Interferon regulatory factor 1 (Q21173368)

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mammalian protein found in Homo sapiens

interferon regulatory factor 1 isoform delta4
interferon regulatory factor 1 isoform d9,10+
interferon regulatory factor 1 isoform delta7
interferon regulatory factor 1 isoform +I9
interferon regulatory factor 1 isoform d78
IRF1
interferon regulatory factor 1

Language	Label	Description	Also known as
English	Interferon regulatory factor 1	mammalian protein found in Homo sapiens	interferon regulatory factor 1 isoform delta4 interferon regulatory factor 1 isoform d9,10+ interferon regulatory factor 1 isoform delta7 interferon regulatory factor 1 isoform +I9 interferon regulatory factor 1 isoform d78 IRF1 interferon regulatory factor 1

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

winged helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10914

Winged helix-like DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10914

Interferon regulatory factor 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10914

interferon regulatory factors

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method or standard

3 references

sequence-specific DNA binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method or standard

2 references

27 March 2018

Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10914&geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method or standard

protein binding

determination method or standard

3 references

8 April 2019

Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method or standard

3 references

7 November 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10914&geneProductId=UniProtKB:P10914

determination method or standard

7 November 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10914&geneProductId=UniProtKB:P10914

determination method or standard

7 November 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10914&geneProductId=UniProtKB:P10914

determination method or standard

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method or standard

4 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

determination method or standard

3 references

7 November 2018

Activities of IRF-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10914&geneProductId=UniProtKB:P10914

determination method or standard

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10914&geneProductId=UniProtKB:P10914

determination method or standard

7 November 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10914&geneProductId=UniProtKB:P10914

determination method or standard

determination method or standard

4 references

8 April 2019

Activities of IRF-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

biological process

CD8-positive, alpha-beta T cell differentiation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

regulation of innate immune response

determination method or standard

1 reference

8 April 2019

Activities of IRF-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

regulation of transcription, DNA-templated

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

cellular response to interferon-beta

determination method or standard

1 reference

8 April 2019

Regulation of XAF1 expression in human colon cancer cell by interferon beta: activation by the transcription regulator STAT1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

interferon-gamma-mediated signaling pathway

determination method or standard

immune system process

determination method or standard

1 reference

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10914&geneProductId=UniProtKB:P10914

determination method or standard

regulation of adaptive immune response

determination method or standard

1 reference

8 April 2019

Activities of IRF-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

blood coagulation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10914&geneProductId=UniProtKB:P10914

determination method or standard

regulation of cell cycle

determination method or standard

1 reference

8 April 2019

IRF-1 as a negative regulator of cell proliferation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

positive regulation of transcription, DNA-templated

determination method or standard

6 references

8 April 2019

Interferon regulatory factor 1 transactivates expression of human DNA polymerase η in response to carcinogen N-methyl-N'-nitro-N-nitrosoguanidine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

Central role of interferon regulatory factor-1 (IRF-1) in controlling retinoic acid inducible gene-I (RIG-I) expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

Interferon Regulatory Factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

cellular response to mechanical stimulus

determination method or standard

1 reference

8 April 2019

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

defense response to virus

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

Human papillomavirus type 16 E5 protein induces expression of beta interferon through interferon regulatory factor 1 in human keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

type I interferon signaling pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

regulation of immune response

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

regulation of gene expression

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

innate immune response

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

negative regulation of transcription, DNA-templated

determination method or standard

3 references

8 April 2019

Interferon Regulatory Factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

RNA interference of interferon regulatory factor-1 gene expression in THP-1 cell line leads to Toll-like receptor-4 overexpression/activation as well as up-modulation of annexin-II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

positive regulation of interferon-beta production

determination method or standard

1 reference

8 April 2019

Human papillomavirus type 16 E5 protein induces expression of beta interferon through interferon regulatory factor 1 in human keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914

determination method or standard

Interferon regulatory factor DNA-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10914

Interferon regulatory factor, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10914

Identifiers

MeSH descriptor ID

subject named as

IRF1 protein, human

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000405655

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000405655

ENSP00000473661

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000473661

ENSP00000384406

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000384406

ENSP00000396318

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000396318

ENSP00000480887

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000480887

ENSP00000245414

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000245414

ENSP00000392455

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000392455

PDB structure ID

1 reference

10 November 2015

http://www.uniprot.org/uniprot/P15314.txt?version=131

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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