Activating transcription factor 4 (Q21102119)

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mammalian protein found in Homo sapiens
  • tax-responsive enhancer element B67
  • cAMP-dependent transcription factor ATF-4
  • DNA-binding protein TAXREB67
  • cyclic AMP-responsive element-binding protein 2
  • cAMP response element-binding protein 2
  • CREB-2
  • cAMP-responsive element-binding protein 2
  • cyclic AMP-dependent transcription factor ATF-4
  • tax-responsive enhancer element-binding protein 67
  • ATF4
  • TaxREB67
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    English
    Activating transcription factor 4
    mammalian protein found in Homo sapiens
    • tax-responsive enhancer element B67
    • cAMP-dependent transcription factor ATF-4
    • DNA-binding protein TAXREB67
    • cyclic AMP-responsive element-binding protein 2
    • cAMP response element-binding protein 2
    • CREB-2
    • cAMP-responsive element-binding protein 2
    • cyclic AMP-dependent transcription factor ATF-4
    • tax-responsive enhancer element-binding protein 67
    • ATF4
    • TaxREB67

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    26 references
    retrieved
    3 January 2017
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q96AQ3
    determination method or standard
    IPI
    retrieved
    3 January 2017
    stated in
    Towards a proteome-scale map of the human protein–protein interaction network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q96AQ3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene
    GOA
    curator
    UniProt
    UniProt protein ID
    P18848
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia
    GOA
    curator
    UniProt
    UniProt protein ID
    P18848
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mitosin/CENP-F as a negative regulator of activating transcription factor-4
    GOA
    curator
    UniProt
    UniProt protein ID
    P18848
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A human protein-protein interaction network: a resource for annotating the proteome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ZIP Kinase, a Novel Serine/Threonine Kinase Which Mediates Apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Involvement of Nrf2 in proteasome inhibition-mediated induction of ORP150 in thyroid cancer cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Towards a proteome-scale map of the human protein–protein interaction network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Widespread macromolecular interaction perturbations in human genetic disorders
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A human MAP kinase interactome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4)
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Toward an understanding of the protein interaction network of the human liver
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Construction and characterization of a normalized yeast two-hybrid library derived from a human protein-coding clone collection
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Shifted Transversal Design smart-pooling for high coverage interactome mapping
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IPI
    DNA-binding transcription factor activity, RNA polymerase II-specific
    determination method or standard
    IC
    IDA
    ISA
    ISM
    NAS
    6 references
    retrieved
    5 June 2018
    stated in
    A census of human transcription factors: function, expression and evolution
    GOA
    curator
    Norwegian University of Science and Technology, Systems Biology team
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
    determination method or standard
    NAS
    retrieved
    5 June 2018
    stated in
    A census of human transcription factors: function, expression and evolution
    GOA
    curator
    Norwegian University of Science and Technology, Systems Biology team
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
    determination method or standard
    ISM
    retrieved
    5 June 2018
    stated in
    GOA
    curator
    Norwegian University of Science and Technology, Systems Biology team
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
    determination method or standard
    ISA
    retrieved
    5 June 2018
    stated in
    Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
    determination method or standard
    IDA
    retrieved
    5 June 2018
    stated in
    The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
    determination method or standard
    IDA
    retrieved
    5 June 2018
    stated in
    Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
    determination method or standard
    IC
    DNA-binding transcription factor activity, RNA polymerase II-specific
    determination method or standard
    IBA
    IDA
    IEA
    ISA
    ISM
    NAS
    7 references
    retrieved
    8 April 2019
    stated in
    A census of human transcription factors: function, expression and evolution
    GOA
    curator
    Norwegian University of Science and Technology, Systems Biology team
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    NAS
    retrieved
    8 April 2019
    stated in
    A census of human transcription factors: function, expression and evolution
    GOA
    curator
    Norwegian University of Science and Technology, Systems Biology team
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    ISM
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Norwegian University of Science and Technology, Systems Biology team
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    ISA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IBA
    cell component
    nucleus
    determination method or standard
    IEA
    ISS
    IDA
    7 references
    retrieved
    5 June 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P18848
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
    determination method or standard
    ISS
    retrieved
    5 June 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P18848
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
    determination method or standard
    IEA
    retrieved
    5 June 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
    determination method or standard
    IEA
    retrieved
    5 June 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
    determination method or standard
    IEA
    retrieved
    5 June 2018
    stated in
    ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
    determination method or standard
    IDA
    retrieved
    5 June 2018
    stated in
    The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
    determination method or standard
    IDA
    retrieved
    5 June 2018
    stated in
    The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
    determination method or standard
    IDA
    nucleus
    determination method or standard
    IBA
    IDA
    IEA
    ISS
    8 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P18848
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    ISS
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P18848
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IBA
    biological process
    positive regulation of transcription by RNA polymerase II
    determination method or standard
    IEA
    ISS
    IDA
    IMP
    6 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P18848
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    ISS
    retrieved
    8 April 2019
    stated in
    The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism
    GOA
    curator
    UniProt
    UniProt protein ID
    P18848
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IDA
    positive regulation of transcription, DNA-templated
    determination method or standard
    IEA
    ISS
    IMP
    IDA
    NAS
    6 references
    retrieved
    8 April 2019
    stated in
    Functional interaction of the HTLV-1 transactivator Tax with activating transcription factor-4 (ATF4)
    GOA
    curator
    UniProt
    UniProt protein ID
    P18848
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    NAS
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P18848
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    ISS
    retrieved
    8 April 2019
    stated in
    ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene
    GOA
    curator
    UniProt
    UniProt protein ID
    P18848
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
    GOA
    curator
    UniProt
    UniProt protein ID
    P18848
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene
    GOA
    curator
    UniProt
    UniProt protein ID
    P18848
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
    determination method or standard
    IDA

    Identifiers

    Freebase ID
    /m/03cwkv6
    0 references
     
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