Find Reactions, Proteins and Pathways
Pathway Browser
Visualize and interact with Reactome biological pathways
Analysis Tools
Merges pathway identifier mapping,
over-representation, and expression analysis
ReactomeFIViz
Designed to find pathways and network patterns related to cancer and other types of diseases
Documentation
Information to browse the database and use its principal tools for data analysis
Reactome Research Spotlight
[March 1, 2025] In the January 2025 issue of Frontiers in Genetics, Jensen et al. explored the relationship between DNA methylation patterns and adolescent brain development. By analyzing a cohort of adolescents aged 9 to 14, they identified co-methylation networks linked to cognitive improvements and structural brain changes. Pathway analysis using Reactome revealed that these networks are enriched in neuronal-related pathways, suggesting that epigenetic modifications play a significant role in the maturation of the adolescent brain.
Why Reactome
Reactome is a free, open-source, curated and peer-reviewed pathway database. Our goal is to provide intuitive bioinformatics tools for the visualization, interpretation and analysis of pathway knowledge to support basic research, genome analysis, modeling, systems biology and education.
The development of Reactome is supported by grants from the US National Institutes of Health (U24 HG012198) and the European Molecular Biology Laboratory.
Version 91 released on December 4, 2024
2,751
Human Pathways
15,591
Reactions
11,541
Proteins
2,125
Small Molecules
1,057
Drugs
39,806
Literature References
