Extended Data Fig. 7: Kaplan-Meier survival curves for full dataset and subgroups stratified by drusen stage and presence of HRF.

a, A Kaplan-Meier survival curve for fellow eye conversion to exAMD from baseline (defined as the first presentation of first eye conversion) in number of months, showing a little over 40% of patients converted during over 6 years of available follow up. The table shows number of eyes remaining at risk per month. b, The same plot for comparison with following plots. (c–g) Plots for varying amounts of drusen, showing increasing numbers of patient convert as drusen volume increases. Drusen size categories are calculated as quartiles. The same plots are shown for patients h, without and i, with geographic atrophy (GA), those j, without and k, with hyper-reflective foci (HRF), and those l, without and m, with fibrovascular pigment epithelial detachment (PED). In all plots the timeline is with reference to the first incidence of the feature in the eye.