New and Updated Topics and Pathways. In V85, Topics with new or revised pathways include Developmental Biology (Cardiogenesis, Formation of intermediate mesoderm, Formation of paraxial mesoderm, Somitogenesis, Specification of primordial germ cells ), Cell-Cell communication (Regulation of Expression and Function of Type II Classical Cadherins, Regulation of CDH11 Expression and Function, and Regulation of CDH19 Expression and Function), Cellular responses to stimuli (ATF6B (ATF6-beta) activates chaperones), Immune System (IFNG signaling activates MAPKs and Interferon gamma signaling), and Metabolism (Fructose biosynthesis and Fructose catabolism).  

New and Updated Illustrations.  New or revised Illustrations with embedded navigation features have been created for  Developmental Biology, Gastrulation, and Reproduction.

Thanks to our Contributors.   Ravindra Chalamalasetty and Terry Yamaguchi are our external authors.  Julia Brasch, Ravindra Chalamalasetty, David Hill, Patrick Tam,  and Terry  Yamaguchi are our external reviewers.

Annotation Statistics. Reactome comprises  14,628 human reactions organized into 2,629   pathways involving 30,155  proteins and modified forms of proteins encoded by 11,396 different human genes,  14,277 complexes, 2,004 small molecules, and 1,114 drugs. These annotations are supported by 36,706 literature references. We have projected these reactions onto 84,167 orthologous proteins, creating 19,505 orthologous pathways in 14 non-human species. Version 85 has annotations for 4,919 protein variants (mutated proteins) and their post-translationally modified forms, derived from 354  proteins, which have contributed to the annotation of 1,659 disease-specific reactions and 707 pathways. 

Tools and Data. Our services and software tools are designed for biologists, bioinformaticians, and software developers. Pathway data is available to view in our Pathway Browser, to analyze your own dataset, to download, and access programmatically through our Content and Analysis Services. The ReactomeFIViz app and ReactomeGSA package provide tools for multi-omics data analysis. The idg.reactome.org Web Portal provides a collection of web-based tools to help researchers place understudied proteins in a pathway context. 

Documentation and Training. Visit our online User Guide to access documentation supporting pathway analysis of experimental data. The Developer's Zone provides detailed documentation regarding our software, tools, and web services. Training and learning materials can be found here.

About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The EMBL - European Bioinformatics Institute. Reactome is an ELIXIR Core Data Resource as well as a Global Core Biodata Resource. Reactome annotation files and interaction data derived from Reactome are distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence. A Creative Commons Attribution 4.0 International (CC BY 4.0) Licence applies to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials. A full description of the new and updated content is available on the Reactome website.

Follow us on Twitter: @reactome to get frequent updates about new and updated pathways, feature updates, and more!

For more information: If you have a question, want to provide feedback, or are interested in collaborating with us to annotate a topic, please contact us at This email address is being protected from spambots. You need JavaScript enabled to view it..