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      Drug deliveryPhotodynamic TherapyCell lineEndocytosis
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      Fluorescence MicroscopyMembrane ProteinsMitochondriaNeurospora crassa
Perforated whole-cell patch-clamp recordings obtained with nystatin are frequently used to preserve intracellular integrity. However, the perforated-patch configuration may sometimes undergo a spontaneous change into the conventional... more
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      PhysiologyFluorescent Dyes and ReagentsPatch-clamp and imaging techniquesCell line
Mutations in human mitochondrial DNA (mtDNA) can cause mitochondrial disease and have been associated with neurodegenerative disorders, cancer, diabetes and aging. Yet our progress toward delineating the precise contributions of mtDNA... more
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Chronic opioid receptor (OR) activation by morphine causes distinct cellular adaptations responsible for the development of tolerance. The present study examines the effect of chronic morphine exposure on the ability of high-efficacy... more
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      Enzyme InhibitorsCell lineKidneyMice
A continuous-time model that incorporates several key elements in tumor dynamics is analyzed. More precisely, the form of proliferating and quiescent cell lines comes out from their relations with the whole tumor mass, giving rise to a... more
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      Cell CycleApoptosisSignal TransductionMitosis
We have analyzed cell cycle parameters for the Aedes albopictus C7-10 mosquito cell line, which has been systematically developed for somatic cell genetics, expression of transfected genes, and synthesis of hormone-inducible proteins. In... more
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      GeneticsZoologyKineticsFlow Cytometry
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      KineticsGene expressionMultidisciplinaryCell line
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      Molecular BiologyEnvironmental HealthMolecular GeneticsGene expression
OBJECTIVE: TSH receptor (TSHr) mediates the activating action of TSH on the thyroid gland resulting in the growth and proliferation of thyrocytes and thyroid hormone production. TSHr is a major autoantigen in…
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      Cell lineThyroid glandcyclic AMPClinical Sciences
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Aims/hypothesis We evaluated the insulinotropic and antihyperglycaemic actions of glucokinase activators (GKAs), especially through acute and subchronic studies in rodent diabetes models with... more
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      KineticsCryopreservationCell lineBlood Glucose
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      EMElectron TomographyMitochondriaConfocal Microscopy
Troxacitabine (Troxatyl; BCH-4556; (-)-2'-deoxy-3'-oxacytidine), a deoxycytidine analogue with an unusual dioxolane structure and nonnatural L-configuration, has potent antitumor activity in animal models and is in clinical... more
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Tumors evade host immunity at both the induction and effector phases. Most studies have focused on tumor evasion at the induction phase, and, due in part to poor antitumor CTL responses to most tumors, the mech- anism for evasion of CTL... more
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Methodology was developed for quantifying the photocytotoxicity of fluoranthene to a gill cell line from rainbow trout for future use in screening polycyclic aromatic hydrocarbons for their relative photocytotoxicity to fish.... more
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We hypothesize that estrogen receptors (ERs) are differentially expressed in endometrial cancer. To test this hypothesis, we investigated the expression profile of ERalpha (ERalpha-A, ERalpha-B, ERalpha-C) and ERbeta genes and CpG... more
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