Zinc transporter ZIP1

SLC39A1
Identifiers
Aliases	SLC39A1, ZIP1, ZIRTL, solute carrier family 39 member 1
External IDs	OMIM: 604740; MGI: 1353474; HomoloGene: 40906; GeneCards: SLC39A1; OMA:SLC39A1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,968,184 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,160,919 bp
RNA expression pattern
	Top expressed in
	placenta; ; Achilles tendon; ; upper lobe of left lung; ; right lung; ; stromal cell of endometrium; ; gallbladder; ; right adrenal gland; ; left adrenal gland; ; Descending thoracic aorta; ; ascending aorta;
	Top expressed in
	prostate; ; umbilical cord; ; epidermis; ; lip; ; uterus; ; placenta; ; urinary bladder; ; gallbladder; ; duodenum; ; stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion transmembrane transporter activity; inorganic cation transmembrane transporter activity; zinc ion transmembrane transporter activity; signaling receptor binding;
Cellular component	integral component of membrane; plasma membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum;
Biological process	embryonic cranial skeleton morphogenesis; metal ion transport; zinc ion transmembrane transport; cation transport; zinc ion transport; in utero embryonic development; ion transport; limb development; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	27173
	30791
	ENSG00000143570
	ENSMUSG00000052310
	Q9NY26
	Q9QZ03
NM_014437; NM_001271957; NM_001271958; NM_001271959; NM_001271960;
	NM_001271961
	NM_013901
NP_001258886; NP_001258887; NP_001258888; NP_001258889; NP_001258890;
	NP_055252
	NP_038929
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.^[5]^[6]^[7]

The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143570 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052310 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.
^ Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.
^ "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".
^ Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Gaither LA, Eide DJ (2001). "The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells". J. Biol. Chem. 276 (25): 22258–64. doi:10.1074/jbc.M101772200. PMID 11301334.
Milon B, Dhermy D, Pountney D, et al. (2001). "Differential subcellular localization of hZip1 in adherent and non-adherent cells". FEBS Lett. 507 (3): 241–6. doi:10.1016/S0014-5793(01)02950-7. PMID 11696349. S2CID 19962909.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Franklin RB, Ma J, Zou J, et al. (2003). "Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells". J. Inorg. Biochem. 96 (2–3): 435–42. doi:10.1016/S0162-0134(03)00249-6. PMC 4465841. PMID 12888280.
Dufner-Beattie J, Langmade SJ, Wang F, et al. (2004). "Structure, function, and regulation of a subfamily of mouse zinc transporter genes". J. Biol. Chem. 278 (50): 50142–50. doi:10.1074/jbc.M304163200. PMID 14525987.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Franklin RB, Feng P, Milon B, et al. (2006). "hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer". Mol. Cancer. 4: 32. doi:10.1186/1476-4598-4-32. PMC 1243239. PMID 16153295.
Tang Z, Sahu SN, Khadeer MA, et al. (2006). "Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells". Bone. 38 (2): 181–98. doi:10.1016/j.bone.2005.08.010. PMID 16203195.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Huang L, Kirschke CP (2007). "A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein". FEBS J. 274 (15): 3986–97. doi:10.1111/j.1742-4658.2007.05933.x. PMID 17635580. S2CID 21792127.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143570 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052310 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10610721-5] Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.

[pmid10681536-6] Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.

[entrez-7] "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".

[pmid16700911-8] Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.

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[8]

Zinc transporter ZIP1

See also

References

Further reading