I've been having trouble with setting up SLIME to work with both Clojure and Common Lisp. Most Clojure devs tend to use the stripped down SLIME available via ELPA that is frozen for Clojure compatibility. I, however, do a lot of Common Lisp hacking as well and I generally use the SLIME CVS version (obtained via QuickLisp). There are some well known problems with the swank implementation for Clojur
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