Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
This review highlights the cellular and molecular mechanisms in which ROS are involved in normal wound healing and chronic wound pathogenesis, as well as recent advances in therapeutic methods.
Gram-negative bacteria envelope controls drug accumulation via passive influx and active efflux mechanisms. This article discusses recent in cellulo, in vitro, and in silico methods highlighting key “drug-transporters†dialogues and proposes new perspectives to overcome drug resistance.
A review summarizes the recent advances in ferroptosis and tumor suppression, including the metabolic regulation of lipid peroxidation, the role of ferroptosis in tumor immunity response, and ferroptosis-based tumor therapeutics and clinical trials.
A review summarizes the effects of abiotic (ionizing radiation, altered gravity, geomagnetic field, pressure, and light conditions) and both beneficial and pathogenic biotic space-related factors on plant physiology.
For amphibians, a taxon characterized by small distributions, microreserves can contain similar amphibian species richness and augment the coverage of amphibian diversity by a growing reserve network more rapidly when compared to larger reserves.
This perspective explores the dual role of the tumor suppressor BAP1 in placental development and cancer. By integrating insights from tumor and developmental biology, the study offers new therapeutic targets for pregnancy disorders and cancer.
A new neurodevelopmental perspective of temporal processing aiming to untangle the puzzling trajectory of temporal processing’s aspects throughout the lifetime.
Ichthyosporea are unicellular eukaryotes crucial for understanding animal origins and evolution. This Review outlines the history and recent advancements in ichthyosporean biology, genomics, and genetics, and provides insight into their environmental diversity.
This perspective describes how insects, such as Hermetia illucens, which are already used to process organic wastes at industrial scales, could be developed as a synthetic biology platform for sustainable biomanufacturing and bioremediation.
This Perspective discusses DNA-loop extrusion generated by SMC. The model details how the “DNA baton†is transferred from the hinge domain to a DNA pocket through anisotropic hinge motion, ensuring loop stability and providing insights into the dynamic process of DNA-loop extrusion.
Authors discuss big bottlenecks that inhibit vascular regeneration in the disease context of aortic aneurysm, stroke, and peripheral artery disease, along with emerging opportunities to overcome these challenges.
This perspective highlights the limitations of empirically evaluating causal gene discovery methods in the absence of completely labeled reference gene sets. It shows that sensitivity, specificity, and AUC may be critically biased, and advocate for increased reliance on probabilistic modeling.
Mammalian reproduction hinges on maternal-fetal communication mediated by extracellular vesicles. Their role in diagnostics and therapeutics shows promise, but questions about uptake, cargo delivery, and specific biomolecules remain.
A Mini Review summarizing the current understanding of epithelial-mesenchymal transition (EMT) and 3D genome organization, focusing on the role of chromatin conformation and accessibility changes during the transitional phases of EMT.
This perspective discusses five conservation challenges using a landscape in Ethiopia as the lens, exploring a story on how the ecology and evolution of coffee shape biodiversity conservation can inspire to view other landscapes with fresh eyes.
This article explores novel routes to better analyze neural processes underlying the brain’s adaptability and cognitive functioning, focusing on executive functions and cognitive control. It delves into the concept of “metacontrolâ€, proposing a dynamic balance of processes based on situational demands, and discusses the role of different concepts of neural dynamics in supporting adaptive behavior and understanding psychiatric disorders.
This review discusses recent advances demonstrating the role of replication stress as an ultimate driver of cellular senescence and aging, highlighting connections to hallmarks of aging, hereditary accelerated aging disorders, and senotherapeutics.
A review synthesizes interplays between photoperiodism and circadian regulation of the vegetative to reproductive transition in Arabidopsis and crops in responses to changing day lengths that ensures optimal timing for flowering and seed production.
