Sodium/hydrogen exchanger 8

SLC9A8
Identifiers
Aliases	SLC9A8, NHE-8, NHE8, solute carrier family 9 member A8
External IDs	OMIM: 612730; MGI: 1924281; HomoloGene: 75041; GeneCards: SLC9A8; OMA:SLC9A8 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	49,892,242 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	167,477,000 bp
RNA expression pattern
	Top expressed in
	blood; ; granulocyte; ; gastrocnemius muscle; ; nasal epithelium; ; gonad; ; spleen; ; muscle of thigh; ; right lobe of liver; ; gastric mucosa; ; bone marrow cells;
	Top expressed in
	right kidney; ; Rostral migratory stream; ; Ileal epithelium; ; proximal tubule; ; muscle of thigh; ; genital tubercle; ; tail of embryo; ; yolk sac; ; spermatocyte; ; human kidney;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	solute:proton antiporter activity; antiporter activity; sodium:proton antiporter activity; potassium:proton antiporter activity;
Cellular component	integral component of membrane; Golgi membrane; membrane; plasma membrane; Golgi apparatus;
Biological process	proton transmembrane transport; potassium ion transport; cation transport; ion transport; sodium ion transmembrane transport; regulation of pH; sodium ion transport; regulation of intracellular pH; sodium ion import across plasma membrane; potassium ion transmembrane transport; transmembrane transport; anion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	23315
	77031
	ENSG00000197818
	ENSMUSG00000039463
	Q9Y2E8
	Q8R4D1
	NM_001260491; NM_015266
	NM_148929; NM_178371; NM_001304540; NM_001304542
	NP_001247420; NP_056081
	NP_001291469; NP_001291471; NP_683731
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium/hydrogen exchanger 8 is a protein that in humans is encoded by the SLC9A8 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197818 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039463 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Goyal S; Vanden Heuvel G; Aronson PS (Jan 2003). "Renal expression of novel Na+/H+ exchanger isoform NHE8". Am J Physiol Renal Physiol. 284 (3): F467–73. doi:10.1152/ajprenal.00352.2002. PMID 12409279.
^ "Entrez Gene: SLC9A8 solute carrier family 9 (sodium/hydrogen exchanger), member 8".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Orlowski J; Grinstein S (2004). "Diversity of the mammalian sodium/proton exchanger SLC9 gene family". Pflügers Arch. 447 (5): 549–65. doi:10.1007/s00424-003-1110-3. PMID 12845533. S2CID 5691463.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Nakamura N, Tanaka S, Teko Y, et al. (2005). "Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation". J. Biol. Chem. 280 (2): 1561–72. doi:10.1074/jbc.M410041200. PMID 15522866.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Xu H; Li J; Chen H; Wang C; Ghishan FK (2013). "NHE8 plays important roles in gastric mucosal protection". Am J Physiol Gastrointest Liver Physiol. 304 (3): G257-61. doi:10.1152/ajpgi.00433.2012. PMC 3566513. PMID 23220221.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197818 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039463 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12409279-5] Goyal S; Vanden Heuvel G; Aronson PS (Jan 2003). "Renal expression of novel Na+/H+ exchanger isoform NHE8". Am J Physiol Renal Physiol. 284 (3): F467–73. doi:10.1152/ajprenal.00352.2002. PMID 12409279.

[entrez-6] "Entrez Gene: SLC9A8 solute carrier family 9 (sodium/hydrogen exchanger), member 8".

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Sodium/hydrogen exchanger 8

See also

References

Further reading