Genomic and epidemiologic data suggest that the rapid spread of MPox Clade I in the Democratic Republic of the Congo has happened mostly through sexual contact within densely populated areas.

A modeling study highlights the benefits of a global aircraft-based wastewater surveillance network, but the best early warning system is likely to involve a combination of methodologies within an integrated, end-to-end bioinformatics pipeline.

The global south should become self-reliant by investing in health.

The MI-CLAIM checklist has been revised to take account of new capabilities of large language models and other generative artificial intelligence tools.

In a randomized controlled trial in individuals with persistent atrial fibrillation, an individualized ablation procedure, in which areas with abnormal electrophysiological characteristics—as detected by an AI algorithm—were targeted for ablation, led to improved efficacy for reducing arrhythmia recurrence at 12 months following the ablation procedure.

By simulating the implementation of airport-based wastewater surveillance sites at the global level, a modeling study shows how this early warning system would perform in identifying sources of pandemic outbreaks, in time and space, and what the optimal location of monitoring sites would be.

Using 1,854 routinely collected clinical samples from early in pregnancy, with validation in an external cohort, low-coverage cfDNA sequence data identified distinctive features among those who developed preeclampsia.

Genomic and epidemiologic data suggest that the rapid spread of MPox Clade I in the Democratic Republic of the Congo has happened mostly through sexual contact within densely populated areas.

Two new phosphorylation sites, p-tau₂₆₂ and p-tau₃₅₆, detect the formation of prefibrillar tau aggregates and may serve as early-stage biofluid-based biomarkers of tau neurofibrillary tangle pathology in Alzheimer’s disease.

Epigenetic editing of PCSK9 in the liver, designed to induce DNA methylation and silence gene expression, achieved long-lasting reductions in LDL cholesterol levels in both transgenic mice expressing the human PCSK9 gene and cynomolgus monkeys.

Genomic medicine is not just for the wealthy elite, it is for everyone.

A diet ‘restoration’ strategy that mimics non-industrialized dietary habits showed beneficial effects on the gut microbiome that were predictive of cardiometabolic benefits.

Radionuclide therapies can target and treat several cancer types, spurring growing interest from pharma.

The global south should become self-reliant by investing in health.

Rusty Gage describes how evidence for neurogenesis in the adult human hippocampus shaped our understanding of learning, memory and mental health.