Izvorni kod stranice CCL13

__NOTC__
{{Infobox protein-lat
| Name = Hemokin (C-C motiv) ligand 13
| caption = 
| image = 
| width = 
| HGNCid = 10611
| Symbol = CCL13
| AltSymbols = SCYA13, MCP-4, NCC-1, SCYL1, CKb10
| EntrezGene = 6357
| OMIM = 601391
| RefSeq = NM_005408
| UniProt = Q99616
| PDB = 
| ECnumber = 
| Chromosome = 17
| Arm = q
| Band = 11.2
| LocusSupplementaryData = 
}}

'''CCL13''', ''[[hemokin]] (C-C motiv) [[ligand (biohemija)|ligand]] 13'', je mali [[citokin]] iz CC [[hemokin]] familije. Njegov [[gen]] se nalazi na ljudskom [[hromozom 17 (čovek)|hromozomu 17]] unutar velikog klastera CC hemokina.<ref>{{cite journal |author=Garcia-Zepeda EA, et al. |title=Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and no allergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3 |journal=J Immunol |year=1996 |volume=157 |pages=5613–5626}}</ref><ref>{{cite journal |author=Naruse et al. |title=A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2 |journal=Genomics |year=1996 |volume=34 |issue=2 |pages=236-40}}</ref> CCL13 indukuje hemotaksu [[monocit]]a, [[eozinofil]]a, [[T limfocit]]a, i [[bazofil]]a putem vezivanja za [[G protein spregnuti receptori|G-protein spregnute]] [[hemokin receptor]]e kao što su [[CC hemokin receptori#CCR2|CCR2]], [[CC hemokin receptori#CCR3|CCR3]] i [[CC hemokin receptori#CCR5|CCR5]].<ref>{{cite journal |author=Blanpain et al. |title=CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist |journal=Blood |year=1999 |volume=94 |pages=1899-905}}</ref> Aktivnost ovog hemokina je bila implicirana u [[alergija|alergijske]] reakcije kao što je [[astma]].<ref>{{cite journal |author=Lamkhioued et al. |title=Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines |journal=Am J Respir Crit Care Med |year=2000 |volume=162 |pages=723-32}}</ref> CCL13 može biti indukovan inflamatornim citokinima [[interleukin 1]] i [[TNF-α]].<ref>{{MireSluisCytokines}}</ref>

== Reference ==
{{reflist|2}}

== Spoljašnje veze ==
* [http://www.genecards.org/cgi-bin/carddisp.pl?gene=CCL13#disorders CCL13 GeneCard]
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[[Kategorija:Citokini]]