The following article lists the characters in Nickelodeon/DreamWorks' The Modifyers and its film adaptation.
Main[]
Primary[]
- Mina Lynne Sparkles / Agent Xero (voiced by Mae Whitman) - a happy-go-lucky, naive and friendly teenage Modifyer agent who heads out for peril and adventure. It is known that her parents disappeared sometime before the series' start, although The Modifyers Movie reveals Xero's unnamed father was a Modifyer agent who was killed by Vain.
- Mole (voiced by Jeff Bennett) - Xero's shapeshifting robotic assistant who helps her with her missions by using his powers to aid her. He is usually the straight man to Xero's childish nature and crazy ideas.
Secondary[]
- Starlight (vocal effects also by Mae Whitman) - Xero's pet cat who occasionally follows her in her missions.
- Sparko (vocal effects by Dee Bradley Baker) - Xero's playful pet dog who occasionally follows her in her missions.
- Nigel Barbera / Agent Dos (voiced by James Arnold Taylor) - a funny Modifyer agent who is Xero's cousin and occasionally helps her with her missions as well as giving some advice to her.
- Carrie Germain / Agent TBD (voiced by Ashley Johnson) - one of Xero's best friends who is a Modifyer agent as well and often aids her whenever she needs extra help.
- Kenny Tartakovsky / Agent TBD (voiced by Tom Kenny) - a geeky Modifyers scientist and agent who is Dr. Tartakovsky's son and Mole's co-creator and provides Xero with several gadgets and disguises, even though she uses some of the gadgets for personal needs, and occasionally follows her and Mole in missions.
- Megawatt (voiced by John Leguizamo) - TBD
- Lucy Carlson / Agent TBD (voiced by Tara Strong) - Xero's self-absorbed friendly rival who sometimes competes with her to become the best agent around the Modifyers as she often prefers to work by herself, but there are times where they team up and work together, having a love-hate relationship as they usually hang on with the rest of the main agents.
- Marc Forward / Agent TBD (voiced by Kyle Kaplan) - TBD
- Charlotte Springer / Agent TBD (voiced by Raven-Symoné) - TBD
- Argle Smith / Agent TBD (voiced by David Kaufman) - TBD
- Cathy Wiseman / Agent TBD (voiced by TBD) - TBD
- Tom Watterson / Agent TBD (voiced by Hank Azaria) - TBD
- Alex Molotova / Agent TBD (voiced by Christy Carlson Romano) - TBD
- Earl Murray / Agent TBD (voiced by Will Friedle) - TBD
- Suzy Jones / Agent TBD (voiced by TBD) - TBD
- Adam McPines / Agent TBD (voiced by TBD) - TBD
- Kate Walters / Agent TBD (voiced by TBD) - TBD
Supporting[]
- Katz (voiced by Paul Rugg) - the charismatic head of the Modifyers who assigns Xero and Mole with their missions.
- Blake "Black" Weaselo (also voiced by John Leguizamo) - a goofy weasel who serves as Katz's assistant. He is good friends with Xero and Mole.
- Dr. William Tartakovsky (voiced by Billy West) - the lead scientist and gadget inventor on the Modifyers who is the main one supplying Agent Xero and other agents within the Modifyers with various gadgets, and is the father/co-creator of Mole along with his son Kenny.
- Mikey the Blue Ghost (voiced by Bill Fagerbakke) - TBD
- Kathy (voiced by Nika Futterman) - a friendly merchant who sells special goods to Xero and Mole like food and drinks.
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- Dr. Verzilla (voiced by TBD) - a crocodile and Xero's dentist. TBD
- Denta (voiced by Jesica DiCicco) - a lizard and Dr. Verzilla's assistant.
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Antagonists[]
- Baron Vain (also voiced by Paul Rugg) - a clumsy and idiotic wannabe supervillain and the series' main antagonist who aims to rule over the entire world, but his plans are always foiled by Xero and Mole.
- Rat (also voiced by Jeff Bennett) - Baron Vain's insane henchman who is rather stupid and often TBD.
- Gatodile (voiced by Thomas F. Wilson) - TBD
- Roach (voiced by Doug Lawrence) - TBD
- Frog and Toad (also voiced by Grey DeLisle and Hank Azaria) - TBD
- Snake (voiced by Jim Cummings) - a beatnik snake with arms.
- Mr. Hyde (voiced by Stephen Hillenburg) - TBD
- The McKimsons - a family of thieves who are usually sent by Vain to either rob banks or steal heists for his next plan, though Xero and Mole frequently outsmart them and put them in jail.
- Stanford McKimson (also voiced by Tom Kenny) - TBD
- Marie McKimson (voiced by Jill Talley) - TBD
- Jack McKimson (voiced by Seth Green) - TBD
- Nelly McKimson (also voiced by Tara Strong) - TBD
- TBD McKimson - the McKimsons' baby son.
- Laura the Adventurer (also voiced by Grey DeLisle) - an energetic "little" girl who is actually a forty-year-old hungry for every food she finds.
- Haggie (voiced by Wendie Malick) - a TBD witch who TBD.
- Satan (vocal effects by Frank Welker) - Haggie's pet cat.
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- B.A.D. - a crime organization of anthropomorphic mammals; consisting of:
- Dr. Dogz P. Bulldog (voiced by Travis Willingham) - an anthropomorphic bulldog and the vicious yet childish head of B.A.D. who TBD.
- One Weaseltte (voiced by Lacey Chabert) - an anthropomorphic weasel and B.A.D.'s self-absorbed head agent who is the stereotypical femme fatale and TBD.
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- Wolfa (voiced by Courtenay Taylor) - a sadistic anthropomorphic wolf criminal who TBD.
- Charlotte Rogue (also voiced by Mae Whitman) - one of Xero's disguises who has split into Wolfa's seductive and dimwitted henchgirl and TBD.
- Madame Taxidermy (voiced by Susanne Blakeslee) - TBD
- Maximus the Rough (voiced by John DiMaggio) - a stupid warlord who aims for take over the world, even though he doesn't know how to be a ruler.
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- Dr. Maniacal (voiced by Carlos Alazraqui) - a mad scientist who TBD. Like Rat, he likes to reveal secrets, but he's even crazier. He's a parody of Dr. Evil from the Austin Powers film series and his design was also based on Erk from Imp, Inc., a pilot Chris Reccardi originally pitched to Cartoon Network with Charlie Bean.
- Kat and Wayne (voiced by Kath Soucie and Jim Cummings) - a married couple of criminals whose goal is to trap innocent citizens in prison cubes. They are a parody of Jessie and James from Pokémon.
- The Pastry Gang - TBD. They later got their own spin-off series on Drio in 2022 due to their popularity among fans; consisting of:
- Filo Rotunde III (voiced by Clancy Brown) - a hippopotamus who is the owner of the Rotunde Bakery, and leader of the Pastry Gang who plots to take over the world but is always defeated by Xero and Mole.
- Zephyrus Sugarcoat - TBD
- Snatch Syrup (also voiced by Bill Fagerbakke) - TBD
- Marzipan "Scratch" Mousse (also voiced by Tom Kenny) - TBD
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One-time[]
- Jonah Knockout (voiced by Nolan North) - a tough actor who is known for his rather narcissistic TBD.
- Sylvianne Barnier (voiced by Hynden Walch) - a greedy French-accented fashion designer who has perfected a line of clothes that act on their own to become rich.
- Countess Elizabeth (voiced by Cassandra Lee Morris) - a TBD vampire who leads an army of vampires to turn the world she lives into a TBD.
- Maximilien Timebomb (voiced by Rob Paulsen) - a geeky unemployed nerd who created a massive computer virus to cause TBD.
- Mr. E (voiced by Kevin Michael Richardson) - a TBD former military officer who commands TBD.
- Computus (voiced by Jim Meskimen) - a TBD android who TBD.
- Overshadow (voiced by Tim Curry) - TBD
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Film-exclusive[]
Minor[]
- Johns Bomb (voiced by Daniel Craig) - Xero's favorite movie spy hero TBD. He is a parody of James Bound.
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- Xero's missing parents - TBD
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- Santa Claus (voiced by Kenneth Mars, later voiced by Jim Cummings) - TBD
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Xero's disguises[]
Recurring[]
- Lacey Shadows - Baron Vain's tomboyish and competent henchgirl who is willing to steal and kill for Vain, and frequently taunts all of Vain's other henchmen. Most of Vain's henchmen (such as Rat, Snake, and Haggie) know that she is actually Xero in disguise, but Vain does not believe them due to his extreme idiocy. She is one of Xero's most recurring disguises although she is only used in most episodes featuring Vain.
- Greta Undge - a rough rock star who is known for her rather rebellious attitude and her massive stardom status.
- Princess Renée Lee - a beautiful princess who rules the non-existing distant land of Opius and TBD.
- Hilda Bee - a cool hippie who often gets into TBD.
- Ava Wright - a fearless aviator who TBD.
- Annie Rockins - a fancy British maid who works as a nanny to anyone who needs TBD.
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- Sailor Cure - a TBD magical girl who TBD.
- Captain Wonder - a Batgirl-esque superheroine who saves people from criminals with her several gadgets.
- Charlotte Rogue (formerly) - a seductive yet dimwitted criminal who serves Wolfa and is more cowardly than her boss, later splitting off from Xero and becoming her own person.
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