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      CancerTreatmentBrain TumorGlioma
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      Cognitive ScienceBrainGliomaCancer Therapy
Objective: To analyze the 3-dimensional relationships of the inferior fronto-occipital fasciculus (IFOF) within the temporal stem using anatomic dissection and to study the surgical application. Methods: Ten postmortem human hemispheres... more
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      SurgeryNeurosurgeryLanguageTemporal Lobe
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      Computed TomographyClinical TrialMagnetic Resonance ImagingDrug delivery
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      AdolescentGliomaClinical SciencesAged
Over 80% of diffuse intrinsic pontine gliomas (DIPGs) harbor a point mutation in histone H3.3 where lysine 27 is substituted with methionine (H3.3K27M); however, how the mutation affects kinetics and function of PcG proteins remains... more
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      MultidisciplinaryMutationGliomaMice
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      Magnetic Resonance ImagingAdolescentNeuro-OncologyChild
The pathological classification of gliomas constitutes a critical step of the clinical management of patients, yet it is frequently challenging. To assess the relationship between genetic abnormalities and clinicopathological... more
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      CancerSurvival AnalysisMultivariate AnalysisGlioma
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      Nonparametric StatisticsStatistical AnalysisNuclear medicineQuantitative analysis
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      Clinical TrialClinical NeurosciencePhotodynamic TherapyGlioma
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      GliomaClinical SciencesAgedAdverse Event
Among brain tumors, gliomas are the most common and aggressive, leading to a very short life expectancy in their highest grade. Thus, treatment planning is a key stage to improve the quality of life of oncological patients. Magnetic... more
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      EngineeringImage ProcessingMachine LearningMagnetic Resonance Imaging
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      Cognitive ScienceChemistryCatalysisCalcium
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      Risk assessmentAdolescentLogistic RegressionSweden
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      Wound HealingGliomaMathematical ModelSpectrum
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      AdolescentGliomaPolymerase Chain ReactionClinical Sciences
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      Clinical TrialAdolescentPositron Emission TomographyProspective studies
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      Flow CytometryMitochondriaApoptosisEssential Oil
The current understanding of glioma biology reveals targets for anti-invasive therapy which include manipulations of extracellular matrix and receptors, growth factors and cytokines, proteases, cytoskeletal components, oncogenes and tumor... more
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      Comparative GenomicsForecastingExtracellular MatrixCytoskeleton
Primary low-grade gliomas are common brain tumors of childhood, many of which require radiation therapy (RT) as definitive treatment. Increased conformality of RT could decrease the incidence and severity of late effects. We report our... more
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      IntelligenceCognitionTreatment OutcomeAdolescent
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      AlgorithmsBiomedical EngineeringConfocal MicroscopyComputer Simulation
Chemokines have been involved in cellular processes associated to malignant transformation such as proliferation, migration and angiogenesis. The expression of five CXC chemokine receptors and their main ligands was analysed by RT-PCR in... more
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      NeurochemistryCell MigrationImmunohistochemistryCell Culture
OBJECT Cervicomedullary tumors (CMTs) represent a heterogeneous group of intrinsic neoplasms that are typically low grade and generally carry a good prognosis. This single-institution study was undertaken to document the outcomes and... more
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      Treatment OutcomeAdolescentBiopsyDecision Trees
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      Cognitive ScienceKineticsGene expressionBrain
The identification of signaling pathways that are involved in gliomagenesis is crucial for targeted therapy design. In this study we assessed the biological and therapeutic effect of ingenol-3-dodecanoate (IngC) on glioma. IngC exhibited... more
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      Organic ChemistryMedicinal PlantsGliomaAnticancer Drugs
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      Clinical NeuroscienceTreatment OutcomeGliomaFollow-up studies
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      NeuroscienceHealth SciencesMedical SciencesNeurosurgery
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      Statistical AnalysisMagnetic Resonance ImagingMagnetic Resonance SpectroscopyAdolescent
Add to CiteULike Add to Complore Add to Connotea Add to Del.icio.us Add to Digg Add to Facebook Add to Reddit Add to Technorati Add to Twitter What's this? ... From the Odette Cancer Centre and Sunnybrook Health Sciences Centre;... more
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      Treatment OutcomeCanadaProspective studiesGlioma
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      NeurochemistryDexamethasoneCell DifferentiationGlioma
Cognitive function, with survival and response on brain imaging, is increasingly regarded as an important outcome measure in patients with brain tumours. This measure provides us with information on a patient's clinical situation and... more
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      Brain ImagingRadiotherapyBrainGlioma
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      FaceGliomaAnti-inflammatory agentsClinical Sciences
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      Cell DivisionBrain TumorComputer SimulationGlioma
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      BiochemistryAnalytical ChemistryKineticsMicrocirculation
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      Stem CellsCell CycleImmunohistochemistryStem Cell
As a group, children with low-grade gliomas (LGGs) enjoy a high rate of long-term survival and do not require the intensity of neurotoxic treatments used with higher risk pediatric brain tumors. Because they are generally considered to... more
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      AdolescentChildGliomaSurvivors
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      Evidence Based MedicineSurvival AnalysisRisk assessmentEurope
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      Clinical TrialClinical NeuroscienceEnzyme InhibitorsGlioma
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      Cognitive ScienceMagnetic Resonance ImagingMovement disordersGlioma
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      Analytical ChemistryInorganic ChemistryOrganic ChemistryMedicinal Chemistry
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      Cancer ResearchApoptosisMedicineGlioma
Cancers are one of the leading causes of morbidity and mortality worldwide, accounting for 8.8 million deaths in 2015 [1, 2]. In the US, it is estimated that 1,688,780 new cancers will be diagnosed in 2017 [3] and 600,920 people will die... more
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      PharmacologyPharmacyCancerCancer Biology
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      EngineeringMagnetic Resonance ImagingDiffusion Tensor ImagingMedulloblastoma
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      Organic ChemistryCell CycleCell DivisionCell line
INTRODUCTION: Treatment recommendations for newly diagnosed anaplastic oligodendroglioma (AO) or oligo-astrocytoma (AOA) vary widely. We sought to describe actual treatment over 3 decades and explore clinical correlates of administered... more
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      ChemotherapyBrain cancerGliomaCerebral Gliomas
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      TechnologyStem CellsFlow CytometryCell Migration
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      Organic ChemistryMultiple sclerosisGliomaNeuropathic pain
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      Complementary and Alternative MedicinePlant BiologyApoptosisPhytotherapy
Grade II and III gliomas are generally slowly progressing brain cancers, many of which eventually transform into more aggressive tumors. Despite recent findings of frequent mutations in IDH1 and other genes, knowledge about their... more
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      Biological SciencesMutationGliomaGenetic Association Studies