Naftilizopropilamin

Naphthylaminopropane
(IUPAC) ime
	(±)-1-(2-naftil)propan-2-amin
Klinički podaci
Identifikatori
CAS broj	18085-03-5
ATC kod	nije dodeljen
PubChem	10219723
ChemSpider	8395215
Hemijski podaci
Formula	C13H15N
Mol. masa	185,27 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C13H15N/c1-10(14)8-11-6-7-12-4-2-3-5-13(12)9-11/h2-7,9-10H,8,14H2,1H3 ; Key: UPQSZFKXKRKCGZ-UHFFFAOYSA-N
Sinonimi	1-(2-naftil)-2-aminopropan; alfa-metilnaptiletilamin
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Nije kontrolisan
Način primene	Oralno

Naftilizopropilamin (PAL-287) je eksperimentalni lek koje se istražuje kao potencijalni tretmant za alkoholnu i stimulansnu adikciju.^[4]

Naftilizopropilamin deluje kao agens otpuštanja serotonina, norepinefrina, i dopamina koji nije neurotoksičan^[5], sa EC₅₀ vrednostima od 3,4 nM, 11,1 nM, i 12,6 nM, respektivno.^[6] On takođe ima visok afinitet za 5-HT_2A, 5-HT_2B, i 5-HT_2C receptore (EC₅₀ vrednosti = 466 nM, 40 nM, i 2.3 nM, respektivno),^[4] i deluje kao pun agonist na 5-HT_2B i kao parcijalni agonist na 5-HT_2C, dok je njegov afinitet za 5-HT_2A verovatno suviše nizak da bi bio značajan.^[4]

U životinjskim studijama, je pokazano da naftilizopropilamin redukuje kokainsku samoadministraciju, mada ima relativno slam stimulatorni efekat kad se samostalno dozira.^[5]^[7]^[8]^[9]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ ^4,0 ^4,1 ^4,2 Rothman, Richard B.; Blough, Bruce E.; Baumann, Michael H. (2007). „Dual dopamine/serotonin releasers as potential medications for stimulante and alcohol addictions”. The AAPS Journal 9 (1): E1–E10. DOI:10.1208/aapsj0901001. PMC 2751297. PMID 17408232.
↑ ^5,0 ^5,1 Rothman, R. B.; Blough, BE; Woolverton, WL; Anderson, KG; Negus, SS; Mello, NK; Roth, BL; Baumann, MH (2005). „Development of a Rationally Designed, Low Abuse Potential, Biogenic Amine Releaser That Suppresses Cocaine Self-Administration”. Journal of Pharmacology and Experimental Therapeutics 313 (3): 1361–1369. DOI:10.1124/jpet.104.082503. PMID 15761112.
↑ Wee, S.; Anderson, KG; Baumann, MH; Rothman, RB; Blough, BE; Woolverton, WL (2004). „Relationship between the Serotonergic Activity and Reinforcing Effects of a Series of Amphetamine Analogs”. Journal of Pharmacology and Experimental Therapeutics 313 (2): 848–854. DOI:10.1124/jpet.104.080101. PMID 15677348.
↑ Mehes, G (1952). „On the pharmacological effects of 1-(alpha-naphthyl)-, and 1-(beta-naphthyl)-2-aminopropane; a contribution on the problem of chemical structure and effect”. Acta physiologica Hungarica 3 (1): 137–51. PMID 13050439.
↑ Glennon, RA; Young, R; Hauck, AE; McKenney, JD (1984). „Structure-activity studies on amphetamine analogs using drug discrimination methodology”. Pharmacology, Biochemistry, and Behavior 21 (6): 895–901. DOI:10.1016/S0091-3057(84)80071-4. PMID 6522418.
↑ Negus, S. S.; Mello, N. K.; Blough, B. E.; Baumann, M. H.; Rothman, R. B. (2006). „Monoamine Releasers with Varying Selectivity for Dopamine/Norepinephrine versus Serotonin Release as Candidate "Agonist" Medications for Cocaine Dependence: Studies in Assays of Cocaine Discrimination and Cocaine Self-Administration in Rhesus Monkeys”. Journal of Pharmacology and Experimental Therapeutics 320 (2): 627–636. DOI:10.1124/jpet.106.107383. PMID 17071819.

Povezano

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[pmid17408232-4] 4,0 ^4,1 ^4,2 Rothman, Richard B.; Blough, Bruce E.; Baumann, Michael H. (2007). „Dual dopamine/serotonin releasers as potential medications for stimulante and alcohol addictions”. The AAPS Journal 9 (1): E1–E10. DOI:10.1208/aapsj0901001. PMC 2751297. PMID 17408232.

[pmid15761112-5] 5,0 ^5,1 Rothman, R. B.; Blough, BE; Woolverton, WL; Anderson, KG; Negus, SS; Mello, NK; Roth, BL; Baumann, MH (2005). „Development of a Rationally Designed, Low Abuse Potential, Biogenic Amine Releaser That Suppresses Cocaine Self-Administration”. Journal of Pharmacology and Experimental Therapeutics 313 (3): 1361–1369. DOI:10.1124/jpet.104.082503. PMID 15761112.

[pmid15677348-6] Wee, S.; Anderson, KG; Baumann, MH; Rothman, RB; Blough, BE; Woolverton, WL (2004). „Relationship between the Serotonergic Activity and Reinforcing Effects of a Series of Amphetamine Analogs”. Journal of Pharmacology and Experimental Therapeutics 313 (2): 848–854. DOI:10.1124/jpet.104.080101. PMID 15677348.

[pmid13050439-7] Mehes, G (1952). „On the pharmacological effects of 1-(alpha-naphthyl)-, and 1-(beta-naphthyl)-2-aminopropane; a contribution on the problem of chemical structure and effect”. Acta physiologica Hungarica 3 (1): 137–51. PMID 13050439.

[pmid6522418-8] Glennon, RA; Young, R; Hauck, AE; McKenney, JD (1984). „Structure-activity studies on amphetamine analogs using drug discrimination methodology”. Pharmacology, Biochemistry, and Behavior 21 (6): 895–901. DOI:10.1016/S0091-3057(84)80071-4. PMID 6522418.

[pmid17071819-9] Negus, S. S.; Mello, N. K.; Blough, B. E.; Baumann, M. H.; Rothman, R. B. (2006). „Monoamine Releasers with Varying Selectivity for Dopamine/Norepinephrine versus Serotonin Release as Candidate "Agonist" Medications for Cocaine Dependence: Studies in Assays of Cocaine Discrimination and Cocaine Self-Administration in Rhesus Monkeys”. Journal of Pharmacology and Experimental Therapeutics 320 (2): 627–636. DOI:10.1124/jpet.106.107383. PMID 17071819.

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