CCL13
| Hemokin (C-C motiv) ligand 13 | |
|---|---|
| Identifikatori | |
| Simbol | CCL13 |
| Alt. simboli | SCYA13, MCP-4, NCC-1, SCYL1, CKb10 |
| Entrez | 6357 |
| HUGO | 10611 |
| OMIM | 601391 |
| RefSeq | NM_005408 |
| UniProt | Q99616 |
| Drugi podaci | |
| Lokus | Hromozom 17 q11.2 |
CCL13, hemokin (C-C motiv) ligand 13, je mali citokin iz CC hemokin familije. Njegov gen se nalazi na ljudskom hromozomu 17 unutar velikog klastera CC hemokina.[1][2] CCL13 indukuje hemotaksu monocita, eozinofila, T limfocita, i bazofila putem vezivanja za G-protein spregnute hemokin receptore kao što su CCR2, CCR3 i CCR5.[3] Aktivnost ovog hemokina je bila implicirana u alergijske reakcije kao što je astma.[4] CCL13 može biti indukovan inflamatornim citokinima interleukin 1 i TNF-α.[5]
- ↑ Garcia-Zepeda EA, et al. (1996). „Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and no allergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3”. J Immunol 157: 5613–5626.
- ↑ Naruse et al. (1996). „A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2”. Genomics 34 (2): 236-40.
- ↑ Blanpain et al. (1999). „CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist”. Blood 94: 1899-905.
- ↑ Lamkhioued et al. (2000). „Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines”. Am J Respir Crit Care Med 162: 723-32.
- ↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.