OMA:SLC27A1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	17,506,168 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,587,302 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; pancreatic ductal cell; ; right hemisphere of cerebellum; ; muscle of thigh; ; left ovary; ; sural nerve; ; right ovary; ; C1 segment; ; right adrenal cortex; ; myocardium of left ventricle;
	Top expressed in
	neural layer of retina; ; muscle of thigh; ; superior frontal gyrus; ; choroid plexus of fourth ventricle; ; lip; ; white adipose tissue; ; primary visual cortex; ; ventricular zone; ; subcutaneous adipose tissue; ; phalanx of third toe;
	More reference expression data
	n/a
Gene ontology
Molecular function	long-chain fatty acid-CoA ligase activity; nucleotide binding; protein homodimerization activity; ligase activity; catalytic activity; very long-chain fatty acid-CoA ligase activity; fatty acid transmembrane transporter activity; long-chain fatty acid transporter activity; protein binding;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; endoplasmic reticulum; endomembrane system; mitochondrion; mitochondrial inner membrane; cytosol; integral component of plasma membrane;
Biological process	phosphatidic acid biosynthetic process; phosphatidylserine biosynthetic process; lipid transport; lipid metabolism; medium-chain fatty acid transport; phosphatidylglycerol biosynthetic process; fatty acid transport; phosphatidylethanolamine biosynthetic process; adiponectin-activated signaling pathway; fatty acid metabolic process; positive regulation of protein serine/threonine kinase activity; response to insulin; negative regulation of phospholipid biosynthetic process; positive regulation of heat generation; cardiolipin biosynthetic process; phosphatidylinositol biosynthetic process; response to cold; phosphatidylcholine biosynthetic process; metabolism; long-chain fatty acid metabolic process; long-chain fatty acid transport; regulation of lipid metabolic process; transport; positive regulation of triglyceride biosynthetic process; long-chain fatty acid import into cell;
	Sources:Amigo / QuickGO
Orthologs
	376497
	26457
	ENSG00000130304
	ENSMUSG00000031808
	Q6PCB7
	Q60714
	NM_198580
	NM_011977; NM_001357180; NM_001357181; NM_001357182
	NP_940982
	NP_036107; NP_001344109; NP_001344110; NP_001344111
	Wikidata
View/Edit Human	View/Edit Mouse

Long-chain fatty acid transport protein 1 (FATP1) is a protein that in humans is encoded by the SLC27A1 gene.^[5]^[6]

Structure

The SLC27A1 gene is located on the 19th chromosome, with its specific location being 19p13.11. The gene contains 15 exons.^[6] SLC27A1 encodes a 71.1 kDa protein that is composed of 646 amino acids; 26 peptides have been observed through mass spectrometry data.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130304 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031808 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Martin G, Nemoto M, Gelman L, Geffroy S, Najib J, Fruchart JC, Roevens P, de Martinville B, Deeb S, Auwerx J (June 2000). "The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression". Genomics. 66 (3): 296–304. doi:10.1006/geno.2000.6191. PMID 10873384.
^ ^a ^b "Entrez Gene: SLC27A1 solute carrier family 27 (fatty acid transporter), member 1".
^ ]Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (October 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
^ "Long-chain fatty acid transport protein 1". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).

Meirhaeghe A, Cottel D, Amouyel P, Dallongeville J (2006). "Lack of association between certain candidate gene polymorphisms and the metabolic syndrome". Molecular Genetics and Metabolism. 86 (1–2): 293–9. doi:10.1016/j.ymgme.2005.05.006. PMID 15978856.
García-Martínez C, Marotta M, Moore-Carrasco R, Guitart M, Camps M, Busquets S, Montell E, Gómez-Foix AM (June 2005). "Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells". American Journal of Physiology. Cell Physiology. 288 (6): C1264-72. doi:10.1152/ajpcell.00271.2004. PMID 15897321.
Gertow K, Skoglund-Andersson C, Eriksson P, Boquist S, Orth-Gomér K, Schenck-Gustafsson K, Hamsten A, Fisher RM (April 2003). "A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution". Atherosclerosis. 167 (2): 265–73. doi:10.1016/S0021-9150(02)00454-9. PMID 12818409.
Hatch GM, Smith AJ, Xu FY, Hall AM, Bernlohr DA (September 2002). "FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells". Journal of Lipid Research. 43 (9): 1380–9. doi:10.1194/jlr.M200130-JLR200. PMID 12235169.
Hirsch D, Stahl A, Lodish HF (July 1998). "A family of fatty acid transporters conserved from mycobacterium to man". Proceedings of the National Academy of Sciences of the United States of America. 95 (15): 8625–9. Bibcode:1998PNAS...95.8625H. doi:10.1073/pnas.95.15.8625. PMC 21126. PMID 9671728.
Schaffer JE, Lodish HF (November 1994). "Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein". Cell. 79 (3): 427–36. doi:10.1016/0092-8674(94)90252-6. PMID 7954810. S2CID 20637905.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130304 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031808 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10873384-5] Martin G, Nemoto M, Gelman L, Geffroy S, Najib J, Fruchart JC, Roevens P, de Martinville B, Deeb S, Auwerx J (June 2000). "The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression". Genomics. 66 (3): 296–304. doi:10.1006/geno.2000.6191. PMID 10873384.

[entrez-6] "Entrez Gene: SLC27A1 solute carrier family 27 (fatty acid transporter), member 1".

[COPaKB-7] ]Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (October 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.

[url_COPaKB-8] "Long-chain fatty acid transport protein 1". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).

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Long-chain fatty acid transport protein 1

Structure

See also

References

Further reading