Fentolamin

Fentolamin
(IUPAC) ime
	3-[(4,5-dihidro-1H-imidazol-2-ilmetil)(4-metilfenil)amino]fenol
Klinički podaci
Robne marke	Regitine
AHFS/Drugs.com	Mikromedeks, detaljne potrošačke informacije
Identifikatori
CAS broj	50-60-2
ATC kod	C04AB01 V03AB36
PubChem	5775
DrugBank	DB00692
ChemSpider	5571
UNII	Z468598HBV
KEGG	D08362
ChEMBL	CHEMBL597
Hemijski podaci
Formula	C17H19N3O
Mol. masa	281,352 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19) ; Key: MRBDMNSDAVCSSF-UHFFFAOYSA-N
Farmakokinetički podaci
Metabolizam	Hepatic
Poluvreme eliminacije	19 minuta
Farmakoinformacioni podaci
Trudnoća	?
Pravni status
Način primene	obično IV ili IM

Fentolamin (regitin) je reverzibilni^[6] neselektivni alfa-adrenergički antagonist.^[7]

Mehanizam

Njegovo primarno dejstvo je vazodilatacija putem α₁ blokade.^[8]

On takođe može da dovede do refleksne tahikardije zbog hipotenzije i α₂ inhibicije, čime se povišava simpatetički ton.^[9]

Hemija

Fentolamin, 2-[[N-(3′-hidroksifenil)-para-toluidion]metil]-2-imidazolin, se sintetiše putem alkilacije 3-(4-metilanilino)fenola koristeći 2-hlorometilimidazolin.^[10]^[11]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Jewell, John R.; Longworth, David L.; Stoller, James K.; Casey, David (2003). The Cleveland Clinic internal medicine case reviews. Hagerstown, MD: Lippincott Williams & Wilkins. str. 32. ISBN 0-7817-4266-8.
↑ MeSH Phentolamine
↑ Brock G. Oral phentolamine (Vasomax). Drugs Today (Barcelona). 2000 Feb-Mar;36(2-3):121-4.
↑ Shen, Howard (2008). Illustrated Pharmacology Memory Cards: PharMnemonics. Minireview. str. 14. ISBN 1-59541-101-1.
↑ K. Miescher, A. Marxer, E. Urech, U.S. Patent 2.503.059 (1950).
↑ E. Urech, A. Marxer, K. Miescher, Helv. Chim. Acta, 33, 1386 (1950).

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[isbn0-7817-4266-8-6] Jewell, John R.; Longworth, David L.; Stoller, James K.; Casey, David (2003). The Cleveland Clinic internal medicine case reviews. Hagerstown, MD: Lippincott Williams & Wilkins. str. 32. ISBN 0-7817-4266-8.

[7] MeSH Phentolamine

[8] Brock G. Oral phentolamine (Vasomax). Drugs Today (Barcelona). 2000 Feb-Mar;36(2-3):121-4.

[pharmnemonics-9] Shen, Howard (2008). Illustrated Pharmacology Memory Cards: PharMnemonics. Minireview. str. 14. ISBN 1-59541-101-1.

[10] K. Miescher, A. Marxer, E. Urech, U.S. Patent 2.503.059 (1950).

[11] E. Urech, A. Marxer, K. Miescher, Helv. Chim. Acta, 33, 1386 (1950).

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