FGD2
| edit |
| Protein 2 koji sadrži FYVE, RhoGEF i PH domene | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | FGD2; ZFYVE4 | ||||||||||
| Vanjski ID | OMIM: 605091 MGI: 1347084 HomoloGene: 8438 GeneCards: FGD2 Gene | ||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 221472 | 26382 | |||||||||
| Ensembl | ENSG00000146192 | ENSMUSG00000024013 | |||||||||
| UniProt | Q7Z6J4 | Q8BY35 | |||||||||
| Ref. Sekv. (iRNK) | NM_173558 | NM_001159538 | |||||||||
| Ref. Sekv. (protein) | NP_775829 | NP_001153010 | |||||||||
| Lokacija (UCSC) | Chr 6: 36.97 - 37 Mb | Chr 17: 29.36 - 29.38 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Protein 2 koji sadrži FYVE, RhoGEF i PH domene (FGD2), takođe poznat kao protein 4 koji sadrži zinkov prst FYVE doein (ZFYVE4), je protein koji je kod ljudi kodiran FGD2 genom.[1]
On je član familije proteina koji sadrže FYVE, RhoGEF i PH domene .
- Salehi AH, Xanthoudakis S, Barker PA (2002). „NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.”. J. Biol. Chem. 277 (50): 48043–50. DOI:10.1074/jbc.M205324200. PMID 12376548.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). „The DNA sequence and analysis of human chromosome 6.”. Nature 425 (6960): 805–11. DOI:10.1038/nature02055. PMID 14574404.
- Hattori A, Okumura K, Nagase T, et al. (2000). „Characterization of long cDNA clones from human adult spleen.”. DNA Res. 7 (6): 357–66. DOI:10.1093/dnares/7.6.357. PMID 11214971.
- Pasteris NG, Gorski JL (1999). „Isolation, characterization, and mapping of the mouse and human Fgd2 genes, faciogenital dysplasia (FGD1; Aarskog syndrome) gene homologues.”. Genomics 60 (1): 57–66. DOI:10.1006/geno.1999.5903. PMID 10458911.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Harrington AW, Kim JY, Yoon SO (2002). „Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.”. J. Neurosci. 22 (1): 156–66. PMID 11756498.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Rabizadeh S, Bredesen DE (2003). „Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).”. Cytokine Growth Factor Rev. 14 (3-4): 225–39. DOI:10.1016/S1359-6101(03)00018-2. PMID 12787561.
- Huber C, MÃ¥rtensson A, Bokoch GM, et al. (2008). „FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles.”. J. Biol. Chem. 283 (49): 34002–12. DOI:10.1074/jbc.M803957200. PMC 2590680. PMID 18838382.
- Delague V, Jacquier A, Hamadouche T, et al. (2007). „Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H.”. Am. J. Hum. Genet. 81 (1): 1–16. DOI:10.1086/518428. PMC 1950914. PMID 17564959.